Tap2

Summary

Gene Symbol: Tap2
Description: transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)
Alias: ABC18, AI462429, APT2, Abcb3, Ham-2, Ham2, MTP2, PSF2, RING11, Tap-2, jas, antigen peptide transporter 2, ATP dependent transport protein family member, ATP-binding cassette sub-family B member 3, ATP-binding cassette, sub-family B (MDR/TAP), member 3, histocompatibility antigen modifier 2, transporter 2 ATP-binding cassette sub-family B, transporter 2, ABC (ATP binding cassette)
Species: mouse
Products:     Tap2

Top Publications

  1. Andria M, Barsh G, Levy S. Expression of TAPA-1 in preimplantation mouse embryos. Biochem Biophys Res Commun. 1992;186:1201-6 pubmed
    ..Using a sensitive reverse transcription/polymerase chain reaction assay, we show that TAPA-1 RNA is present in oocytes, fertilized eggs and cleavage stage embryos. ..
  2. Zhou P, Zanelli E, Smart M, David C. Genomic organization and tissue expression of mouse proteasome gene Lmp-2. Genomics. 1993;16:664-8 pubmed
    ..The Lmp-2 gene is expressed in most tissues of unstimulated mice, except for brain tissue. The comparison of the 5'-flanking region of human and mouse sequences is discussed. ..
  3. Arons E, Kunin V, Schechter C, Ehrlich R. Organization and functional analysis of the mouse transporter associated with antigen processing 2 promoter. J Immunol. 2001;166:3942-51 pubmed
    ..and are transported to the endoplasmic reticulum by a peptide transport pump consisting of two subunits, TAP1 and TAP2. The proteasome low molecular weight polypeptide (2 and 7), as well as TAP (1 and 2) genes, are coordinately ..
  4. Zheng P, Guo Y, Niu Q, Levy D, Dyck J, Lu S, et al. Proto-oncogene PML controls genes devoted to MHC class I antigen presentation. Nature. 1998;396:373-6 pubmed
    ..PML also regulates MHC expression in untransformed fibroblasts. We conclude that malfunction of PML may enable a tumour to evade the immune defence of its host. ..
  5. Cho S, Attaya M, Brown M, Monaco J. A cluster of transcribed sequences between the Pb and Ob genes of the murine major histocompatibility complex. Proc Natl Acad Sci U S A. 1991;88:5197-201 pubmed
    ..Two of the remaining four genes, HAM1 and HAM2, are homologous to one another and to a family of eukaryotic and prokaryotic transport proteins and may be involved ..
  6. Yang Y, Fruh K, Chambers J, Waters J, Wu L, Spies T, et al. Major histocompatibility complex (MHC)-encoded HAM2 is necessary for antigenic peptide loading onto class I MHC molecules. J Biol Chem. 1992;267:11669-72 pubmed
    ..As proteasomes and the putative peptide transporters HAM1 and HAM2 have been implicated in class I antigen processing, we have investigated their expression in RMA-S and its wild-..
  7. Miyazaki T, Muller U, Campbell K. Normal development but differentially altered proliferative responses of lymphocytes in mice lacking CD81. EMBO J. 1997;16:4217-25 pubmed
  8. Kasahara M, Hayashi M, Tanaka K, Inoko H, Sugaya K, Ikemura T, et al. Chromosomal localization of the proteasome Z subunit gene reveals an ancient chromosomal duplication involving the major histocompatibility complex. Proc Natl Acad Sci U S A. 1996;93:9096-101 pubmed
    ..3 and 9q33-q34). These observations have implications in understanding the genomic organization of the present-day MHC and offer insights into the origin of the MHC. ..
  9. Cooper J, Fernandez N, Joly E, Dealtry G. Regulation of major histocompatibility complex and TAP gene products in preimplantation mouse stage embryos. Am J Reprod Immunol. 1998;40:165-71 pubmed
    ..To determine the ontogeny of major histocompatibility complex (MHC) expression and TAP products in mouse embryos...

