Gene Symbol: Tdgf1
Description: teratocarcinoma-derived growth factor 1
Alias: CR1, cripto, teratocarcinoma-derived growth factor, TERATOCARCINOMA-DERIVED GROWTH FACTOR PRECURSOR (EPIDERMAL GROWTH FACTOR-LIKE CRIPTO PROTEIN) (CRIPTO GROWTH FACTOR), cripto growth factor, epidermal growth factor-like Cripto protein
Species: mouse
Products:     Tdgf1

Top Publications

  1. Xu C, Liguori G, Adamson E, Persico M. Specific arrest of cardiogenesis in cultured embryonic stem cells lacking Cripto-1. Dev Biol. 1998;196:237-47 pubmed
    ..Here we describe the involvement of a growth factor with an EGF-like domain, Cripto-1 (Cr-1), in cardiac differentiation...
  2. Acampora D, Mazan S, Lallemand Y, Avantaggiato V, Maury M, Simeone A, et al. Forebrain and midbrain regions are deleted in Otx2-/- mutants due to a defective anterior neuroectoderm specification during gastrulation. Development. 1995;121:3279-90 pubmed
  3. Dono R, Scalera L, Pacifico F, Acampora D, Persico M, Simeone A. The murine cripto gene: expression during mesoderm induction and early heart morphogenesis. Development. 1993;118:1157-68 pubmed
    The murine cripto gene encodes a 171-aminoacid epidermal growth factor-related protein, with 93% similarity to its human counterpart in the 'EGF-like' domain...
  4. Ciccodicola A, Dono R, Obici S, Simeone A, Zollo M, Persico M. Molecular characterization of a gene of the 'EGF family' expressed in undifferentiated human NTERA2 teratocarcinoma cells. EMBO J. 1989;8:1987-91 pubmed
    ..Introduction of the cDNA under the control of a viral LTR induces transformation of NIH3T3 cells. ..
  5. Ding J, Yang L, Yan Y, Chen A, Desai N, Wynshaw Boris A, et al. Cripto is required for correct orientation of the anterior-posterior axis in the mouse embryo. Nature. 1998;395:702-7 pubmed
    ..Here we show that correct localization of both head- and trunk-organizing centres requires Cripto, a putative signalling molecule that is a member of the EGF-CFC gene family...
  6. Minchiotti G, Parisi S, Liguori G, D Andrea D, Persico M. Role of the EGF-CFC gene cripto in cell differentiation and embryo development. Gene. 2002;287:33-7 pubmed
    ..b>Cripto is the founder member of the EGF-CFC family initially related to the epidermal growth factor (EGF); its expression ..
  7. Persico M, Liguori G, Parisi S, D ANDREA D, Salomon D, Minchiotti G. Cripto in tumors and embryo development. Biochim Biophys Acta. 2001;1552:87-93 pubmed
  8. Brennan J, Lu C, Norris D, Rodriguez T, Beddington R, Robertson E. Nodal signalling in the epiblast patterns the early mouse embryo. Nature. 2001;411:965-9 pubmed
    ..Our experiments show that proximal-distal and subsequent anterior-posterior polarity of the pregastrulation embryo result from reciprocal cell-cell interactions between the epiblast and the two extra-embryonic tissues. ..
  9. Yeo C, Whitman M. Nodal signals to Smads through Cripto-dependent and Cripto-independent mechanisms. Mol Cell. 2001;7:949-57 pubmed
    ..We have investigated the role of Cripto, an EGF-CFC factor, in Nodal signaling...

More Information


  1. Chu J, Ding J, Jeays Ward K, Price S, Placzek M, Shen M. Non-cell-autonomous role for Cripto in axial midline formation during vertebrate embryogenesis. Development. 2005;132:5539-51 pubmed for Nodal; by contrast, cell culture data have suggested that the mammalian EGF-CFC protein Cripto can act as a secreted signaling factor...
