Gene Symbol: Tas1r3
Description: taste receptor, type 1, member 3
Alias: Sac, T1r3, taste receptor type 1 member 3, saccharin preference protein, sweet taste receptor T1R3
Species: mouse
Products:     Tas1r3

Top Publications

  1. Blizard D, Kotlus B, Frank M. Quantitative trait loci associated with short-term intake of sucrose, saccharin and quinine solutions in laboratory mice. Chem Senses. 1999;24:373-85 pubmed
    ..The present experiment illustrates the utility of a 6 h fluid intake test in the mapping of Sac and Qui loci...
  2. Ariyasu T, Matsumoto S, Kyono F, Hanaya T, Arai S, Ikeda M, et al. Taste receptor T1R3 is an essential molecule for the cellular recognition of the disaccharide trehalose. In Vitro Cell Dev Biol Anim. 2003;39:80-8 pubmed
    ..We demonstrate for the first time that the candidate sweet taste receptor T1R3 is essential for the recognition and response to the disaccharide trehalose...
  3. Zhao G, Zhang Y, Hoon M, Chandrashekar J, Erlenbach I, Ryba N, et al. The receptors for mammalian sweet and umami taste. Cell. 2003;115:255-66 pubmed
    ..We now report the behavioral and physiological characterization of T1R1, T1R2, and T1R3 knockout mice...
  4. Morini G, Temussi P. Micro and macro models of the sweet receptor. Chem Senses. 2005;30 Suppl 1:i86-7 pubmed
  5. Ohkuri T, Yasumatsu K, Horio N, Jyotaki M, Margolskee R, Ninomiya Y. Multiple sweet receptors and transduction pathways revealed in knockout mice by temperature dependence and gurmarin sensitivity. Am J Physiol Regul Integr Comp Physiol. 2009;296:R960-71 pubmed publisher
    Sweet taste transduction involves taste receptor type 1, member 2 (T1R2), taste receptor type 1, member 3 (T1R3), gustducin, and TRPM5...
  6. Treesukosol Y, Smith K, Spector A. Behavioral evidence for a glucose polymer taste receptor that is independent of the T1R2+3 heterodimer in a mouse model. J Neurosci. 2011;31:13527-34 pubmed publisher
    Although it is clear that the heterodimer formed by the T1R2 and T1R3 proteins serves as the primary taste receptor for sweeteners, there is growing evidence that responses to glucose polymers may be mediated by a different taste receptor...
  7. Zukerman S, Glendinning J, Margolskee R, Sclafani A. T1R3 taste receptor is critical for sucrose but not Polycose taste. Am J Physiol Regul Integr Comp Physiol. 2009;296:R866-76 pubmed publisher
    ..g., Polycose). T1R3 is a component of the mammalian sweet taste receptor that mediates the preference for sugars and artificial ..
  8. Yee K, Sukumaran S, Kotha R, Gilbertson T, Margolskee R. Glucose transporters and ATP-gated K+ (KATP) metabolic sensors are present in type 1 taste receptor 3 (T1r3)-expressing taste cells. Proc Natl Acad Sci U S A. 2011;108:5431-6 pubmed publisher
    Although the heteromeric combination of type 1 taste receptors 2 and 3 (T1r2 + T1r3) is well established as the major receptor for sugars and noncaloric sweeteners, there is also evidence of T1r-independent sweet taste in mice, ..
  9. Nelson G, Chandrashekar J, Hoon M, Feng L, Zhao G, Ryba N, et al. An amino-acid taste receptor. Nature. 2002;416:199-202 pubmed
    ..This receptor, T1R1+3, is a heteromer of the taste-specific T1R1 and T1R3 G-protein-coupled receptors...

More Information


  1. Wauson E, Zaganjor E, Lee A, Guerra M, Ghosh A, Bookout A, et al. The G protein-coupled taste receptor T1R1/T1R3 regulates mTORC1 and autophagy. Mol Cell. 2012;47:851-62 pubmed publisher
    ..We identify the G protein-coupled receptor (GPCR) T1R1/T1R3 as a direct sensor of the fed state and amino acid availability...
