Tal1

Summary

Gene Symbol: Tal1
Description: T cell acute lymphocytic leukemia 1
Alias: Hpt, SCL/tal-1, Scl, bHLHa17, tal-1, T-cell acute lymphocytic leukemia protein 1 homolog, stem cell protein
Species: mouse
Products:     Tal1

Top Publications

  1. Wilson N, Miranda Saavedra D, Kinston S, Bonadies N, Foster S, Calero Nieto F, et al. The transcriptional program controlled by the stem cell leukemia gene Scl/Tal1 during early embryonic hematopoietic development. Blood. 2009;113:5456-65 pubmed publisher
    The basic helix-loop-helix transcription factor Scl/Tal1 controls the development and subsequent differentiation of hematopoietic stem cells (HSCs)...
  2. Curtis D, Hall M, Van Stekelenburg L, Robb L, Jane S, Begley C. SCL is required for normal function of short-term repopulating hematopoietic stem cells. Blood. 2004;103:3342-8 pubmed
    The stem cell leukemia (SCL) gene is essential for the development of hematopoietic stem cells in the embryo. Here, we used a conditional gene targeting approach to examine the function of SCL in adult hematopoietic stem cells (HSCs)...
  3. Bockamp E, McLaughlin F, Murrell A, Gottgens B, Robb L, Begley C, et al. Lineage-restricted regulation of the murine SCL/TAL-1 promoter. Blood. 1995;86:1502-14 pubmed
    The SCL/TAL-1 gene encodes a basic helix-loop-helix transcription factor that is expressed in multipotent hematopoietic progenitors before lineage commitment...
  4. Robb L, Elwood N, Elefanty A, Kontgen F, Li R, Barnett L, et al. The scl gene product is required for the generation of all hematopoietic lineages in the adult mouse. EMBO J. 1996;15:4123-9 pubmed
    Homozygosity for a null mutation in the scl gene causes mid-gestational embryonic lethality in the mouse due to failure of development of primitive hematopoiesis...
  5. Aplan P, Jones C, Chervinsky D, Zhao X, Ellsworth M, Wu C, et al. An scl gene product lacking the transactivation domain induces bony abnormalities and cooperates with LMO1 to generate T-cell malignancies in transgenic mice. EMBO J. 1997;16:2408-19 pubmed
    The product of the scl (also called tal-1 or TCL5) gene is a basic domain, helix-loop-helix (bHLH) transcription factor required for the development of hematopoietic cells...
  6. Goardon N, Schuh A, Hajar I, Ma X, Jouault H, Dzierzak E, et al. Ectopic expression of TAL-1 protein in Ly-6E.1-htal-1 transgenic mice induces defects in B- and T-lymphoid differentiation. Blood. 2002;100:491-500 pubmed
    ..Altogether, these results enlighten the fine-tuning of TAL-1 expression during adult hematopoiesis and indicate why TAL-1 expression has to be switched off in the lymphoid lineages. ..
  7. Ono Y, Fukuhara N, Yoshie O. TAL1 and LIM-only proteins synergistically induce retinaldehyde dehydrogenase 2 expression in T-cell acute lymphoblastic leukemia by acting as cofactors for GATA3. Mol Cell Biol. 1998;18:6939-50 pubmed
    Previously, we have shown that TAL1 and the LIM-only protein gene (LMO) are regularly coactivated in T-cell acute lymphoblastic leukemia (T-ALL)...
  8. Souroullas G, Salmon J, Sablitzky F, Curtis D, Goodell M. Adult hematopoietic stem and progenitor cells require either Lyl1 or Scl for survival. Cell Stem Cell. 2009;4:180-6 pubmed publisher
    b>Scl and Lyl1 encode two related basic-helix-loop-helix transcription factors implicated in T cell acute lymphoblastic leukemia...
  9. Wozniak R, Keles S, Lugus J, Young K, Boyer M, Tran T, et al. Molecular hallmarks of endogenous chromatin complexes containing master regulators of hematopoiesis. Mol Cell Biol. 2008;28:6681-94 pubmed publisher
    ..has emerged in which the important regulators of hematopoiesis GATA-1 and GATA-2 function combinatorially with Scl/TAL1, another key regulator of hematopoiesis...