  2. Rangel M, Karasawa H, Castro N, Nagaoka T, Salomon D, Bianco C. Role of Cripto-1 during epithelial-to-mesenchymal transition in development and cancer. Am J Pathol. 2012;180:2188-200 pubmed publisher
    ..b>Cripto-1, a member of the epidermal growth factor-Cripto-1/FRL-1/Cryptic (EGF/CFC) gene family, together with the ..
  3. Liguori G, Borges A, D Andrea D, Liguoro A, Gonçalves L, Salgueiro A, et al. Cripto-independent Nodal signaling promotes positioning of the A-P axis in the early mouse embryo. Dev Biol. 2008;315:280-9 pubmed publisher
    ..However, the extent to which Nodal activity depends on EGF-CFC proteins is still debated. Cripto is the earliest EGF-CFC gene expressed during mouse embryogenesis and is involved in both A-P axis orientation and ..
  4. Wechselberger C, Strizzi L, Kenney N, Hirota M, Sun Y, Ebert A, et al. Human Cripto-1 overexpression in the mouse mammary gland results in the development of hyperplasia and adenocarcinoma. Oncogene. 2005;24:4094-105 pubmed
    Human Cripto-1 (CR-1) is overexpressed in approximately 80% of human breast, colon and lung carcinomas. Mouse Cr-1 upregulation is also observed in a number of transgenic (Tg) mouse mammary tumors...
  5. Gray P, Shani G, Aung K, Kelber J, Vale W. Cripto binds transforming growth factor beta (TGF-beta) and inhibits TGF-beta signaling. Mol Cell Biol. 2006;26:9268-78 pubmed
    b>Cripto is a developmental oncoprotein and a member of the epidermal growth factor-Cripto, FRL-1, Cryptic family of extracellular signaling molecules...
  6. Ben Haim N, Lu C, Guzman Ayala M, Pescatore L, Mesnard D, Bischofberger M, et al. The nodal precursor acting via activin receptors induces mesoderm by maintaining a source of its convertases and BMP4. Dev Cell. 2006;11:313-23 pubmed
    ..Based on mathematical modeling, we discuss how these sequential loops control cell fate. ..
  7. Liguori G, Echevarria D, Bonilla S, D Andrea D, Liguoro A, Persico M, et al. Characterization of the functional properties of the neuroectoderm in mouse Cripto(-/-) embryos showing severe gastrulation defects. Int J Dev Biol. 2009;53:549-57 pubmed publisher
    ..Mouse Cripto(-/-) embryos could potentially help settle this debate because they lack almost all embryonic endoderm and ..
  8. Xu C, Liguori G, Persico M, Adamson E. Abrogation of the Cripto gene in mouse leads to failure of postgastrulation morphogenesis and lack of differentiation of cardiomyocytes. Development. 1999;126:483-94 pubmed
    b>Cripto-1(Cr1) protein encoded by the tdgf1 gene, is a secreted growth factor that is expressed early in embryonic development and is re-expressed in some tumors of the breast and colon...
  9. Norris D, Brennan J, Bikoff E, Robertson E. The Foxh1-dependent autoregulatory enhancer controls the level of Nodal signals in the mouse embryo. Development. 2002;129:3455-68 pubmed
    ..The feedback loop is thus essential for maintenance of Nodal signals that selectively regulate target gene expression in a temporally and spatially controlled fashion in the mouse embryo. ..
  10. Sun Y, Strizzi L, Raafat A, Hirota M, Bianco C, Feigenbaum L, et al. Overexpression of human Cripto-1 in transgenic mice delays mammary gland development and differentiation and induces mammary tumorigenesis. Am J Pathol. 2005;167:585-97 pubmed
    Overexpression of Cripto-1 has been reported in several types of human cancers including breast cancer...
  11. Liguori G, Echevarria D, Improta R, Signore M, Adamson E, Martinez S, et al. Anterior neural plate regionalization in cripto null mutant mouse embryos in the absence of node and primitive streak. Dev Biol. 2003;264:537-49 pubmed
    ..Mouse embryos homozygous for null mutation in the cripto gene die at about 9.0 days postcoitum (d.p.c.) and fail to gastrulate and to form the node (the primary organizer)...
