Gene Symbol: Tbp
Description: TATA box binding protein
Alias: GTF2D1, Gtf2d, SCA17, TFIID, TATA-box-binding protein, TATA sequence-binding protein, TATA-binding factor, TATA-binding protein, TATA-box factor, TFIID core protein, transcription initiation factor TFIID TBP subunit
Species: mouse
Products:     Tbp

Top Publications

  1. Pavri R, Lewis B, Kim T, Dilworth F, Erdjument Bromage H, Tempst P, et al. PARP-1 determines specificity in a retinoid signaling pathway via direct modulation of mediator. Mol Cell. 2005;18:83-96 pubmed
    ..PARP-1 appears to function as a specificity factor regulating the RA-induced switch of Mediator from the inactive (Cdk8+) to the active (Cdk8-) state in RAR-dependent transcription. ..
  2. Sumita K, Makino Y, Katoh K, Kishimoto T, Muramatsu M, Mikoshiba K, et al. Structure of a mammalian TBP (TATA-binding protein) gene: isolation of the mouse TBP genome. Nucleic Acids Res. 1993;21:2769 pubmed
  3. Prigge J, Schmidt E. Interaction of protein inhibitor of activated STAT (PIAS) proteins with the TATA-binding protein, TBP. J Biol Chem. 2006;281:12260-9 pubmed
    ..system to screen mouse pregnancy-associated libraries for proteins that interact with TATA-binding protein (TBP)...
  4. Trachtulec Z, Forejt J. Synteny of orthologous genes conserved in mammals, snake, fly, nematode, and fission yeast. Mamm Genome. 2001;12:227-31 pubmed
    ..In human, mouse, and snake, the PDCD2-, and TATA-binding protein (TBP)-encoding genes are adjacent tail-to-tail...
  5. Ohbayashi T, Schmidt E, Makino Y, Kishimoto T, Nabeshima Y, Muramatsu M, et al. Promoter structure of the mouse TATA-binding protein (TBP) gene. Biochem Biophys Res Commun. 1996;225:275-80 pubmed
    5'-RACE and genomic cloning were used to determine that the mouse TBP (mTBP) gene consists of one 5'-terminal non-coding exon followed by seven protein-coding exons. The region upstream of the first exon lacks a TATA-box...
  6. Gazdag E, Rajkovic A, Torres Padilla M, Tora L. Analysis of TATA-binding protein 2 (TBP2) and TBP expression suggests different roles for the two proteins in regulation of gene expression during oogenesis and early mouse development. Reproduction. 2007;134:51-62 pubmed
    ..Here, we have examined the expression and localisation of the TATA-binding protein (TBP) and the related protein TBP2 (also called TRF3, TBP-related factor 3) during oogenesis and in early mouse embryos...
  7. Martianov I, Viville S, Davidson I. RNA polymerase II transcription in murine cells lacking the TATA binding protein. Science. 2002;298:1036-9 pubmed
    Inactivation of the murine TATA binding protein (TBP) gene by homologous recombination leads to growth arrest and apoptosis at the embryonic blastocyst stage...
  8. Trachtulec Z, Hamvas R, Forejt J, Lehrach H, Vincek V, Klein J. Linkage of TATA-binding protein and proteasome subunit C5 genes in mice and humans reveals synteny conserved between mammals and invertebrates. Genomics. 1997;44:1-7 pubmed
    The TATA-binding protein (TBP) is a factor required for the transcription of all classes of eukaryotic genes...
  9. Pitulescu M, Teichmann M, Luo L, Kessel M. TIPT2 and geminin interact with basal transcription factors to synergize in transcriptional regulation. BMC Biochem. 2009;10:16 pubmed publisher
    ..Geminin, also TIPT2 interacts with several polycomb factors, with the general transcription factor TBP (TATA box binding protein), and with the related protein TBPL1 (TRF2)...

More Information


  1. Kaestner K, Monaghan A, Kern H, Ang S, Weitz S, Lichter P, et al. The mouse fkh-2 gene. Implications for notochord, foregut, and midbrain regionalization. J Biol Chem. 1995;270:30029-35 pubmed
  2. Portal E, Riess O, Nguyen H. Automated home cage assessment shows behavioral changes in a transgenic mouse model of spinocerebellar ataxia type 17. Behav Brain Res. 2013;250:157-65 pubmed publisher
    Spinocerebellar Ataxia type 17 (SCA17) is an autosomal dominantly inherited, neurodegenerative disease characterized by ataxia, involuntary movements, and dementia...
