Gene Symbol: Tap1
Description: transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
Alias: ABC17, APT1, Abcb2, Ham-1, Ham1, MTP1, PSF1, RING4, TAP, Tap-1, antigen peptide transporter 1, ABC transporter, MHC, 1, ATP dependent transport protein family member, ATP-binding cassette sub-family B member 2, ATP-binding cassette transporter, major histocompatibility complex, 1, ATP-binding cassette, sub-family B (MDR/TAP), member 2, histocompatibility antigen modifier 1, peptide supply factor 1, peptide transporter PSF1, peptide transporter TAP1, transporter 1 ATP-binding cassette sub-family B, transporter 1, ABC (ATP binding cassette), transporter associated with antigen processing 1, transporter, ABC, MHC, 1, transporter, ATP-binding cassette, major histocompatibility complex, 1
Species: mouse
Products:     Tap1

Top Publications

  1. Tilloy F, Treiner E, Park S, Garcia C, Lemonnier F, De La Salle H, et al. An invariant T cell receptor alpha chain defines a novel TAP-independent major histocompatibility complex class Ib-restricted alpha/beta T cell subpopulation in mammals. J Exp Med. 1999;189:1907-21 pubmed
    ..present in major histocompatibility complex (MHC) class II- and transporter associated with antigen processing (TAP)-deficient humans and mice and also in classical MHC class I- and CD1-deficient mice but were absent from beta2-..
  2. Davey G, Starr R, Cornish A, Burghardt J, Alexander W, Carbone F, et al. SOCS-1 regulates IL-15-driven homeostatic proliferation of antigen-naive CD8 T cells, limiting their autoimmune potential. J Exp Med. 2005;202:1099-108 pubmed
    ..Therefore, impaired deletion of highly autoreactive CD8 T cells, together with uncontrolled activation of naive CD8 T cells by homeostatic survival ligands, may provide a basis for the T cell-mediated disease of SOCS-1-/- mice. ..
  3. Behar S, Dascher C, Grusby M, Wang C, Brenner M. Susceptibility of mice deficient in CD1D or TAP1 to infection with Mycobacterium tuberculosis. J Exp Med. 1999;189:1973-80 pubmed
    ..I MHC-restricted T cells in the defense against tuberculosis as transporter associated with antigen processing (TAP)1-deficient mice died rapidly, bore a greater bacterial burden, and had more severe tissue pathology than control ..
  4. Li L, Sullivan B, Aldrich C, Soloski M, Forman J, Grandea A, et al. Differential requirement for tapasin in the presentation of leader- and insulin-derived peptide antigens to Qa-1b-restricted CTLs. J Immunol. 2004;173:3707-15 pubmed
    The loading of MHC class I molecules with peptides involves a variety of accessory proteins, including TAP-associated glycoprotein (tapasin), which tethers empty MHC class I molecules to the TAP peptide transporter...
  5. Shen L, Sigal L, Boes M, Rock K. Important role of cathepsin S in generating peptides for TAP-independent MHC class I crosspresentation in vivo. Immunity. 2004;21:155-65 pubmed
    ..Exogenous antigens are crosspresented through TAP-dependent (cytosolic) or poorly understood TAP-independent (vacuolar) pathways...
  6. Pearce R, Trigler L, Svaasand E, Peterson C. Polymorphism in the mouse Tap-1 gene. Association with abnormal CD8+ T cell development in the nonobese nondiabetic mouse. J Immunol. 1993;151:5338-47 pubmed
    b>Tap-1 and Tap-2 genes code for a heterodimeric peptide transporter required for the normal maturation and surface expression of class I molecules. Polymorphic variants of these MHC encoded genes occur in rats and humans...
  7. Schumacher T, Kantesaria D, Heemels M, Ashton Rickardt P, Shepherd J, Fruh K, et al. Peptide length and sequence specificity of the mouse TAP1/TAP2 translocator. J Exp Med. 1994;179:533-40 pubmed
    The transporter associated with antigen processing (TAP) delivers peptides to the lumen of the endoplasmic reticulum in an adenosine triphosphate (ATP) dependent fashion for presentation by major histocompatibility complex class I ..
  8. Bertholet S, Goldszmid R, Morrot A, Debrabant A, Afrin F, Collazo Custodio C, et al. Leishmania antigens are presented to CD8+ T cells by a transporter associated with antigen processing-independent pathway in vitro and in vivo. J Immunol. 2006;177:3525-33 pubmed
    ..We show that presentation of Lm nucleotidase (NT)-OVA is TAP independent in vivo and in vitro, and is inhibited by chloroquine, but not by proteasome inhibitors...
