Gene Symbol: Tcap
Description: titin-cap
Alias: AI503981, AJ223855, telethonin, titin cap protein
Species: mouse
Products:     Tcap

Top Publications

  1. Gregorio C, Trombitas K, Centner T, Kolmerer B, Stier G, Kunke K, et al. The NH2 terminus of titin spans the Z-disc: its interaction with a novel 19-kD ligand (T-cap) is required for sarcomeric integrity. J Cell Biol. 1998;143:1013-27 pubmed
  2. Knoll R, Hoshijima M, Hoffman H, Person V, Lorenzen Schmidt I, Bang M, et al. The cardiac mechanical stretch sensor machinery involves a Z disc complex that is defective in a subset of human dilated cardiomyopathy. Cell. 2002;111:943-55 pubmed
    ..MLP interacts with and colocalizes with telethonin (T-cap), a titin interacting protein...
  3. Ibrahim M, Siedlecka U, Buyandelger B, Harada M, Rao C, Moshkov A, et al. A critical role for Telethonin in regulating t-tubule structure and function in the mammalian heart. Hum Mol Genet. 2013;22:372-83 pubmed publisher
    ..b>Telethonin (Tcap) is a stretch-sensitive Z-disc protein that binds to proteins in the t-tubule membrane...
  4. Candasamy A, Haworth R, Cuello F, Ibrahim M, Aravamudhan S, Kruger M, et al. Phosphoregulation of the titin-cap protein telethonin in cardiac myocytes. J Biol Chem. 2014;289:1282-93 pubmed publisher
    b>Telethonin (also known as titin-cap or t-cap) is a muscle-specific protein whose mutation is associated with cardiac and skeletal myopathies through unknown mechanisms...
  5. Valle G, Faulkner G, De Antoni A, Pacchioni B, Pallavicini A, Pandolfo D, et al. Telethonin, a novel sarcomeric protein of heart and skeletal muscle. FEBS Lett. 1997;415:163-8 pubmed
    In this paper we describe a novel 19 kDa sarcomeric protein named telethonin. The cDNA sequence discloses an open reading frame of 167 amino acids that does not resemble any known protein...
  6. Moreira E, Wiltshire T, Faulkner G, Nilforoushan A, Vainzof M, Suzuki O, et al. Limb-girdle muscular dystrophy type 2G is caused by mutations in the gene encoding the sarcomeric protein telethonin. Nat Genet. 2000;24:163-6 pubmed
    ..2 Mb. The gene encoding telethonin, a sarcomeric protein, lies within this candidate region...
  7. Markert C, Meaney M, Voelker K, Grange R, Dalley H, Cann J, et al. Functional muscle analysis of the Tcap knockout mouse. Hum Mol Genet. 2010;19:2268-83 pubmed publisher
    ..The disease is caused by mutations in Tcap, a z-disc protein of skeletal muscle, although the precise mechanisms resulting in clinical symptoms are unknown...
  8. Knoll R, Linke W, Zou P, Miocic S, Kostin S, Buyandelger B, et al. Telethonin deficiency is associated with maladaptation to biomechanical stress in the mammalian heart. Circ Res. 2011;109:758-69 pubmed publisher
    b>Telethonin (also known as titin-cap or t-cap) is a 19-kDa Z-disk protein with a unique ?-sheet structure, hypothesized to assemble in a palindromic way with the N-terminal portion of titin and to constitute a signalosome participating in ..
  9. Mason P, Bayol S, Loughna P. The novel sarcomeric protein telethonin exhibits developmental and functional regulation. Biochem Biophys Res Commun. 1999;257:699-703 pubmed
    ..muscle library which is preferentially expressed in striated muscle and exhibits a high homology to human telethonin, a sarcomeric protein...

More Information


  1. Zhang S, Londhe P, Zhang M, Davie J. Transcriptional analysis of the titin cap gene. Mol Genet Genomics. 2011;285:261-72 pubmed publisher
    Mutations in titin cap (Tcap), also known as telethonin, cause limb-girdle muscular dystrophy type 2G (LGMD2G). Tcap is one of the titin interacting Z-disc proteins involved in the regulation and development of normal sarcomeric structure...
  2. Frey N, Olson E. Calsarcin-3, a novel skeletal muscle-specific member of the calsarcin family, interacts with multiple Z-disc proteins. J Biol Chem. 2002;277:13998-4004 pubmed
    ..calsarcin-2, calsarcin-3 interacts with calcineurin, and the Z-disc proteins alpha-actinin, gamma-filamin, and telethonin. In addition, we show that calsarcins interact with the PDZ-LIM domain protein ZASP/Cypher/Oracle, which also ..
  3. Weinert S, Bergmann N, Luo X, Erdmann B, Gotthardt M. M line-deficient titin causes cardiac lethality through impaired maturation of the sarcomere. J Cell Biol. 2006;173:559-70 pubmed
  4. Markert C, Ning J, Staley J, Heinzke L, Childers C, Ferreira J, et al. TCAP knockdown by RNA interference inhibits myoblast differentiation in cultured skeletal muscle cells. Neuromuscul Disord. 2008;18:413-22 pubmed publisher
    Null mutation of titin-cap (TCAP) causes limb-girdle muscular dystrophy type 2G (LGMD2G). LGMD2G patients develop muscle atrophy, and lose the ability to walk by their third decade...
  5. Podobed P, Alibhai F, Chow C, Martino T. Circadian regulation of myocardial sarcomeric Titin-cap (Tcap, telethonin): identification of cardiac clock-controlled genes using open access bioinformatics data. PLoS ONE. 2014;9:e104907 pubmed publisher
    ..Lastly, we validated findings by demonstrating that Titin cap (Tcap, telethonin) was targeted by transcriptional activators CLOCK and BMAL1 by showing 1) Tcap mRNA and TCAP protein had a ..