Gene Symbol: Tead2
Description: TEA domain family member 2
Alias: ETEF-1, ETF, Etdf, TEAD-2, TEF-4, TEF4, transcriptional enhancer factor TEF-4, embryonic TEA domain-containing factor
Species: mouse
Products:     Tead2

Top Publications

  1. Yasunami M, Suzuki K, Houtani T, Sugimoto T, Ohkubo H. Molecular characterization of cDNA encoding a novel protein related to transcriptional enhancer factor-1 from neural precursor cells. J Biol Chem. 1995;270:18649-54 pubmed
    ..The putative polypeptide, termed embryonic TEA domain-containing factor (ETF), deduced from the nucleotide sequence contains 445 amino acids and shares 66% amino acid identity with mouse and ..
  2. Brady J, Duncan M, Wawrousek E, Piatigorsky J. The transcription factor, Kid-1, is highly expressed in both eye and kidney of the mouse. Exp Eye Res. 1997;64:287-90 pubmed
  3. Kaneko K, Rein T, Guo Z, Latham K, DePamphilis M. DNA methylation may restrict but does not determine differential gene expression at the Sgy/Tead2 locus during mouse development. Mol Cell Biol. 2004;24:1968-82 pubmed
    Soggy (Sgy) and Tead2, two closely linked genes with CpG islands, were coordinately expressed in mouse preimplantation embryos and embryonic stem (ES) cells but were differentially expressed in differentiated cells...
  4. Sawada A, Kiyonari H, Ukita K, Nishioka N, Imuta Y, Sasaki H. Redundant roles of Tead1 and Tead2 in notochord development and the regulation of cell proliferation and survival. Mol Cell Biol. 2008;28:3177-89 pubmed publisher
    ..Here we examined the role of Tead genes by generating mouse mutants for Tead1 and Tead2. Tead2(-/-) mice appeared normal, but Tead1(-/-); Tead2(-/-) embryos died at embryonic day 9.5 (E9...
  5. Kaneko K, Kohn M, Liu C, DePamphilis M. Transcription factor TEAD2 is involved in neural tube closure. Genesis. 2007;45:577-87 pubmed
    b>TEAD2, one of the first transcription factors expressed at the beginning of mammalian development, appears to be required during neural development...
  6. Vassilev A, Kaneko K, Shu H, Zhao Y, DePamphilis M. TEAD/TEF transcription factors utilize the activation domain of YAP65, a Src/Yes-associated protein localized in the cytoplasm. Genes Dev. 2001;15:1229-41 pubmed
    ..Because TEAD-dependent transcription was limited by YAP65, and YAP65 also binds Src/Yes protein tyrosine kinases, we propose that YAP65 regulates TEAD-dependent transcription in response to mitogenic signals. ..
  7. Sawada A, Nishizaki Y, Sato H, Yada Y, Nakayama R, Yamamoto S, et al. Tead proteins activate the Foxa2 enhancer in the node in cooperation with a second factor. Development. 2005;132:4719-29 pubmed
    ..These results suggest that Tead activates the Foxa2 enhancer core element in the mouse node in cooperation with a second factor that binds to the 5' element, and that a similar mechanism also operates in the zebrafish shield...
  8. Milewski R, Chi N, Li J, Brown C, Lu M, Epstein J. Identification of minimal enhancer elements sufficient for Pax3 expression in neural crest and implication of Tead2 as a regulator of Pax3. Development. 2004;131:829-37 pubmed
    ..We show that Tead2, a member of the Tead box family of transcription factors, binds to a neural crest enhancer and activates Pax3 ..
  9. Ota M, Sasaki H. Mammalian Tead proteins regulate cell proliferation and contact inhibition as transcriptional mediators of Hippo signaling. Development. 2008;135:4059-69 pubmed publisher
    ..b>Tead2-VP16 mimicked Yap1 overexpression, including increased cell proliferation, reduced cell death, promotion of EMT, ..

More Information


  1. Poncy A, Antoniou A, Cordi S, Pierreux C, Jacquemin P, Lemaigre F. Transcription factors SOX4 and SOX9 cooperatively control development of bile ducts. Dev Biol. 2015;404:136-48 pubmed publisher
    ..We conclude that SOX4 is a new regulator of liver development and that it exerts a pleiotropic control on bile duct development in cooperation with SOX9. ..
  2. Jacquemin P, Sapin V, Alsat E, Evain Brion D, Dolle P, Davidson I. Differential expression of the TEF family of transcription factors in the murine placenta and during differentiation of primary human trophoblasts in vitro. Dev Dyn. 1998;212:423-36 pubmed
    ..We further propose that the hTEF factors may play a more general role in placental gene regulation and development. ..