  2. Max M, Shanker Y, Huang L, Rong M, Liu Z, Campagne F, et al. Tas1r3, encoding a new candidate taste receptor, is allelic to the sweet responsiveness locus Sac. Nat Genet. 2001;28:58-63 pubmed
    ..Mouse Tas1r3 (encoding T1r3) maps to within 20,000 bp of the marker closest to Sac (ref...
  3. Margolskee R, Dyer J, Kokrashvili Z, Salmon K, Ilegems E, Daly K, et al. T1R3 and gustducin in gut sense sugars to regulate expression of Na+-glucose cotransporter 1. Proc Natl Acad Sci U S A. 2007;104:15075-80 pubmed
    ..Here, we show that the sweet taste receptor subunit T1R3 and the taste G protein gustducin, expressed in enteroendocrine cells, underlie intestinal sugar sensing and ..
  4. Nie Y, Vigues S, Hobbs J, Conn G, Munger S. Distinct contributions of T1R2 and T1R3 taste receptor subunits to the detection of sweet stimuli. Curr Biol. 2005;15:1948-52 pubmed
    ..Here, we report that each of the two subunits in the heteromeric T1R2:T1R3 sweet taste receptor binds sweet stimuli though with distinct affinities and conformational changes...
  5. Simon B, Parlee S, Learman B, Mori H, Scheller E, Cawthorn W, et al. Artificial sweeteners stimulate adipogenesis and suppress lipolysis independently of sweet taste receptors. J Biol Chem. 2013;288:32475-89 pubmed publisher
    ..The sweet taste receptors T1R2 and T1R3 are G protein-coupled receptors that function as carbohydrate sensors in taste buds, gut, and pancreas...
  6. Riera C, Vogel H, Simon S, Damak S, le Coutre J. Sensory attributes of complex tasting divalent salts are mediated by TRPM5 and TRPV1 channels. J Neurosci. 2009;29:2654-62 pubmed publisher
    ..preference tests (two bottles, brief access) were performed in wild-type (WT) mice and in mice lacking (1) the T1R3 receptor, (2) TRPV1, the capsaicin receptor, or (3) the TRPM5 channel, the latter being necessary for the ..
  7. Treesukosol Y, Blonde G, Spector A. T1R2 and T1R3 subunits are individually unnecessary for normal affective licking responses to Polycose: implications for saccharide taste receptors in mice. Am J Physiol Regul Integr Comp Physiol. 2009;296:R855-65 pubmed publisher
    The T1R2 and T1R3 proteins are expressed in taste receptor cells and form a heterodimer binding with compounds described as sweet by humans...
  8. Kitagawa M, Kusakabe Y, Miura H, Ninomiya Y, Hino A. Molecular genetic identification of a candidate receptor gene for sweet taste. Biochem Biophys Res Commun. 2001;283:236-42 pubmed
    A cDNA clone encoding a novel member of the putative taste receptor T1R family, designated T1R3, was isolated from circumvallate papillae of the mouse tongue using degenerate primers...
  9. Zukerman S, Glendinning J, Margolskee R, Sclafani A. Impact of T1r3 and Trpm5 on carbohydrate preference and acceptance in C57BL/6 mice. Chem Senses. 2013;38:421-37 pubmed publisher
    Knockout (KO) mice missing the sweet taste receptor subunit T1r3 or the signaling protein Trpm5 have greatly attenuated sweetener preferences but learn to prefer sucrose in 24-h tests...
  10. Glendinning J, Gillman J, Zamer H, Margolskee R, Sclafani A. The role of T1r3 and Trpm5 in carbohydrate-induced obesity in mice. Physiol Behav. 2012;107:50-8 pubmed publisher
    ..T1r3, encoded by Tas1r3, is part of the T1r2+T1r3 sugar taste receptor, while Trpm5 mediates signaling for G protein-coupled receptors in ..
  11. Montmayeur J, Liberles S, Matsunami H, Buck L. A candidate taste receptor gene near a sweet taste locus. Nat Neurosci. 2001;4:492-8 pubmed
    ..Here we describe a candidate taste receptor gene, T1r3, that is located at or near the mouse Sac locus, a genetic locus that controls the detection of certain sweet ..