More Information

Publications64

  1. Gottgens B, Broccardo C, Sanchez M, Deveaux S, Murphy G, Gothert J, et al. The scl +18/19 stem cell enhancer is not required for hematopoiesis: identification of a 5' bifunctional hematopoietic-endothelial enhancer bound by Fli-1 and Elf-1. Mol Cell Biol. 2004;24:1870-83 pubmed
    Analysis of cis-regulatory elements is central to understanding the genomic program for development. The scl/tal-1 transcription factor is essential for lineage commitment to blood cell formation and previous studies identified an scl ..
  2. Palis J, Robertson S, Kennedy M, Wall C, Keller G. Development of erythroid and myeloid progenitors in the yolk sac and embryo proper of the mouse. Development. 1999;126:5073-84 pubmed
    ..Development of these progenitors was associated with the expression of SCL/tal-1 and GATA-1, genes known to be involved in the development and maturation of the hematopoietic system...
  3. Chagraoui H, Kassouf M, Banerjee S, Goardon N, Clark K, Atzberger A, et al. SCL-mediated regulation of the cell-cycle regulator p21 is critical for murine megakaryopoiesis. Blood. 2011;118:723-35 pubmed publisher
    ..The key hematopoietic transcription factor stem cell leukemia (SCL)/TAL1 is required in early hematopoietic progenitors for specification of the megakaryocytic lineage...
  4. Elefanty A, Robb L, Birner R, Begley C. Hematopoietic-specific genes are not induced during in vitro differentiation of scl-null embryonic stem cells. Blood. 1997;90:1435-47 pubmed
    The helix-loop-helix transcription factor, scl, plays an essential role in hematopoietic development...
  5. Begley C, Robb L, Rockman S, Visvader J, Bockamp E, Chan Y, et al. Structure of the gene encoding the murine SCL protein. Gene. 1994;138:93-9 pubmed
    We have determined the molecular structure of the gene encoding the murine SCL protein (helix-loop-helix transcription factor). The gene consists of seven exons spanning approx. 20 kb...
  6. LaCombe J, Krosl G, Tremblay M, Gerby B, Martin R, Aplan P, et al. Genetic interaction between Kit and Scl. Blood. 2013;122:1150-61 pubmed publisher
    SCL/TAL1, a tissue-specific transcription factor of the basic helix-loop-helix family, and c-Kit, a tyrosine kinase receptor, control hematopoietic stem cell survival and quiescence...
  7. Salmon J, Slater N, Hall M, McCormack M, Nutt S, Jane S, et al. Aberrant mast-cell differentiation in mice lacking the stem-cell leukemia gene. Blood. 2007;110:3573-81 pubmed
    The stem cell leukemia (SCL) gene encodes a basic helix-loop-helix transcription factor expressed in erythroid, megakaryocyte, and mast-cell lineages. SCL is essential for growth of megakaryocyte and erythroid progenitors...
  8. Lecuyer E, Herblot S, Saint Denis M, Martin R, Begley C, Porcher C, et al. The SCL complex regulates c-kit expression in hematopoietic cells through functional interaction with Sp1. Blood. 2002;100:2430-40 pubmed
    ..Stem cell leukemia (SCL, also known as TAL1 [T-cell acute lymphoblastic leukemia 1]) is a tissue-specific basic helix-loop-helix (bHLH) factor that plays a ..
  9. Tremblay M, Herblot S, Lecuyer E, Hoang T. Regulation of pT alpha gene expression by a dosage of E2A, HEB, and SCL. J Biol Chem. 2003;278:12680-7 pubmed
    ..Furthermore, E2A/HEB transcriptional activity is repressed by heterodimerization with SCL, a transcription factor that is turned off in differentiating thymocytes exactly at a stage when pT alpha is up-..
  10. Sinclair A, Gottgens B, Barton L, Stanley M, Pardanaud L, Klaine M, et al. Distinct 5' SCL enhancers direct transcription to developing brain, spinal cord, and endothelium: neural expression is mediated by GATA factor binding sites. Dev Biol. 1999;209:128-42 pubmed