  3. Tamm C, Böwer N, Annerén C. Regulation of mouse embryonic stem cell self-renewal by a Yes-YAP-TEAD2 signaling pathway downstream of LIF. J Cell Sci. 2011;124:1136-44 pubmed publisher
    ..Here, we show that TEAD2 and its transcriptional co-activator, the Yes-associated protein YAP, co-operate in a signaling pathway downstream ..
  4. Belandia B, Parker M. Functional interaction between the p160 coactivator proteins and the transcriptional enhancer factor family of transcription factors. J Biol Chem. 2000;275:30801-5 pubmed
    ..These results suggest that the p160 proteins could be bona fide coactivators of the TEF family of transcription factors. ..
  5. Pijuan Galitó S, Tamm C, Annerén C. Serum Inter-α-inhibitor activates the Yes tyrosine kinase and YAP/TEAD transcriptional complex in mouse embryonic stem cells. J Biol Chem. 2014;289:33492-502 pubmed publisher
    We have previously demonstrated that the Src family kinase Yes, the Yes-associated protein (YAP) and TEA domain TEAD2 transcription factor pathway are activated by leukemia inhibitory factor (LIF) and contribute to mouse embryonic stem (..
  6. Suzuki K, Yasunami M, Matsuda Y, Maeda T, Kobayashi H, Terasaki H, et al. Structural organization and chromosomal assignment of the mouse embryonic TEA domain-containing factor (ETF) gene. Genomics. 1996;36:263-70 pubmed
    ..Isolation and characterization of the cosmid clones encoding the mouse ETF gene (Etdf) revealed that Etdf spans approximately 17.9 kb and consists of 12 exons...
  7. Jacquemin P, Hwang J, Martial J, Dolle P, Davidson I. A novel family of developmentally regulated mammalian transcription factors containing the TEA/ATTS DNA binding domain. J Biol Chem. 1996;271:21775-85 pubmed
    ..These observations suggest additional roles for the TEF proteins in central nervous system development and organogenesis. ..
  8. Zhao P, Caretti G, Mitchell S, McKeehan W, Boskey A, Pachman L, et al. Fgfr4 is required for effective muscle regeneration in vivo. Delineation of a MyoD-Tead2-Fgfr4 transcriptional pathway. J Biol Chem. 2006;281:429-38 pubmed
    ..The Fgfr4 promoter region contained a Tead protein binding site (M-CAT 5'-CATTCCT-3'), and Tead2 showed induction during regeneration commensurate with Fgfr4 regulation...
  9. Liu Chittenden Y, Huang B, Shim J, Chen Q, Lee S, Anders R, et al. Genetic and pharmacological disruption of the TEAD-YAP complex suppresses the oncogenic activity of YAP. Genes Dev. 2012;26:1300-5 pubmed publisher
    ..These findings provide proof of principle that inhibiting TEAD-YAP interactions is a pharmacologically viable strategy against the YAP oncoprotein. ..
  10. Zellmer S, Schmidt Heck W, Godoy P, Weng H, Meyer C, Lehmann T, et al. Transcription factors ETF, E2F, and SP-1 are involved in cytokine-independent proliferation of murine hepatocytes. Hepatology. 2010;52:2127-36 pubmed publisher
    ..The latter genes showed an overrepresentation of transcription factor binding sites (TFBS) for ETF (TEA domain family member 2), E2F1 (E2F transcription factor 1), and SP-1 (Sp1 transcription factor) (P < 0...
  11. Yin X, Oltvai Z, Veis Novack D, Linette G, Korsmeyer S. Bcl-2 gene family and the regulation of programmed cell death. Cold Spring Harb Symp Quant Biol. 1994;59:387-93 pubmed
  12. Yagi R, Kohn M, Karavanova I, Kaneko K, Vullhorst D, DePamphilis M, et al. Transcription factor TEAD4 specifies the trophectoderm lineage at the beginning of mammalian development. Development. 2007;134:3827-36 pubmed
    ..Thus, Tead4 is the earliest gene shown to be uniquely required for specification of the trophectoderm lineage. ..
  13. Jacquemin P, Chen Z, Martial J, Davidson I. Genomic structure and chromosomal mapping of the mouse transcription factor TEF-5 (Tead3) gene. Mamm Genome. 1999;10:632-4 pubmed
  14. Yamashita Y, Fukuta D, Tsuji A, Nagabukuro A, Matsuda Y, Nishikawa Y, et al. Genomic structures and chromosomal location of p91, a novel murine regulatory receptor family. J Biochem. 1998;123:358-68 pubmed
    ..The gene was found to be located on human chromosome 19q13.3-13.4. These results establish the existence of a novel set of potent regulatory receptors in mouse and man, similar but different from the KIR family. ..
