Gene Symbol: Tas2r108
Description: taste receptor, type 2, member 108
Alias: T2R108, T2r8, Tas2r4, Tas2r8, mGR08, mt2r8, taste receptor type 2 member 4, T2R4, candidate taste receptor T2R8, taste receptor T2R8, taste receptor type 2 member 8
Wu S, Chen M, Rozengurt E. Genomic organization, expression, and function of bitter taste receptors (T2R) in mouse and rat. Physiol Genomics. 2005;22:139-49 pubmed
Chandrashekar J, Mueller K, Hoon M, Adler E, Feng L, Guo W, et al
. T2Rs function as bitter taste receptors. Cell. 2000;100:703-11 pubmed
..Since a single taste receptor cell expresses a large repertoire of T2Rs, these findings provide a plausible explanation for the uniform bitter taste that is evoked by many structurally unrelated toxic compounds. ..
Nelson T, Munger S, Boughter J. Taste sensitivities to PROP and PTC vary independently in mice. Chem Senses. 2003;28:695-704 pubmed
..Most strikingly, these results demonstrate that in mice, unlike in humans, PTC and PROP taste sensitivities vary independently, thereby suggesting a subtle functional diversity of bitter-taste mechanisms across mammalian species. ..
Kim M, Kusakabe Y, Miura H, Shindo Y, Ninomiya Y, Hino A. Regional expression patterns of taste receptors and gustducin in the mouse tongue. Biochem Biophys Res Commun. 2003;312:500-6 pubmed
..These results suggested that in fungiform papillae, gustducin might play a role in the sweet taste signal transduction cascade mediated by a sweet receptor based on the T1r2 and T1r3 combination, in fungiform papillae. ..
Krasteva G, Canning B, Hartmann P, Veres T, Papadakis T, Mühlfeld C, et al
. Cholinergic chemosensory cells in the trachea regulate breathing. Proc Natl Acad Sci U S A. 2011;108:9478-83 pubmed publisher
..Here we show that brush cells of the mouse trachea express the receptors (Tas2R105, Tas2R108), the downstream signaling molecules (?-gustducin, phospholipase C(?2)) of bitter taste transduction, the ..
Yamaguchi T, Yamashita J, Ohmoto M, Aoudé I, Ogura T, Luo W, et al
. Skn-1a/Pou2f3 is required for the generation of Trpm5-expressing microvillous cells in the mouse main olfactory epithelium. BMC Neurosci. 2014;15:13 pubmed publisher
..Thus, Skn-1a is a critical regulator for the generation of Trpm5-expressing microvillous cells in the main olfactory epithelium in mice. ..
Prandi S, Bromke M, Hübner S, Voigt A, Boehm U, Meyerhof W, et al
. A subset of mouse colonic goblet cells expresses the bitter taste receptor Tas2r131. PLoS ONE. 2013;8:e82820 pubmed publisher
..Expression in colonic goblet cells is consistent with a role of Tas2rs in defense mechanisms against potentially harmful xenobiotics. ..
Avau B, Bauters D, Steensels S, Vancleef L, Laermans J, Lesuisse J, et al
. The Gustatory Signaling Pathway and Bitter Taste Receptors Affect the Development of Obesity and Adipocyte Metabolism in Mice. PLoS ONE. 2015;10:e0145538 pubmed publisher
..Intra-gastric bitter treatment inhibits weight gain, possibly by directly affecting adipocyte metabolism. ..