Gene Symbol: Tcte3
Description: t-complex-associated testis expressed 3
Alias: D17Leh117c, LC2, Tcte-3, Tctex-2, Tctex-4, Tctex2, Tctex4, tctex1 domain-containing protein 3, T-complex testis-specific protein 2, T-complex testis-specific protein 3, T-complex-associated testis-expressed protein 3, T-complex-associated testis-expressed protein 4, t-complex testis-expressed 4
Species: mouse
Products:     Tcte3

Top Publications

  1. Rashid S, Grzmil P, Drenckhahn J, Meinhardt A, Adham I, Engel W, et al. Disruption of the murine dynein light chain gene Tcte3-3 results in asthenozoospermia. Reproduction. 2010;139:99-111 pubmed publisher
    To elucidate the role of the mouse gene Tcte3 (Tctex2), which encodes a putative light chain of the outer dynein arm of cilia and sperm flagella, we have inactivated this gene in mice using targeted disruption...
  2. Ha H, Howard C, Yeom Y, Abe K, Uehara H, Artzt K, et al. Several testis-expressed genes in the mouse t-complex have expression differences between wild-type and t-mutant mice. Dev Genet. 1991;12:318-32 pubmed
    ..Interestingly, four Tctex genes show differences in the amount of transcript between wild-type and t-mutant testes. The chromosomal location and expression pattern imply that Tctex genes might be candidate genes for sterility or TRD. ..
  3. Huw L, Goldsborough A, Willison K, Artzt K. Tctex2: a sperm tail surface protein mapping to the t-complex. Dev Biol. 1995;170:183-94 pubmed
    ..The characterization of Tctex2 (t-complex testis expressed 2) shows it to be one of several candidates for involvement in TRD...
  4. Trachtulec Z, Vincek V, Hamvas R, Forejt J, Lehrach H, Klein J. Physical map of mouse chromosome 17 in the region relevant for positional cloning of the Hybrid sterility 1 gene. Genomics. 1994;23:132-7 pubmed
    ..The Hst1 gene maps approximately 0.2 cM proximal to the D17Ph1 locus encompassed by the YAC contig. Since the contig extends at least 1200 kb proximal to D17Ph1, it should contain the Hst1 gene. ..
  5. Trachtulec Z, Mnukov√° Fajdelov√° M, Hamvas R, Gregorova S, Mayer W, Lehrach H, et al. Isolation of candidate hybrid sterility 1 genes by cDNA selection in a 1.1 megabase pair region on mouse chromosome 17. Mamm Genome. 1997;8:312-6 pubmed
    ..The presented physical and genetic mapping data indicate there are no gross rearrangements distinguishing the Hst1(f) and Hst1(s) alleles. ..
  6. Jones E, Kumanovics A, Yoshino M, Fischer Lindahl K. Mhc class I and non-class I gene organization in the proximal H2-M region of the mouse. Immunogenetics. 1999;49:183-95 pubmed
    ..kilobase interval in the distal part of the class I region in mouse, and their order Znf173-Rfb30-Tctex5-Tctex6- Tctex4-Mog was found conserved between human and mouse...
  7. Neesen J, Drenckhahn J, Tiede S, Burfeind P, Grzmil M, Konietzko J, et al. Identification of the human ortholog of the t-complex-encoded protein TCTE3 and evaluation as a candidate gene for primary ciliary dyskinesia. Cytogenet Genome Res. 2002;98:38-44 pubmed
    ..In order to identify novel PCD genes we have isolated the human ortholog of the murine TCTE3 gene...
  8. Geremek M, Witt M. Primary ciliary dyskinesia: genes, candidate genes and chromosomal regions. J Appl Genet. 2004;45:347-61 pubmed
    ..In this review, the disease pathomechanism is discussed along with the genes that are or may be involved in the pathogenesis of primary ciliary dyskinesia and the Kartagener syndrome. ..
  9. Chan W, Wu S, Ruszczyk L, Law E, Lee T, Baxendale V, et al. The complexity of antisense transcription revealed by the study of developing male germ cells. Genomics. 2006;87:681-92 pubmed
    ..Thus antisense transcripts have complex origins and structures and the sense and antisense transcripts can be regulated independently. ..

More Information


  1. Rappold G, Trowsdale J, Lichter P. Assignment of the human homologue of the mouse t-complex gene TCTE3 to human chromosome 6q27. Genomics. 1992;13:1337-9 pubmed
    The gene TCTE3 from the mouse t-complex region is expressed specifically in testicular germ cells...
  2. Rappold G, Stubbs L, Labeit S, Crkvenjakov R, Lehrach H. Identification of a testis-specific gene from the mouse t-complex next to a CpG-rich island. EMBO J. 1987;6:1975-80 pubmed
    ..Sequence analysis verified the existence of a CpG-rich element on the 5' end of the gene and predicts a unique protein species with no significant homologies to those previously determined. ..
  3. DiBella L, Benashski S, Tedford H, Harrison A, Patel King R, King S. The Tctex1/Tctex2 class of dynein light chains. Dimerization, differential expression, and interaction with the LC8 protein family. J Biol Chem. 2001;276:14366-73 pubmed
    The Tctex1/Tctex2 family of dynein light chains associates with the intermediate chains at the base of the soluble dynein particle. These components are essential for dynein assembly and participate in specific motor-cargo interactions...
  4. Bai X, Chan E, Xu X. The protein of a new gene, Tctex4, interacts with protein kinase CK2beta subunit and is highly expressed in mouse testis. Biochem Biophys Res Commun. 2003;307:86-91 pubmed
    ..isolated a cDNA clone encoding a 14-kDa protein with homology to dynein light chains and have designated it as Tctex4. CK2beta interacts specifically with Tctex4 both in a yeast two-hybrid system and in an in vitro interaction assay...
  5. Malcov M, Cesarkas K, Stelzer G, Shalom S, Dicken Y, Naor Y, et al. Aym1, a mouse meiotic gene identified by virtue of its ability to activate early meiotic genes in the yeast Saccharomyces cerevisiae. Dev Biol. 2004;276:111-23 pubmed
    ..The potential functional relationship between AYM1 and yeast proteins that regulate expression of early meiotic genes is discussed. ..
  6. Lader E, Ha H, O Neill M, Artzt K, Bennett D. tctex-1: a candidate gene family for a mouse t complex sterility locus. Cell. 1989;58:969-79 pubmed
    ..The aberrant expression of tctex-1 is solely dependent on the t haplotype genes and occurs only in germ cells. The chromosomal location and pattern of expression of tctex-1 make it a candidate for involvement in male sterility. ..
  7. Himmelbauer H, Artzt K, Barlow D, Fischer Lindahl K, Lyon M, Klein J, et al. Encyclopedia of the mouse genome III. October 1993. Mouse chromosome 17. Mamm Genome. 1993;4 Spec No:S230-52 pubmed
  8. Li B, Nair M, Mackay D, Bilanchone V, Hu M, Fallahi M, et al. Ovol1 regulates meiotic pachytene progression during spermatogenesis by repressing Id2 expression. Development. 2005;132:1463-73 pubmed
    ..Taken together, our studies demonstrate a role for Ovol1 in regulating pachytene progression of male germ cells, and identify Id2 as a Ovol1 target. ..