Tcf3

Summary

Gene Symbol: Tcf3
Description: transcription factor 3
Alias: AA408400, ALF2, AW209082, E12, E12/E47, E2A, E47, ME2, Pan1, Pan2, TCF-3, Tcfe2a, VDIR, bHLHb21, immunoglobulin enhancer-binding factor E12/E47, transcription factor A1, transcription factor E2-alpha, transcription factor E2a
Species: mouse

Top Publications

  1. pmc Differential functions for the transcription factor E2A in positive and negative gene regulation in pre-B lymphocytes
    Stephen Greenbaum
    Department of Immunology, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Biol Chem 279:45028-35. 2004
  2. pmc Inhibition of glycogen synthase kinase-3 alleviates Tcf3 repression of the pluripotency network and increases embryonic stem cell resistance to differentiation
    Jason Wray
    Wellcome Trust Centre for Stem Cell Research and Department of Biochemistry, University of Cambridge, Tennis Court Road, Cambridge CB2 1QR, UK
    Nat Cell Biol 13:838-45. 2011
  3. doi Mouse Tcf3 represses canonical Wnt signaling by either competing for β-catenin binding or through occupation of DNA-binding sites
    Nina Solberg
    SFI CAST Biomedical Innovation Center, Unit for Cell Signaling, Oslo University Hospital, Forskningsparken, Gaustadalleen 21, 0349 Oslo, Norway
    Mol Cell Biochem 365:53-63. 2012
  4. ncbi Failure of B-cell differentiation in mice lacking the transcription factor EBF
    H Lin
    Howard Hughes Medical Institute, Department of Microbiology and Immunology, University of California, San Francisco 94143, USA
    Nature 376:263-7. 1995
  5. doi Instructive role of the transcription factor E2A in early B lymphopoiesis and germinal center B cell development
    Kyongrim Kwon
    Research Institute of Molecular Pathology, Vienna Biocenter, Dr Bohr Gasse 7, A 1030 Vienna, Austria
    Immunity 28:751-62. 2008
  6. pmc T-cell factor 3 (Tcf3) deletion increases somatic cell reprogramming by inducing epigenome modifications
    Frederic Lluis
    Centre de Regulacio Genomica, Universitat Pompeu Fabra, 08003 Barcelona, Spain
    Proc Natl Acad Sci U S A 108:11912-7. 2011
  7. pmc Uncovering early response of gene regulatory networks in ESCs by systematic induction of transcription factors
    Akira Nishiyama
    National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA
    Cell Stem Cell 5:420-33. 2009
  8. ncbi E2A proteins are required for proper B cell development and initiation of immunoglobulin gene rearrangements
    G Bain
    Department of Biology, University of California, San Diego, La Jolla 92130
    Cell 79:885-92. 1994
  9. pmc E2A deficiency leads to abnormalities in alphabeta T-cell development and to rapid development of T-cell lymphomas
    G Bain
    Department of Biology, University of California, San Diego, La Jolla 92093, USA
    Mol Cell Biol 17:4782-91. 1997
  10. doi Characterization and functional analysis of the 5'-flanking promoter region of the mouse Tcf3 gene
    Nina Solberg
    Department of Microbiology, Oslo University Hospital, Rikshospitalet, Forskningsparken, Oslo, Norway
    Mol Cell Biochem 360:289-99. 2012

Research Grants

  1. SENESCENE AND PREB CELL DEVELOPMENT
    Richard Riley; Fiscal Year: 2003
  2. Regulation of E2A in Normal and Aged B Lymphopoiesis
    Richard Riley; Fiscal Year: 2007
  3. Selection of the B cell repertoire in senescence
    Richard Riley; Fiscal Year: 2007
  4. Selection of B cell repertoire in senescence
    Richard L Riley; Fiscal Year: 2010
  5. Regulation of Lymphocyte Development by HLH Proteins
    BARBARA LYNNE KEE; Fiscal Year: 2010
  6. E2A/HEB TRANSCRIPTION FACTORS IN T CELL DEVELOPMENT
    Yuan Zhuang; Fiscal Year: 2010
  7. Regulation of Lymphocyte Development by HLH Proteins
    Barbara Kee; Fiscal Year: 2007
  8. Transcriptional Control of Hematopoiesis
    BARBARA LYNNE KEE; Fiscal Year: 2010
  9. The role of E47 in uncommitted hematopoietic progenitors
    Lisa Borghesi; Fiscal Year: 2010
  10. Regulation of Lymphocyte Development by HLH Proteins
    BARBARA LYNNE KEE; Fiscal Year: 2010

Scientific Experts

Detail Information

Publications121 found, 100 shown here

  1. pmc Differential functions for the transcription factor E2A in positive and negative gene regulation in pre-B lymphocytes
    Stephen Greenbaum
    Department of Immunology, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Biol Chem 279:45028-35. 2004
    The transcription factors encoded by the E2A gene have been shown to play essential roles in the initiation and progression of lymphocyte development...
  2. pmc Inhibition of glycogen synthase kinase-3 alleviates Tcf3 repression of the pluripotency network and increases embryonic stem cell resistance to differentiation
    Jason Wray
    Wellcome Trust Centre for Stem Cell Research and Department of Biochemistry, University of Cambridge, Tennis Court Road, Cambridge CB2 1QR, UK
    Nat Cell Biol 13:838-45. 2011
    ..However, requirement for Gsk3 inhibition is dictated by expression of T-cell factor 3 (Tcf3) and mediated by direct interaction with β-catenin...
  3. doi Mouse Tcf3 represses canonical Wnt signaling by either competing for β-catenin binding or through occupation of DNA-binding sites
    Nina Solberg
    SFI CAST Biomedical Innovation Center, Unit for Cell Signaling, Oslo University Hospital, Forskningsparken, Gaustadalleen 21, 0349 Oslo, Norway
    Mol Cell Biochem 365:53-63. 2012
    b>Tcf3 acts as a transcription factor controlling gene expression in canonical Wnt signaling. In this study we show that mouse Tcf3 represses canonical Wnt signaling in mouse neural stem cells and in human HEK 293 cells...
  4. ncbi Failure of B-cell differentiation in mice lacking the transcription factor EBF
    H Lin
    Howard Hughes Medical Institute, Department of Microbiology and Immunology, University of California, San Francisco 94143, USA
    Nature 376:263-7. 1995
    ....
  5. doi Instructive role of the transcription factor E2A in early B lymphopoiesis and germinal center B cell development
    Kyongrim Kwon
    Research Institute of Molecular Pathology, Vienna Biocenter, Dr Bohr Gasse 7, A 1030 Vienna, Austria
    Immunity 28:751-62. 2008
    The transcription factor E2A controls the initiation of B lymphopoiesis, which is arrested at the pre-pro-B cell stage in E2A-deficient mice...