  12. Parisi S, D Andrea D, Lago C, Adamson E, Persico M, Minchiotti G. Nodal-dependent Cripto signaling promotes cardiomyogenesis and redirects the neural fate of embryonic stem cells. J Cell Biol. 2003;163:303-14 pubmed
    ..We have investigated the role of Cripto, an EGF-CFC factor, in the earliest stages of cardiomyogenesis...
  13. Chen C, Ware S, Sato A, Houston Hawkins D, Habas R, Matzuk M, et al. The Vg1-related protein Gdf3 acts in a Nodal signaling pathway in the pre-gastrulation mouse embryo. Development. 2006;133:319-29 pubmed
    ..Thus, in cell culture, Gdf3 signaling requires the EGF-CFC co-receptor Cripto and can be inhibited by Lefty antagonists...
  14. Shen M, Wang H, Leder P. A differential display strategy identifies Cryptic, a novel EGF-related gene expressed in the axial and lateral mesoderm during mouse gastrulation. Development. 1997;124:429-42 pubmed
    ..We named this gene Cryptic, based on its predicted protein sequence similarity with Cripto, which encodes an EGF-related growth factor...
  15. Shani G, Fischer W, Justice N, Kelber J, Vale W, Gray P. GRP78 and Cripto form a complex at the cell surface and collaborate to inhibit transforming growth factor beta signaling and enhance cell growth. Mol Cell Biol. 2008;28:666-77 pubmed
    b>Cripto is a multifunctional cell surface protein with important roles in vertebrate embryogenesis and the progression of human tumors...
  16. Andersson O, Bertolino P, Ibanez C. Distinct and cooperative roles of mammalian Vg1 homologs GDF1 and GDF3 during early embryonic development. Dev Biol. 2007;311:500-11 pubmed
    ..signaling can be mediated by the type I receptor ALK4, type II receptors ActRIIA and ActRIIB, and the co-receptor Cripto to activate Smad-dependent reporter genes...
  17. Yan Y, Liu J, Luo Y, E C, Haltiwanger R, Abate Shen C, et al. Dual roles of Cripto as a ligand and coreceptor in the nodal signaling pathway. Mol Cell Biol. 2002;22:4439-49 pubmed
    The EGF-CFC gene Cripto encodes an extracellular protein that has been implicated in the signaling pathway for the transforming growth factor beta (TGF beta) ligand Nodal...
  18. Minchiotti G, Parisi S, Liguori G, Signore M, Lania G, Adamson E, et al. Membrane-anchorage of Cripto protein by glycosylphosphatidylinositol and its distribution during early mouse development. Mech Dev. 2000;90:133-42 pubmed
    b>cripto is the original member of the family of EGF-CFC genes, recently recognized as novel extracellular factors essential for vertebrate development...
  19. Adamson E, Minchiotti G, Salomon D. Cripto: a tumor growth factor and more. J Cell Physiol. 2002;190:267-78 pubmed
    b>Cripto, a growth factor with an EGF-like domain, and the first member of the EGF-CFC family of genes to be sequenced and characterized, contributes to deregulated growth of cancer cells...
  20. Tao Q, Yokota C, Puck H, Kofron M, Birsoy B, Yan D, et al. Maternal wnt11 activates the canonical wnt signaling pathway required for axis formation in Xenopus embryos. Cell. 2005;120:857-71 pubmed
    ..Second, we show that activation requires the glycosyl transferase X.EXT1. Third, we find that the EGF-CFC protein, FRL1, is also essential and interacts with Wnt11 to activate canonical Wnt signaling. ..
  21. Georgiades P, Rossant J. Ets2 is necessary in trophoblast for normal embryonic anteroposterior axis development. Development. 2006;133:1059-68 pubmed
    ..This study provides new insights about the genetic and cellular basis of the patterning role and development of the early trophoblast. ..
  22. Miura S, Singh A, Mishina Y. Bmpr1a is required for proper migration of the AVE through regulation of Dkk1 expression in the pre-streak mouse embryo. Dev Biol. 2010;341:246-54 pubmed publisher
    ..Thus, our results suggest that BMP signaling regulates the expression patterns of Dkk1 for anterior migration of the AVE. ..