  3. Malecova B, Dall Agnese A, Madaro L, Gatto S, Coutinho Toto P, Albini S, et al. TBP/TFIID-dependent activation of MyoD target genes in skeletal muscle cells. elife. 2016;5: pubmed publisher
    ..Replacement of the canonical TFIID-TBP complex with TRF3/TBP2 was reported to be required for activation of muscle-gene expression...
  4. D Alessio J, Ng R, Willenbring H, Tjian R. Core promoter recognition complex changes accompany liver development. Proc Natl Acad Sci U S A. 2011;108:3906-11 pubmed publisher
    ..coactivator complex switching in cellular differentiation, we have examined changes in transcription factor IID (TFIID) and cofactor required for Sp1 activation/Mediator during mouse liver development...
  5. Zhong S, Machida K, Tsukamoto H, Johnson D. Alcohol induces RNA polymerase III-dependent transcription through c-Jun by co-regulating TATA-binding protein (TBP) and Brf1 expression. J Biol Chem. 2011;286:2393-401 pubmed publisher
    ..through the ability of ethanol to induce expression of the TFIIIB components, Brf1, and the TATA-binding protein (TBP). Induction of TBP, Brf1, and RNA pol III-dependent gene expression is driven by enhanced c-Jun expression...
  6. Friedman M, Wang C, Li X, Li S. Polyglutamine expansion reduces the association of TATA-binding protein with DNA and induces DNA binding-independent neurotoxicity. J Biol Chem. 2008;283:8283-90 pubmed publisher
    ..Expansion of the polyQ domain to >42 glutamines typically results in spinocerebellar ataxia type 17 (SCA17), a neurodegenerative disorder that resembles Huntington disease...
  7. Hernandez M, Janusonis S. Quantitative mRNA analysis of serotonin 5-HT? and adrenergic ?? receptors in the mouse embryonic telencephalon. Dev Neurosci. 2010;32:278-87 pubmed publisher
    ..These findings suggest that 5-HT?-R splice variants and ??-ARs are differentially regulated in the embryonic telencephalon and that their relative amounts may carry developmentally important information. ..
  8. Staahl B, Tang J, Wu W, Sun A, Gitler A, Yoo A, et al. Kinetic analysis of npBAF to nBAF switching reveals exchange of SS18 with CREST and integration with neural developmental pathways. J Neurosci. 2013;33:10348-61 pubmed publisher
  9. Clotman F, Lannoy V, Reber M, Cereghini S, Cassiman D, Jacquemin P, et al. The onecut transcription factor HNF6 is required for normal development of the biliary tract. Development. 2002;129:1819-28 pubmed
    ..We conclude that HNF6 is essential for differentiation and morphogenesis of the biliary tract and that intrahepatic bile duct development is controlled by a HNF6-->HNF1beta cascade...
  10. Li L, Martinez S, Hu W, Liu Z, Tjian R. A specific E3 ligase/deubiquitinase pair modulates TBP protein levels during muscle differentiation. elife. 2015;4:e08536 pubmed publisher
    b>TFIID-a complex of TATA-binding protein (TBP) and TBP-associated factors (TAFs)-is a central component of the Pol II promoter recognition apparatus...
  11. Li C, Li A, Li M, Xing Y, Chen H, Hu L, et al. Stabilized beta-catenin in lung epithelial cells changes cell fate and leads to tracheal and bronchial polyposis. Dev Biol. 2009;334:97-108 pubmed publisher
    ..Thus, excess beta-catenin can alter cell fate determination by both direct and paracrine mechanisms. ..
  12. Veith A, Klattig J, Dettai A, Schmidt C, Englert C, Volff J. Male-biased expression of X-chromosomal DM domain-less Dmrt8 genes in the mouse. Genomics. 2006;88:185-95 pubmed
    ..Dmrt8.1 mRNA was detected in Sertoli cells by in situ hybridization. In embryos, Dmrt8.2 shows a dynamic expression restricted to male and female gonads and might therefore be involved in sexual development in the mouse. ..