  12. Damak S, Rong M, Yasumatsu K, Kokrashvili Z, Varadarajan V, Zou S, et al. Detection of sweet and umami taste in the absence of taste receptor T1r3. Science. 2003;301:850-3 pubmed
    ..Molecular genetics and heterologous expression implicate T1r2 plus T1r3 as a sweet-responsive receptor,and T1r1 plus T1r3,as well as a truncated form of the type 4 metabotropic glutamate ..
  13. Simon B, Learman B, Parlee S, Scheller E, Mori H, Cawthorn W, et al. Sweet taste receptor deficient mice have decreased adiposity and increased bone mass. PLoS ONE. 2014;9:e86454 pubmed publisher
    Functional expression of sweet taste receptors (T1R2 and T1R3) has been reported in numerous metabolic tissues, including the gut, pancreas, and, more recently, in adipose tissue...
  14. Iwatsuki K, Nomura M, Shibata A, Ichikawa R, Enciso P, Wang L, et al. Generation and characterization of T1R2-LacZ knock-in mouse. Biochem Biophys Res Commun. 2010;402:495-9 pubmed publisher
    ..has been identified as a sole sweet taste receptor in mammals that mediates sweet signals upon dimerization with T1R3. However, because of limited availability of reliable antibodies and low expression level of G protein-coupled ..
  15. Jiang P, Ji Q, Liu Z, Snyder L, Benard L, Margolskee R, et al. The cysteine-rich region of T1R3 determines responses to intensely sweet proteins. J Biol Chem. 2004;279:45068-75 pubmed
    ..It has been shown that heterologous expression of T1R2 plus T1R3 together yields a receptor responsive to many of the above-mentioned sweet tasting ligands...
  16. Nelson G, Hoon M, Chandrashekar J, Zhang Y, Ryba N, Zuker C. Mammalian sweet taste receptors. Cell. 2001;106:381-90 pubmed
    ..First, transgenic rescue experiments prove that the Sac locus encodes T1R3, a member of the T1R family of candidate taste receptors...
  17. Nie Y, Hobbs J, Vigues S, Olson W, Conn G, Munger S. Expression and purification of functional ligand-binding domains of T1R3 taste receptors. Chem Senses. 2006;31:505-13 pubmed
    ..The NTD of mouse T1R3 was expressed as two distinct fusion proteins in Escherichia coli and purified by column chromatography...
  18. Kyriazis G, Soundarapandian M, Tyrberg B. Sweet taste receptor signaling in beta cells mediates fructose-induced potentiation of glucose-stimulated insulin secretion. Proc Natl Acad Sci U S A. 2012;109:E524-32 pubmed publisher
    ..Our results unveil a pathway for the regulation of insulin release by postprandial nutrients that involves beta cell sweet TR signaling. ..
  19. Sclafani A, Glass D, Margolskee R, Glendinning J. Gut T1R3 sweet taste receptors do not mediate sucrose-conditioned flavor preferences in mice. Am J Physiol Regul Integr Comp Physiol. 2010;299:R1643-50 pubmed publisher
    Most mammals prefer the sweet taste of sugars, which is mediated by the heterodimeric T1R2+T1R3 taste receptor. Sugar appetite is also enhanced by the post-oral reinforcing actions of the nutrient in the gut...
  20. Eylam S, Spector A. Stimulus processing of glycine is dissociable from that of sucrose and glucose based on behaviorally measured taste signal detection in Sac 'taster' and 'non-taster' mice. Chem Senses. 2004;29:639-49 pubmed
    ..These phenotypic differences appear to be due to a polymorphism in the gene at the Sac locus encoding for the T1R3 taste receptor selectively affecting the functionality of the T1R2+3 heterodimer...
  21. Sainz E, Korley J, Battey J, Sullivan S. Identification of a novel member of the T1R family of putative taste receptors. J Neurochem. 2001;77:896-903 pubmed
    ..Here, we report the identification of a third member, T1R3, of this family of receptors...