  23. Xiao C, Shim J, Klüppel M, Zhang S, Dong C, Flavell R, et al. Ecsit is required for Bmp signaling and mesoderm formation during mouse embryogenesis. Genes Dev. 2003;17:2933-49 pubmed
    ..Therefore, these results show that Ecsit functions as an essential component in two important signal transduction pathways and establishes a novel role for Ecsit as a cofactor for Smad proteins in the Bmp signaling pathway. ..
  24. Brown D, Wagner D, Li X, Richardson J, Olson E. Dual role of the basic helix-loop-helix transcription factor scleraxis in mesoderm formation and chondrogenesis during mouse embryogenesis. Development. 1999;126:4317-29 pubmed
    ..These results reveal an essential early role for scleraxis in mesoderm formation, as well as a later role in formation of somite-derived chondrogenic lineages, and suggest that scleraxis target genes mediate these processes. ..
  25. Tian E, Kimura C, Takeda N, Aizawa S, Matsuo I. Otx2 is required to respond to signals from anterior neural ridge for forebrain specification. Dev Biol. 2002;242:204-23 pubmed
    ..These results further suggest that Otx2 dosage may be crucial in the neural plate with respect to response to inductive signals primarily from the ANR for forebrain specification. ..
  26. Arnold S, Hofmann U, Bikoff E, Robertson E. Pivotal roles for eomesodermin during axis formation, epithelium-to-mesenchyme transition and endoderm specification in the mouse. Development. 2008;135:501-11 pubmed publisher
    ..Collectively, our experiments establish that Eomes is a key regulator of anteroposterior axis formation, EMT and definitive endoderm specification in the mouse. ..
  27. Kimura Yoshida C, Tian E, Nakano H, Amazaki S, Shimokawa K, Rossant J, et al. Crucial roles of Foxa2 in mouse anterior-posterior axis polarization via regulation of anterior visceral endoderm-specific genes. Proc Natl Acad Sci U S A. 2007;104:5919-24 pubmed
    ..These findings provide profound insights into conserved roles of Foxa2 transcription factors in anterior specification throughout the evolution of the chordate body plan. ..
  28. Klauzinska M, McCurdy D, Rangel M, Vaidyanath A, Castro N, Shen M, et al. Cripto-1 ablation disrupts alveolar development in the mouse mammary gland through a progesterone receptor-mediated pathway. Am J Pathol. 2015;185:2907-22 pubmed publisher
    b>Cripto-1, a member of the epidermal growth factor-Cripto-1/FRL-1/Cryptic family, is critical for early embryonic development...
  29. Zhang Y, Cleary M, Si Y, Liu G, Eto Y, Kritzik M, et al. Inhibition of activin signaling induces pancreatic epithelial cell expansion and diminishes terminal differentiation of pancreatic beta-cells. Diabetes. 2004;53:2024-33 pubmed
    ..Interestingly, the expression of endogenous cellular inhibitors of activin signaling, follistatin and Cripto, were also found to be augmented...
  30. Spiller C, Gillis A, Burnet G, Stoop H, Koopman P, Bowles J, et al. Cripto: Expression, epigenetic regulation and potential diagnostic use in testicular germ cell tumors. Mol Oncol. 2016;10:526-37 pubmed publisher
    ..The Nodal co-receptor Cripto is expressed transiently during normal germ cell development and is ectopically expressed in non-seminomas that ..
  31. Johnson S, Rothstein J, Knowles B. Expression of epidermal growth factor family gene members in early mouse development. Dev Dyn. 1994;201:216-26 pubmed
    Transcription of four members of the epidermal growth factor (EGF) family, EGF, TGF-alpha, Amphiregulin, and Cripto, was investigated in the ovulated unfertilized egg and preimplantation embryo using cDNA libraries...
  32. Strizzi L, Mancino M, Bianco C, Raafat A, Gonzales M, Booth B, et al. Netrin-1 can affect morphogenesis and differentiation of the mouse mammary gland. J Cell Physiol. 2008;216:824-34 pubmed publisher
    Netrin-1 has been shown to regulate the function of the EGF-like protein Cripto-1 (Cr-1) and affect mammary gland development...