  13. Prigge J, Schmidt E. HAP1 can sequester a subset of TBP in cytoplasmic inclusions via specific interaction with the conserved TBP(CORE). BMC Mol Biol. 2007;8:76 pubmed
    Huntington's disease, spinal and bulbar muscular atrophy, and spinocerebellar ataxia 17 (SCA17) are caused by expansions in the polyglutamine (polyQ) repeats in Huntingtin protein (Htt), androgen receptor protein (AR), and TATA-binding ..
  14. Collombat P, Mansouri A, Hecksher Sorensen J, Serup P, Krull J, Gradwohl G, et al. Opposing actions of Arx and Pax4 in endocrine pancreas development. Genes Dev. 2003;17:2591-603 pubmed
    ..We propose that the antagonistic functions of Arx and Pax4 for proper islet cell specification are related to the pancreatic levels of the respective transcripts. ..
  15. Mihola O, Trachtulec Z, Vlcek C, Schimenti J, Forejt J. A mouse speciation gene encodes a meiotic histone H3 methyltransferase. Science. 2009;323:373-5 pubmed publisher
    ..These defects, seen also in Prdm9-null mutants, are rescued by the Prdm9 transgene. Identification of a vertebrate hybrid sterility gene reveals a role for epigenetics in speciation and opens a window to a hybrid sterility gene network. ..
  16. Tucker T, Kundert J, Bondareva A, Schmidt E. Reproductive and neurological Quaking(viable) phenotypes in a severe combined immune deficient mouse background. Immunogenetics. 2005;57:226-31 pubmed
    ..Results showed that neither defect was ameliorated in the immune-deficient background. We conclude that the Qkv pathologies do not likely involve a B- or T-cell-dependent response against these immune-privileged sites...
  17. Gregorova S, Mnuková Fajdelová M, Trachtulec Z, Capkova J, Loudova M, Hoglund M, et al. Sub-milliMorgan map of the proximal part of mouse Chromosome 17 including the hybrid sterility 1 gene. Mamm Genome. 1996;7:107-13 pubmed
    ..Two candidate genes for Hst1 were identified based on their location and testicular expression. These are Tbp and D17Ph4e. The submilliMorgan map of the T-H2 region revealed significant clustering of (CA)n loci...
  18. Eberhard D, Tora L, Egly J, Grummt I. A TBP-containing multiprotein complex (TIF-IB) mediates transcription specificity of murine RNA polymerase I. Nucleic Acids Res. 1993;21:4180-6 pubmed
    ..One of the subunits present in this protein complex is the TATA-binding protein (TBP) as revealed by copurification of TIF-IB activity and TBP over different chromatographic steps including ..
  19. Danciger M, Kozak C, Suzuki S, Chang M, Shinohara T, Farber D. Transcription factor IID probes localize a single gene to the proximal region of mouse chromosome 17. Gene. 1993;130:283-6 pubmed
    We have used a 5' fragment of the gene GTF2D, which encodes human transcription factor IID, and Chinese hamster-mouse somatic cell hybrids to map the murine homologue, Gtf2d, to a single locus on mouse chromosome 17 (Chr 17)...
  20. Mulder J, Spence L, Tortoriello G, DiNieri J, Uhlen M, Shui B, et al. Secretagogin is a Ca2+-binding protein identifying prospective extended amygdala neurons in the developing mammalian telencephalon. Eur J Neurosci. 2010;31:2166-77 pubmed publisher
    ..Overall, our findings emphasize the developmentally shared origins of neurons populating the extended amygdala, and suggest that secretagogin can be relevant to the generation of functional modalities in specific neuronal circuitries. ..
  21. Bouzin C, Clotman F, Renauld J, Lemaigre F, Rousseau G. The onecut transcription factor hepatocyte nuclear factor-6 controls B lymphopoiesis in fetal liver. J Immunol. 2003;171:1297-303 pubmed
    ..This work identifies HNF-6 as the first noncell-intrinsic transcription factor known to control B lymphopoiesis specifically in fetal liver. ..
  22. Pittoggi C, Magnano A, Sciamanna I, Giordano R, Lorenzini R, Spadafora C. Specific localization of transcription factors in the chromatin of mouse mature spermatozoa. Mol Reprod Dev. 2001;60:97-106 pubmed
    ..also contains clusters of potential sites for transcription factors: among those, binding sites for Oct-1, Oct-4, TBP, Ets-1, and C/EBP are most abundant...