  6. pmc T-cell factor 3 (Tcf3) deletion increases somatic cell reprogramming by inducing epigenome modifications
    Frederic Lluis
    Centre de Regulacio Genomica, Universitat Pompeu Fabra, 08003 Barcelona, Spain
    Proc Natl Acad Sci U S A 108:11912-7. 2011
    ..Here, we show that the absence of T-cell factor 3 (Tcf3), a repressor of β-catenin target genes, strikingly and rapidly enhances the efficiency of neural precursor cell (..
  7. pmc Uncovering early response of gene regulatory networks in ESCs by systematic induction of transcription factors
    Akira Nishiyama
    National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA
    Cell Stem Cell 5:420-33. 2009
    ..Of the 50 TFs, Cdx2 provoked the most extensive transcriptome perturbation in ESCs, followed by Esx1, Sox9, Tcf3, Klf4, and Gata3. ChIP-Seq revealed that CDX2 binds to promoters of upregulated target genes...
  8. ncbi E2A proteins are required for proper B cell development and initiation of immunoglobulin gene rearrangements
    G Bain
    Department of Biology, University of California, San Diego, La Jolla 92130
    Cell 79:885-92. 1994
    E12 and E47 are two helix-loop-helix transcription factors that arise by alternative splicing of the E2A gene. Both have been implicated in the regulation of immunoglobulin gene expression...
  9. pmc E2A deficiency leads to abnormalities in alphabeta T-cell development and to rapid development of T-cell lymphomas
    G Bain
    Department of Biology, University of California, San Diego, La Jolla 92093, USA
    Mol Cell Biol 17:4782-91. 1997
    The E2A gene products, E12 and E47, are critical for proper early B-cell development and commitment to the B-cell lineage. Here we reveal a new role for E2A in T-lymphocyte development...
  10. doi Characterization and functional analysis of the 5'-flanking promoter region of the mouse Tcf3 gene
    Nina Solberg
    Department of Microbiology, Oslo University Hospital, Rikshospitalet, Forskningsparken, Oslo, Norway
    Mol Cell Biochem 360:289-99. 2012
    b>Tcf3 is a nuclear mediator of canonical Wnt signaling which functions in many systems as a repressor of target gene transcription. In this study, we have cloned and characterized a 6...
  11. pmc Function of Wnt/β-catenin in counteracting Tcf3 repression through the Tcf3-β-catenin interaction
    Chun I Wu
    Department of Biochemistry and Molecular Genetics, University of Illinois at Chicago, Chicago, IL 60607, USA
    Development 139:2118-29. 2012
    ..In contrast to β-catenin-dependent functions described for Tcf1, Tcf4 and Lef1, the known embryonic functions for Tcf3 in mice, frogs and fish are consistent with β-catenin-independent repressor activity...
  12. ncbi Interactions between heterologous helix-loop-helix proteins generate complexes that bind specifically to a common DNA sequence
    C Murre
    Whitehead Institute for Biomedical Research, Cambridge, Massachusetts 02142
    Cell 58:537-44. 1989
    ..HLH motif), has recently been identified in various proteins, including two that bind to immunoglobulin enhancers (E12 and E47)...
  13. pmc An essential role for the transcription factor HEB in thymocyte survival, Tcra rearrangement and the development of natural killer T cells
    Louise M D'Cruz
    University of California San Diego, Division of Biology, La Jolla, California, USA
    Nat Immunol 11:240-9. 2010
    ..Thus, our results show that HEB is a specific and essential factor in T cell development and in the generation of the iNKT cell lineage, defining a unique role for HEB in the regulation of lymphocyte maturation...
  14. ncbi The helix-loop-helix gene E2A is required for B cell formation
    Y Zhuang
    Howard Hughes Medical Institute, Fred Hutchinson Cancer Research Center, Seattle, WA 98104
    Cell 79:875-84. 1994
    Heterodimers between tissue-specific basic-helix-loop-helix proteins and the gene products of E2A play major roles in determining tissue-specific cell fate...
  15. ncbi Coordinate regulation of B cell differentiation by the transcription factors EBF and E2A
    M O'RIORDAN
    Howard Hughes Medical Institute, Department of Microbiology and Immunology, University of California, San Francisco 94143, USA
    Immunity 11:21-31. 1999
    The transcription factors EBF and E2A are required at a similar step in early B cell differentiation. EBF and E2A synergistically upregulate transcription of endogenous B cell-specific genes in a non-B cell line...
  16. pmc Pre-TCR signaling inactivates Notch1 transcription by antagonizing E2A
    Yumi Yashiro-Ohtani
    Department of Pathology and Laboratory Medicine, Abramson Family Cancer Research Institute, Institute for Medicine and Engineering, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Genes Dev 23:1665-76. 2009
    ..We show that Notch1 and E2A directly regulate Notch1 transcription in pre-beta-selected thymocytes...
  17. pmc E proteins and Notch signaling cooperate to promote T cell lineage specification and commitment
    Tomokatsu Ikawa
    Division of Biological Sciences, University of California, San Diego, La Jolla, CA 92093, USA
    J Exp Med 203:1329-42. 2006
    ..expression of the intracellular domain of Notch rescues the developmental arrest at the T cell commitment stage in E2A-deficient fetal thymocytes...
  18. pmc Distinct roles for E12 and E47 in B cell specification and the sequential rearrangement of immunoglobulin light chain loci
    Kristina Beck
    Division of Biological Sciences, University of California, San Diego, La Jolla, CA 92093, USA
    J Exp Med 206:2271-84. 2009
    The E2A gene products, E12 and E47, are critical regulators of B cell development. However, it remains elusive whether E12 and E47 have overlapping and/or distinct functions during B lymphopoiesis...
  19. pmc Acquisition of a functional T cell receptor during T lymphocyte development is enforced by HEB and E2A transcription factors
    Mary Elizabeth Jones
    Department of Immunology, Duke University Medical Center, Box 3010, Durham, NC 27710, USA
    Immunity 27:860-70. 2007
    ..We have shown here that the structurally and functionally related transcription factors HEB and E2A work together to maintain DP fate and to control the DP to SP transition...
  20. ncbi An analysis of T cell intrinsic roles of E2A by conditional gene disruption in the thymus
    Lihua Pan
    Department of Immunology and Pathology, Duke University Medical Center, Durham, NC 27710, USA
    J Immunol 168:3923-32. 2002
    The importance of E2A transcription factors in T cell development has been demonstrated in studies of E2A-deficient mice, which display abnormal T cell development and a high frequency of T cell lymphomas...