  33. Cai W, Guzzo R, Wei K, Willems E, Davidovics H, Mercola M. A Nodal-to-TGF? cascade exerts biphasic control over cardiopoiesis. Circ Res. 2012;111:876-81 pubmed publisher
    ..TGF?, however, becomes uniquely responsible for controlling subsequent lineage segregation by stimulating vascular smooth muscle and endothelial lineages and simultaneously blocking cardiomyocyte differentiation. ..
  34. Beppu H, Kawabata M, Hamamoto T, Chytil A, Minowa O, Noda T, et al. BMP type II receptor is required for gastrulation and early development of mouse embryos. Dev Biol. 2000;221:249-58 pubmed
    ..Our results suggest that the function of BMPR-II is essential for epiblast differentiation and mesoderm induction during early mouse development. ..
  35. Polydorou C, Georgiades P. Ets2-dependent trophoblast signalling is required for gastrulation progression after primitive streak initiation. Nat Commun. 2013;4:1658 pubmed publisher
    ..We propose a model that provides a genetic explanation as to how Ets2 in trophoblast mediates the progression of gastrulation within the epiblast. ..
  36. Ishimura A, Chida S, Osada S. Man1, an inner nuclear membrane protein, regulates left-right axis formation by controlling nodal signaling in a node-independent manner. Dev Dyn. 2008;237:3565-76 pubmed publisher
    ..These results suggest that Man1 regulates LR asymmetry by controlling Nodal signaling in a node-independent manner. ..
  37. Robertson E, Norris D, Brennan J, Bikoff E. Control of early anterior-posterior patterning in the mouse embryo by TGF-beta signalling. Philos Trans R Soc Lond B Biol Sci. 2003;358:1351-7; discussion 1357 pubmed
  38. Mesnard D, Donnison M, Fuerer C, Pfeffer P, Constam D. The microenvironment patterns the pluripotent mouse epiblast through paracrine Furin and Pace4 proteolytic activities. Genes Dev. 2011;25:1871-80 pubmed publisher
    ..Adding cell-cell communication to the pleiotropic portfolio of these proteases provides a new framework to study proprotein processing also in other relevant contexts. ..
  39. Giorgio E, Liguoro A, D Orsi L, Mancinelli S, Barbieri A, Palma G, et al. Cripto haploinsufficiency affects in vivo colon tumor development. Int J Oncol. 2014;45:31-40 pubmed publisher
    ..b>Cripto (also called Teratocarcinoma-derived growth factor), the original member of the vertebrate EGF-CFC family, plays a ..
  40. Jin J, Ding J. Cripto is required for mesoderm and endoderm cell allocation during mouse gastrulation. Dev Biol. 2013;381:170-8 pubmed publisher
    ..In this study, we focused on the function of mouse Cripto, a member of the EGF-CFC gene family that is highly expressed in the primitive streak and migrating mesoderm cells ..
  41. Mitchem K, Hibbard E, Beyer L, Bosom K, Dootz G, Dolan D, et al. Mutation of the novel gene Tmie results in sensory cell defects in the inner ear of spinner, a mouse model of human hearing loss DFNB6. Hum Mol Genet. 2002;11:1887-98 pubmed
    ..The spinner mutant is thus a valuable model for insight into mechanisms of human deafness and development of sensory cell function. ..
  42. Takaoka K, Yamamoto M, Shiratori H, Meno C, Rossant J, Saijoh Y, et al. The mouse embryo autonomously acquires anterior-posterior polarity at implantation. Dev Cell. 2006;10:451-9 pubmed
    ..This asymmetry in molecular patterning of the mouse embryo pushes back the origin of the A-P body axis to the peri-implantation stage. ..
  43. Minocha S, Bessonnard S, Sung T, Moret C, Constam D, Herr W. Epiblast-specific loss of HCF-1 leads to failure in anterior-posterior axis specification. Dev Biol. 2016;418:75-88 pubmed publisher
    ..We note that the pattern of Hcfc1(epiKO/Y) lethality displays many similarities to loss of ?-catenin function. These results reveal essential new roles for HCF-1 in early embryonic cell proliferation and development. ..