  9. Wang B, Chun T, Wang C. Comparative contribution of CD1 on the development of CD4+ and CD8+ T cell compartments. J Immunol. 2000;164:739-45 pubmed
    ..Our data suggest that, unlike other MHC class I molecules, CD1 does not contribute in a major way to the development of CD8+ T cells...

More Information


  1. Garbi N, Tan P, Diehl A, Chambers B, Ljunggren H, Momburg F, et al. Impaired immune responses and altered peptide repertoire in tapasin-deficient mice. Nat Immunol. 2000;1:234-8 pubmed
    ..In addition, the repertoire of class I-bound peptides is altered towards less stably binding ones. Thus tapasin plays a role in CTL and NK immune responses and in optimal peptide selection. ..
  2. Grandea A, Golovina T, Hamilton S, Sriram V, Spies T, Brutkiewicz R, et al. Impaired assembly yet normal trafficking of MHC class I molecules in Tapasin mutant mice. Immunity. 2000;13:213-22 pubmed
    ..These findings reveal a critical role of TPN for ER retention of empty class I molecules. Tpn mutant animals should prove useful for studies on alternative antigen-processing pathways that involve post-ER peptide loading. ..
  3. Sandberg J, Chambers B, van Kaer L, Karre K, Ljunggren H. TAP1-deficient mice select a CD8+ T cell repertoire that displays both diversity and peptide specificity. Eur J Immunol. 1996;26:288-93 pubmed
    Mice deficient in the gene encoding the transporter associated with antigen processing 1 (TAP1) are defective in providing major histocompatibility complex (MHC) class I molecules with cytosolic peptides...
  4. Fujiura Y, Kawaguchi M, Kondo Y, Obana S, Yamamoto H, Nanno M, et al. Development of CD8 alpha alpha+ intestinal intraepithelial T cells in beta 2-microglobulin- and/or TAP1-deficient mice. J Immunol. 1996;156:2710-5 pubmed
    ..to either a mutated beta 2-microglobulin (beta 2m) gene or a mutated transporter associated with Ag processing 1 (TAP1) gene, and in mice doubly homozygous for beta 2m and TAPI mutations...
  5. Neefjes J, Momburg F, Hammerling G. Selective and ATP-dependent translocation of peptides by the MHC-encoded transporter. Science. 1993;261:769-71 pubmed
    ..Two MHC-encoded putative transporter proteins, TAP1 and TAP2, are required for efficient assembly of class I molecules and presentation of endogenous peptides...
  6. Dorfman J, Zerrahn J, Coles M, Raulet D. The basis for self-tolerance of natural killer cells in beta2-microglobulin- and TAP-1- mice. J Immunol. 1997;159:5219-25 pubmed
    Cells from mice with mutations in the genes for beta2-microglobulin (beta2m) or for TAP-1 express only low levels of MHC class I proteins on their surfaces, and are thus sensitive to attack by normal NK cells...
  7. Brossay L, Jullien D, Cardell S, Sydora B, Burdin N, Modlin R, et al. Mouse CD1 is mainly expressed on hemopoietic-derived cells. J Immunol. 1997;159:1216-24 pubmed
    ..The pattern of expression of mCD1 correlates with the distribution of NK1 T cells and is consistent with an important Ag-presenting function for this molecule. ..
  8. Momburg F, Roelse J, Howard J, Butcher G, Hammerling G, Neefjes J. Selectivity of MHC-encoded peptide transporters from human, mouse and rat. Nature. 1994;367:648-51 pubmed
    ..ER) for binding to class I molecules by means of the MHC-encoded transporters associated with antigen processing, TAP1 and TAP2...
  9. Treiner E, Duban L, Bahram S, Radosavljevic M, Wanner V, Tilloy F, et al. Selection of evolutionarily conserved mucosal-associated invariant T cells by MR1. Nature. 2003;422:164-9 pubmed
    ..This indicates that MAIT cells are probably involved in the host response at the site of pathogen entry, and may regulate intestinal B-cell activity. ..
  10. Hammer G, Gonzalez F, James E, Nolla H, Shastri N. In the absence of aminopeptidase ERAAP, MHC class I molecules present many unstable and highly immunogenic peptides. Nat Immunol. 2007;8:101-8 pubmed
    ..Thus, ERAAP is a 'quintessential editor' of the peptide-MHC repertoire and, paradoxically, its absence enhances immunogenicity. ..