  23. Wansleeben C, van Gurp L, de Graaf P, Mousson F, Marc Timmers H, Meijlink F. An ENU-induced point mutation in the mouse Btaf1 gene causes post-gastrulation embryonic lethality and protein instability. Mech Dev. 2011;128:279-88 pubmed publisher
    ..has been studied mainly in yeast and human cells, which has revealed that it binds directly to TBP, forming the B-TFIID complex...
  24. Huang S, Yang S, Guo J, Yan S, Gaertig M, Li S, et al. Large Polyglutamine Repeats Cause Muscle Degeneration in SCA17 Mice. Cell Rep. 2015;13:196-208 pubmed publisher
    ..By studying knockin mouse models of spinal cerebellar ataxia-17 (SCA17), we found that a large polyQ (105 glutamines) in the TATA-box-binding protein (TBP) preferentially causes muscle ..
  25. Beaudry J, Pierreux C, Hayhurst G, Plumb Rudewiez N, Weiss M, Rousseau G, et al. Threshold levels of hepatocyte nuclear factor 6 (HNF-6) acting in synergy with HNF-4 and PGC-1alpha are required for time-specific gene expression during liver development. Mol Cell Biol. 2006;26:6037-46 pubmed
    ..Our observations on the regulation of g6pc by HNF-6 provide a model whereby synergism, interdependency, and threshold concentrations of LETFs and coactivators determine time-specific expression of genes during liver development. ..
  26. Murai K, Naruse Y, Shaul Y, Agata Y, Mori N. Direct interaction of NRSF with TBP: chromatin reorganization and core promoter repression for neuron-specific gene transcription. Nucleic Acids Res. 2004;32:3180-9 pubmed
    ..Here we show evidence that NRSF interacts with core promoter factors, including TATA-binding protein (TBP)...
  27. Yang S, Huang S, Gaertig M, Li X, Li S. Age-dependent decrease in chaperone activity impairs MANF expression, leading to Purkinje cell degeneration in inducible SCA17 mice. Neuron. 2014;81:349-65 pubmed publisher
    ..We established spinocerebellar ataxia 17 (SCA17) knockin mice that inducibly express one copy of mutant TATA box binding protein (TBP) at different ages by tamoxifen-mediated Cre recombination...
  28. Bottardi S, Zmiri F, Bourgoin V, Ross J, Mavoungou L, Milot E. Ikaros interacts with P-TEFb and cooperates with GATA-1 to enhance transcription elongation. Nucleic Acids Res. 2011;39:3505-19 pubmed publisher
    ..Ikaros contributes to transcription initiation and elongation of the hu?-genes, since it is not only required for TBP and RNA Polymerase II (Pol II) assembly at the hu?-promoters but also for conversion of Pol II into the elongation-..
  29. Wang K, Sun F, Sheng H. Regulated expression of TAF1 in 1-cell mouse embryos. Zygote. 2006;14:209-15 pubmed
    b>TATA binding protein (TBP) associated factor 1 (TAF1) is a member of the general transcription machinery. Interference in the function of TAF1 causes a broad transcriptional defect in early development...
  30. Pijnappel W, Esch D, Baltissen M, Wu G, Mischerikow N, Bergsma A, et al. A central role for TFIID in the pluripotent transcription circuitry. Nature. 2013;495:516-9 pubmed publisher
    ..Here we show that knockdown of the transcription factor IID (TFIID) complex affects the pluripotent circuitry in mouse ES cells and inhibits reprogramming of fibroblasts...
  31. Falender A, Freiman R, Geles K, Lo K, Hwang K, Lamb D, et al. Maintenance of spermatogenesis requires TAF4b, a gonad-specific subunit of TFIID. Genes Dev. 2005;19:794-803 pubmed
    ..The gonad-specific TAF4b component of TFIID (formerly TAF(II)105) is a transcriptional regulator enriched in the mouse testis...
  32. Oka M, Hashimoto K, Yamaguchi Y, Saitoh S, Sugiura Y, Motoi Y, et al. Arl8b is required for lysosomal degradation of maternal proteins in the visceral yolk sac endoderm of mouse embryos. J Cell Sci. 2017;130:3568-3577 pubmed publisher
    ..Taken together, these results suggest that Arl8b mediates lysosomal degradation of maternal proteins in the VYSE, thereby contributing to mouse embryonic development. ..
  33. Donohoe M, Zhang X, McGinnis L, Biggers J, Li E, Shi Y. Targeted disruption of mouse Yin Yang 1 transcription factor results in peri-implantation lethality. Mol Cell Biol. 1999;19:7237-44 pubmed
    ..Our studies demonstrate an essential function for YY1 in the development of the mouse embryo. ..