  44. Kenney N, Huang R, Johnson G, Wu J, Okamura D, Matheny W, et al. Detection and location of amphiregulin and Cripto-1 expression in the developing postnatal mouse mammary gland. Mol Reprod Dev. 1995;41:277-86 pubmed
    Amphiregulin (Ar) and Cripto-1 (Cr-1) are growth promoting peptides that share amino acid sequence homology with epidermal growth factor (EGF)...
  45. Sonntag K, Simantov R, Björklund L, Cooper O, Pruszak J, Kowalke F, et al. Context-dependent neuronal differentiation and germ layer induction of Smad4-/- and Cripto-/- embryonic stem cells. Mol Cell Neurosci. 2005;28:417-29 pubmed
    ..differentiated mouse embryonic stem (ES) cells with deletion of the TGF-beta pathway-related factors Smad4 or Cripto exhibited increased numbers of neurons...
  46. Krentz A, Murphy M, Zhang T, Sarver A, Jain S, Griswold M, et al. Interaction between DMRT1 function and genetic background modulates signaling and pluripotency to control tumor susceptibility in the fetal germ line. Dev Biol. 2013;377:67-78 pubmed publisher
    ..Given the strong evidence for involvement of DMRT1 in human TGCT, the downstream genes and pathways identified in this study provide potentially useful candidates for roles in the human disease. ..
  47. Nowotschin S, Costello I, Piliszek A, Kwon G, Mao C, Klein W, et al. The T-box transcription factor Eomesodermin is essential for AVE induction in the mouse embryo. Genes Dev. 2013;27:997-1002 pubmed publisher
    ..Thus, Eomes function in the visceral endoderm (VE) initiates an instructive transcriptional program controlling AP identity. ..
  48. Donnison M, Beaton A, Davey H, Broadhurst R, L Huillier P, Pfeffer P. Loss of the extraembryonic ectoderm in Elf5 mutants leads to defects in embryonic patterning. Development. 2005;132:2299-308 pubmed
    ..Embryos without ExE tissue are able to form the anterior visceral endoderm but fail to undergo gastrulation, demonstrating an essential role for the ExE in embryonic patterning during a defined window of development. ..
  49. Blanchet M, Le Good J, Oorschot V, Baflast S, Minchiotti G, Klumperman J, et al. Cripto localizes Nodal at the limiting membrane of early endosomes. Sci Signal. 2008;1:ra13 pubmed publisher
    b>Cripto is a glycosylphosphatidylinositol (GPI)-anchored co-receptor of Nodal and several other transforming growth factor-beta (TGF-beta) family ligands...
  50. Uehara M, Yashiro K, Takaoka K, Yamamoto M, Hamada H. Removal of maternal retinoic acid by embryonic CYP26 is required for correct Nodal expression during early embryonic patterning. Genes Dev. 2009;23:1689-98 pubmed publisher
    ..These observations suggest that maternal RA must be removed by embryonic CYP26 for correct Nodal expression during embryonic patterning. ..
  51. Jin J, Tan M, Ding J. Analysis of Cripto expression during mouse cardiac myocyte differentiation. Int J Dev Biol. 2013;57:793-7 pubmed publisher
    ..In this study, we have examined the expression of the mouse Cripto gene and the lineage of Cripto-expressing cells, focusing on its relationship with cardiac myocyte differentiation...
  52. Barnes R, Harris I, Jaehnig E, Sauls K, Sinha T, Rojas A, et al. MEF2C regulates outflow tract alignment and transcriptional control of Tdgf1. Development. 2016;143:774-9 pubmed publisher
    ..We identify Tdgf1, which encodes a Nodal co-receptor (also known as Cripto), as a direct transcriptional target of MEF2C in the outflow tract via an AHF-restricted Tdgf1 enhancer...