  22. Murovets V, Zolotarev V, Bachmanov A. The role of the Sac locus in the alcohol taste preference in inbred mouse strains. Dokl Biol Sci. 2010;432:181-3 pubmed publisher
  23. Liao J, Schultz P. Three sweet receptor genes are clustered in human chromosome 1. Mamm Genome. 2003;14:291-301 pubmed
    ..A genetic marker, DVL1, which is linked to the Sac locus, is within 1700 bp of human T1R3. Recently, the murine T1Rs and its human ortholog have been independently identified in combination as sweet and ..
  24. Capeless C, Whitney G. The genetic basis of preference for sweet substances among inbred strains of mice: preference ratio phenotypes and the alleles of the Sac and dpa loci. Chem Senses. 1995;20:291-8 pubmed
    ..If a single locus (presumably dpa or Sac) determines these phenotypes, there are likely to be three alleles...
  25. Yasumatsu K, Ogiwara Y, Takai S, Yoshida R, Iwatsuki K, Torii K, et al. Umami taste in mice uses multiple receptors and transduction pathways. J Physiol. 2012;590:1155-70 pubmed publisher
    ..Proposed umami receptors include heteromers of taste receptor type 1, members 1 and 3 (T1R1+T1R3), and metabotropic glutamate receptors 1 and 4 (mGluR1 and mGluR4)...
  26. Saqui Salces M, Keeley T, Grosse A, Qiao X, El Zaatari M, Gumucio D, et al. Gastric tuft cells express DCLK1 and are expanded in hyperplasia. Histochem Cell Biol. 2011;136:191-204 pubmed publisher
    ..TRPM5. In summary, tuft cells appear in the gastric antrum and intestine at E18.5, but their maximal numbers in the corpus are not achieved until after weaning. Tuft cell numbers increase with inflammation, hyperplasia, and metaplasia. ..
  27. Lush I. The genetics of tasting in mice. VI. Saccharin, acesulfame, dulcin and sucrose. Genet Res. 1989;53:95-9 pubmed
    ..The difference between C57BL/6Ty and DBA/2Ty is largely due to a single gene, Sac.
  28. Blednov Y, Walker D, Martinez M, Levine M, Damak S, Margolskee R. Perception of sweet taste is important for voluntary alcohol consumption in mice. Genes Brain Behav. 2008;7:1-13 pubmed
    ..mice, each lacking a gene expressed in taste buds and critical to taste transduction: alpha-gustducin (Gnat3), Tas1r3 or Trpm5...
  29. Treesukosol Y, Spector A. Orosensory detection of sucrose, maltose, and glucose is severely impaired in mice lacking T1R2 or T1R3, but Polycose sensitivity remains relatively normal. Am J Physiol Regul Integr Comp Physiol. 2012;303:R218-35 pubmed publisher
    ..Here, we assessed the necessity of the T1R2 and T1R3 subunits in the maintenance of normal taste sensitivity to carbohydrate stimuli...
  30. Oya M, Suzuki H, Watanabe Y, Sato M, Tsuboi T. Amino acid taste receptor regulates insulin secretion in pancreatic ?-cell line MIN6 cells. Genes Cells. 2011;16:608-16 pubmed publisher
    ..acid taste receptor (heterodimer of type 1 taste G protein-coupled receptor member 1 and member 3; Tas1R1 and Tas1R3, respectively)...
  31. Sclafani A, Marambaud P, Ackroff K. Sucrose-conditioned flavor preferences in sweet ageusic T1r3 and Calhm1 knockout mice. Physiol Behav. 2014;126:25-9 pubmed publisher
    The present study compared the ability of sweet ageusic T1r3 knockout (KO) and Calhm1 KO mice to acquire preferences for a sucrose-paired flavor as well as for unflavored sucrose...
  32. Murovets V, Bachmanov A, Travnikov S, Tchurikova A, Zolotarev V. [Involvement of Tas1r3 receptor protein in control of the metabolism of glucose at different levels of glycemia in mice]. Zh Evol Biokhim Fiziol. 2014;50:296-304 pubmed
    ..of the T1R3 protein in regulation of glucose metabolism in experiments with the gene-knockout mouse strain C57BL6J-Tas1r3(tm1Rfm) (Tas1r3-/-), with a deletion of the Tas1r3 gene encoding T1R3, and the control strain C57BL/6ByJ with the ..