  21. pmc A tamoxifen inducible knock-in allele for investigation of E2A function
    Mary E Jones
    Department of Immunology, Duke University Medical Center, Durham, NC 27710, USA
    BMC Dev Biol 9:51. 2009
    ..was created by inserting a tamoxifen-responsive region of the estrogen receptor (ER) at the carboxyl end of the tcfe2a gene to generate E2AER fusion proteins...
  22. ncbi PU.1 regulates expression of the interleukin-7 receptor in lymphoid progenitors
    Rodney P DeKoter
    Howard Hughes Medical Institute, Department of Molecular Genetics and Cell Biology, The University of Chicago, 5841 S Maryland Ave, MC1028, Chicago, IL 60637, USA
    Immunity 16:297-309. 2002
    ..1 in early B cell development, it is not required. These results demonstrate that PU.1 functions to regulate early B cell development in part by controlling the expression of the IL-7Ralpha gene...
  23. pmc E2A and HEB are required to block thymocyte proliferation prior to pre-TCR expression
    Jason Wojciechowski
    Department of Immunology, Duke University Medical Center, Durham, NC 27710, USA
    J Immunol 178:5717-26. 2007
    ..b>E2A and HEB are structurally and functionally related basic helix-loop-helix transcription factors involved in T cell ..
  24. pmc Receptor editing and marginal zone B cell development are regulated by the helix-loop-helix protein, E2A
    Melanie W Quong
    Division of Biological Sciences, University of California, San Diego, La Jolla, CA 92093, USA
    J Exp Med 199:1101-12. 2004
    Previous studies have indicated that the E2A gene products are required to initiate B lineage development...
  25. pmc Tcf3 and Tcf4 are essential for long-term homeostasis of skin epithelia
    Hoang Nguyen
    Howard Hughes Medical Institute, Laboratory of Mammalian Cell Biology and Development, The Rockefeller University, New York, New York, USA
    Nat Genet 41:1068-75. 2009
    ..We have discovered that embryonic progenitor cells and postnatal hair follicle stem cells coexpress Tcf3 and Tcf4, which can act as transcriptional activators or repressors...
  26. ncbi E-proteins directly regulate expression of activation-induced deaminase in mature B cells
    Camil Elie Sayegh
    Division of Biological Sciences, University of California San Diego, La Jolla, California 92093, USA
    Nat Immunol 4:586-93. 2003
    ..Taken together, our observations link helix-loop-helix activity and Aicda gene expression in a common pathway, in which E-protein activity is required for the efficient induction of Aicda transcription...
  27. pmc E2A proteins enforce a proliferation checkpoint in developing thymocytes
    Isaac Engel
    Division of Biological Sciences, University of California, San Diego, La Jolla, CA, USA
    EMBO J 23:202-11. 2004
    b>E2A proteins regulate multiple stages of thymocyte development and suppress T-cell lymphoma. The activity of E2A proteins throughout thymocyte development is modulated by signals emanating from the pre-TCR and TCR...
  28. ncbi Decreased E12 and/or E47 transcription factor activity in the bone marrow as well as in the spleen of aged mice
    Daniela Frasca
    Department of Microbiology and Immunology, University of Miami School of Medicine, FL 33136, USA
    J Immunol 170:719-26. 2003
    The E2A-encoded transcription factors E12 and E47 are key regulators of B cell functions...
  29. ncbi Regulation of pT alpha gene expression by a dosage of E2A, HEB, and SCL
    Mathieu Tremblay
    Clinical Research Institute of Montreal, Montreal, Quebec H2W 1R7, Canada
    J Biol Chem 278:12680-7. 2003
    ..We have shown that the transcription factors E2A and HEB associate with high affinity to these E-boxes...
  30. pmc E2A and IRF-4/Pip promote chromatin modification and transcription of the immunoglobulin kappa locus in pre-B cells
    Adam S Lazorchak
    Department of Immunology, Duke University Medical Center, Box 3010, 328 Jones Building, Research Drive, Durham, NC 27710, USA
    Mol Cell Biol 26:810-21. 2006
    ..b>E2A transcription factors have been indicated to be directly involved in the regulation of Igkappa locus activation...
  31. ncbi Id3 inhibits B lymphocyte progenitor growth and survival in response to TGF-beta
    B L Kee
    Department of Biology, University of California, San Diego, La Jolla 92093, USA
    Nat Immunol 2:242-7. 2001
    ..Our data show a key role for E proteins in lymphocyte survival and link the activity of E proteins, and their antagonists, to members of the TGF-beta family of cytokines...
  32. ncbi Regulation of T cell receptor beta gene rearrangements and allelic exclusion by the helix-loop-helix protein, E47
    Yasutoshi Agata
    Horizontal Medical Research Organization, Graduate School of Medicine, Kyoto University, Kyoto 606 8501, Japan
    Immunity 27:871-84. 2007
    ..Here, we demonstrated that the basic helix-loop-helix protein, E47, promoted T cell receptor beta (TCRbeta) gene rearrangement by directly binding to target gene segments to increase ..
  33. pmc E2A proteins maintain the hematopoietic stem cell pool and promote the maturation of myelolymphoid and myeloerythroid progenitors
    Craig L Semerad
    Division of Biological Sciences, 0377, University of California at San Diego, La Jolla, CA 92093, USA
    Proc Natl Acad Sci U S A 106:1930-5. 2009
    ..Pre CFU-E, Pre GM, MkP, and granulocyte-macrophage compartments were all significantly reduced in E2A-deficient bone marrow...
  34. ncbi Long-term cultured E2A-deficient hematopoietic progenitor cells are pluripotent
    Tomokatsu Ikawa
    Division of Biological Sciences, 0377 University of California, San Diego, La Jolla, CA 92093, USA
    Immunity 20:349-60. 2004
    b>E2A proteins are essential for the development of B cells beyond the progenitor cell stage...
  35. pmc E2A promotes the survival of precursor and mature B lymphocytes
    Adam S Lazorchak
    Department of Immunology, Duke University Medical Center, Research Drive, Durham, NC 27710, USA
    J Immunol 177:2495-504. 2006
    The basic helix-loop-helix transcription factor E2A is an essential regulator of B lymphocyte lineage commitment and is required to activate the expression of numerous B lineage-specific genes...
  36. ncbi Early B cell factor cooperates with Runx1 and mediates epigenetic changes associated with mb-1 transcription
    Holly Maier
    Integrated Department of Immunology, National Jewish Medical and Research Center, Denver, Colorado 80206, USA
    Nat Immunol 5:1069-77. 2004
    ..EBF function was enhanced by interaction with the transcription factor Runx1. These data suggest a molecular basis for the hierarchical dependence of Pax5 function on EBF and E2A in B lymphocyte development.
