Gene Symbol: Tead1
Description: TEA domain family member 1
Alias: 2610024B07Rik, B230114H05Rik, Gtrgeo5, TEAD-1, TEF-1, Tcf13, mTEF-1, transcriptional enhancer factor TEF-1, NTEF-1, TCF-13, transcription factor 13
Species: mouse
Products:     Tead1

Top Publications

  1. Günther S, Mielcarek M, Kruger M, Braun T. VITO-1 is an essential cofactor of TEF1-dependent muscle-specific gene regulation. Nucleic Acids Res. 2004;32:791-802 pubmed
    ..We conclude that VITO-1 is a crucial new cofactor of the muscle regulatory programme. ..
  2. Burglin T. The TEA domain: a novel, highly conserved DNA-binding motif. Cell. 1991;66:11-2 pubmed
  3. Lian I, Kim J, Okazawa H, Zhao J, Zhao B, Yu J, et al. The role of YAP transcription coactivator in regulating stem cell self-renewal and differentiation. Genes Dev. 2010;24:1106-18 pubmed publisher
    ..Moreover, YAP binds directly to promoters of a large number of genes known to be important for stem cells and stimulates their expression. Our observations establish a critical role of YAP in maintaining stem cell pluripotency. ..
  4. Milewski R, Chi N, Li J, Brown C, Lu M, Epstein J. Identification of minimal enhancer elements sufficient for Pax3 expression in neural crest and implication of Tead2 as a regulator of Pax3. Development. 2004;131:829-37 pubmed
    ..In addition, a Tead2-Engrailed fusion protein is able to repress retinoic acid-induced Pax3 expression in P19 cells and in vivo. These results suggest that Tead2 is an endogenous activator of Pax3 in neural crest. ..
  5. Ota M, Sasaki H. Mammalian Tead proteins regulate cell proliferation and contact inhibition as transcriptional mediators of Hippo signaling. Development. 2008;135:4059-69 pubmed publisher
    ..However, only a few of the Tead/Yap1-regulated genes in NIH3T3 cells were affected in Tead1(-/-);Tead2(-/-) or Yap1(-/-) embryos...
  6. Sawada A, Nishizaki Y, Sato H, Yada Y, Nakayama R, Yamamoto S, et al. Tead proteins activate the Foxa2 enhancer in the node in cooperation with a second factor. Development. 2005;132:4719-29 pubmed
    ..These results suggest that Tead activates the Foxa2 enhancer core element in the mouse node in cooperation with a second factor that binds to the 5' element, and that a similar mechanism also operates in the zebrafish shield...
  7. Chen H, Maeda T, Mullett S, Stewart A. Transcription cofactor Vgl-2 is required for skeletal muscle differentiation. Genesis. 2004;39:273-9 pubmed
    ..These results demonstrate that Vgl-2 is required for muscle gene expression, in part by switching DNA binding of TEF-1 factors during muscle differentiation. ..
  8. Chen Z, Friedrich G, Soriano P. Transcriptional enhancer factor 1 disruption by a retroviral gene trap leads to heart defects and embryonic lethality in mice. Genes Dev. 1994;8:2293-301 pubmed
    ..Although transcription of a number of muscle-specific genes believed to be TEF-1 targets appears normal, the defect in cardiogenesis is likely attributable to diminished transcription of one or several cardiac-specific genes. ..
  9. Shimizu N, Smith G, Izumo S. Both a ubiquitous factor mTEF-1 and a distinct muscle-specific factor bind to the M-CAT motif of the myosin heavy chain beta gene. Nucleic Acids Res. 1993;21:4103-10 pubmed
    ..These results suggest that the M-CAT binding factors consist of two different factors; the ubiquitous A2 is encoded by mTEF-1, but the muscle-specific A1 factor is distinct from mTEF-1. ..

More Information


  1. Sawada A, Kiyonari H, Ukita K, Nishioka N, Imuta Y, Sasaki H. Redundant roles of Tead1 and Tead2 in notochord development and the regulation of cell proliferation and survival. Mol Cell Biol. 2008;28:3177-89 pubmed publisher
    ..Here we examined the role of Tead genes by generating mouse mutants for Tead1 and Tead2. Tead2(-/-) mice appeared normal, but Tead1(-/-); Tead2(-/-) embryos died at embryonic day 9.5 (E9...