  33. Masubuchi Y, Nakagawa Y, Medina J, Nagasawa M, Kojima I, Rasenick M, et al. T1R3 homomeric sweet taste receptor regulates adipogenesis through G?s-mediated microtubules disassembly and Rho activation in 3T3-L1 cells. PLoS ONE. 2017;12:e0176841 pubmed publisher
    We previously reported that 3T3-L1 cells express a functional sweet taste receptor possibly as a T1R3 homomer that is coupled to Gs and negatively regulates adipogenesis by a G?s-mediated but cAMP-independent mechanism...
  34. Martin B, Wang R, Cong W, Daimon C, Wu W, Ni B, et al. Altered learning, memory, and social behavior in type 1 taste receptor subunit 3 knock-out mice are associated with neuronal dysfunction. J Biol Chem. 2017;292:11508-11530 pubmed publisher
    The type 1 taste receptor member 3 (T1R3) is a G protein-coupled receptor involved in sweet-taste perception...
  35. Hass N, Schwarzenbacher K, Breer H. T1R3 is expressed in brush cells and ghrelin-producing cells of murine stomach. Cell Tissue Res. 2010;339:493-504 pubmed publisher
    ..We demonstrate the expression of the T1R subtype T1R3, which is essential for the detection of both sugars and amino acids in the gustatory system, in two distinct cell ..
  36. Galbraith D, Wolff G. Aberrant regulation of the Agouti pigment pattern in the viable yellow mouse. J Hered. 1974;65:137-40 pubmed
  37. Inoue M, Glendinning J, Theodorides M, Harkness S, Li X, Bosak N, et al. Allelic variation of the Tas1r3 taste receptor gene selectively affects taste responses to sweeteners: evidence from 129.B6-Tas1r3 congenic mice. Physiol Genomics. 2007;32:82-94 pubmed
    The Tas1r3 gene encodes the T1R3 receptor protein, which is involved in sweet taste transduction...
  38. Riera C, Vogel H, Simon S, Damak S, le Coutre J. The capsaicin receptor participates in artificial sweetener aversion. Biochem Biophys Res Commun. 2008;376:653-7 pubmed publisher
    ..of the above compounds, preference tests were performed in wild-type mice and mice lacking the TRPV1 channel or the T1R3 receptor, the latter being necessary for the perception of sweet taste...
  39. Belknap J, Crabbe J, Plomin R, McClearn G, Sampson K, O Toole L, et al. Single-locus control of saccharin intake in BXD/Ty recombinant inbred (RI) mice: some methodological implications for RI strain analysis. Behav Genet. 1992;22:81-100 pubmed
    The sac locus, with a major effect on saccharin preference, was discovered by Fuller (1974) in C57BL/6J (B6), DBA/2J (D2), and derived crosses, and is now supported in the BXD/Ty recombinant inbred (RI) series by a marked bimodal ..
  40. Gong T, Wei Q, Mao D, Shi F. Expression patterns of taste receptor type 1 subunit 3 and α-gustducin in the mouse testis during development. Acta Histochem. 2016;118:20-30 pubmed publisher
    Taste receptor type 1 subunit 3 (T1R3) and its associated heterotrimeric G protein α-gustducin (Gα) are involved in sweet and umami sensing in taste cells...
  41. Li X, Inoue M, Reed D, Huque T, Puchalski R, Tordoff M, et al. High-resolution genetic mapping of the saccharin preference locus (Sac) and the putative sweet taste receptor (T1R1) gene (Gpr70) to mouse distal Chromosome 4. Mamm Genome. 2001;12:13-6 pubmed
    The Sac (saccharin preference) locus affecting mouse behavioral and neural responsiveness to sweeteners has been mapped to distal Chr 4...
  42. Ogawa N, Kanki K, Honda K, Tomooka Y, Ryoke K, Watanabe T. Involvement of glucocorticoid in induction of lingual T1R3 in rodents. Eur J Pharmacol. 2015;761:262-7 pubmed publisher
    We previously reported that in rats, chronic exposure to stress inhibits the induction of the common receptor (T1R3) for sweet and umami tastes...