  37. ncbi Both E12 and E47 allow commitment to the B cell lineage
    G Bain
    Department of Biology, University of California, San Diego, La Jolla 92093, USA
    Immunity 6:145-54. 1997
    The E2A gene products, E12 and E47, are required for proper B cell development. Mice lacking the E2A gene products generate only a very small number of B220+ cells, which lack immunoglobulin DJ(H) rearrangements...
  38. pmc IL-7Ralpha and E47: independent pathways required for development of multipotent lymphoid progenitors
    Barbara L Kee
    Department of Biology, University of California San Diego, La Jolla, CA 92093, USA
    EMBO J 21:103-13. 2002
    Mice that lack the transcription factors encoded by the E2A gene or the receptor for interleukin 7 (IL-7R) have severe overlapping defects in lymphocyte development...
  39. pmc E2A proteins promote development of lymphoid-primed multipotent progenitors
    Sheila Dias
    Department of Pathology, The University of Chicago, Chicago, IL 60637, USA
    Immunity 29:217-27. 2008
    ..Here, we demonstrated that the E2A transcription factors were required for proper development of LMPPs...
  40. pmc Positive and negative regulation of V(D)J recombination by the E2A proteins
    G Bain
    Department of Biology, University of California San Diego, La Jolla, California 92093, USA
    J Exp Med 189:289-300. 1999
    ..Here we show that the E2A gene products are essential for the proper coordinated temporal regulation of V(D)J rearrangements within the T ..
  41. ncbi Regulation of E2A gene expression in B-lymphocyte development
    Yuan Zhuang
    Department of Immunology, Duke University Medical Center, Jones Building Room 329, Box 3010, Durham, NC 27710, USA
    Mol Immunol 40:1165-77. 2004
    Biochemical and genetic studies have demonstrated that transcription factors encoded by the E2A gene are essential in regulating B lineage specific gene expression and B lineage commitment...
  42. pmc E47 is required for V(D)J recombinase activity in common lymphoid progenitors
    Lisa Borghesi
    Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    J Exp Med 202:1669-77. 2005
    ..Here, we show that loss of the transcription factor E47 produces a reduced CLP population that lacks V(D)J recombinase activity and D-J(H) rearrangements in vivo...
  43. pmc E47 controls the developmental integrity and cell cycle quiescence of multipotential hematopoietic progenitors
    Qi Yang
    Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    J Immunol 181:5885-94. 2008
    ..Herein, we show that multipotent LSKs (lineage(-)Sca(high)c-kit(+)) from E47-deficient mice exhibit a striking hyperproliferation associated with a loss of cell cycle quiescence and increased ..
  44. pmc Early B cell factor promotes B lymphopoiesis with reduced interleukin 7 responsiveness in the absence of E2A
    Christopher S Seet
    Department of Pathology, University of Chicago, 5841 S Maryland Avenue, MC 1089, Chicago, IL 60637, USA
    J Exp Med 199:1689-700. 2004
    The basic helix-loop-helix transcription factors encoded by the E2A gene function at the apex of a transcriptional hierarchy involving E2A, early B cell factor (EBF), and Pax5, which is essential for B lymphopoiesis...
  45. pmc Thymocyte maturation is regulated by the activity of the helix-loop-helix protein, E47
    G Bain
    Department of Biology, University of California, San Diego, La Jolla, California 92093, USA
    J Exp Med 190:1605-16. 1999
    The E2A proteins, E12 and E47, are required for progression through multiple developmental pathways, including early B and T lymphopoiesis...
  46. pmc B-lymphocyte development is regulated by the combined dosage of three basic helix-loop-helix genes, E2A, E2-2, and HEB
    Y Zhuang
    Fred Hutchinson Cancer Research Center, Seattle, Washington 98104, USA
    Mol Cell Biol 16:2898-905. 1996
    B-lymphocyte development requires the basic helix-loop-helix proteins encoded by the E2A gene. In this study, the control mechanism of E2A was further explored by disruption of the E2A-related genes, E2-2 and HEB...
  47. pmc Notch-induced E2A degradation requires CHIP and Hsc70 as novel facilitators of ubiquitination
    Zhong Huang
    Immunobiology and Cancer Program, Oklahoma Medical Research Foundation, 825 NE 13th St, Oklahoma City, OK 73104, USA
    Mol Cell Biol 24:8951-62. 2004
    b>E2A transcription factors, E12 and E47, are important regulators of lymphocyte development...
  48. pmc Identification of E2A target genes in B lymphocyte development by using a gene tagging-based chromatin immunoprecipitation system
    Stephen Greenbaum
    Department of Immunology, Duke University Medical Center, Box 3010, Durham, NC 27710, USA
    Proc Natl Acad Sci U S A 99:15030-5. 2002
    The transcription factors encoded by the E2A gene are known to be essential for B lymphocyte development, and ectopic expression or gene inactivation studies have revealed several potential lineage-specific E2A target genes...
  49. pmc Functional replacement of the mouse E2A gene with a human HEB cDNA
    Y Zhuang
    Department of Immunology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Mol Cell Biol 18:3340-9. 1998
    The mammalian E2A, HEB, and E2-2 genes encode a unique class of basic helix-loop-helix (bHLH) transcription factors that are evolutionarily conserved and essential for embryonic and postnatal development...
  50. pmc β-Selection-induced proliferation is required for αβ T cell differentiation
    Taras Kreslavsky
    Department of Cancer Immunology and AIDS, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA
    Immunity 37:840-53. 2012
    ..Consistently, pharmacological inhibition of the cell cycle machinery also blocked differentiation in vivo. Thus the proliferation step is strictly required prior to differentiation of immature thymocytes...
  51. pmc Loss of E protein transcription factors E2A and HEB delays memory-precursor formation during the CD8+ T-cell immune response
    Louise M D'Cruz
    Division of Biology, University of California San Diego, La Jolla, CA 92093, USA
    Eur J Immunol 42:2031-41. 2012
    The transcription factors E2A and HEB (members of the E protein family) have been shown to play essential roles in lymphocyte development, while their negative regulators, the Id proteins, have been implicated in both lymphocyte ..
  52. doi Inhibitors of DNA binding proteins restrict T cell potential by repressing Notch1 expression in Flt3-negative common lymphoid progenitors
    Ana Pereira de Sousa
    Institut Pasteur, Unité de Lymphopoièse, 75015 Paris, France
    J Immunol 189:3822-30. 2012
    ..cell precursor potential, both in vivo and in vitro, is due to low Notch1 expression and secondary to inhibition of E2A activity by members of the inhibitor of DNA binding (Id) protein family...
