Gene Symbol: Tarbp2
Description: TARBP2, RISC loading complex RNA binding subunit
Alias: Prbp, TRBP, RISC-loading complex subunit TARBP2, PRM-1 RNA-binding protein, TAR (HIV) RNA binding protein 2, TAR RNA-binding protein 2, protamine-1 RNA-binding protein
Species: mouse
Products:     Tarbp2

Top Publications

  1. Zhong J, Peters A, Lee K, Braun R. A double-stranded RNA binding protein required for activation of repressed messages in mammalian germ cells. Nat Genet. 1999;22:171-4 pubmed
    ..We have previously suggested that the double-stranded (ds) RNA binding protein Prbp (encoded by the gene Tarbp2) functions as a translational regulator during mouse spermatogenesis...
  2. Kozak C, Gatignol A, Graham K, Jeang K, McBride O. Genetic mapping in human and mouse of the locus encoding TRBP, a protein that binds the TAR region of the human immunodeficiency virus (HIV-1). Genomics. 1995;25:66-72 pubmed
    ..Here we demonstrate that this factor is encoded by a gene, TARBP2, that maps to human chromosome 12 and mouse chromosome 15, and we also identify and map one human pseudogene (..
  3. Zhong J, Edelhoff S, Disteche C, Braun R. The gene encoding PRBP, the mouse homolog of human TRBP, maps to distal chromosome 15. Mamm Genome. 1998;9:413-4 pubmed
  4. Kok K, Ng M, Ching Y, Jin D. Human TRBP and PACT directly interact with each other and associate with dicer to facilitate the production of small interfering RNA. J Biol Chem. 2007;282:17649-57 pubmed
    Mammalian Dicer interacts with double-stranded RNA-binding protein TRBP or PACT to mediate RNA interference and micro-RNA processing. TRBP and PACT are structurally related but exert opposite regulatory activities on PKR...
  5. Daniels S, Melendez Peña C, Scarborough R, Daher A, Christensen H, El Far M, et al. Characterization of the TRBP domain required for dicer interaction and function in RNA interference. BMC Mol Biol. 2009;10:38 pubmed publisher
    ..Immunofluorescence shows that while full-length TRBPs colocalize with Dicer, TRBPsDeltaC4 do not. tarbp2-/- cells, which do not express TRBP, do not support RNA interference (RNAi) mediated by short hairpin or micro ..
  6. Daher A, Laraki G, Singh M, Melendez Peña C, Bannwarth S, Peters A, et al. TRBP control of PACT-induced phosphorylation of protein kinase R is reversed by stress. Mol Cell Biol. 2009;29:254-65 pubmed publisher
    ..PACT-induced PKR phosphorylation was restored in Tarbp2(-/-) murine tail fibroblasts and in HEK293T or HeLa cells when TRBP expression was reduced by RNA interference...
  7. Byun S, Kim J, Han D, Kwon M, Cho J, Ng H, et al. TRBP maintains mammalian embryonic neural stem cell properties by acting as a novel transcriptional coactivator of the Notch signaling pathway. Development. 2017;144:778-783 pubmed publisher
    Transactivation response element RNA-binding protein (TRBP; TARBP2) is known to play important roles in human immunodeficiency virus (HIV) replication and microRNA biogenesis...
  8. Delpire E, Lu J, England R, Dull C, Thorne T. Deafness and imbalance associated with inactivation of the secretory Na-K-2Cl co-transporter. Nat Genet. 1999;22:192-5 pubmed
    ..We localized the co-transporter to key secreting epithelia of the mouse inner ear and show that absence of functional co-transporter leads to structural damages in the inner ear consistent with a decrease in endolymph secretion. ..
  9. Wilson R, Tambe A, Kidwell M, Noland C, Schneider C, Doudna J. Dicer-TRBP complex formation ensures accurate mammalian microRNA biogenesis. Mol Cell. 2015;57:397-407 pubmed publisher
    ..Although the phylogenetically conserved RNA-binding proteins TRBP and PACT are known to contribute to this process, their mode of Dicer binding and their genome-wide effects on ..