  11. McNeil L, Starr T, Hogquist K. A requirement for sustained ERK signaling during thymocyte positive selection in vivo. Proc Natl Acad Sci U S A. 2005;102:13574-9 pubmed
    ..These results demonstrate that the in vivo duration of ERK signaling must be sustained to support positive selection. ..
  12. Attaya M, Jameson S, Martinez C, Hermel E, Aldrich C, Forman J, et al. Ham-2 corrects the class I antigen-processing defect in RMA-S cells. Nature. 1992;355:647-9 pubmed
    ..These data indicate that both MHC-linked transporter genes are probably required for class I antigen processing, and that the functional transporter in this pathway may consist of a Ham-1/Ham-2 heterodimer...
  13. van Kaer L, Ashton Rickardt P, Ploegh H, Tonegawa S. TAP1 mutant mice are deficient in antigen presentation, surface class I molecules, and CD4-8+ T cells. Cell. 1992;71:1205-14 pubmed
    The transporter associated with the antigen processing 1 (TAP1) gene encodes a subunit for a transporter, presumed to be involved in the delivery of peptides across the endoplasmic reticulum membrane to class I molecules...
  14. Hammer G, Gonzalez F, Champsaur M, Cado D, Shastri N. The aminopeptidase ERAAP shapes the peptide repertoire displayed by major histocompatibility complex class I molecules. Nat Immunol. 2006;7:103-12 pubmed
    ..Thus, trimming of antigenic peptides by ERAAP in the endoplasmic reticulum is essential for the generation of the normal repertoire of processed peptides. ..
  15. Park S, Guy Grand D, Lemonnier F, Wang C, Bendelac A, Jabri B. Selection and expansion of CD8alpha/alpha(1) T cell receptor alpha/beta(1) intestinal intraepithelial lymphocytes in the absence of both classical major histocompatibility complex class I and nonclassical CD1 molecules. J Exp Med. 1999;190:885-90 pubmed
    ..Using transporter associated with antigen processing (TAP)-deficient mice, this cell population can be further separated into a TAP-dependent and a TAP-independent subset, ..
  16. Burdin N, Brossay L, Kronenberg M. Immunization with alpha-galactosylceramide polarizes CD1-reactive NK T cells towards Th2 cytokine synthesis. Eur J Immunol. 1999;29:2014-25 pubmed
  17. Yan J, Parekh V, Mendez Fernandez Y, Olivares Villagómez D, Dragovic S, Hill T, et al. In vivo role of ER-associated peptidase activity in tailoring peptides for presentation by MHC class Ia and class Ib molecules. J Exp Med. 2006;203:647-59 pubmed
    ..These findings reveal an important in vivo role of ER-associated peptidase activity in tailoring peptides for presentation by MHC class Ia and class Ib molecules. ..
  18. Park S, Roark J, Bendelac A. Tissue-specific recognition of mouse CD1 molecules. J Immunol. 1998;160:3128-34 pubmed
    ..They suggest that CD1.1 may be naturally associated with a variety of self ligands that overlap only partially in different cell types. ..
  19. Markiewicz M, Girao C, Opferman J, Sun J, Hu Q, Agulnik A, et al. Long-term T cell memory requires the surface expression of self-peptide/major histocompatibility complex molecules. Proc Natl Acad Sci U S A. 1998;95:3065-70 pubmed
    ..These data suggest that positive selection plays a role not only in T cell development but also in the maintenance of T cell memory...
  20. Ljunggren H, van Kaer L, Ploegh H, Tonegawa S. Altered natural killer cell repertoire in Tap-1 mutant mice. Proc Natl Acad Sci U S A. 1994;91:6520-4 pubmed
    ..complex (MHC)-encoded transporter gene associated with MHC class I-restricted antigen presentation (Tap-1)...
  21. Salcedo M, Diehl A, Olsson Alheim M, Sundbäck J, van Kaer L, Karre K, et al. Altered expression of Ly49 inhibitory receptors on natural killer cells from MHC class I-deficient mice. J Immunol. 1997;158:3174-80 pubmed
    ..1+ cells from B6 (H-2b) and D8 (B6 mice transgenic for H-2Dd) mice as well as corresponding TAP1 -/-, beta2m -/-, and TAP1/beta2m -/- mutants of these mice. We demonstrate that receptor expression on NK1...
