Tec

Summary

Gene Symbol: Tec
Description: tec protein tyrosine kinase
Alias: tyrosine-protein kinase Tec, cytoplasmic tyrosine kinase, Dscr28C related, protein tyrosine kinase TecI, protein tyrosine kinase TecIIA, protein tyrosine kinase TecIIB, protein tyrosine kinase TecIII, protein tyrosine kinase TecIV
Species: mouse
Products:     Tec

Top Publications

  1. Mano H, Ishikawa F, Nishida J, Hirai H, Takaku F. A novel protein-tyrosine kinase, tec, is preferentially expressed in liver. Oncogene. 1990;5:1781-6 pubmed
    ..Using low stringency screening, we could isolate cDNAs of a putative protein-tyrosine kinase, tec (tyrosine kinase expressed in hepatocellular carcinoma)...
  2. Ellmeier W, Jung S, Sunshine M, Hatam F, Xu Y, Baltimore D, et al. Severe B cell deficiency in mice lacking the tec kinase family members Tec and Btk. J Exp Med. 2000;192:1611-24 pubmed
    The cytoplasmic protein tyrosine kinase Tec has been proposed to have important functions in hematopoiesis and lymphocyte signal transduction...
  3. Shinohara M, Koga T, Okamoto K, Sakaguchi S, Arai K, Yasuda H, et al. Tyrosine kinases Btk and Tec regulate osteoclast differentiation by linking RANK and ITAM signals. Cell. 2008;132:794-806 pubmed publisher
    ..Here we report that mice lacking the tyrosine kinases Btk and Tec show severe osteopetrosis caused by a defect in bone resorption...
  4. Jongstra Bilen J, Puig Cano A, Hasija M, Xiao H, Smith C, Cybulsky M. Dual functions of Bruton's tyrosine kinase and Tec kinase during Fcgamma receptor-induced signaling and phagocytosis. J Immunol. 2008;181:288-98 pubmed
    b>Tec family nonreceptor tyrosine kinases are expressed by hematopoietic cells, activate phospholipase C (PLC)gamma, and regulate cytoskeletal rearrangement, yet their role in FcgammaR-induced signaling and phagocytosis remains unknown...
  5. Schmidt U, Abramova A, Boucheron N, Eckelhart E, Schebesta A, Bilic I, et al. The protein tyrosine kinase Tec regulates mast cell function. Eur J Immunol. 2009;39:3228-38 pubmed publisher
    ..Here, we demonstrate that the protein tyrosine kinase Tec is a crucial regulator of murine mast cell function...
  6. Mano H, Mano K, Tang B, Koehler M, Yi T, Gilbert D, et al. Expression of a novel form of Tec kinase in hematopoietic cells and mapping of the gene to chromosome 5 near Kit. Oncogene. 1993;8:417-24 pubmed
    The Tec kinase was initially identified as a novel cytoplasmic protein tyrosine kinase that is preferentially expressed in the liver and is highly homologous to the Drosophila Dsrc28C src-related tyrosine kinase...
  7. Melcher M, Unger B, Schmidt U, Rajantie I, Alitalo K, Ellmeier W. Essential roles for the Tec family kinases Tec and Btk in M-CSF receptor signaling pathways that regulate macrophage survival. J Immunol. 2008;180:8048-56 pubmed
    b>Tec family kinases have important roles in lymphocytes; however, little is known about their function in monocytes/macrophages...
  8. Merkel A, Atmosukarto I, Stevens K, Rathjen P, Booker G. Splice variants of the mouse Tec gene are differentially expressed in vivo. Cytogenet Cell Genet. 1999;84:132-9 pubmed
    b>Tec is a cytoplasmic protein tyrosine kinase that participates in the signalling pathways of a broad range of cytokines. Up to five different Tec isoforms have been reported in the literature...
  9. Boucheron N, Sharif O, Schebesta A, Croxford A, Raberger J, Schmidt U, et al. The protein tyrosine kinase Tec regulates a CD44highCD62L- Th17 subset. J Immunol. 2010;185:5111-9 pubmed publisher
    ..study, we report an increase in a CD44(high)CD62L(-) Th17 subset in mice deficient for the protein tyrosine kinase Tec. CD44(high)CD62L(-) Tec(-/-) CD4(+) T cells produced enhanced IL-17 upon activation, showed increased expression ..