  2. Vassilev A, Kaneko K, Shu H, Zhao Y, DePamphilis M. TEAD/TEF transcription factors utilize the activation domain of YAP65, a Src/Yes-associated protein localized in the cytoplasm. Genes Dev. 2001;15:1229-41 pubmed
    ..Because TEAD-dependent transcription was limited by YAP65, and YAP65 also binds Src/Yes protein tyrosine kinases, we propose that YAP65 regulates TEAD-dependent transcription in response to mitogenic signals. ..
  3. Ambrosino C, Iwata T, Scafoglio C, Mallardo M, Klein R, Nebreda A. TEF-1 and C/EBPbeta are major p38alpha MAPK-regulated transcription factors in proliferating cardiomyocytes. Biochem J. 2006;396:163-72 pubmed
  4. Nishioka N, Yamamoto S, Kiyonari H, Sato H, Sawada A, Ota M, et al. Tead4 is required for specification of trophectoderm in pre-implantation mouse embryos. Mech Dev. 2008;125:270-83 pubmed
    ..Here we show that the TEA domain family transcription factor, Tead4, is required for TE development. Tead1, Tead2 and Tead4 were expressed in pre-implantation embryos, and at least Tead1 and Tead4 were expressed widely in ..
  5. Mamada H, Sato T, Ota M, Sasaki H. Cell competition in mouse NIH3T3 embryonic fibroblasts is controlled by the activity of Tead family proteins and Myc. J Cell Sci. 2015;128:790-803 pubmed publisher
    ..Establishment of this in vitro model system should be useful for analyses of the mechanisms of cell competition in mammals and in fibroblasts. ..
  6. Castro D, Martynoga B, Parras C, Ramesh V, Pacary E, Johnston C, et al. A novel function of the proneural factor Ascl1 in progenitor proliferation identified by genome-wide characterization of its targets. Genes Dev. 2011;25:930-45 pubmed publisher
  7. Ribas R, Moncaut N, Siligan C, Taylor K, Cross J, Rigby P, et al. Members of the TEAD family of transcription factors regulate the expression of Myf5 in ventral somitic compartments. Dev Biol. 2011;355:372-80 pubmed publisher
  8. Wen T, Yin Q, Yu L, Hu G, Liu J, Zhang W, et al. Characterization of mice carrying a conditional TEAD1 allele. Genesis. 2017;55: pubmed publisher
    ..signaling in the nucleus is achieved by interaction with the transcription factor TEA domain transcription factor (TEAD1). The YAP/TEAD1 complex binds to DNA element and regulates the expression of genes involved in cell growth...
  9. Kitagawa M. A Sveinsson's chorioretinal atrophy-associated missense mutation in mouse Tead1 affects its interaction with the co-factors YAP and TAZ. Biochem Biophys Res Commun. 2007;361:1022-6 pubmed
    ..A missense mutation in the gene encoding the transcription factor TEAD1/TEF-1 (Y421H) is genetically linked to SCRA, but the mechanisms of pathology remain unclear...
  10. Blatt C, DePamphilis M. Striking homology between mouse and human transcription enhancer factor-1 (TEF-1). Nucleic Acids Res. 1993;21:747-8 pubmed
  11. Karasseva N, Tsika G, Ji J, Zhang A, Mao X, Tsika R. Transcription enhancer factor 1 binds multiple muscle MEF2 and A/T-rich elements during fast-to-slow skeletal muscle fiber type transitions. Mol Cell Biol. 2003;23:5143-64 pubmed
  12. Lopez Anido C, Poitelon Y, Gopinath C, Moran J, Ma K, Law W, et al. Tead1 regulates the expression of Peripheral Myelin Protein 22 during Schwann cell development. Hum Mol Genet. 2016;25:3055-3069 pubmed
    ..We discovered that Tead1 and co-activators Yap and Taz are required for Pmp22 expression, as well as for the expression of Egr2 Tead1 ..
  13. Bhattaram P, Penzo Méndez A, Sock E, Colmenares C, Kaneko K, Vassilev A, et al. Organogenesis relies on SoxC transcription factors for the survival of neural and mesenchymal progenitors. Nat Commun. 2010;1:9 pubmed publisher
    ..SoxC genes therefore ensure neural and mesenchymal progenitor cell survival, and function in part by activating this transcriptional mediator of the Hippo signalling pathway. ..