  53. pmc Id2-mediated inhibition of E2A represses memory CD8+ T cell differentiation
    Frederick Masson
    Division of Molecular Immunology, Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria 3052, Australia
    J Immunol 190:4585-94. 2013
    ..We demonstrate that Id2 restrains CD8(+) T cell memory differentiation by inhibiting E2A-mediated direct activation of Tcf7 and that Id2 expression level mirrors T cell memory recall capacity...
  54. pmc Mature natural killer cell and lymphoid tissue-inducing cell development requires Id2-mediated suppression of E protein activity
    Markus D Boos
    Committee on Immunology, University of Chicago, Chicago, IL 60657, USA
    J Exp Med 204:1119-30. 2007
    ..define the mechanism by which Id2 functions by showing that a reduction in E protein activity, through deletion of E2A, overcomes the need for Id2 in development of BM mNK cells, LTi cells, and secondary lymphoid tissues...
  55. pmc Identification of Phox2b-regulated genes by expression profiling of cranial motoneuron precursors
    Patrick Pla
    Ecole Normale Superieure, Departement de Biologie, 75005 Paris, France
    Neural Dev 3:14. 2008
    ..How Phox2b exerts its pleiotropic functions, both as a proneural gene and a neuronal subtype determinant, has remained unknown...
  56. ncbi Pax1/E2a double-mutant mice develop non-lethal neural tube defects that resemble human malformations
    Paulus H L J Joosten
    Department of Cell Biology, Faculty of Science, Radboud University Nijmegen, The Netherlands
    Transgenic Res 14:983-7. 2005
    ..The genes for E2a and Pax1 have both been implicated in not only paraxial mesodermal development, but also in that of the immune ..
  57. pmc The E-protein Tcf4 interacts with Math1 to regulate differentiation of a specific subset of neuronal progenitors
    Adriano Flora
    Howard Hughes Medical Institute, Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 104:15382-7. 2007
    ....
  58. pmc Notch1 promotes survival of E2A-deficient T cell lymphomas through pre-T cell receptor-dependent and -independent mechanisms
    Erica J Reschly
    Department of Pathology, MC1089, The University of Chicago, 5841 S Maryland Avenue, Chicago, IL 60637, USA
    Blood 107:4115-21. 2006
    Loss of E2A transcription factor activity or activation of the intracellular form of Notch1 (ICN) leads to the development of leukemia or lymphoma in humans or mice, respectively...
  59. pmc SCL and associated proteins distinguish active from repressive GATA transcription factor complexes
    Tamara Tripic
    Division of Hematology, The Children s Hospital of Philadelphia, PA 19104, USA
    Blood 113:2191-201. 2009
    ..erythroid rescue system as well as through the use of tiling arrays we detected the SCL/TAL1, LMO2, Ldb1, E2A complex at all positively acting GATA-1-bound elements examined...
  60. ncbi Scleraxis and NFATc regulate the expression of the pro-alpha1(I) collagen gene in tendon fibroblasts
    Véronique Lejard
    INSERM U652 and Paris Descartes University, 75006 Paris, France
    J Biol Chem 282:17665-75. 2007
    ..transcription factor that is expressed selectively in tendon fibroblasts, binds TSE2, preferentially as a SCX/E47 heterodimer...
  61. doi Synergistic nuclear import of NeuroD1 and its partner transcription factor, E47, via heterodimerization
    Rashid Mehmood
    Department of Frontier Biosciences, Graduate School of Frontier Biosciences, Osaka University, Suita, Osaka, Japan
    Exp Cell Res 315:1639-52. 2009
    ..Its dimerization with E47, a type I bHLH transcription factor, leads to the transcriptional regulation of target genes...
  62. pmc Control of the differentiation of regulatory T cells and T(H)17 cells by the DNA-binding inhibitor Id3
    Takashi Maruyama
    Mucosal Immunology Unit, Oral Infection and Immunity Branch, National Institutes of Health, Bethesda, Maryland, USA
    Nat Immunol 12:86-95. 2011
    ..Enhanced binding of the transcription factor E2A to the Foxp3 promoter promoted Foxp3 transcription...
  63. ncbi Capsulin: a novel bHLH transcription factor expressed in epicardial progenitors and mesenchyme of visceral organs
    J Lu
    Department of Molecular Biology and Oncology, The University of Texas, Southwestern Medical Center, 6000 Harry Hines Boulevard, Dallas, TX 75235 9148, USA
    Mech Dev 73:23-32. 1998
    ..Capsulin binds a specific E-box consensus sequence (CANNTG) as a heterodimer with the widely-expressed bHLH protein E12, but it does not activate transcription through that sequence on its own...
  64. pmc The basic helix-loop-helix transcription factors dHAND and eHAND exhibit dimerization characteristics that suggest complex regulation of function
    B A Firulli
    Department of Physiology, The University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229 3900, USA
    J Biol Chem 275:33567-73. 2000
    ..competition gel shift analysis demonstrates that dHAND and eHAND can negatively regulate the DNA binding of MyoD/E12 heterodimers in a manner similar to MISTI and Id proteins, suggesting a possible transcriptional inhibitory role ..
  65. ncbi A carboxy-terminal deletion mutant of Notch1 accelerates lymphoid oncogenesis in E2A-PBX1 transgenic mice
    B J Feldman
    Department of Pathology, Stanford University Medical Center, Stanford, CA 94305, USA
    Blood 96:1906-13. 2000
    ..It was discovered as a fusion with the E2A gene after chromosomal translocations in a subset of acute leukemias...
  66. ncbi Cooperative transcriptional activation by the neurogenic basic helix-loop-helix protein MASH1 and members of the myocyte enhancer factor-2 (MEF2) family
    B L Black
    Department of Molecular Biology and Oncology, Hamon Center for Basic Cancer Research, University of Texas Southwestern Medical Center, Dallas, Texas 75235, USA
    J Biol Chem 271:26659-63. 1996
    ..These results suggest that members of the MEF2 family perform similar roles in synergistic activation of transcription in myogenic and neurogenic lineages by serving as cofactors for cell type-specific bHLH proteins...
  67. pmc Targeted deletion of Hand2 in cardiac neural crest-derived cells influences cardiac gene expression and outflow tract development
    Kristen L Holler
    Department of Neurosciences and Program in Neurosciences and Degenerative Disease, Health Sciences Campus, University of Toledo, 3000 Arlington Ave, Toledo, OH 43614 1007, USA
    Dev Biol 341:291-304. 2010
    ..Our genetic model has made it possible to investigate the molecular genetics of neural crest contributions to outflow tract morphogenesis and cell differentiation...