  43. Pal Choudhuri S, Delay R, Delay E. Metabotropic glutamate receptors are involved in the detection of IMP and L-amino acids by mouse taste sensory cells. Neuroscience. 2016;316:94-108 pubmed publisher
    ..These include the heterodimer taste receptor type 1 member 1 (T1r1)+taste receptor type 1 member 3 (T1r3), taste and brain variants of mGluR4 and mGluR1, and calcium sensors...
  44. Blizard D, McClearn G. Association between ethanol and sucrose intake in the laboratory mouse: exploration via congenic strains and conditioned taste aversion. Alcohol Clin Exp Res. 2000;24:253-8 pubmed
  45. Reed D, Li S, Li X, Huang L, Tordoff M, Starling Roney R, et al. Polymorphisms in the taste receptor gene (Tas1r3) region are associated with saccharin preference in 30 mouse strains. J Neurosci. 2004;24:938-46 pubmed
    The results of recent studies suggest that the mouse Sac (saccharin preference) locus is identical to the Tas1r3 (taste receptor) gene...
  46. Inoue M, Reed D, Li X, Tordoff M, Beauchamp G, Bachmanov A. Allelic variation of the Tas1r3 taste receptor gene selectively affects behavioral and neural taste responses to sweeteners in the F2 hybrids between C57BL/6ByJ and 129P3/J mice. J Neurosci. 2004;24:2296-303 pubmed
    Recent studies have shown that the T1R3 receptor protein encoded by the Tas1r3 gene is involved in transduction of sweet taste...
  47. Smith K, Spector A. The importance of the presence of a 5'-ribonucleotide and the contribution of the T1R1 + T1R3 heterodimer and an additional low-affinity receptor in the taste detection of L-glutamate as assessed psychophysically. J Neurosci. 2014;34:13234-45 pubmed publisher
    ..Evidence supports the involvement of the T1R1 + T1R3 heterodimer, a GPCR broadly tuned to l-amino acids, but variants of two mGluRs expressed in taste buds have also ..
  48. Feng J, Petersen C, Coy D, Jiang J, Thomas C, Pollak M, et al. Calcium-sensing receptor is a physiologic multimodal chemosensor regulating gastric G-cell growth and gastrin secretion. Proc Natl Acad Sci U S A. 2010;107:17791-6 pubmed publisher
    ..Medicinals targeting diseases of Ca(2+) homeostasis should be reviewed for effects outside traditional Ca(2+)-regulating tissues in view of the broader distribution and function of CaR. ..
  49. Brasser S, Norman M, Lemon C. T1r3 taste receptor involvement in gustatory neural responses to ethanol and oral ethanol preference. Physiol Genomics. 2010;41:232-43 pubmed publisher
    ..Here, we directly examined the contribution of the T1r3 receptor protein, important for sweet taste detection in mammals, to ethanol intake and preference and the neural ..
  50. Damak S, Mosinger B, Margolskee R. Transsynaptic transport of wheat germ agglutinin expressed in a subset of type II taste cells of transgenic mice. BMC Neurosci. 2008;9:96 pubmed publisher
    ..To determine how WGA produced in T1r3-expressing taste cells is transported into gustatory neurons, transgenic mice expressing WGA-IRES-GFP driven by the ..
  51. Yasumatsu K, Manabe T, Yoshida R, Iwatsuki K, Uneyama H, Takahashi I, et al. Involvement of multiple taste receptors in umami taste: analysis of gustatory nerve responses in metabotropic glutamate receptor 4 knockout mice. J Physiol. 2015;593:1021-34 pubmed publisher
    The taste receptor T1R1 + T1R3 heterodimer and metabotropic glutamate receptors (mGluR) may function as umami taste receptors...
  52. Toda Y, Nakagita T, Hayakawa T, Okada S, Narukawa M, Imai H, et al. Two distinct determinants of ligand specificity in T1R1/T1R3 (the umami taste receptor). J Biol Chem. 2013;288:36863-77 pubmed publisher
    Umami taste perception in mammals is mediated by a heteromeric complex of two G-protein-coupled receptors, T1R1 and T1R3. T1R1/T1R3 exhibits species-dependent differences in ligand specificity; human T1R1/T1R3 specifically responds to L-..