  15. Kaneko K, Cullinan E, Latham K, DePamphilis M. Transcription factor mTEAD-2 is selectively expressed at the beginning of zygotic gene expression in the mouse. Development. 1997;124:1963-73 pubmed
  16. Tsika R, Schramm C, Simmer G, Fitzsimons D, Moss R, Ji J. Overexpression of TEAD-1 in transgenic mouse striated muscles produces a slower skeletal muscle contractile phenotype. J Biol Chem. 2008;283:36154-67 pubmed publisher
    ..These novel in vivo data support a role for TEAD-1 in modulating slow muscle gene expression. ..
  17. Bhattaram P, Penzo Méndez A, Sock E, Colmenares C, Kaneko K, Vassilev A, et al. Organogenesis relies on SoxC transcription factors for the survival of neural and mesenchymal progenitors. Nat Commun. 2010;1:9 pubmed publisher
    ..b>Tead2 functionally interacts with SoxC genes in embryonic development, and is a direct target of SoxC proteins...
  18. Diepenbruck M, Waldmeier L, Ivanek R, Berninger P, Arnold P, van Nimwegen E, et al. Tead2 expression levels control the subcellular distribution of Yap and Taz, zyxin expression and epithelial-mesenchymal transition. J Cell Sci. 2014;127:1523-36 pubmed publisher
    ..We have uncovered a previously unanticipated role of the transcription factor Tead2 during EMT...
  19. Burglin T. The TEA domain: a novel, highly conserved DNA-binding motif. Cell. 1991;66:11-2 pubmed
  20. Ribas R, Moncaut N, Siligan C, Taylor K, Cross J, Rigby P, et al. Members of the TEAD family of transcription factors regulate the expression of Myf5 in ventral somitic compartments. Dev Biol. 2011;355:372-80 pubmed publisher
  21. Yockey C, Shimizu N. cDNA cloning and characterization of mouse DTEF-1 and ETF, members of the TEA/ATTS family of transcription factors. DNA Cell Biol. 1998;17:187-96 pubmed
    ..In this article, we describe the cDNA cloning and characterization of the murine TEA proteins DTEF-1 (mDTEF-1) and ETF. Using in situ hybridization analysis of mouse embryos, we found that mDTEF-1 and ETF transcript distributions ..
  22. Mamada H, Sato T, Ota M, Sasaki H. Cell competition in mouse NIH3T3 embryonic fibroblasts is controlled by the activity of Tead family proteins and Myc. J Cell Sci. 2015;128:790-803 pubmed publisher
    ..Establishment of this in vitro model system should be useful for analyses of the mechanisms of cell competition in mammals and in fibroblasts. ..
  23. Yao Y, Minor P, Zhao Y, Jeong Y, Pani A, King A, et al. Cis-regulatory architecture of a brain signaling center predates the origin of chordates. Nat Genet. 2016;48:575-80 pubmed publisher
    ..These findings support a strategy for delineating functionally conserved enhancers in the absence of overt sequence homologies and over extensive evolutionary distances. ..
  24. Nishioka N, Yamamoto S, Kiyonari H, Sato H, Sawada A, Ota M, et al. Tead4 is required for specification of trophectoderm in pre-implantation mouse embryos. Mech Dev. 2008;125:270-83 pubmed
    ..Here we show that the TEA domain family transcription factor, Tead4, is required for TE development. Tead1, Tead2 and Tead4 were expressed in pre-implantation embryos, and at least Tead1 and Tead4 were expressed widely in both ..
  25. Kaneko K, DePamphilis M. Soggy, a spermatocyte-specific gene, lies 3.8 kb upstream of and antipodal to TEAD-2, a transcription factor expressed at the beginning of mouse development. Nucleic Acids Res. 2000;28:3982-90 pubmed
    ..Since mTEAD-2 and mSgy were not expressed in the same cells, the mSgy/mTEAD-2 locus provides a unique paradigm for differential regulation of gene expression during mammalian development. ..
  26. Castro D, Martynoga B, Parras C, Ramesh V, Pacary E, Johnston C, et al. A novel function of the proneural factor Ascl1 in progenitor proliferation identified by genome-wide characterization of its targets. Genes Dev. 2011;25:930-45 pubmed publisher