  34. Glenn D, Maurer R. MRG1 binds to the LIM domain of Lhx2 and may function as a coactivator to stimulate glycoprotein hormone alpha-subunit gene expression. J Biol Chem. 1999;274:36159-67 pubmed
    ..These data suggest a model in which the Lhx2 LIM domain activates transcription through interaction with MRG1 leading to recruitment of p300/CBP and the TATA-binding protein. ..
  35. Wang G, Balamotis M, Stevens J, Yamaguchi Y, Handa H, Berk A. Mediator requirement for both recruitment and postrecruitment steps in transcription initiation. Mol Cell. 2005;17:683-94 pubmed
    ..These results indicate that an interaction with MED23 stimulates initiation by promoter bound Pol II in addition to Pol II and GTF recruitment. ..
  36. Plumb Rudewiez N, Clotman F, Strick Marchand H, Pierreux C, Weiss M, Rousseau G, et al. Transcription factor HNF-6/OC-1 inhibits the stimulation of the HNF-3alpha/Foxa1 gene by TGF-beta in mouse liver. Hepatology. 2004;40:1266-74 pubmed
    ..This identifies a new mechanism of interaction between liver-enriched transcription factors whereby one factor indirectly controls another by modulating the activity of a signaling pathway. ..
  37. Koudelka J, Horn J, Vatanashevanopakorn C, Minichiello L. Genetic dissection of TrkB activated signalling pathways required for specific aspects of the taste system. Neural Dev. 2014;9:21 pubmed publisher
    ..These results advance our knowledge of the biology of the taste system, one of the fundamental sensory systems crucial for an organism to relate to the environment. ..
  38. Mittal V, Hernandez N. Role for the amino-terminal region of human TBP in U6 snRNA transcription. Science. 1997;275:1136-40 pubmed
    ..from the human RNA polymerase III U6 promoter depends on a TATA box that recruits the TATA box-binding protein (TBP) and a proximal sequence element that recruits the small nuclear RNA (snRNA)-activating protein complex (SNAPc)...
  39. Hobbs N, Bondareva A, Barnett S, Capecchi M, Schmidt E. Removing the vertebrate-specific TBP N terminus disrupts placental beta2m-dependent interactions with the maternal immune system. Cell. 2002;110:43-54 pubmed
    Mammalian TBP consists of a 180 amino acid core that is common to all eukaryotes, fused to a vertebrate-specific N-terminal domain...
  40. Schmidt E, Ohbayashi T, Makino Y, Tamura T, Schibler U. Spermatid-specific overexpression of the TATA-binding protein gene involves recruitment of two potent testis-specific promoters. J Biol Chem. 1997;272:5326-34 pubmed
    The gene encoding the TATA-binding protein, TBP, is highly overexpressed during the haploid stages of spermatogenesis in rodents...
  41. Mihola O, Forejt J, Trachtulec Z. Conserved alternative and antisense transcripts at the programmed cell death 2 locus. BMC Genomics. 2007;8:20 pubmed
    ..The antisense RNAs are alternative transcripts of the neighboring TATA-binding protein gene (Tbp) that are located mainly in the cell nucleus...
  42. Reichardt H, Schutz G. Feedback control of glucocorticoid production is established during fetal development. Mol Med. 1996;2:735-44 pubmed
    ..GR-dependent regulation of the HPA axis is established during fetal development, suggesting that maternal factors have an important role in influencing the HPA axis of the adult offspring. ..
  43. Worrad D, Schultz R. Regulation of gene expression in the preimplantation mouse embryo: temporal and spatial patterns of expression of the transcription factor Sp1. Mol Reprod Dev. 1997;46:268-77 pubmed
    ..The relative abundance of Sp1 transcripts, as well as transcripts for the TATA box-binding protein TBP, decreases during oocyte maturation and reaches a minimum level in the two-cell stage, after which time the ..