  68. ncbi Stra13 homodimers repress transcription through class B E-box elements
    Benoit St-Pierre
    Programs in Cancer Research and Developmental Biology, The Hospital for Sick Children, Toronto, Ontario M5G 1X8, Canada
    J Biol Chem 277:46544-51. 2002
    ..Our data suggest that Stra13 regulates cellular functions through antagonism of E-box activator proteins and also through active repression from E-box elements...
  69. ncbi Ubiquitous, but variable, expression of two alternatively spliced mRNAs encoding mouse homologues of transcription factors E47 and E12
    H Watada
    First Department of Medicine, Osaka University School of Medicine, Suita, Japan
    Gene 153:255-9. 1995
    ..Although both generated from a single gene (E2A) by means of alternative splicing, the structural difference in these bHLH regions between the two suggests that ..
  70. pmc Mixed lineage kinase phosphorylates transcription factor E47 and inhibits TrkB expression to link neuronal death and survival pathways
    Neus Pedraza
    Departament de Ciencies Mediques Basiques, IRBLLEIDA, Universitat de Lleida, 25008 Lleida, Catalonia, Spain
    J Biol Chem 284:32980-8. 2009
    b>E47 is a basic helix-loop-helix transcription factor involved in neuronal differentiation and survival...
  71. ncbi Effects of aging on proliferation and E47 transcription factor activity induced by different stimuli in murine splenic B cells
    Daniela Frasca
    Department of Microbiology and Immunology, University of Miami School of Medicine, RMSB, 3146A, 1600 N W 10th Ave, Miami, FL 33136, USA
    Mech Ageing Dev 124:361-9. 2003
    In the present paper, we have investigated the effects of aging on the expression and function of the E2A-encoded transcription factor E47 in splenic B lymphocytes, unactivated or activated with different stimuli (LPS, anti-CD40, anti-..
  72. ncbi E2A/HEB and Id3 proteins control the sensitivity to glucocorticoid-induced apoptosis in thymocytes by regulating the SRG3 expression
    Myunggon Ko
    School of Biological Sciences and Institute of Molecular Biology and Genetics, Seoul National University, Seoul 151 742
    J Biol Chem 279:21916-23. 2004
    The E protein family transcription factors encoded by the E2A and HEB genes are known to play critical roles in the coordinate regulation of lymphocyte development...
  73. ncbi MEKK1 signaling through p38 leads to transcriptional inactivation of E47 and repression of skeletal myogenesis
    Jeanine L Page
    Department of Poultry Science, The Pennsylvania State University, University Park, Pennsylvania 16802, USA
    J Biol Chem 279:30966-72. 2004
    ..MyoD-directed transcriptional activity without altering the ability of the protein to form heterodimers with E2A proteins or bind DNA...
  74. doi Initiation of antigen receptor-dependent differentiation into plasma cells by calmodulin inhibition of E2A
    Jannek Hauser
    Department of Molecular Biology, Umea University, Umea, Sweden
    J Immunol 183:1179-87. 2009
    ..Furthermore, the transcription factor E2A is required for the rapid key down-regulations after BCR activation, and the Ca(2+) sensor protein ..
  75. pmc Helix-loop-helix transcription factors E12 and E47 are not essential for skeletal or cardiac myogenesis, erythropoiesis, chondrogenesis, or neurogenesis
    Y Zhuang
    Fred Hutchinson Cancer Research Center, Seattle, WA
    Proc Natl Acad Sci U S A 89:12132-6. 1992
    E12 and E47 are two non-tissue-specific helix-loop-helix (HLH) transcription factors encoded by the E2A gene...
  76. pmc Tcf/Lef repressors differentially regulate Shh-Gli target gene activation thresholds to generate progenitor patterning in the developing CNS
    Hui Wang
    Department of Neuroscience and Cell Biology, Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, 675 Hoes Lane, Piscataway, NJ 08854, USA
    Development 138:3711-21. 2011
    ..The current study demonstrates a role for Tcf/Lef repressor activity in this process. We show that Tcf3 and Tcf7L2 (Tcf4) are required for proper ventral patterning and function by independently regulating two Shh-Gli ..
  77. doi Stem cell-specific epigenetic priming and B cell-specific transcriptional activation at the mouse Cd19 locus
    Korden Walter
    Section of Experimental Haematology, Leeds Institute of Molecular Medicine, University of Leeds, St James s University Hospital, Leeds, United Kingdom
    Blood 112:1673-82. 2008
    ..Cd19 chromatin is first remodeled at the upstream enhancer, and this remodeling is associated with binding of E2A. This is followed by the binding of EBF and PAX5 during B-cell differentiation...
  78. pmc The helix-loop-helix factors Id3 and E47 are novel regulators of adiponectin
    Amanda C Doran
    Cardiovascular Research Center Cardiovascular Division, University of Virginia, Charlottesville, VA 22908, USA
    Circ Res 103:624-34. 2008
    ..Id3 is a helix-loop-helix factor that binds to E-proteins such as E47 and inhibits their binding to DNA...
  79. pmc NK cells in the CD19- B220+ bone marrow fraction are increased in senescence and reduce E2A and surrogate light chain proteins in B cell precursors
    Anne M King
    Department of Microbiology and Immunology, University of Miami Miller School of Medicine, Miami, FL 33101, USA
    Mech Ageing Dev 130:384-92. 2009
    b>E2A encoded proteins, key transcriptional regulators in B lineage specification and commitment, have been shown to decrease in B cell precursors in old age...
  80. pmc Ebf1-mediated down-regulation of Id2 and Id3 is essential for specification of the B cell lineage
    Melissa A Thal
    Department of Microbiology, The University of Alabama Birmingham, Birmingham, AL 35294, USA
    Proc Natl Acad Sci U S A 106:552-7. 2009
    Gene knockout experiments in mice have suggested a hierarchical model of early B cell commitment wherein E2A proteins (E47 and E12) activate early B cell factor (Ebf1), which in turn activates expression of the B cell commitment factor, ..
  81. pmc Ly6d marks the earliest stage of B-cell specification and identifies the branchpoint between B-cell and T-cell development
    Matthew A Inlay
    Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, California 94305, USA
    Genes Dev 23:2376-81. 2009
    ....
  82. pmc Ras orchestrates exit from the cell cycle and light-chain recombination during early B cell development
    Malay Mandal
    Department of Medicine, Section of Rheumatology, University of Chicago, Chicago, Illinois, USA
    Nat Immunol 10:1110-7. 2009
    ..of Ccnd3 (encoding cyclin D3) and coordinated exit from the cell cycle with induction of the transcription factor E2A and the initiation of Igk recombination...