  22. Aldrich C, Ljunggren H, van Kaer L, Ashton Rickardt P, Tonegawa S, Forman J. Positive selection of self- and alloreactive CD8+ T cells in Tap-1 mutant mice. Proc Natl Acad Sci U S A. 1994;91:6525-8 pubmed
    Mice with a homozygous deletion in their Tap-1 gene (-/- mice) express very low levels of cell membrane major histocompatibility complex class I molecules and have < 1% peripheral CD8+ T cells...
  23. Joyce S, Negishi I, Boesteanu A, DeSilva A, Sharma P, Chorney M, et al. Expansion of natural (NK1+) T cells that express alpha beta T cell receptors in transporters associated with antigen presentation-1 null and thymus leukemia antigen positive mice. J Exp Med. 1996;184:1579-84 pubmed
    ..positive selection of natural T cells occurs independent of transporters associated with antigen presentation-1 (TAP-1) function. Moreover, natural T cells in TAP-1o/o mice are numerically expanded...
  24. Tourne S, van Santen H, van Roon M, Berns A, Benoist C, Mathis D, et al. Biosynthesis of major histocompatibility complex molecules and generation of T cells in Ii TAP1 double-mutant mice. Proc Natl Acad Sci U S A. 1996;93:1464-9 pubmed
    ..Mice carrying null mutations of the TAP1 or Ii genes (TAP10) or Ii0, respectively) have been useful tools for elucidating the two MHC/peptide loading ..
  25. Medina F, Ramos M, Iborra S, de Leon P, Rodríguez Castro M, Del Val M. Furin-processed antigens targeted to the secretory route elicit functional TAP1-/-CD8+ T lymphocytes in vivo. J Immunol. 2009;183:4639-47 pubmed publisher
    ..Notably, the secretory construct activated a similar percentage of Ag-specific CD8+ T cells in wild type as in TAP1-deficient mice, which allow only secretory routes but which have a 10- to 20-fold smaller CD8 compartment...
  26. van Hall T, Wolpert E, van Veelen P, Laban S, van der Veer M, Roseboom M, et al. Selective cytotoxic T-lymphocyte targeting of tumor immune escape variants. Nat Med. 2006;12:417-24 pubmed
    ..in MHC class I at the surface of cells with impaired function of transporter associated with antigen processing (TAP), tapasin or the proteasome...
  27. Ljunggren H, van Kaer L, Ashton Rickardt P, Tonegawa S, Ploegh H. Differential reactivity of residual CD8+ T lymphocytes in TAP1 and beta 2-microglobulin mutant mice. Eur J Immunol. 1995;25:174-8 pubmed
    b>TAP1 -/- and beta 2-microglobulin (beta 2m) -/- mice (H-2b background) express very low levels of major histocompatibility complex (MHC) class I molecules on the cell surface...
  28. Ikegami H, Makino S, Yamato E, Kawaguchi Y, Ueda H, Sakamoto T, et al. Identification of a new susceptibility locus for insulin-dependent diabetes mellitus by ancestral haplotype congenic mapping. J Clin Invest. 1995;96:1936-42 pubmed
    ..segment of chromosome 17 adjacent to, but distinct from, previously known Idd-1 candidates, class II A, E, and Tap genes...
  29. Leng Q, Ge Q, Nguyen T, Eisen H, Chen J. Stage-dependent reactivity of thymocytes to self-peptide--MHC complexes. Proc Natl Acad Sci U S A. 2007;104:5038-43 pubmed
  30. Paliard X, Doe B, Selby M, Hartog K, Lee A, Burke R, et al. Induction of herpes simplex virus gB-specific cytotoxic T lymphocytes in TAP1-deficient mice by genetic immunization but not HSV infection. Virology. 2001;282:56-64 pubmed
    ..We describe an HSV-2/1 cross-reactive cytotoxic T-cell (CTL) epitope that is processed in a TAP1-independent manner in vivo following immunization of TAP1-/- mice with naked DNA or a recombinant vaccinia virus...
  31. Uldrich A, Crowe N, Kyparissoudis K, Pellicci D, Zhan Y, Lew A, et al. NKT cell stimulation with glycolipid antigen in vivo: costimulation-dependent expansion, Bim-dependent contraction, and hyporesponsiveness to further antigenic challenge. J Immunol. 2005;175:3092-3101 pubmed
    ..In summary, this study significantly enhances our understanding of how NKT cells respond to primary and secondary antigenic challenge in vivo. ..
  32. McCoy W, Wang X, Yokoyama W, Hansen T, Fremont D. Structural mechanism of ER retrieval of MHC class I by cowpox. PLoS Biol. 2012;10:e1001432 pubmed publisher
    ..These studies clarify mechanistically how CPXV203 coordinates with other cowpox proteins to thwart antigen presentation. ..