  44. Jacquemin P, Yoshitomi H, Kashima Y, Rousseau G, Lemaigre F, Zaret K. An endothelial-mesenchymal relay pathway regulates early phases of pancreas development. Dev Biol. 2006;290:189-99 pubmed
  45. Hsu L, Liu S, Abedinpour F, Beech R, Lahti J, Kidd V, et al. The murine G+C-rich promoter binding protein mGPBP is required for promoter-specific transcription. Mol Cell Biol. 2003;23:8773-85 pubmed
  46. Huang H, Kaku S, Knights C, Park B, Clifford J, Kulesz Martin M. Repression of transcription and interference with DNA binding of TATA-binding protein by C-terminal alternatively spliced p53. Exp Cell Res. 2002;279:248-59 pubmed
    ..The p53as protein, like p53r, associated with TATA-binding protein (TBP), indicating that this interaction does not require the last 26 amino acids of p53...
  47. Le Douarin B, Zechel C, Garnier J, Lutz Y, Tora L, Pierrat P, et al. The N-terminal part of TIF1, a putative mediator of the ligand-dependent activation function (AF-2) of nuclear receptors, is fused to B-raf in the oncogenic protein T18. EMBO J. 1995;14:2020-33 pubmed
    ..Interestingly, the TIF1 N-terminal moiety is fused to B-raf in the mouse oncoprotein T18. ..
  48. Anderson D, Beres B, Wilson Rawls J, Rawls A. The homeobox gene Mohawk represses transcription by recruiting the sin3A/HDAC co-repressor complex. Dev Dyn. 2009;238:572-80 pubmed publisher
    ..co-repressor complex (Sin3A, Hdac1, and Sap18) and a subset of Polymerase II general transcription factors (Tbp, TFIIA1 and TFIIB)...
  49. Itoh T, Miyake K, Yamaguchi T, Tsuge M, Kaneoka H, Iijima S. Constitutive expression of the brg1 gene requires GC-boxes near to the transcriptional start site. J Biochem. 2011;149:301-9 pubmed publisher
    ..In vivo and in vitro binding assays showed that Sp3 and YY1 interacted with each other. Together, these results suggest that Sp3 and YY1 recruit general transcription factors and facilitate the assembly of a preinitiation complex. ..
  50. Heix J, Zomerdijk J, Ravanpay A, Tjian R, Grummt I. Cloning of murine RNA polymerase I-specific TAF factors: conserved interactions between the subunits of the species-specific transcription initiation factor TIF-IB/SL1. Proc Natl Acad Sci U S A. 1997;94:1733-8 pubmed
    ..three classes of eukaryotic RNA polymerases is brought about by multimeric protein complexes containing TATA box binding protein (TBP) and specific TBP-associated factors (TAFs)...
  51. Gewies A, Castineiras Vilarino M, Ferch U, Jährling N, Heinrich K, Hoeckendorf U, et al. Prdm6 is essential for cardiovascular development in vivo. PLoS ONE. 2013;8:e81833 pubmed publisher
    ..We thus identified Prdm6 as a factor that is essential for the physiological control of cardiovascular development. ..
  52. Huang S, Ling J, Yang S, Li X, Li S. Neuronal expression of TATA box-binding protein containing expanded polyglutamine in knock-in mice reduces chaperone protein response by impairing the function of nuclear factor-Y transcription factor. Brain. 2011;134:1943-58 pubmed publisher
    ..These findings demonstrate how mutant TATA box-binding protein at the endogenous level affects neuronal function, with important implications for the pathogenesis and treatment of polyglutamine diseases. ..
  53. Yang Y, Yang S, Guo J, Cui Y, Tang B, Li X, et al. Synergistic Toxicity of Polyglutamine-Expanded TATA-Binding Protein in Glia and Neuronal Cells: Therapeutic Implications for Spinocerebellar Ataxia 17. J Neurosci. 2017;37:9101-9115 pubmed publisher
    Spinocerebellar ataxia 17 (SCA17) is caused by polyglutamine (polyQ) repeat expansion in the TATA-binding protein (TBP) and is among a family of neurodegenerative diseases in which polyQ expansion leads to preferential neuronal loss in ..
  54. Wu G, Han D, Gong Y, Sebastiano V, Gentile L, Singhal N, et al. Establishment of totipotency does not depend on Oct4A. Nat Cell Biol. 2013;15:1089-97 pubmed publisher
  55. Oda T, Kayukawa K, Hagiwara H, Yudate H, Masuho Y, Murakami Y, et al. A novel TATA-binding protein-binding protein, ABT1, activates basal transcription and has a yeast homolog that is essential for growth. Mol Cell Biol. 2000;20:1407-18 pubmed
    ..nuclear protein termed activator of basal transcription 1 (mABT1) that associates with the TATA-binding protein (TBP) and enhances basal transcription activity of class II promoters is described...