More Information

Publications53

  1. Manne B, Badolia R, Dangelmaier C, Eble J, Ellmeier W, Kahn M, et al. Distinct pathways regulate Syk protein activation downstream of immune tyrosine activation motif (ITAM) and hemITAM receptors in platelets. J Biol Chem. 2015;290:11557-68 pubmed publisher
    ..Ibrutinib, a Tec family kinase inhibitor, also completely abolished CLEC-2-mediated aggregation and Syk phosphorylation in human and ..
  2. Atherly L, Brehm M, Welsh R, Berg L. Tec kinases Itk and Rlk are required for CD8+ T cell responses to virus infection independent of their role in CD4+ T cell help. J Immunol. 2006;176:1571-81 pubmed
    Itk and Rlk are members of the Tec kinase family of nonreceptor protein tyrosine kinases that are expressed in T cells, NK cells, and mast cells...
  3. Sato K, Mano H, Ariyama T, Inazawa J, Yazaki Y, Hirai H. Molecular cloning and analysis of the human Tec protein-tyrosine kinase. Leukemia. 1994;8:1663-72 pubmed
    Mouse Tec is a non-receptor type protein-tyrosine kinase and is highly expressed in many hematopoietic cell lines...
  4. Guillemot F, Nagy A, Auerbach A, Rossant J, Joyner A. Essential role of Mash-2 in extraembryonic development. Nature. 1994;371:333-6 pubmed
    ..Mash-2 is the first transcription factor shown to play a critical part in the development of the mammalian trophoblast lineage. ..
  5. de Bruijn M, Rip J, van der Ploeg E, van Greuningen L, Ta V, Kil L, et al. Distinct and Overlapping Functions of TEC Kinase and BTK in B Cell Receptor Signaling. J Immunol. 2017;198:3058-3068 pubmed publisher
    The Tec tyrosine kinase is expressed in many cell types, including hematopoietic cells, and is a member of the Tec kinase family that also includes Btk...
  6. Ruiz J, Conlon F, Robertson E. Identification of novel protein kinases expressed in the myocardium of the developing mouse heart. Mech Dev. 1994;48:153-64 pubmed
    ..75-8.5 dpc developing heart. Subsequently, msk mRNA expression is rapidly downregulated. The patterns of Hek2 and msk expression suggest that these protein kinases may function during development of the primitive heart. ..
  7. Pursglove S, Mulhern T, Mackay J, Hinds M, Booker G. The solution structure and intramolecular associations of the Tec kinase SRC homology 3 domain. J Biol Chem. 2002;277:755-62 pubmed
    b>Tec is the prototypic member of a family of intracellular tyrosine kinases that includes Txk, Bmx, Itk, and Btk...
  8. Wang F, Zhang W, Wang C, Fang X, Cheng H, Liu S, et al. Inhibitor of Tec kinase, LFM-A13, decreases pro-inflammatory mediators production in LPS-stimulated RAW264.7 macrophages via NF-κB pathway. Oncotarget. 2017;8:34099-34110 pubmed publisher
    b>Tec kinase, a prototypical member of the Tec tyrosine kinases family, was shown to mainly govern lymphocyte proliferation...
  9. Wilks A, Kurban R, Hovens C, Ralph S. The application of the polymerase chain reaction to cloning members of the protein tyrosine kinase family. Gene. 1989;85:67-74 pubmed
    ..In addition to a number of previously described PTK sequences, a novel mammalian PTK-related sequence was uncovered. ..
  10. Garcon F, Bismuth G, Isnardon D, Olive D, Nunes J. Tec kinase migrates to the T cell-APC interface independently of its pleckstrin homology domain. J Immunol. 2004;173:770-5 pubmed
    b>Tec is the prototypical member of the Tec tyrosine kinases family, which plays an important role in T cell signaling. We show in this study that Tec translocates to the immunological synapse when a T cell contacts a dendritic cell...
  11. Wang G, Yang X, Jia Y, Xia Z. Tec kinase mediating IL-8 transcription in monocytes stimulated with LPS. Inflammation. 2009;32:265-9 pubmed publisher
    The purpose of present study was to explore the possibility of Tec kinase as a mediator for IL-8 transcription in monocytes stimulated with LPS...
  12. Yu L, Simonson O, Mohamed A, Smith C. NF-kappaB regulates the transcription of protein tyrosine kinase Tec. FEBS J. 2009;276:6714-24 pubmed publisher
    The tyrosine kinase expressed in hepatocellular carcinoma (Tec) is a non-receptor protein tyrosine kinase (PTK) that is expressed in hematopoietic cells, such as B and T lymphocytes, myeloid lineage cells and neutrophils...