  53. Ilegems E, Iwatsuki K, Kokrashvili Z, Benard O, Ninomiya Y, Margolskee R. REEP2 enhances sweet receptor function by recruitment to lipid rafts. J Neurosci. 2010;30:13774-83 pubmed publisher
  54. Alioto T, Ngai J. The repertoire of olfactory C family G protein-coupled receptors in zebrafish: candidate chemosensory receptors for amino acids. BMC Genomics. 2006;7:309 pubmed
  55. Koudelka J, Horn J, Vatanashevanopakorn C, Minichiello L. Genetic dissection of TrkB activated signalling pathways required for specific aspects of the taste system. Neural Dev. 2014;9:21 pubmed publisher
    ..These results advance our knowledge of the biology of the taste system, one of the fundamental sensory systems crucial for an organism to relate to the environment. ..
  56. LopezJimenez N, Cavenagh M, Sainz E, Cruz Ithier M, Battey J, Sullivan S. Two members of the TRPP family of ion channels, Pkd1l3 and Pkd2l1, are co-expressed in a subset of taste receptor cells. J Neurochem. 2006;98:68-77 pubmed
    ..These results provide the first evidence for a role of TRPP channels in taste receptor cell function. ..
  57. Muroi Y, Ishii T. Umami taste receptor functions as an amino acid sensor via G?s subunit in N1E-115 neuroblastoma cells. J Cell Biochem. 2012;113:1654-62 pubmed publisher
    ..we examined the function of umami taste receptor, which has a dimeric protein structure composed of Tas1r1 and Tas1r3, as amino acid sensor in the cells...
  58. Tordoff M. Phosphorus Taste Involves T1R2 and T1R3. Chem Senses. 2017;42:425-433 pubmed publisher
    ..Recently, we found that the preference for trisodium pyrophosphate (Na3HP2O7) was greater in T1R3 knockout (KO) mice than wild-type (WT) controls, suggesting that T1R3 is a pyrophosphate detector...
  59. Yamaguchi T, Yamashita J, Ohmoto M, Aoudé I, Ogura T, Luo W, et al. Skn-1a/Pou2f3 is required for the generation of Trpm5-expressing microvillous cells in the mouse main olfactory epithelium. BMC Neurosci. 2014;15:13 pubmed publisher
    ..Thus, Skn-1a is a critical regulator for the generation of Trpm5-expressing microvillous cells in the main olfactory epithelium in mice. ..
  60. Shin Y, Martin B, Golden E, Dotson C, Maudsley S, Kim W, et al. Modulation of taste sensitivity by GLP-1 signaling. J Neurochem. 2008;106:455-63 pubmed publisher
    ..A modest increase in citric acid taste sensitivity in these knockout mice suggests GLP-1 signaling may modulate sour taste, as well. Together, these findings suggest a novel paracrine mechanism for the regulation of taste function. ..
  61. Meyer D, Voigt A, Widmayer P, Borth H, Huebner S, Breit A, et al. Expression of Tas1 taste receptors in mammalian spermatozoa: functional role of Tas1r1 in regulating basal Ca²? and cAMP concentrations in spermatozoa. PLoS ONE. 2012;7:e32354 pubmed publisher
    ..The present manuscript documents that Tas1r1 and Tas1r3, which form the functional receptor for monosodium glutamate (umami) in taste buds on the tongue, are expressed in ..
  62. Pal Choudhuri S, Delay R, Delay E. L-Amino Acids Elicit Diverse Response Patterns in Taste Sensory Cells: A Role for Multiple Receptors. PLoS ONE. 2015;10:e0130088 pubmed publisher
    ..using human embryonic kidney (HEK) cells suggested that there is one broadly tuned receptor heterodimer, T1r1+T1r3, which detects L-glutamate and all other L-amino acids...