  53. Lu C, Robertson E. Multiple roles for Nodal in the epiblast of the mouse embryo in the establishment of anterior-posterior patterning. Dev Biol. 2004;273:149-59 pubmed
  54. Uez N, Lickert H, Kohlhase J, de Angelis M, Kühn R, Wurst W, et al. Sall4 isoforms act during proximal-distal and anterior-posterior axis formation in the mouse embryo. Genesis. 2008;46:463-77 pubmed publisher
    ..This observation was supported through genetic interaction with beta-catenin mutants, since compound heterozygous mutants recapitulated the defects of Wnt3a mutants in posterior development. ..
  55. Gotoh N, Manova K, Tanaka S, Murohashi M, Hadari Y, Lee A, et al. The docking protein FRS2alpha is an essential component of multiple fibroblast growth factor responses during early mouse development. Mol Cell Biol. 2005;25:4105-16 pubmed
    ..These experiments underscore the critical role of FRS2alpha in mediating multiple processes during embryonic development and reveal a potential new link between FGF and Bmp4 signaling pathways in early embryogenesis. ..
  56. Kimura Yoshida C, Nakano H, Okamura D, Nakao K, Yonemura S, Belo J, et al. Canonical Wnt signaling and its antagonist regulate anterior-posterior axis polarization by guiding cell migration in mouse visceral endoderm. Dev Cell. 2005;9:639-50 pubmed
    ..We propose that Wnt/beta-catenin signaling mediates A-P axis polarization by guiding cell migration toward the prospective anterior in the pregastrula mouse embryo...
  57. Donnison M, Broadhurst R, Pfeffer P. Elf5 and Ets2 maintain the mouse extraembryonic ectoderm in a dosage dependent synergistic manner. Dev Biol. 2015;397:77-88 pubmed publisher
  58. Sebastiano V, Dalvai M, Gentile L, Schubart K, Sutter J, Wu G, et al. Oct1 regulates trophoblast development during early mouse embryogenesis. Development. 2010;137:3551-60 pubmed publisher
    ..Our data also suggest that Oct1 is required in the embryo proper from late gastrulation stages onwards. ..
  59. Chambery A, Vissers J, Langridge J, Lonardo E, Minchiotti G, Ruvo M, et al. Qualitative and quantitative proteomic profiling of cripto(-/-) embryonic stem cells by means of accurate mass LC-MS analysis. J Proteome Res. 2009;8:1047-58 pubmed publisher
    b>Cripto is one of the key regulators of embryonic stem cells (ESCs) differentiation into cardiomyocites vs neuronal fate...
  60. Hanna L, Foreman R, Tarasenko I, Kessler D, Labosky P. Requirement for Foxd3 in maintaining pluripotent cells of the early mouse embryo. Genes Dev. 2002;16:2650-61 pubmed
    ..These results establish Foxd3 as a factor required for the maintenance of progenitor cells in the mammalian embryo. ..
  61. Bianco C, Cotten C, Lonardo E, Strizzi L, Baraty C, Mancino M, et al. Cripto-1 is required for hypoxia to induce cardiac differentiation of mouse embryonic stem cells. Am J Pathol. 2009;175:2146-58 pubmed publisher
    b>Cripto-1 is a membrane-bound protein that is highly expressed in embryonic stem cells and in human tumors...
  62. Guardiola O, Lafuste P, Brunelli S, Iaconis S, Touvier T, Mourikis P, et al. Cripto regulates skeletal muscle regeneration and modulates satellite cell determination by antagonizing myostatin. Proc Natl Acad Sci U S A. 2012;109:E3231-40 pubmed publisher
    ..Here, we show that Cripto, a regulator of early embryogenesis, is a novel regulator of muscle regeneration and satellite cell progression ..
  63. Izzi L, Silvestri C, Von Both I, Labbé E, Zakin L, Wrana J, et al. Foxh1 recruits Gsc to negatively regulate Mixl1 expression during early mouse development. EMBO J. 2007;26:3132-43 pubmed
    ..As Gsc is itself induced in a Foxh1-dependent manner, we propose that Foxh1 initiates positive and negative transcriptional circuits to refine cell fate decisions during gastrulation. ..