  56. Freiman R, Albright S, Zheng S, Sha W, Hammer R, Tjian R. Requirement of tissue-selective TBP-associated factor TAFII105 in ovarian development. Science. 2001;293:2084-7 pubmed
    Transcription factor TFIID, composed of TBP and TAFII subunits, is a central component of the RNA polymerase II machinery...
  57. Mitsiou D, Stunnenberg H. p300 is involved in formation of the TBP-TFIIA-containing basal transcription complex, TAC. EMBO J. 2003;22:4501-11 pubmed
    ..Our data suggest that p300 plays a role in formation of the TBP-TFIIA-containing basal transcription complex, TAC.
  58. Sekine K, Chen Y, Kojima N, Ogata K, Fukamizu A, Miyajima A. Foxo1 links insulin signaling to C/EBPalpha and regulates gluconeogenesis during liver development. EMBO J. 2007;26:3607-15 pubmed
    ..These results indicate that Foxo1 regulates gluconeogenesis cooperatively with C/EBPalpha, and also links insulin signaling to C/EBPalpha during liver development. ..
  59. Gorski J, Pathak S, Panov K, Kasciukovic T, Panova T, Russell J, et al. A novel TBP-associated factor of SL1 functions in RNA polymerase I transcription. EMBO J. 2007;26:1560-8 pubmed
    In mammalian RNA polymerase I transcription, SL1, an assembly of TBP and associated factors (TAFs), is essential for preinitiation complex formation at ribosomal RNA gene promoters in vitro...
  60. Sengupta S, Robles A, Linke S, Sinogeeva N, Zhang R, Pedeux R, et al. Functional interaction between BLM helicase and 53BP1 in a Chk1-mediated pathway during S-phase arrest. J Cell Biol. 2004;166:801-13 pubmed
    ..Once the ATR/Chk1- and 53BP1-mediated signal from replicational stress is received, BLM functions in multiple downstream repair processes, thereby fulfilling its role as a caretaker tumor suppressor. ..
  61. Xiao L, Kim M, DeJong J. Developmental and cell type-specific regulation of core promoter transcription factors in germ cells of frogs and mice. Gene Expr Patterns. 2006;6:409-19 pubmed
    ..In frogs we tested TBP, TRF2/TLF, TRF3, TFIIAalphabeta, and ALF, as well as variant forms of TAFs 4, 5, and 6...
  62. Sun S, Wang X, Ma X, Huang X, Li J, Liu H. TBP dynamics during mouse oocyte meiotic maturation and early embryo development. PLoS ONE. 2013;8:e55425 pubmed publisher
    ..In mitosis, TBP (TATA-binding protein), a transcription factor which belongs to TFIID was associated with M phase chromosomes and was proved to be a bookmark for cellular memory...
  63. Choukrallah M, Kobi D, Martianov I, Pijnappel W, Mischerikow N, Ye T, et al. Interconversion between active and inactive TATA-binding protein transcription complexes in the mouse genome. Nucleic Acids Res. 2012;40:1446-59 pubmed publisher
    The TATA binding protein (TBP) plays a pivotal role in RNA polymerase II (Pol II) transcription through incorporation into the TFIID and B-TFIID complexes. The role of mammalian B-TFIID composed of TBP and B-TAF1 is poorly understood...
  64. Saghizadeh M, Gribanova Y, Akhmedov N, Farber D. ZBED4, a cone and Müller cell protein in human retina, has a different cellular expression in mouse. Mol Vis. 2011;17:2011-8 pubmed
    ..The patterns of spatial and temporal expression of Zbed4 in the mouse retina suggest a possible involvement of this protein in retinal morphogenesis and Müller cell function. ..
  65. Medeiros L, Dennis L, Gill M, Houbaviy H, Markoulaki S, Fu D, et al. Mir-290-295 deficiency in mice results in partially penetrant embryonic lethality and germ cell defects. Proc Natl Acad Sci U S A. 2011;108:14163-8 pubmed publisher
    ..Female mir-290-295(-/-) mice are unable to recover and are sterile, due to premature ovarian failure. ..