  13. Liu C, Lai C, Yen W, Lin Y, Chang H, Tai T, et al. Reciprocal regulation of C-Maf tyrosine phosphorylation by Tec and Ptpn22. PLoS ONE. 2015;10:e0127617 pubmed publisher
    ..In this study, we demonstrate that Tec kinase family member Tec, but not Rlk or Itk, is a tyrosine kinase of c-Maf and that Tec enhances c-Maf-dependent ..
  14. Atkinson B, Ellmeier W, Watson S. Tec regulates platelet activation by GPVI in the absence of Btk. Blood. 2003;102:3592-9 pubmed
    The Tec family kinase Btk plays an important role in the regulation of phospholipase C gamma 2 (PLC gamma 2) downstream of the collagen receptor glycoprotein VI (GPVI) in human platelets...
  15. Hurlin P, Queva C, Koskinen P, Steingrimsson E, Ayer D, Copeland N, et al. Mad3 and Mad4: novel Max-interacting transcriptional repressors that suppress c-myc dependent transformation and are expressed during neural and epidermal differentiation. EMBO J. 1995;14:5646-59 pubmed
  16. Yoshida K, Yamashita Y, Miyazato A, Ohya K, Kitanaka A, Ikeda U, et al. Mediation by the protein-tyrosine kinase Tec of signaling between the B cell antigen receptor and Dok-1. J Biol Chem. 2000;275:24945-52 pubmed
    A variety of growth factor receptors induce the tyrosine phosphorylation of a nonreceptor protein-tyrosine kinase Tec as well as that of a Tec-binding protein of 62 kDa...
  17. Mainigi M, Olalere D, Burd I, Sapienza C, Bartolomei M, Coutifaris C. Peri-implantation hormonal milieu: elucidating mechanisms of abnormal placentation and fetal growth. Biol Reprod. 2014;90:26 pubmed publisher
  18. Kluppel M, Donoviel D, Brunkow M, Motro B, Bernstein A. Embryonic and adult expression patterns of the Tec tyrosine kinase gene suggest a role in megakaryocytopoiesis, blood vessel development, and melanogenesis. Cell Growth Differ. 1997;8:1249-56 pubmed
    The Tec cytoplasmic tyrosine kinase is a member of a family of src-like proteins that are thought to play important roles in hematopoiesis...
  19. Zhang M, Franklin S, Li Y, Wang S, Ru X, Mitchell Jordan S, et al. Stress signaling by Tec tyrosine kinase in the ischemic myocardium. Am J Physiol Heart Circ Physiol. 2010;299:H713-22 pubmed publisher
    ..To investigate novel tasks for members of the Tec family of nonreceptor tyrosine kinases in cardiac phenotype, we examined the behavior of the Tec isoform in ..
  20. Tampella G, Kerns H, Niu D, Singh S, Khim S, Bosch K, et al. The Tec Kinase-Regulated Phosphoproteome Reveals a Mechanism for the Regulation of Inhibitory Signals in Murine Macrophages. J Immunol. 2015;195:246-56 pubmed publisher
    Previous work has shown conflicting roles for Tec family kinases in regulation of TLR-dependent signaling in myeloid cells...
  21. Kitaura J, Eto K, Kinoshita T, Kawakami Y, Leitges M, Lowell C, et al. Regulation of highly cytokinergic IgE-induced mast cell adhesion by Src, Syk, Tec, and protein kinase C family kinases. J Immunol. 2005;174:4495-504 pubmed
    ..Thus, binding of HC IgEs to Fc epsilon RI induces adhesion of mast cells to fibronectin by modulating cellular activation signals in a unique fashion. ..
  22. Yokohari K, Yamashita Y, Okada S, Ohya K, Oda S, Hatano M, et al. Isoform-dependent interaction of BRDG1 with Tec kinase. Biochem Biophys Res Commun. 2001;289:414-20 pubmed
    b>Tec is the prototype of an emerging family of protein-tyrosine kinases. Tec and Btk, another member of this family, together participate in the development of B-cell immune system...
  23. Kazama A, Mano H, Morishita Y, Mori S. High expression of the tec gene product in murine testicular germ cells and erythroblasts. Pathol Int. 1996;46:341-7 pubmed
    b>Tec is a novel non-receptor-type protein tyrosine kinase that was originally identified from a murine liver cDNA library...