  14. Geng J, Yu S, Zhao H, Sun X, Li X, Wang P, et al. The transcriptional coactivator TAZ regulates reciprocal differentiation of TH17 cells and Treg cells. Nat Immunol. 2017;18:800-812 pubmed publisher
    ..In contrast, under Treg cell-skewing conditions, TEAD1 expression and sequestration of TAZ from the transcription factors RORγt and Foxp3 promoted Treg ..
  15. Tsika R, Schramm C, Simmer G, Fitzsimons D, Moss R, Ji J. Overexpression of TEAD-1 in transgenic mouse striated muscles produces a slower skeletal muscle contractile phenotype. J Biol Chem. 2008;283:36154-67 pubmed publisher
    ..These novel in vivo data support a role for TEAD-1 in modulating slow muscle gene expression. ..
  16. Liu Chittenden Y, Huang B, Shim J, Chen Q, Lee S, Anders R, et al. Genetic and pharmacological disruption of the TEAD-YAP complex suppresses the oncogenic activity of YAP. Genes Dev. 2012;26:1300-5 pubmed publisher
    ..These findings provide proof of principle that inhibiting TEAD-YAP interactions is a pharmacologically viable strategy against the YAP oncoprotein. ..
  17. Huraskin D, Eiber N, Reichel M, Zidek L, Kravic B, Bernkopf D, et al. Wnt/?-catenin signaling via Axin2 is required for myogenesis and, together with YAP/Taz and Tead1, active in IIa/IIx muscle fibers. Development. 2016;143:3128-42 pubmed publisher
    ..In the same fibers, immunofluorescence staining for YAP/Taz and Tead1 was detected. Wnt/?-catenin signaling was absent in quiescent and activated satellite cells...
  18. Xiao J, Davidson I, Matthes H, Garnier J, Chambon P. Cloning, expression, and transcriptional properties of the human enhancer factor TEF-1. Cell. 1991;65:551-68 pubmed
    ..These results strongly suggest that the trans-activation function of TEF-1 is mediated by a highly limiting, possible cell-specific, titratable transcriptional intermediary factor(s). ..
  19. Tsika R, Ma L, Kehat I, Schramm C, Simmer G, Morgan B, et al. TEAD-1 overexpression in the mouse heart promotes an age-dependent heart dysfunction. J Biol Chem. 2010;285:13721-35 pubmed publisher
    ..These data provide the first in vivo evidence that increased TEAD-1 can induce characteristics of cardiac remodeling associated with cardiomyopathy and heart failure. ..
  20. Gan Q, Yoshida T, Li J, Owens G. Smooth muscle cells and myofibroblasts use distinct transcriptional mechanisms for smooth muscle alpha-actin expression. Circ Res. 2007;101:883-92 pubmed
    ..Results also indicate that the MCAT element-mutated SM alpha-actin promoter-enhancer is a useful tool to direct gene expression selectively in differentiated SMCs. ..
  21. Kaneko K, Cullinan E, Latham K, DePamphilis M. Transcription factor mTEAD-2 is selectively expressed at the beginning of zygotic gene expression in the mouse. Development. 1997;124:1963-73 pubmed
  22. Parlakian A, Tuil D, Hamard G, Tavernier G, Hentzen D, Concordet J, et al. Targeted inactivation of serum response factor in the developing heart results in myocardial defects and embryonic lethality. Mol Cell Biol. 2004;24:5281-9 pubmed
    ..5, GATA4, myocardin, and the SRF target gene c-fos prior to overt maldevelopment. We conclude that SRF is crucial for cardiac differentiation and maturation, acting as a global regulator of multiple developmental genes. ..
  23. Jacquemin P, Hwang J, Martial J, Dolle P, Davidson I. A novel family of developmentally regulated mammalian transcription factors containing the TEA/ATTS DNA binding domain. J Biol Chem. 1996;271:21775-85 pubmed
    ..These observations suggest additional roles for the TEF proteins in central nervous system development and organogenesis. ..
  24. von Gise A, Lin Z, Schlegelmilch K, Honor L, Pan G, Buck J, et al. YAP1, the nuclear target of Hippo signaling, stimulates heart growth through cardiomyocyte proliferation but not hypertrophy. Proc Natl Acad Sci U S A. 2012;109:2394-9 pubmed publisher
    ..Activation of Yap1 in postnatal cardiomyocytes may be a useful strategy to stimulate cardiomyocyte expansion in therapeutic myocardial regeneration. ..