  66. Catena R, Argentini M, Martianov I, Parello C, Brancorsini S, Parvinen M, et al. Proteolytic cleavage of ALF into alpha- and beta-subunits that form homologous and heterologous complexes with somatic TFIIA and TRF2 in male germ cells. FEBS Lett. 2005;579:3401-10 pubmed
    ..Our observations highlight how cleavage of ALF and coexpression with TFIIA and TRF2 increases the combinatorial possibilities for gene regulation at different developmental stages of spermatogenesis. ..
  67. Martianov I, Brancorsini S, Gansmuller A, Parvinen M, Davidson I, Sassone Corsi P. Distinct functions of TBP and TLF/TRF2 during spermatogenesis: requirement of TLF for heterochromatic chromocenter formation in haploid round spermatids. Development. 2002;129:945-55 pubmed
    TLF (TBP-like factor) is a protein commonly thought to belong to the general transcription initiation complex. TLF is evolutionarily conserved and has been shown to be essential for early development in C. elegans, zebrafish and Xenopus...
  68. Aoki T, Okada N, Ishida M, Yogosawa S, Makino Y, Tamura T. TIP120B: a novel TIP120-family protein that is expressed specifically in muscle tissues. Biochem Biophys Res Commun. 1999;261:911-6 pubmed
    TATA-binding protein (TBP) forms complexes with various nuclear proteins and plays roles in all eukaryotic transcription. We previously identified TBP-interacting protein 120 (TIP120) from rat liver...
  69. Yotov W, Moreau A, St Arnaud R. The alpha chain of the nascent polypeptide-associated complex functions as a transcriptional coactivator. Mol Cell Biol. 1998;18:1303-11 pubmed
    ..affinity chromatography, and protein blotting assays, while interactions with TATA box-binding protein (TBP) were detected by immunoprecipitation, affinity chromatography, and protein blotting assays...
  70. Trachtulec Z, Vincek V, Hamvas R, Forejt J, Lehrach H, Klein J. Physical map of mouse chromosome 17 in the region relevant for positional cloning of the Hybrid sterility 1 gene. Genomics. 1994;23:132-7 pubmed
    ..The Hst1 gene maps approximately 0.2 cM proximal to the D17Ph1 locus encompassed by the YAC contig. Since the contig extends at least 1200 kb proximal to D17Ph1, it should contain the Hst1 gene. ..
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    ..factors for OR gene expression and among them confirmed by chromatin immunoprecipitation the binding of TBP, EBF1 (OLF1), and MEF2A to OR promoters...
  72. Benlhabib H, Mendelson C. Epigenetic regulation of surfactant protein A gene (SP-A) expression in fetal lung reveals a critical role for Suv39h methyltransferases during development and hypoxia. Mol Cell Biol. 2011;31:1949-58 pubmed publisher
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    ..5 to 14.5 dpc irrespective of sex. Based on our analysis, we suggest that Rn18s, Rps29, Tbp and Sdha are suitable reference genes for qRT-PCR expression studies during early gonad differentiation in the ..
  74. Shah A, Friedman M, Huang S, Roberts M, Li X, Li S. Transcriptional dysregulation of TrkA associates with neurodegeneration in spinocerebellar ataxia type 17. Hum Mol Genet. 2009;18:4141-52 pubmed publisher
    b>TATA binding protein (TBP), a universal transcription factor, is broadly required by nuclear RNA polymerases for the initiation of transcription...
  75. Spencer C, Pajovic S, Devlin H, Dinh Q, Corson T, Gallie B. Distinct patterns of expression of the RB gene family in mouse and human retina. Gene Expr Patterns. 2005;5:687-94 pubmed
    ..The RB gene family is dynamically and variably expressed through retinal development in specific retinal cells. ..
  76. Mohan W, Scheer E, Wendling O, Metzger D, Tora L. TAF10 (TAF(II)30) is necessary for TFIID stability and early embryogenesis in mice. Mol Cell Biol. 2003;23:4307-18 pubmed
    TAF10 (formerly TAF(II)30), is a component of TFIID and the TATA box-binding protein (TBP)-free TAF-containing complexes (TFTC/PCAF/STAGA)...
  77. Okuda A, Fukushima A, Nishimoto M, Orimo A, Yamagishi T, Nabeshima Y, et al. UTF1, a novel transcriptional coactivator expressed in pluripotent embryonic stem cells and extra-embryonic cells. EMBO J. 1998;17:2019-32 pubmed
    ..Further analyses revealed that UTF1 interacts not only with the activation domain of ATF-2, but also with the TFIID complex in vivo...