Gene Symbol: Tcea1
Description: transcription elongation factor A (SII) 1
Alias: S-II, transcription elongation factor A protein 1, transcription elongation factor S-II protein 1, transcription elongation factor TFIIS.o
Kanai A, Kuzuhara T, Sekimizu K, Natori S. Heterogeneity and tissue-specific expression of eukaryotic transcription factor S-II-related protein mRNA. J Biochem. 1991;109:674-7 pubmed
..Analyses of these clones suggested that S-II proteins are a family of proteins with relatively conserved C-terminal regions but variable N-terminal regions, and that some members of this family are expressed in a tissue-specific manner. ..
Hirashima S, Hirai H, Nakanishi Y, Natori S. Molecular cloning and characterization of cDNA for eukaryotic transcription factor S-II. J Biol Chem. 1988;263:3858-63 pubmed
..The results of analysis of the genomic structure suggested that the polymorphism of mRNA may be due to alternative splicing, or differences in initiation or termination of transcription. ..
Sasaki N, Nagaoka S, Itoh M, Izawa M, Konno H, Carninci P, et al
. Characterization of gene expression in mouse blastocyst using single-pass sequencing of 3995 clones. Genomics. 1998;49:167-79 pubmed
..Although the human EST project is considered to represent roughly half of all genes, our findings indicate that many early stage developmental genes remain to be identified. ..
Yeh C, Shatkin A. A HeLa-cell-encoded p21 is homologous to transcription elongation factor SII. Gene. 1994;143:285-7 pubmed
..The deduced amino-acid sequence of p21 indicates that it is hydrophilic, basic and contains nuclear localization signals, as well as multiple consensus phosphorylation sites. ..
Taira Y, Kubo T, Natori S. Molecular cloning of cDNA and tissue-specific expression of the gene for SII-K1, a novel transcription elongation factor SII. Genes Cells. 1998;3:289-96 pubmed
..This factor was expressed exclusively in the heart, liver, kidney and skeletal muscle. During mouse embryonic development, no significant expression of the SII-K1 gene was detected before the formation of these tissues. ..
Ito T, Seldin M, Taketo M, Kubo T, Natori S. Gene structure and chromosome mapping of mouse transcription elongation factor S-II (Tcea1). Gene. 2000;244:55-63 pubmed
We report the organization and chromosome localization of the mouse transcription elongation factor S-II gene (Tcea1). This gene was found to be a single copy gene consisting of 10 exons spanning approximately 30kb...
Saso K, Ito T, Natori S, Sekimizu K. Identification of a novel tissue-specific transcriptional activator FESTA as a protein that interacts with the transcription elongation factor S-II. J Biochem. 2003;133:493-500 pubmed
..This study is the first report of a transcriptional activator that directly interacts with S-II and contains a transcriptional activation domain that cooperates with S-II via direct interaction. ..
Ito T, Arimitsu N, Takeuchi M, Kawamura N, Nagata M, Saso K, et al
. Transcription elongation factor S-II is required for definitive hematopoiesis. Mol Cell Biol. 2006;26:3194-203 pubmed
..Thus, S-II has critical and nonredundant roles in definitive hematopoiesis. ..
Nagata M, Ito T, Arimitsu N, Koyama H, Sekimizu K. Transcription arrest relief by S-II/TFIIS during gene expression in erythroblast differentiation. Genes Cells. 2009;14:371-80 pubmed publisher
..These results suggest that S-II is involved in transcription of the Bcl-x and beta(major)-globin gene during erythroblast differentiation, by relieving transcription arrest or affecting histone modification on chromatin template. ..