  33. Nelson P, Sage J, Wood S, Davenport C, Anagnostaras S, Boulanger L. MHC class I immune proteins are critical for hippocampus-dependent memory and gate NMDAR-dependent hippocampal long-term depression. Learn Mem. 2013;20:505-17 pubmed publisher
    ..In ?2m(-/-)TAP(-/-)mice, which lack stable cell-surface expression of most MHC class I proteins, NMDAR-dependent LTD in area CA1 ..
  34. Kingsbury D, Mear J, Witte D, Taurog J, Roopenian D, Colbert R. Development of spontaneous arthritis in beta2-microglobulin-deficient mice without expression of HLA-B27: association with deficiency of endogenous major histocompatibility complex class I expression. Arthritis Rheum. 2000;43:2290-6 pubmed
    ..B6], BALB/cJ, SJL/J, MRL/MpJ, and B6,129), mice deficient in the transporter associated with antigen processing (TAP1(0)) on a B6,129 background, and HLA-B27-transgenic beta2m(0) mice on a B6 background...
  35. Ke X, Warner C. Regulation of Ped gene expression by TAP protein. J Reprod Immunol. 2000;46:1-15 pubmed
    ..We chose Tap 1 knockout mice and their control mice (B6.129) as our experimental system...
  36. Hemmi H, Zaidi N, Wang B, Matos I, Fiorese C, Lubkin A, et al. Treml4, an Ig superfamily member, mediates presentation of several antigens to T cells in vivo, including protective immunity to HER2 protein. J Immunol. 2012;188:1147-55 pubmed publisher
    ..Therefore, Treml4 participates in Ag presentation in vivo, and targeting Ags with anti-Treml4 Abs enhances immunization of otherwise naive mice. ..
  37. Seaman M, Perarnau B, Lindahl K, Lemonnier F, Forman J. Response to Listeria monocytogenes in mice lacking MHC class Ia molecules. J Immunol. 1999;162:5429-36 pubmed
    ..showed that B6 and Kb-/- Db-/- mice clear LM from the spleen and liver rapidly with similar kinetics, whereas TAP.1-/- mice, which are deficient in class Ia and Ib molecules, clear LM slowly upon infection...
  38. Verweij M, Ressing M, Knetsch W, Quinten E, Halenius A, van Bel N, et al. Inhibition of mouse TAP by immune evasion molecules encoded by non-murine herpesviruses. Mol Immunol. 2011;48:835-45 pubmed publisher
    ..The transporter associated with antigen processing (TAP) forms a bottleneck in the MHC I antigen presentation pathway...
  39. Deverson E, Gow I, Coadwell W, Monaco J, Butcher G, Howard J. MHC class II region encoding proteins related to the multidrug resistance family of transmembrane transporters. Nature. 1990;348:738-41 pubmed
    ..Such molecules are credible candidates for peptide pumps that move fragments of antigenic proteins from the cytosol into the ER. ..
  40. Marques L, Brucet M, Lloberas J, Celada A. STAT1 regulates lipopolysaccharide- and TNF-alpha-dependent expression of transporter associated with antigen processing 1 and low molecular mass polypeptide 2 genes in macrophages by distinct mechanisms. J Immunol. 2004;173:1103-10 pubmed
    ..In murine bone marrow-derived macrophages, LPS and TNF-alpha induced Tap1 and up-regulated Lmp2, which is constitutively expressed at low levels...
  41. Ueno M, Itoh M, Kong L, Sugihara K, Asano M, Takakura N. PSF1 is essential for early embryogenesis in mice. Mol Cell Biol. 2005;25:10528-32 pubmed
    b>Psf1 (partner of sld five 1) forms a novel heterotetramer complex, GINS (Go, Ichi, Nii, and San; five, one, two, and three, respectively, in Japanese), with Sld5, Psf2, and Psf3...
  42. Chefalo P, Grandea A, Van Kaer L, Harding C. Tapasin-/- and TAP1-/- macrophages are deficient in vacuolar alternate class I MHC (MHC-I) processing due to decreased MHC-I stability at phagolysosomal pH. J Immunol. 2003;170:5825-33 pubmed
    ..report the first study of alternate MHC-I Ag processing in tapasin(-/-) cells and experiments with tapasin(-/-) and TAP1(-/-) macrophages that characterize alternate MHC-I processing...