  25. Yu F, Luo J, Mo J, Liu G, Kim Y, Meng Z, et al. Mutant Gq/11 promote uveal melanoma tumorigenesis by activating YAP. Cancer Cell. 2014;25:822-30 pubmed publisher
    ..This study reveals an essential role of the Hippo-YAP pathway in Gq/11-induced tumorigenesis and suggests YAP as a potential drug target for UM patients carrying mutations in GNAQ or GNA11. ..
  26. Wang F, Wang H, Wu H, Qiu H, Zeng C, Sun L, et al. TEAD1 controls C2C12 cell proliferation and differentiation and regulates three novel target genes. Cell Signal. 2013;25:674-81 pubmed publisher
    b>TEAD1 is a transcription factor involved in activation of muscle specific genes, such as the cardiac muscle troponin T gene, skeletal muscle actin, myosin heavy chains genes...
  27. Stewart A, Richard C, Suzow J, Stephan D, Weremowicz S, Morton C, et al. Cloning of human RTEF-1, a transcriptional enhancer factor-1-related gene preferentially expressed in skeletal muscle: evidence for an ancient multigene family. Genomics. 1996;37:68-76 pubmed
    ..Phylogenetic analysis of all known TEF-1-related proteins identified human RTEF-1 as one of four vertebrate members of this multigene family and further suggests that these genes diverged in the earliest metazoan ancestors. ..
  28. Fernandez L A, Northcott P, Dalton J, Fraga C, Ellison D, Angers S, et al. YAP1 is amplified and up-regulated in hedgehog-associated medulloblastomas and mediates Sonic hedgehog-driven neural precursor proliferation. Genes Dev. 2009;23:2729-41 pubmed publisher
    ..Post-irradiation, YAP1 was found in newly growing tumor cells. These findings implicate YAP1 as a new Shh effector that may be targeted by medulloblastoma therapies aimed at eliminating medulloblastoma recurrence. ..
  29. Tanaka M, Chen Z, Bartunkova S, Yamasaki N, Izumo S. The cardiac homeobox gene Csx/Nkx2.5 lies genetically upstream of multiple genes essential for heart development. Development. 1999;126:1269-80 pubmed
    ..5 null cells exert dominant interfering effects on cardiac development, and (6) there were severe defects in yolk sac angiogenesis and hematopoiesis in the Csx/Nkx2.5 null embryos. ..
  30. Schlegelmilch K, Mohseni M, Kirak O, Pruszak J, Rodriguez J, Zhou D, et al. Yap1 acts downstream of ?-catenin to control epidermal proliferation. Cell. 2011;144:782-95 pubmed publisher
    ..Together, these data identify Yap1 as a determinant of the proliferative capacity of epidermal stem cells and as an important effector of a "crowd control" molecular circuitry in mammalian skin. ..
  31. Mo J, Meng Z, Kim Y, Park H, Hansen C, Kim S, et al. Cellular energy stress induces AMPK-mediated regulation of YAP and the Hippo pathway. Nat Cell Biol. 2015;17:500-10 pubmed publisher
    ..Our study establishes a molecular mechanism and functional significance of AMPK in linking cellular energy status to the Hippo-YAP pathway. ..
  32. Shimomura T, Miyamura N, Hata S, Miura R, Hirayama J, Nishina H. The PDZ-binding motif of Yes-associated protein is required for its co-activation of TEAD-mediated CTGF transcription and oncogenic cell transforming activity. Biochem Biophys Res Commun. 2014;443:917-23 pubmed publisher
    ..Taken together, our results indicate that the PDZ-binding motif of YAP is critical for YAP-mediated oncogenesis, and that this effect is mediated by YAP's co-activation of TEAD-mediated CTGF transcription. ..
  33. Carlini L, Getz M, Strauch A, Kelm R. Cryptic MCAT enhancer regulation in fibroblasts and smooth muscle cells. Suppression of TEF-1 mediated activation by the single-stranded DNA-binding proteins, Pur alpha, Pur beta, and MSY1. J Biol Chem. 2002;277:8682-92 pubmed
  34. Joshi S, Davidson G, Le Gras S, Watanabe S, Braun T, Mengus G, et al. TEAD transcription factors are required for normal primary myoblast differentiation in vitro and muscle regeneration in vivo. PLoS Genet. 2017;13:e1006600 pubmed publisher
    The TEAD family of transcription factors (TEAD1-4) bind the MCAT element in the regulatory elements of both growth promoting and myogenic differentiation genes...
