Gene Symbol: Tas2r105
Description: taste receptor, type 2, member 105
Alias: T2R05, T2R9, T2r5, Tas2r5, mGR05, mt2r5, taste receptor type 2 member 105, T2R105, candidate taste receptor T2R5, taste receptor T2R5, taste receptor type 2 member 5, taste receptor type 2 member 9
Species: mouse
Products:     Tas2r105

Top Publications

  1. Kim M, Kusakabe Y, Miura H, Shindo Y, Ninomiya Y, Hino A. Regional expression patterns of taste receptors and gustducin in the mouse tongue. Biochem Biophys Res Commun. 2003;312:500-6 pubmed
    ..These results suggested that in fungiform papillae, gustducin might play a role in the sweet taste signal transduction cascade mediated by a sweet receptor based on the T1r2 and T1r3 combination, in fungiform papillae. ..
  2. Krasteva G, Canning B, Hartmann P, Veres T, Papadakis T, Mühlfeld C, et al. Cholinergic chemosensory cells in the trachea regulate breathing. Proc Natl Acad Sci U S A. 2011;108:9478-83 pubmed publisher
    ..Here we show that brush cells of the mouse trachea express the receptors (Tas2R105, Tas2R108), the downstream signaling molecules (?-gustducin, phospholipase C(?2)) of bitter taste transduction, ..
  3. Yamaguchi T, Yamashita J, Ohmoto M, Aoudé I, Ogura T, Luo W, et al. Skn-1a/Pou2f3 is required for the generation of Trpm5-expressing microvillous cells in the mouse main olfactory epithelium. BMC Neurosci. 2014;15:13 pubmed publisher
    ..Thus, Skn-1a is a critical regulator for the generation of Trpm5-expressing microvillous cells in the main olfactory epithelium in mice. ..
  4. Liu X, Gu F, Jiang L, Chen F, Li F. Expression of bitter taste receptor Tas2r105 in mouse kidney. Biochem Biophys Res Commun. 2015;458:733-8 pubmed publisher
    ..this study, three types of transgenic system were used to investigate the expression of the bitter taste receptor Tas2r105 in mouse renal tissue (Tas2r105-GFP/Cre, Tas2r105-GFP/Cre-DTA and Tas2r105-GFP/Cre-LacZ)...
  5. Gu F, Liu X, Liang J, Chen J, Chen F, Li F. Bitter taste receptor mTas2r105 is expressed in small intestinal villus and crypts. Biochem Biophys Res Commun. 2015;463:934-41 pubmed publisher
    ..other hand, three types of transgenic system were used to investigate the expression of the bitter taste receptor Tas2r105 in mouse intestine (Tas2r105-GFP/Cre, Tas2r105-GFP/Cre-DTA and Tas2r105-GFP/Cre-LacZ)...
  6. Chandrashekar J, Mueller K, Hoon M, Adler E, Feng L, Guo W, et al. T2Rs function as bitter taste receptors. Cell. 2000;100:703-11 pubmed
    ..Since a single taste receptor cell expresses a large repertoire of T2Rs, these findings provide a plausible explanation for the uniform bitter taste that is evoked by many structurally unrelated toxic compounds. ..
  7. Matsunami H, Montmayeur J, Buck L. A family of candidate taste receptors in human and mouse. Nature. 2000;404:601-4 pubmed
    ..Another TRB gene is found on a human contig assigned to chromosome 5p15, the location of a genetic locus (PROP) that controls the detection of the bitter compound 6-n-propyl-2-thiouracil in humans. ..
  8. Mueller K, Hoon M, Erlenbach I, Chandrashekar J, Zuker C, Ryba N. The receptors and coding logic for bitter taste. Nature. 2005;434:225-9 pubmed
    ..Together these results illustrate the fundamental principle of bitter taste coding at the periphery: dedicated cells act as broadly tuned bitter sensors that are wired to mediate behavioural aversion. ..
  9. Li F, Zhou M. Depletion of bitter taste transduction leads to massive spermatid loss in transgenic mice. Mol Hum Reprod. 2012;18:289-97 pubmed publisher
    ..We generated a taste receptor type 2 member 5 (T2R5)-Cre/green fluorescent protein reporter transgenic mouse to investigate the tissue distribution ..

More Information


  1. Koudelka J, Horn J, Vatanashevanopakorn C, Minichiello L. Genetic dissection of TrkB activated signalling pathways required for specific aspects of the taste system. Neural Dev. 2014;9:21 pubmed publisher
    ..These results advance our knowledge of the biology of the taste system, one of the fundamental sensory systems crucial for an organism to relate to the environment. ..