  43. Urdahl K, Liggitt D, Bevan M. CD8+ T cells accumulate in the lungs of Mycobacterium tuberculosis-infected Kb-/-Db-/- mice, but provide minimal protection. J Immunol. 2003;170:1987-94 pubmed
    ..tuberculosis. ..
  44. Khan S, Bijker M, Weterings J, Tanke H, Adema G, van Hall T, et al. Distinct uptake mechanisms but similar intracellular processing of two different toll-like receptor ligand-peptide conjugates in dendritic cells. J Biol Chem. 2007;282:21145-59 pubmed
    ..enhanced antigen presentation, a process that was dependent on endosomal acidification, proteasomal cleavage, and TAP translocation...
  45. Weber S, Tian H, Pirofski L. CD8+ cells enhance resistance to pulmonary serotype 3 Streptococcus pneumoniae infection in mice. J Immunol. 2011;186:432-42 pubmed publisher
  46. Sehrawat S, Koenig P, Kirak O, Schlieker C, Fankhauser M, Ploegh H. A catalytically inactive mutant of the deubiquitylase YOD-1 enhances antigen cross-presentation. Blood. 2013;121:1145-56 pubmed publisher
    ..Enhanced crosspresentation by YOD1-C160S APCs was transporter associated with antigen processing (TAP1)-independent but sensitive to inclusion of inhibitors of acidification and of the proteasome...
  47. Jones Carson J, McCollister B, Clambey E, Vazquez Torres A. Systemic CD8 T-cell memory response to a Salmonella pathogenicity island 2 effector is restricted to Salmonella enterica encountered in the gastrointestinal mucosa. Infect Immun. 2007;75:2708-16 pubmed
    ..MLN restriction represents a novel mechanism by which systemic CD8 T-cell immunity is confined to periods of high risk for extraintestinal dissemination. ..
  48. de Candia P, Torri A, Fedeli M, Viganò V, Carpi D, Gorletta T, et al. The circulating microRNome demonstrates distinct lymphocyte subset-dependent signatures. Eur J Immunol. 2016;46:725-31 pubmed publisher
  49. Burgevin A, Saveanu L, Kim Y, Barilleau E, Kotturi M, Sette A, et al. A detailed analysis of the murine TAP transporter substrate specificity. PLoS ONE. 2008;3:e2402 pubmed publisher
    The transporter associated with antigen processing (TAP) supplies cytosolic peptides into the endoplasmic reticulum for binding to major histocompatibility complex (MHC) class I molecules...
  50. Ruedl C, Storni T, Lechner F, Bächi T, Bachmann M. Cross-presentation of virus-like particles by skin-derived CD8(-) dendritic cells: a dispensable role for TAP. Eur J Immunol. 2002;32:818-25 pubmed
    ..Surprisingly, and in contrast to findings with tumor cells, TAP1-deficient DC and macrophages mediated efficient cross-presentation of VLP-derived p33 in vivo and in vitro...
  51. Salcedo M, Andersson M, Lemieux S, van Kaer L, Chambers B, Ljunggren H. Fine tuning of natural killer cell specificity and maintenance of self tolerance in MHC class I-deficient mice. Eur J Immunol. 1998;28:1315-21 pubmed
    b>TAP1-/-, beta2-microglobulin (beta2m)-/- and TAP1/beta2m-/- mice all express low but quantitatively different levels of MHC class I molecules...
  52. Smith A, Hayday A. Genetic dissection of primary and secondary responses to a widespread natural pathogen of the gut, Eimeria vermiformis. Infect Immun. 2000;68:6273-80 pubmed
    ..I major histocompatibility complex [MHC] and class II MHC and on IFN-gamma and interleukin-6 (IL-6) but not on TAP1, perforin, IL-4, Fas ligand, or inducible nitric oxide synthetase...
  53. Martin E, Treiner E, Duban L, Guerri L, Laude H, Toly C, et al. Stepwise development of MAIT cells in mouse and human. PLoS Biol. 2009;7:e54 pubmed publisher
    ..Thus, their development follows a unique pattern at the crossroad of NKT and gammadelta T cells. ..
  54. Spies T, DeMars R. Restored expression of major histocompatibility class I molecules by gene transfer of a putative peptide transporter. Nature. 1991;351:323-4 pubmed
    ..Like the corresponding genes RING4, HAM1 and mtp1, PSF is related to the multidrug-resistance family of transporters and may be a peptide pump, as ..