  24. Freudenberg J, Lee A, Siminovitch K, Amos C, Ballard D, Li W, et al. Locus category based analysis of a large genome-wide association study of rheumatoid arthritis. Hum Mol Genet. 2010;19:3863-72 pubmed publisher
    ..The intersection of positional and functional candidate information predicts novel RA loci near the genes TEC/TXK, MBL2 and PIK3R1/CD180...
  25. Zwolanek F, Riedelberger M, Stolz V, Jenull S, Istel F, Köprülü A, et al. The non-receptor tyrosine kinase Tec controls assembly and activity of the noncanonical caspase-8 inflammasome. PLoS Pathog. 2014;10:e1004525 pubmed publisher
    b>Tec family kinases are intracellular non-receptor tyrosine kinases implicated in numerous functions, including T cell and B cell regulation. However, a role in microbial pathogenesis has not been described...
  26. Honda H, Ozawa K, Yazaki Y, Hirai H. Identification of PU.1 and Sp1 as essential transcriptional factors for the promoter activity of mouse tec gene. Biochem Biophys Res Commun. 1997;234:376-81 pubmed
    b>Tec is a cytoplasmic protein-tyrosine kinase abundantly expressed in hematopoietic precursor cells...
  27. Honda H, Yamashita Y, Ozawa K, Mano H. Cloning and characterization of mouse tec promoter. Biochem Biophys Res Commun. 1996;223:422-6 pubmed
    b>Tec is a cytoplasmic protein-tyrosine kinase highly expressed in hematopoietic precursor cells. To investigate the mechanism regulating its expression, we cloned and characterized the mouse tec promoter...
  28. Himpe E, Abdul Rahim S, Verdood P, Mano H, Kooijman R. Tec kinase stimulates cell survival in transfected Hek293T cells and is regulated by the anti-apoptotic growth factor IGF-I in human neutrophils. Cell Signal. 2013;25:666-73 pubmed publisher
    ..In this study, we investigated whether IGF-I regulates Tec kinase, an alternative down-stream target of PI(3)K, in neutrophils and whether this molecule is able to affect ..
  29. Li F, Jiang Y, Zheng Q, Yang X, Wang S. TEC protein tyrosine kinase is involved in the Erk signaling pathway induced by HGF. Biochem Biophys Res Commun. 2011;404:79-85 pubmed publisher
    b>TEC, a member of the TEC family of non-receptor type protein tyrosine kinases, has recently been suggested to play a role in hepatocyte proliferation and liver regeneration...
  30. Bermejo D, Jackson S, Gorosito Serrán M, Acosta Rodriguez E, Amezcua Vesely M, Sather B, et al. Trypanosoma cruzi trans-sialidase initiates a program independent of the transcription factors ROR?t and Ahr that leads to IL-17 production by activated B cells. Nat Immunol. 2013;14:514-22 pubmed publisher
    ..Our combined data suggest that the generation of IL-17(+) B cells may be a previously unappreciated feature of innate immune responses required for pathogen control or IL-17-mediated autoimmunity...
  31. Tomlinson M, Kane L, Su J, Kadlecek T, Mollenauer M, Weiss A. Expression and function of Tec, Itk, and Btk in lymphocytes: evidence for a unique role for Tec. Mol Cell Biol. 2004;24:2455-66 pubmed
    The Tec protein tyrosine kinase is the founding member of a family that includes Btk, Itk, Bmx, and Txk...
  32. Takeuchi O, Kawai T, Sanjo H, Copeland N, Gilbert D, Jenkins N, et al. TLR6: A novel member of an expanding toll-like receptor family. Gene. 1999;231:59-65 pubmed
    ..The TLR6 gene, as well as the TLR1 gene, mapped to the proximal region of murine chromosome 5 within 1.7cM of each other. These results suggest that TLR6 is a novel member of an expanding TLR family. ..
  33. Habib T, Park H, Tsang M, de Alboran I, Nicks A, Wilson L, et al. Myc stimulates B lymphocyte differentiation and amplifies calcium signaling. J Cell Biol. 2007;179:717-31 pubmed
    ..mice and E(mu)-myc transgenic mice bred onto genetic backgrounds (recombinase-activating gene 2-/- and Btk-/- Tec-/-) whereby B cell development is arrested, we show that Myc is necessary to stimulate both proliferation and ..