More Information


  1. Ota H, Sakurai M, Gupta R, Valente L, Wulff B, Ariyoshi K, et al. ADAR1 forms a complex with Dicer to promote microRNA processing and RNA-induced gene silencing. Cell. 2013;153:575-89 pubmed publisher
    ..As expected, the expression of miRNAs is globally inhibited in ADAR1(-/-) mouse embryos, which, in turn, alters the expression of their target genes and might contribute to their embryonic lethal phenotype. ..
  2. Kaneko H, Dridi S, Tarallo V, Gelfand B, Fowler B, Cho W, et al. DICER1 deficit induces Alu RNA toxicity in age-related macular degeneration. Nature. 2011;471:325-30 pubmed publisher
    ..These findings reveal a miRNA-independent cell survival function for DICER1 involving retrotransposon transcript degradation, show that Alu RNA can directly cause human pathology, and identify new targets for a major cause of blindness. ..
  3. Ding J, Chen J, Wang Y, Kataoka M, Ma L, Zhou P, et al. Trbp regulates heart function through microRNA-mediated Sox6 repression. Nat Genet. 2015;47:776-83 pubmed publisher
    ..Cardiomyopathy is associated with altered expression of genes encoding contractile proteins. Here we show that Trbp (Tarbp2), an RNA-binding protein, is required for normal heart function...
  4. Nakamura T, Kunz R, Zhang C, Kimura T, Yuan C, Baccaro B, et al. A critical role for PKR complexes with TRBP in Immunometabolic regulation and eIF2α phosphorylation in obesity. Cell Rep. 2015;11:295-307 pubmed publisher
    ..Here, we report the formation of a complex between PKR and TAR RNA-binding protein (TRBP) during metabolic and obesity-induced stress, which is critical for the regulation of eukaryotic translation ..
  5. Zimmermann J, Latta L, Beck A, Leidinger P, Fecher Trost C, Schlenstedt G, et al. Trans-activation response (TAR) RNA-binding protein 2 is a novel modulator of transient receptor potential canonical 4 (TRPC4) protein. J Biol Chem. 2014;289:9766-80 pubmed publisher
    ..b>Tarbp2 was found to bind to the C terminus of TRPC4 and TRPC5 and to modulate agonist-dependent TRPC4-induced Ca(2+) ..
  6. Fukunaga R, Han B, Hung J, Xu J, Weng Z, Zamore P. Dicer partner proteins tune the length of mature miRNAs in flies and mammals. Cell. 2012;151:533-46 pubmed publisher
    ..The longer form of miR-307a represses glycerol kinase and taranis mRNA expression. The mammalian Dicer-partner TRBP, a Loqs-PB homolog, similarly tunes where Dicer cleaves pre-miR-132...
  7. Liu X, Jin D, McManus M, Mourelatos Z. Precursor microRNA-programmed silencing complex assembly pathways in mammals. Mol Cell. 2012;46:507-17 pubmed publisher
    ..Our studies provide a comprehensive view of miRNP/RISC assembly pathways in mammals, and our assay provides a versatile platform for further mechanistic dissection of such pathways in mammals. ..
  8. Eiring A, Harb J, Neviani P, Garton C, Oaks J, Spizzo R, et al. miR-328 functions as an RNA decoy to modulate hnRNP E2 regulation of mRNA translation in leukemic blasts. Cell. 2010;140:652-65 pubmed publisher
    ..Altogether, these data reveal the dual ability of a microRNA to control cell fate both through base pairing with mRNA targets and through a decoy activity that interferes with the function of regulatory proteins. ..
  9. Ding J, Nie M, Liu J, Hu X, Ma L, Deng Z, et al. Trbp Is Required for Differentiation of Myoblasts and Normal Regeneration of Skeletal Muscle. PLoS ONE. 2016;11:e0155349 pubmed publisher
    Global inactivation of Trbp, a regulator of miRNA pathways, resulted in developmental defects and postnatal lethality in mice. Recently, we showed that cardiac-specific deletion of Trbp caused heart failure...
  10. Lee K, Fajardo M, Braun R. A testis cytoplasmic RNA-binding protein that has the properties of a translational repressor. Mol Cell Biol. 1996;16:3023-34 pubmed
    ..From this screen we obtained two independent clones that encode Prbp, a Prm-1 RNA-binding protein. Prbp contains two copies of a double-stranded-RNA-binding domain...