  64. Kimura C, Yoshinaga K, Tian E, Suzuki M, Aizawa S, Matsuo I. Visceral endoderm mediates forebrain development by suppressing posteriorizing signals. Dev Biol. 2000;225:304-21 pubmed
    ..These results suggest that distal visceral endoderm cells move to the future anterior side to generate a prospective forebrain territory indirectly, by preventing posteriorizing signals. ..
  65. Lin X, Zhao W, Jia J, Lin T, Xiao G, Wang S, et al. Ectopic expression of Cripto-1 in transgenic mouse embryos causes hemorrhages, fatal cardiac defects and embryonic lethality. Sci Rep. 2016;6:34501 pubmed publisher
    Targeted disruption of Cripto-1 in mice caused embryonic lethality at E7...
  66. Kruithof de Julio M, Alvarez M, Galli A, Chu J, Price S, Califano A, et al. Regulation of extra-embryonic endoderm stem cell differentiation by Nodal and Cripto signaling. Development. 2011;138:3885-95 pubmed publisher
    ..We have found that XEN cells treated with Nodal or Cripto (Tdgf1), an EGF-CFC co-receptor for Nodal, display upregulation of markers for visceral endoderm as well as ..
  67. Mancino M, Strizzi L, Wechselberger C, Watanabe K, Gonzales M, Hamada S, et al. Regulation of human Cripto-1 gene expression by TGF-beta1 and BMP-4 in embryonal and colon cancer cells. J Cell Physiol. 2008;215:192-203 pubmed
    Human Cripto-1 (CR-1) is a cell membrane protein that is overexpressed in several different types of human carcinomas. In the present study we investigated the mechanisms that regulate the expression of CR-1 gene in cancer cells...
  68. Kannan S, De Santis M, Lohmeyer M, Riese D, Smith G, Hynes N, et al. Cripto enhances the tyrosine phosphorylation of Shc and activates mitogen-activated protein kinase (MAPK) in mammary epithelial cells. J Biol Chem. 1997;272:3330-5 pubmed
    b>Cripto-1 (CR-1), a recently discovered protein of the epidermal growth factor (EGF) family, was found to interact with a high affinity, saturable binding site(s) on HC-11 mouse mammary epithelial cells and on several different human ..
  69. Morkel M, Huelsken J, Wakamiya M, Ding J, van de Wetering M, Clevers H, et al. Beta-catenin regulates Cripto- and Wnt3-dependent gene expression programs in mouse axis and mesoderm formation. Development. 2003;130:6283-94 pubmed
    Gene expression profiling of beta-catenin, Cripto and Wnt3 mutant mouse embryos has been used to characterise the genetic networks that regulate early embryonic development...
  70. Miura S, Mishina Y. Whole-embryo culture of E5.5 mouse embryos: development to the gastrulation stage. Genesis. 2003;37:38-43 pubmed
    ..Although cultured embryos tended to grow a larger extraembryonic portion, more than 80% of them developed the primitive streak and induce mesoderm, which corresponds to the mid-streak stage. ..
  71. Rakeman A, Anderson K. Axis specification and morphogenesis in the mouse embryo require Nap1, a regulator of WAVE-mediated actin branching. Development. 2006;133:3075-83 pubmed
    ..Thus, the Nap1 mutant phenotypes define the crucial roles of Nap1/WAVE-mediated actin regulation in tissue organization and establishment of the body plan of the mammalian embryo. ..
  72. Castro N, Fedorova Abrams N, Merchant A, Rangel M, Nagaoka T, Karasawa H, et al. Cripto-1 as a novel therapeutic target for triple negative breast cancer. Oncotarget. 2015;6:11910-29 pubmed
    ..b>Cripto-1, an embryonic stem cell marker, was present in spindle-like areas and its promoter showed activity in primary ..
  73. Beck S, Le Good J, Guzman M, Ben Haim N, Roy K, Beermann F, et al. Extraembryonic proteases regulate Nodal signalling during gastrulation. Nat Cell Biol. 2002;4:981-5 pubmed
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