More Information

Publications32

  1. Uinuk ool T, Mayer W, Sato A, Takezaki N, Benyon L, Cooper M, et al. Identification and characterization of a TAP-family gene in the lamprey. Immunogenetics. 2003;55:38-48 pubmed
    ..The sequence is closely related to the mammalian ABCB9 protein and the TAP1 and TAP2 proteins that transport peptides for loading onto nascent Mhc class I molecules...
  2. Loflin P, Laud P, Watkins D, Lawlor D. Identification of new TAP2 alleles in gorilla: evolution of the locus within hominoids. Immunogenetics. 1996;44:161-9 pubmed
    Transporters associated with antigen processing molecules (TAP1 and TAP2) mediate the transfer of cytosolic peptides into the lumen of the endoplasmic reticulum for association with newly synthesized class I molecules of the major ..
  3. Momburg F, Roelse J, Howard J, Butcher G, Hammerling G, Neefjes J. Selectivity of MHC-encoded peptide transporters from human, mouse and rat. Nature. 1994;367:648-51 pubmed
    ..binding to class I molecules by means of the MHC-encoded transporters associated with antigen processing, TAP1 and TAP2. These are members of a family of proteins containing an ATP-binding cassette and form heterodimers in the ER ..
  4. Rodgers J, Mehta V, Cook R. Surface expression of beta 2-microglobulin-associated thymus-leukemia antigen is independent of TAP2. Eur J Immunol. 1995;25:1001-7 pubmed
    ..TL is expressed efficiently in the absence of functional transporter associated with antigen processing subunit 2 (TAP2). A putative fourth TLa gene cloned from A.SL1 cells was expressed in RMA and RMA-S cells...
  5. Deverson E, Gow I, Coadwell W, Monaco J, Butcher G, Howard J. MHC class II region encoding proteins related to the multidrug resistance family of transmembrane transporters. Nature. 1990;348:738-41 pubmed
    ..Such molecules are credible candidates for peptide pumps that move fragments of antigenic proteins from the cytosol into the ER. ..
  6. van Hall T, Laban S, Koppers Lalic D, Koch J, Precup C, Asmawidjaja P, et al. The varicellovirus-encoded TAP inhibitor UL49.5 regulates the presentation of CTL epitopes by Qa-1b1. J Immunol. 2007;178:657-62 pubmed
    ..to ICP47 and US6, strongly impairs the activity of the mouse transporter and mediates degradation of mouse TAP1 and TAP2. Inhibition of TAP was witnessed by a strong reduction of surface MHC class I display and a decrease in recognition ..
  7. Schumacher T, Kantesaria D, Heemels M, Ashton Rickardt P, Shepherd J, Fruh K, et al. Peptide length and sequence specificity of the mouse TAP1/TAP2 translocator. J Exp Med. 1994;179:533-40 pubmed
    ..By maintaining a low peptide concentration at the site of class I assembly, this efflux mechanism may ensure that class I molecules are loaded preferentially with high affinity peptides...
  8. Lilic M, Popmihajlov Z, Monaco J, Vukmanovic S. Association of beta2-microglobulin with the alpha3 domain of H-2Db heavy chain. Immunogenetics. 2004;55:740-7 pubmed
    ..Thus, there are allelic differences in the modes of binding of beta2m to the heavy chain of MHC class I...
  9. Ugrinovic S, Brooks C, Robson J, Blacklaws B, Hormaeche C, Robinson J. H2-M3 major histocompatibility complex class Ib-restricted CD8 T cells induced by Salmonella enterica serovar Typhimurium infection recognize proteins released by Salmonella serovar Typhimurium. Infect Immun. 2005;73:8002-8 pubmed
    ..It also expands the range of pathogens that induce H2-M3-restricted CD8 T cells to include an example of gram-negative bacteria. ..
  10. Garbi N, Tiwari N, Momburg F, Hämmerling G. A major role for tapasin as a stabilizer of the TAP peptide transporter and consequences for MHC class I expression. Eur J Immunol. 2003;33:264-73 pubmed
    ..Tpn(-/-)) mice the absence of tapasin was found to have a dramatic effect on the stability of the TAP1/TAP2 heterodimeric peptide transporter...
  11. Kobayashi A, Kasano M, Maeda T, Hori S, Motojima K, Suzuki M, et al. A half-type ABC transporter TAPL is highly conserved between rodent and man, and the human gene is not responsive to interferon-gamma in contrast to TAP1 and TAP2. J Biochem. 2000;128:711-8 pubmed
    TAPL is a half-type ABC transporter with sequence similarity to TAP1 and TAP2 that is transcribed in various rat tissues [Yamaguchi, Y., Kasano, M., Terada, T., Sato, R., and Maeda, M. (1999) FEBS Lett. 457, 231-236]...