  83. pmc Sequestration of E12/E47 and suppression of p27KIP1 play a role in Id2-induced proliferation and tumorigenesis
    Valerie A Trabosh
    Department of Biochemistry and Molecular Biology, Georgetown University School of Medicine, 3900 Reservoir Road NW, Washington, DC 20007, USA
    Carcinogenesis 30:1252-9. 2009
    ..was decreased by Id2; the former by downregulation of its promoter by the Id2 HLH domain-mediated sequestration of E12/E47...
  84. pmc Calcium regulation of myogenesis by differential calmodulin inhibition of basic helix-loop-helix transcription factors
    Jannek Hauser
    Department of Molecular Biology, Umea University, SE 901 87 Umea, Sweden
    Mol Biol Cell 19:2509-19. 2008
    ..These heterodimers must compete successfully with homodimers of E12 and other E-proteins to enable myogenesis...
  85. ncbi A congenic line of the BALB/c mouse strain with the endogenous mouse mammary tumor virus proviral gene Mtv-3: tissue-specific expression and correlation with resistance to mouse mammary tumor virus infection and tumorigenesis
    P Hainaut
    Departement de Microbiologie, B23, CHU, Universite de Liege, Belgium
    Cancer Res 50:3754-60. 1990
    ..The presence of a nontumorigenic endogenous MMTV gene was therefore protective against exogenous MMTV infection...
  86. pmc Murine helix-loop-helix transcriptional activator proteins binding to the E-box motif of the Akv murine leukemia virus enhancer identified by cDNA cloning
    A L Nielsen
    Department of Molecular Biology, Aarhus University, Denmark
    Mol Cell Biol 12:3449-59. 1992
    ..results of sequencing ALF2 cDNA suggests that we have recovered the gene for the basic-helix-loop-helix transcription factor A1, the murine analog of the human transcription factor E47...
  87. pmc Differential regulation of Hand1 homodimer and Hand1-E12 heterodimer activity by the cofactor FHL2
    Alison A Hill
    Molecular Medicine Unit, Institute of Child Health, 30 Guilford St, London WC1N 1EH, United Kingdom
    Mol Cell Biol 24:9835-47. 2004
    ..FHL2 interacts with Hand1 via the bHLH domain and is able to repress Hand1/E12 heterodimer-induced transcription but has no effect on Hand1/Hand1 homodimer activity...
  88. ncbi Restricted expression of a novel murine atonal-related bHLH protein in undifferentiated neural precursors
    G Gradwohl
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM Universite Louis Pasteur, Illkirch, France
    Dev Biol 180:227-41. 1996
    ..in yeast and in vitro demonstrate that MATH4A interacts efficiently with both MASH1 and the ubiquitous bHLH protein E12. MATH4A-E12 heterodimers, but not MATH4A-MASH1, bind to a consensus E-box sequence...
  89. pmc Olig2 and Ngn2 function in opposition to modulate gene expression in motor neuron progenitor cells
    Soo Kyung Lee
    Gene Expression Laboratory, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA
    Genes Dev 19:282-94. 2005
    ....
  90. ncbi The basic helix-loop-helix factor, HAND2, functions as a transcriptional activator by binding to E-boxes as a heterodimer
    Yan Shan Dai
    Department of Anatomy and Cell Biology, Columbia University, New York, NY 10032, USA
    J Biol Chem 277:12604-12. 2002
    ..the consensus DNA binding site of HAND2 and show that HAND2 binds a subset of E-boxes as a heterodimer with E12. Yeast two-hybrid screening of a neuroblastoma cDNA library for HAND2-interacting proteins selected HAND2 and ..
  91. ncbi Novel binding partners of Ldb1 are required for haematopoietic development
    Natalia Meier
    Department of Cell Biology and Genetics, Erasmus MC, PO Box 2040, 3000 CA, Rotterdam, The Netherlands
    Development 133:4913-23. 2006
    ..It interacts with Gata1, Tal1, E2A and Lmo2 to form a transcription factor complex regulating late erythroid genes...
  92. pmc E2A basic-helix-loop-helix transcription factors are negatively regulated by serum growth factors and by the Id3 protein
    D A Loveys
    Division of Pediatric Hematology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Nucleic Acids Res 24:2813-20. 1996
    ..Although it was previously suspected that E2A is constitutively expressed, our data indicate that E2A is induced in quiescent fibroblasts, by growth factor ..
  93. ncbi The age-related decrease in E47 DNA-binding does not depend on increased Id inhibitory proteins in bone marrow-derived B cell precursors
    Daniela Frasca
    Department of Microbiology and Immunology, University of Miami School of Medicine, 1600 N W 10th Ave, Miami, FL 33136, USA
    Front Biosci 8:a110-6. 2003
    ..cells in aged mice were associated with decreases in surrogate light chain, lambda5, and transcription factors E47/E12. In the present paper, we have analyzed IL-7-expanded populations of pro-B/early pre-B cells to evaluate whether ..
  94. pmc Regulation of neurogenin stability by ubiquitin-mediated proteolysis
    Jonathan M D Vosper
    Department of Oncology, Hutchison MRC Research Centre, University of Cambridge, Hills Road, Cambridge CB2 0XZ, UK
    Biochem J 407:277-84. 2007
    ..NGN binds to DNA in complex with its heterodimeric E-protein partners E12 or E47. We observed that NGN was stabilized by the presence of E12/E47...
  95. ncbi The ski/sno protooncogene family in hematopoietic development
    S Pearson-White
    Department of Pediatrics, University of Virginia, Charlottesville, USA
    Blood 86:2146-55. 1995
    ..These results suggest that the ski/sno protooncogenes play a role in hematopoiesis, growth factor responses, and cell cycle-regulation, with the two members of the family showing differing properties...
  96. ncbi Dermo-1: a novel twist-related bHLH protein expressed in the developing dermis
    L Li
    Department of Biochemistry and Molecular Biology, University of Texas M D Anderson Cancer Center, Houston 77030, USA
    Dev Biol 172:280-92. 1995
    ..two-hybrid system to screen for tissue-specific bHLH proteins, which dimerize with the ubiquitous bHLH protein E12, we cloned a novel bHLH protein, named Dermo-1...
  97. ncbi Crystal structure of E47-NeuroD1/beta2 bHLH domain-DNA complex: heterodimer selectivity and DNA recognition
    Antonella Longo
    Department of Molecular and Structural Biochemistry, North Carolina State University, 128 Polk Hall, Raleigh, North Carolina 27695 7622, USA
    Biochemistry 47:218-29. 2008
    The ubiquitous class I basic helix-loop-helix (bHLH) factor E47 forms heterodimers with multiple tissue specific class II bHLH proteins to regulate distinct differentiation pathways...