  63. Mosinger B, Redding K, Parker M, Yevshayeva V, Yee K, Dyomina K, et al. Genetic loss or pharmacological blockade of testes-expressed taste genes causes male sterility. Proc Natl Acad Sci U S A. 2013;110:12319-24 pubmed publisher
    ..Using mouse models, we show that the genetic absence of both TAS1R3, a component of sweet and amino acid taste receptors, and the gustducin ?-subunit GNAT3 leads to male-specific ..
  64. Lemon C, Margolskee R. Contribution of the T1r3 taste receptor to the response properties of central gustatory neurons. J Neurophysiol. 2009;101:2459-71 pubmed publisher
    b>T1r3 is a critical subunit of T1r sweet taste receptors. Here we studied how the absence of T1r3 impacts responses to sweet stimuli by taste neurons in the nucleus tractus solitarius (NTS) of the mouse...
  65. Medina A, Nakagawa Y, Ma J, Li L, Hamano K, Akimoto T, et al. Expression of the glucose-sensing receptor T1R3 in pancreatic islet: changes in the expression levels in various nutritional and metabolic states. Endocr J. 2014;61:797-805 pubmed
    We reported recently that the taste type 1 receptor 3 (T1R3), a subunit of the sweet taste receptor, functions as a cell-surface glucose-sensing receptor in pancreatic ?-cells...
  66. Wauson E, Guerra M, Dyachok J, McGlynn K, Giles J, Ross E, et al. Differential Regulation of ERK1/2 and mTORC1 Through T1R1/T1R3 in MIN6 Cells. Mol Endocrinol. 2015;29:1114-22 pubmed publisher
    ..cell-derived line by extracellular amino acids (AAs) is at least in part mediated by the heterodimeric T1R1/T1R3, a G protein-coupled receptor...
  67. Yoshida R, Ninomiya Y. Taste information derived from T1R-expressing taste cells in mice. Biochem J. 2016;473:525-36 pubmed publisher
    ..This family consists of three members (T1R1, T1R2 and T1R3)...
  68. Elson A, Dotson C, Egan J, Munger S. Glucagon signaling modulates sweet taste responsiveness. FASEB J. 2010;24:3960-9 pubmed publisher
    ..Most of these cells also express the T1R3 taste receptor implicated in sweet and/or umami taste...
  69. Daly K, Al Rammahi M, Moran A, Marcello M, Ninomiya Y, Shirazi Beechey S. Sensing of amino acids by the gut-expressed taste receptor T1R1-T1R3 stimulates CCK secretion. Am J Physiol Gastrointest Liver Physiol. 2013;304:G271-82 pubmed publisher
    ..of a broad spectrum of L-amino acids is accomplished by the heteromeric amino acid (umami) taste receptor (T1R1-T1R3). T1R1 and T1R3 subunits are also expressed in the intestine...
  70. Glendinning J, Chyou S, Lin I, Onishi M, Patel P, Zheng K. Initial licking responses of mice to sweeteners: effects of tas1r3 polymorphisms. Chem Senses. 2005;30:601-14 pubmed
    ..First, transgenic mice lacking the gene for T1R3, Tas1r3, show dramatically reduced lick responsiveness to most sweeteners...
  71. Fuller J. Single-locus control of saccharin preference in mice. J Hered. 1974;65:33-6 pubmed
  72. Shigemura N, Nakao K, Yasuo T, Murata Y, Yasumatsu K, Nakashima A, et al. Gurmarin sensitivity of sweet taste responses is associated with co-expression patterns of T1r2, T1r3, and gustducin. Biochem Biophys Res Commun. 2008;367:356-63 pubmed publisher
    ..Recent studies demonstrated that co-expression levels of genes controlling sweet receptors (T1r2/T1r3 heterodimer) versus Galpha-protein, gustducin, are much lower in Gur-insensitive posterior circumvallate papillae ..
  73. Smith K, Hussain T, Karimian Azari E, Steiner J, Ayala J, Pratley R, et al. Disruption of the sugar-sensing receptor T1R2 attenuates metabolic derangements associated with diet-induced obesity. Am J Physiol Endocrinol Metab. 2016;310:E688-E698 pubmed publisher
    ..Finally, STRs (T1r2/T1r3) were upregulated in the adipose tissue of WT mice in response to HF/LC diet, and their expression positively ..