  12. Ambagala A, Feng Z, Barletta R, Srikumaran S. Molecular cloning, sequencing, and characterization of bovine transporter associated with antigen processing 2 ( BoTAP2). Immunogenetics. 2002;54:30-8 pubmed
    ..BoTAP2 has approximately 80% homology, at the amino acid level, to its mammalian counterparts. Similar to human TAP2, BoTAP2 consists of seven putative transmembrane segments followed by an ATP-binding cassette...
  13. Lapenna A, Omar I, Berger M. A novel spontaneous mutation in the TAP2 gene unravels its role in macrophage survival. Immunology. 2017;150:432-443 pubmed publisher
    ..a new mouse strain with a single point mutation in the type 2 transporter associated with antigen processing (TAP2)...
  14. Urbanska E, Chambers B, Ljunggren H, Norrby E, Kristensson K. Spread of measles virus through axonal pathways into limbic structures in the brain of TAP1 -/- mice. J Med Virol. 1997;52:362-9 pubmed
    ..The findings obtained in the gene-manipulated mice point out that a compromised immune state of the host may potentiate targeting of virus to the limbic system through olfactory projections...
  15. Marusina K, Iyer M, Monaco J. Allelic variation in the mouse Tap-1 and Tap-2 transporter genes. J Immunol. 1997;158:5251-6 pubmed
    The TAP1 and TAP2 proteins form a heterodimer that transports short peptides from the cytosol into the endoplasmic reticulum lumen...
  16. Monaco J, Cho S, Attaya M. Transport protein genes in the murine MHC: possible implications for antigen processing. Science. 1990;250:1723-6 pubmed
    ..Two closely related genes in this region, HAM1 and HAM2, were cloned and had sequence similarities to a superfamily of genes involved in the ATP-dependent transport of a ..
  17. Attaya M, Jameson S, Martinez C, Hermel E, Aldrich C, Forman J, et al. Ham-2 corrects the class I antigen-processing defect in RMA-S cells. Nature. 1992;355:647-9 pubmed
    ..These data indicate that both MHC-linked transporter genes are probably required for class I antigen processing, and that the functional transporter in this pathway may consist of a Ham-1/Ham-2 heterodimer...
  18. van Kaer L, Ashton Rickardt P, Ploegh H, Tonegawa S. TAP1 mutant mice are deficient in antigen presentation, surface class I molecules, and CD4-8+ T cells. Cell. 1992;71:1205-14 pubmed
    ..These properties are strikingly similar to those described for the TAP2 mutant cell line RMA-S...
  19. Ritz U, Momburg F, Pircher H, Strand D, Huber C, Seliger B. Identification of sequences in the human peptide transporter subunit TAP1 required for transporter associated with antigen processing (TAP) function. Int Immunol. 2001;13:31-41 pubmed
    The heterodimeric peptide transporter associated with antigen processing (TAP) consisting of the subunits TAP1 and TAP2 mediates the transport of cytosolic peptides into the lumen of the endoplasmic reticulum (ER)...
  20. Ljunggren H, van Kaer L, Ploegh H, Tonegawa S. Altered natural killer cell repertoire in Tap-1 mutant mice. Proc Natl Acad Sci U S A. 1994;91:6520-4 pubmed
    ..These results support the hypothesis that class I molecules of the MHC influence the sensitivity of target cells to lysis by NK cells, as well as the development of the NK cell repertoire...
  21. Lampton P, Goldstein C, Warner C. The role of tapasin in MHC class I protein trafficking in embryos and T cells. J Reprod Immunol. 2008;78:28-39 pubmed
    ..Here, we report the detection of mRNA for four chaperone molecules (TAP1, TAP2, calnexin and tapasin) in preimplantation embryos...
  22. Theodoratos A, Whittle B, Enders A, Tscharke D, Roots C, Goodnow C, et al. Mouse strains with point mutations in TAP1 and TAP2. Immunol Cell Biol. 2010;88:72-8 pubmed publisher
    ..Jasmine has an A to C transversion in exon 5 of TAP2, resulting in a threonine to proline substitution at position 293 of the protein...
  23. Huang L, Kuhls M, Eisenlohr L. Hydrophobicity as a driver of MHC class I antigen processing. EMBO J. 2011;30:1634-44 pubmed publisher
    ..These insights into intracellular proteolytic pathways and their selective contributions to MHC class I-restricted peptide supply, may point to new approaches in rational vaccine design. ..