  98. pmc Regulation of lymphocyte development by cell-type-specific interpretation of Notch signals
    Lei Nie
    Program in Immunobiology and Cancer Research, Oklahoma Medical Research Foundation, 825 NE 13th Street, Oklahoma City, OK 73104, USA
    Mol Cell Biol 28:2078-90. 2008
    ..activation accelerates ubiquitin-mediated and mitogen-activated protein kinase (MAPK)-dependent degradation of E2A transcription factors and Janus kinases, molecules essential for both B- and T-lymphocyte development...
  99. ncbi differential roles for the E2A activation domains in B lymphocytes and macrophages
    Savita Bhalla
    Department of Pathology, University of Chicago, 5841 South Maryland Avenue, Chicago, IL 60637, USA
    J Immunol 180:1694-703. 2008
    The E2A gene encodes two E protein/class I basic helix-loop-helix transcription factors, E12 and E47, that are essential for B lymphopoiesis...
  100. ncbi Cloning and characterization of GRIPE, a novel interacting partner of the transcription factor E12 in developing mouse forebrain
    Julian Ik Tsen Heng
    Brain Development Group, Howard Florey Institute, University of Melbourne, Parkville, Melbourne, Victoria 3010, Australia
    J Biol Chem 277:43152-9. 2002
    ..NeuroD are intimately involved in neuronal fate determination, the role of the ubiquitously expressed HLH protein, E12, in mammalian neurogenesis remains ambiguous...
  101. pmc High incidence of T-cell tumors in E2A-null mice and E2A/Id1 double-knockout mice
    W Yan
    Program in Cell Biology, Memorial Sloan Kettering Cancer Center, Cornell University Medical College, New York, New York 10021, USA
    Mol Cell Biol 17:7317-27. 1997
    The basic-helix-loop-helix (bHLH) proteins encoded by the E2A gene are broadly expressed transcription regulators which function through binding to the E-box enhancer sequences...

Research Grants62

  1. SENESCENE AND PREB CELL DEVELOPMENT
    Richard Riley; Fiscal Year: 2003
    ..The experiments in this application will provide a cellular and molecular basis for understanding the temporal loss of B lymphopoiesis and altered generation of VH repertoire during senescence. ..
  2. Regulation of E2A in Normal and Aged B Lymphopoiesis
    Richard Riley; Fiscal Year: 2007
    The E2A gene encodes basis helix-loop-helix proteins (E47 and El2) which are crucial to the regulation of B lineage cell development within the bone marrow...
  3. Selection of the B cell repertoire in senescence
    Richard Riley; Fiscal Year: 2007
    ..These studies will advance understanding of the immune defects which accompany old age and their cellular and molecular mechanisms. ..
  4. Selection of B cell repertoire in senescence
    Richard L Riley; Fiscal Year: 2010
    ..Insight into the defects in B cell production in old age may reveal their influence on developing and maintaining effective immune barriers to infectious disease. ..
  5. Regulation of Lymphocyte Development by HLH Proteins
    BARBARA LYNNE KEE; Fiscal Year: 2010
    ..Our studies will provide insight into how to how to manipulate this program to avoid disease and how therapeutic interventions will impact on NK cell development. ..
  6. E2A/HEB TRANSCRIPTION FACTORS IN T CELL DEVELOPMENT
    Yuan Zhuang; Fiscal Year: 2010
    ..Transcription factors encoded by the structurally and functionally related E2A and HEB genes have been shown to participate in both TCR gene rearrangement and TCR mediated selection...
  7. Regulation of Lymphocyte Development by HLH Proteins
    Barbara Kee; Fiscal Year: 2007
    ..Mice that lack the transcription factors encoded by the E2A or EBF genes have a profound B cell immune deficiency resulting from the failure to develop cells that are ..
  8. Transcriptional Control of Hematopoiesis
    BARBARA LYNNE KEE; Fiscal Year: 2010
    ..We have determined that the E proteins encoded by the E2A gene are required for proper maintenance of HSCs and they support the initial specification of multipotent ..
  9. The role of E47 in uncommitted hematopoietic progenitors
    Lisa Borghesi; Fiscal Year: 2010
    Bone marrow hematopoietic stem cells continually seed the blood lineages throughout adult life. E47 is a major transcription factor whose activity is critical for the progression of uncommitted hematopoietic progenitors to the lymphoid ..
  10. Regulation of Lymphocyte Development by HLH Proteins
    BARBARA LYNNE KEE; Fiscal Year: 2010
    ..Our studies will provide insight into how to how to manipulate this program to avoid disease and how therapeutic interventions will impact on NK cell development. ..
  11. FUNCTIONS OF E2A IN B LYMPHOCYTE DEVELOPMENT
    Yuan Zhuang; Fiscal Year: 2009
    ..The bHLH transcription factors encoded by the E2A gene have been shown to play critical roles throughout B cell development...
  12. Mechanisms of Lymphocyte Gene Regulation by E2A and Notch1
    BARBARA LYNNE KEE; Fiscal Year: 2010
    ..The E2A transcription factors are essential regulators of both B- and 1-lymphocyte development...
  13. Regulation of Lymphocyte Development by Helix Loop Helix Proteins
    Barbara Kee; Fiscal Year: 2007
    ..Mice that lack the transcription factors encoded by the E2A or EBF genes have a profound B cell immune deficiency resulting from the failure to develop cells that are ..
  14. FUNCTIONS OF E2A IN B LYMPHOCYTE DEVELOPMENT
    Yuan Zhuang; Fiscal Year: 2003
    ..Genetic and biochemical studies have established that the bHLH transcription factors encoded by the E2A gene play critical roles in the initiation, differentiation, and function of B-lymphocytes...
  15. HEB MEDIATED PATHWAYS AND FUNCTION IN T CELL DEVELOPMENT
    Yuan Zhuang; Fiscal Year: 2002
    ..Evidence indicates that this function of HEB requires collaboration with other regulatory molecules such as E2A, TCF, and CBF1alpha...
  16. Clonal analysis of joint-infiltrating natural Killer cells in chronic arthritis
    Lisa Borghesi; Fiscal Year: 2007
    ..Characterizing the developmental dynamics and functional activities of recombination* inflammatory NK cells could provide insights into the development of alternative therapies for RA. ..
  17. E2A/HEB TRANSCRIPTION FACTORS IN T CELL DEVELOPMENT
    Yuan Zhuang; Fiscal Year: 2007
    ..Recent works have shown that the transcription factors E2A and HEB play important roles in initiating lymphoid specific V(D)J recombination events...