  34. Siyanova E, Serfas M, Mazo I, Tyner A. Tyrosine kinase gene expression in the mouse small intestine. Oncogene. 1994;9:2053-7 pubmed
    ..the identification of the catalytic domains of several characterized tyrosine kinases, including lyn, hck, c-fgr, tec, JAK2, itk, and the putative receptor kinase ryk, and expression of these kinases has not previously been described ..
  35. Machide M, Mano H, Todokoro K. Interleukin 3 and erythropoietin induce association of Vav with Tec kinase through Tec homology domain. Oncogene. 1995;11:619-25 pubmed
    ..Vav, is rapidly and transiently tyrosine-phosphorylated in response to erythropoietin and IL3 stimulations and that Tec kinase is also transiently activated by these cytokines...
  36. Ebert A, Laussmann M, Wegehingel S, Kaderali L, Erfle H, Reichert J, et al. Tec-kinase-mediated phosphorylation of fibroblast growth factor 2 is essential for unconventional secretion. Traffic. 2010;11:813-26 pubmed publisher
    ..Here, using a highly effective RNAi screening approach, we discovered Tec kinase as a novel factor involved in unconventional secretion of FGF2...
  37. Ormsby T, Schlecker E, Ferdin J, Tessarz A, Angelisova P, Koprulu A, et al. Btk is a positive regulator in the TREM-1/DAP12 signaling pathway. Blood. 2011;118:936-45 pubmed publisher
    ..Here, we demonstrate that Bruton tyrosine kinase (Btk), a member of the Tec kinases, becomes phosphorylated upon TREM-1 triggering...
  38. Steingrimsson E, Tessarollo L, Reid S, Jenkins N, Copeland N. The bHLH-Zip transcription factor Tfeb is essential for placental vascularization. Development. 1998;125:4607-16 pubmed
    ..Our results indicate that Tfeb plays a critical role in the signal transduction processes required for normal vascularization of the placenta. ..
  39. Hwang E, Szabo S, Schwartzberg P, Glimcher L. T helper cell fate specified by kinase-mediated interaction of T-bet with GATA-3. Science. 2005;307:430-3 pubmed
    ..These results provide a novel function for tyrosine phosphorylation of a transcription factor in specifying alternate fates of a common progenitor cell. ..
  40. Nagle D, Kozak C, Mano H, Chapman V, Bucan M. Physical mapping of the Tec and Gabrb1 loci reveals that the Wsh mutation on mouse chromosome 5 is associated with an inversion. Hum Mol Genet. 1995;4:2073-9 pubmed
    ..the loci encoding the GABAA (gamma-aminobutyric acid) receptor subunit beta 1, Gabrb1 and a cytoplasmic kinase (Tec) 3 Mb proximal to Kit...
  41. Kane L, Watkins S. Dynamic regulation of Tec kinase localization in membrane-proximal vesicles of a T cell clone revealed by total internal reflection fluorescence and confocal microscopy. J Biol Chem. 2005;280:21949-54 pubmed
    b>Tec family tyrosine kinases are key regulators of lymphocyte activation and effector function...
  42. Altman A, Kaminski S, Busuttil V, Droin N, Hu J, Tadevosyan Y, et al. Positive feedback regulation of PLCgamma1/Ca(2+) signaling by PKCtheta in restimulated T cells via a Tec kinase-dependent pathway. Eur J Immunol. 2004;34:2001-11 pubmed
    ..Regulation of PLCgamma1 signaling by PKCtheta required the tyrosine kinase Tec since a dominant-negative Tec mutant blocked PKCtheta-induced AP-1 (but not NF-kappaB) activation...
  43. Yu P, Tabuchi R, Kato R, Astrakhan A, Humblet Baron S, Kipp K, et al. Sustained correction of B-cell development and function in a murine model of X-linked agammaglobulinemia (XLA) using retroviral-mediated gene transfer. Blood. 2004;104:1281-90 pubmed
    ..Using Btk- and Tec-deficient mice (BtkTec(-/-)) as a model for XLA, we determined if Btk gene therapy could correct this disorder...
  44. Sahu N, Morales J, Fowell D, August A. Modeling susceptibility versus resistance in allergic airway disease reveals regulation by Tec kinase Itk. PLoS ONE. 2010;5:e11348 pubmed publisher
    ..We then use this approach to show that the absence of the Tec family kinase Itk, which regulates the production of Th2 cytokines, leads to R(aai) in the C57BL/6 background, but ..