  55. Hewitt E, Lehner P. The ABC-transporter signature motif is required for peptide translocation but not peptide binding by TAP. Eur J Immunol. 2003;33:422-7 pubmed
    ..Here we show that introduction of mutations into the signature motifs of either TAP1 or TAP2 inhibits the translocation of peptide without affecting binding of either peptide or ATP by TAP...
  56. Park S, Weiss A, Benlagha K, Kyin T, Teyton L, Bendelac A. The mouse CD1d-restricted repertoire is dominated by a few autoreactive T cell receptor families. J Exp Med. 2001;193:893-904 pubmed
    ..Altogether, these findings imply that lipid recognition by CD1d-restricted T cells may have largely evolved as an innate rather than an adaptive arm of the mouse immune system. ..
  57. Kirchner J, Bevan M. ITM2A is induced during thymocyte selection and T cell activation and causes downregulation of CD8 when overexpressed in CD4(+)CD8(+) double positive thymocytes. J Exp Med. 1999;190:217-28 pubmed
    ..mice (RAG-2(-/-)OT-1, selecting thymi), but are not selected on a transporter associated with antigen processing (TAP) null background (RAG-2(-/-)TAP-1(-/-)OT-1, nonselecting thymi)...
  58. Zanelli E, Zhou P, Cao H, Smart M, David C. Genomic organization and tissue expression of the mouse proteasome gene Lmp-7. Immunogenetics. 1993;38:400-7 pubmed
    ..Thus, the Tap-1 3' end gene region and the Lmp-7 initial translation codon are separated by an 1182 nucleotide region which ..
  59. Kobrynski L, Sousa A, Nahmias A, Lee F. Cutting edge: antibody production to pneumococcal polysaccharides requires CD1 molecules and CD8+ T cells. J Immunol. 2005;174:1787-90 pubmed
  60. Nagarajan N, Gonzalez F, Shastri N. Nonclassical MHC class Ib-restricted cytotoxic T cells monitor antigen processing in the endoplasmic reticulum. Nat Immunol. 2012;13:579-86 pubmed publisher
    ..Thus, nonclassical Qa-1(b)-peptide complexes direct cytotoxic T cells to targets with defective antigen processing in the endoplasmic reticulum. ..
  61. Marusina K, Iyer M, Monaco J. Allelic variation in the mouse Tap-1 and Tap-2 transporter genes. J Immunol. 1997;158:5251-6 pubmed
    The TAP1 and TAP2 proteins form a heterodimer that transports short peptides from the cytosol into the endoplasmic reticulum lumen...
  62. Kohyama M, Nanno M, Kawaguchi Miyashita M, Shimada S, Watanabe M, Hibi T, et al. Cytolytic and IFN-gamma-producing activities of gamma delta T cells in the mouse intestinal epithelium are T cell receptor-beta-chain dependent. Proc Natl Acad Sci U S A. 1999;96:7451-5 pubmed
    ..of gamma delta-IEL was maintained in mice doubly homozygous for beta2-microglobulin and transporter associated with antigen processing 1 gene mutations in which a conspicuous decrease was noted in absolute numbers of alpha beta-..
  63. Asano J, Tada H, Onai N, Sato T, Horie Y, Fujimoto Y, et al. Nucleotide oligomerization binding domain-like receptor signaling enhances dendritic cell-mediated cross-priming in vivo. J Immunol. 2010;184:736-45 pubmed publisher
  64. Corcoran K, Wang X, Lybarger L. Adapter-mediated substrate selection for endoplasmic reticulum-associated degradation. J Biol Chem. 2009;284:17475-87 pubmed publisher
    ..This mechanism of substrate recruitment by adapter proteins may explain the ability of some E3 ligases, including cellular ERAD E3 ligases, to specifically target the ubiquitination of multiple substrates that are unrelated in sequence. ..
  65. Lampton P, Goldstein C, Warner C. The role of tapasin in MHC class I protein trafficking in embryos and T cells. J Reprod Immunol. 2008;78:28-39 pubmed
    ..Here, we report the detection of mRNA for four chaperone molecules (TAP1, TAP2, calnexin and tapasin) in preimplantation embryos...
  66. Wang H, Yu X, Guo C, Zuo D, Fisher P, Subjeck J, et al. Enhanced endoplasmic reticulum entry of tumor antigen is crucial for cross-presentation induced by dendritic cell-targeted vaccination. J Immunol. 2013;191:6010-21 pubmed publisher
    ..These results also reinforce the importance of the ER-associated protein quality control machinery and the mode of the Ag delivery in regulating DC-elicited immune outcomes. ..