  35. Yin Z, Jones G, Towns W, Zhang X, Abel E, Binkley P, et al. Heart-specific ablation of Prkar1a causes failure of heart development and myxomagenesis. Circulation. 2008;117:1414-22 pubmed publisher
    ..These biochemical changes lead to myxoma-like changes, indicating that these mice may be a good model with which to study the formation of these tumors. ..
  36. O Connell T, Rokosh D, Simpson P. Cloning and characterization of the mouse alpha1C/A-adrenergic receptor gene and analysis of an alpha1C promoter in cardiac myocytes: role of an MCAT element that binds transcriptional enhancer factor-1 (TEF-1). Mol Pharmacol. 2001;59:1225-34 pubmed
    ..However, the mouse alpha1C gene was not transcribed in the neonatal heart and was not activated by alpha1-AR and other hypertrophic agonists in rat myocytes, and thus differed from other MCAT-dependent genes and the rat alpha1C gene. ..
  37. Tamm C, Böwer N, Annerén C. Regulation of mouse embryonic stem cell self-renewal by a Yes-YAP-TEAD2 signaling pathway downstream of LIF. J Cell Sci. 2011;124:1136-44 pubmed publisher
    ..Episomal supertransfection of cells with inhibitory TEAD2-EnR induced endodermal differentiation, which suggests that this pathway is necessary for ES cell maintenance. ..
  38. Lin Z, Guo H, Cao Y, Zohrabian S, Zhou P, Ma Q, et al. Acetylation of VGLL4 Regulates Hippo-YAP Signaling and Postnatal Cardiac Growth. Dev Cell. 2016;39:466-479 pubmed publisher
    ..While investigating factors that limit YAP's postnatal mitogenic activity, we found that the CM-enriched TEAD1 binding protein VGLL4 inhibits CM proliferation by inhibiting TEAD1-YAP interaction and by targeting TEAD1 for ..
  39. Tosi J, Janisch K, Wang N, Kasanuki J, Flynn J, Lin C, et al. Cellular and molecular origin of circumpapillary dysgenesis of the pigment epithelium. Ophthalmology. 2009;116:971-80 pubmed publisher
    We studied clinical phenotyping and TEAD1 expression in mice and humans to gain a better understanding of the primary origin in the pathogenesis of circumpapillary dysgenesis of the pigment epithelium...
  40. Qiu H, Wang F, Liu C, Xu X, Liu B. TEAD1-dependent expression of the FoxO3a gene in mouse skeletal muscle. BMC Mol Biol. 2011;12:1 pubmed publisher
    b>TEAD1 (TEA domain family member 1) is constitutively expressed in cardiac and skeletal muscles...
  41. Jacquemin P, Sapin V, Alsat E, Evain Brion D, Dolle P, Davidson I. Differential expression of the TEF family of transcription factors in the murine placenta and during differentiation of primary human trophoblasts in vitro. Dev Dyn. 1998;212:423-36 pubmed
    ..We further propose that the hTEF factors may play a more general role in placental gene regulation and development. ..
  42. Hamon A, Masson C, Bitard J, Gieser L, Roger J, Perron M. Retinal Degeneration Triggers the Activation of YAP/TEAD in Reactive Müller Cells. Invest Ophthalmol Vis Sci. 2017;58:1941-1953 pubmed publisher
    ..We found that downstream effectors of this pathway, YAP and TEAD1, are specifically expressed in Müller cells and that their expression, at both the mRNA and protein levels, is ..
  43. Yasunami M, Suzuki K, Ohkubo H. A novel family of TEA domain-containing transcription factors with distinct spatiotemporal expression patterns. Biochem Biophys Res Commun. 1996;228:365-70 pubmed
  44. Liu R, Lee J, Kim B, Wang Q, Buxton S, Balasubramanyam N, et al. Tead1 is required for maintaining adult cardiomyocyte function, and its loss results in lethal dilated cardiomyopathy. JCI Insight. 2017;2: pubmed publisher
    ..However, the requirement of Tead1, the transcriptional effector of this pathway, in the adult heart is unknown...
  45. Liu Y, Xin Y, Ye F, Wang W, Lu Q, Kaplan H, et al. Taz-tead1 links cell-cell contact to zeb1 expression, proliferation, and dedifferentiation in retinal pigment epithelial cells. Invest Ophthalmol Vis Sci. 2010;51:3372-8 pubmed publisher
    ..Here, the authors provide evidence that Taz and its coactivator, Tead1, regulate expression of the EMT transcription factor Zeb1 to control RPE cell proliferation and differentiation...