  67. Shinohara M, Lu L, Bu J, Werneck M, Kobayashi K, Glimcher L, et al. Osteopontin expression is essential for interferon-alpha production by plasmacytoid dendritic cells. Nat Immunol. 2006;7:498-506 pubmed
    ..The finding that Opn-i selectively coupled TLR9 signaling to expression of IFN-alpha but not to that of other proinflammatory cytokines provides new molecular insight into the biology of pDCs. ..
  68. Martien van Santen H, Woolsey A, Rickardt P, van Kaer L, Baas E, Berns A, et al. Increase in positive selection of CD8+ T cells in TAP1-mutant mice by human beta 2-microglobulin transgene. J Exp Med. 1995;181:787-92 pubmed
    Mice harboring a deletion of the gene encoding the transporter associated with antigen presentation-1 (TAP1) are impaired in providing major histocompatibility complex (MHC) class I molecules with peptides of cytosolic origin and lack ..
  69. Smith L, He Y, Park J, Bieri G, Snethlage C, Lin K, et al. β2-microglobulin is a systemic pro-aging factor that impairs cognitive function and neurogenesis. Nat Med. 2015;21:932-7 pubmed publisher
    ..of B2M and heterochronic parabiosis are, in part, mitigated in the hippocampus of young transporter associated with antigen processing 1 (Tap1)-deficient mice with reduced cell surface expression of MHC I...
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    ..Our findings also have important implications for the development of small-molecule inhibitors of Vps34 for therapeutic purposes. ..
  71. Cogen A, Moore T. Beta2-microglobulin-dependent bacterial clearance and survival during murine Klebsiella pneumoniae bacteremia. Infect Immun. 2009;77:360-6 pubmed publisher
    ..Surprisingly, neither CD8 T-cell-deficient (TAP-1 knockout; in vivo anti-CD8 antibody treatment) nor invariant NK (iNK) T-cell-deficient (CD1d knockout, J alpha281 ..
  72. Beauvillain C, Delneste Y, Scotet M, Peres A, Gascan H, Guermonprez P, et al. Neutrophils efficiently cross-prime naive T cells in vivo. Blood. 2007;110:2965-73 pubmed
    ..Cross-presentation by neutrophils was TAP and proteasome dependent and was as efficient as in macrophages...
  73. Johnsen A, France J, Nagy N, Askew D, Abdul Karim F, Gerson S, et al. Systemic deficits in transporter for antigen presentation (TAP)-1 or proteasome subunit LMP2 have little or no effect on tumor incidence. Int J Cancer. 2001;91:366-72 pubmed
    ..have not revealed increased tumor incidence in mice with deficits in T-cell immunity, including mice lacking TAP1 (a subunit of the transporter for antigen presentation) or LMP2 (a regulated subunit of the 20S proteasome)...
  74. Lilic M, Popmihajlov Z, Monaco J, Vukmanovic S. Association of beta2-microglobulin with the alpha3 domain of H-2Db heavy chain. Immunogenetics. 2004;55:740-7 pubmed
    ..Thus, there are allelic differences in the modes of binding of beta2m to the heavy chain of MHC class I...
  75. Belz G, Smith C, Kleinert L, Reading P, Brooks A, Shortman K, et al. Distinct migrating and nonmigrating dendritic cell populations are involved in MHC class I-restricted antigen presentation after lung infection with virus. Proc Natl Acad Sci U S A. 2004;101:8670-5 pubmed
    ..Presentation by a nonairway-derived DC population argues that cytotoxic T lymphocyte priming may involve interplay between different DC subsets, not all of which originate within the site of infection. ..
  76. Kobayashi A, Kasano M, Maeda T, Hori S, Motojima K, Suzuki M, et al. A half-type ABC transporter TAPL is highly conserved between rodent and man, and the human gene is not responsive to interferon-gamma in contrast to TAP1 and TAP2. J Biochem. 2000;128:711-8 pubmed
    TAPL is a half-type ABC transporter with sequence similarity to TAP1 and TAP2 that is transcribed in various rat tissues [Yamaguchi, Y., Kasano, M., Terada, T., Sato, R., and Maeda, M. (1999) FEBS Lett. 457, 231-236]...
  77. Monaco J, Cho S, Attaya M. Transport protein genes in the murine MHC: possible implications for antigen processing. Science. 1990;250:1723-6 pubmed
    ..Two closely related genes in this region, HAM1 and HAM2, were cloned and had sequence similarities to a superfamily of genes involved in the ATP-dependent ..
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