    The SCL gene encodes a basic helix-loop-helix transcription factor with a pivotal role in the development of endothelium and of all hematopoietic lineages...
  11. Schlaeger T, Schuh A, Flitter S, Fisher A, Mikkola H, Orkin S, et al. Decoding hematopoietic specificity in the helix-loop-helix domain of the transcription factor SCL/Tal-1. Mol Cell Biol. 2004;24:7491-502 pubmed
    ..Previously, we demonstrated that the HLH domain of the class II basic HLH (bHLH) protein SCL/Tal-1 is critical for hematopoietic specification...
  12. Courtial N, Smink J, Kuvardina O, Leutz A, Gothert J, Lausen J. Tal1 regulates osteoclast differentiation through suppression of the master regulator of cell fusion DC-STAMP. FASEB J. 2012;26:523-32 pubmed publisher
    ..The transcription factor Tal1 is involved in the establishment of hematopoietic stem cells in the embryo and is a master regulator of ..
  13. Tripic T, Deng W, Cheng Y, Zhang Y, Vakoc C, Gregory G, et al. SCL and associated proteins distinguish active from repressive GATA transcription factor complexes. Blood. 2009;113:2191-201 pubmed publisher
    ..complexes in a conditional erythroid rescue system as well as through the use of tiling arrays we detected the SCL/TAL1, LMO2, Ldb1, E2A complex at all positively acting GATA-1-bound elements examined...
  14. Kelliher M, Seldin D, Leder P. Tal-1 induces T cell acute lymphoblastic leukemia accelerated by casein kinase IIalpha. EMBO J. 1996;15:5160-6 pubmed
    ..These studies prove that dysregulated tal-1 is oncogenic, providing a direct molecular explanation for the malignancies associated with TAL-1 activation in human T-ALL. ..
  15. Delabesse E, Ogilvy S, Chapman M, Piltz S, Gottgens B, Green A. Transcriptional regulation of the SCL locus: identification of an enhancer that targets the primitive erythroid lineage in vivo. Mol Cell Biol. 2005;25:5215-25 pubmed
    The stem cell leukemia (SCL) gene, also known as TAL-1, encodes a basic helix-loop-helix protein that is essential for the formation of all hematopoietic lineages, including primitive erythropoiesis...
  16. Muroyama Y, Fujiwara Y, Orkin S, Rowitch D. Specification of astrocytes by bHLH protein SCL in a restricted region of the neural tube. Nature. 2005;438:360-3 pubmed
    ..Here we show multiple functions of Stem cell leukaemia (Scl, also known as Tal1), which encodes a basic helix-loop-helix (bHLH) transcription factor, in the regulation of both astrocyte versus ..
  17. Calkhoven C, Muller C, Martin R, Krosl G, Pietsch H, Hoang T, et al. Translational control of SCL-isoform expression in hematopoietic lineage choice. Genes Dev. 2003;17:959-64 pubmed
    We investigated the translational regulation of SCL protein expression and its role in hematopoietic lineage choice...
  18. Murrell A, Bockamp E, Gottgens B, Chan Y, Cross M, Heyworth C, et al. Discordant regulation of SCL/TAL-1 mRNA and protein during erythroid differentiation. Oncogene. 1995;11:131-9 pubmed
    The SCL/TAL1 gene was originally identified by virtue of its rearrangement and transcriptional activation in patients with T cell acute lymphoblastic leukaemia...
  19. Wilson N, Foster S, Wang X, Knezevic K, Schütte J, Kaimakis P, et al. Combinatorial transcriptional control in blood stem/progenitor cells: genome-wide analysis of ten major transcriptional regulators. Cell Stem Cell. 2010;7:532-44 pubmed publisher
    ..binding patterns and combinatorial interactions for ten key regulators of blood stem/progenitor cells (SCL/TAL1, LYL1, LMO2, GATA2, RUNX1, MEIS1, PU...
  20. Gottgens B, Nastos A, Kinston S, Piltz S, Delabesse E, Stanley M, et al. Establishing the transcriptional programme for blood: the SCL stem cell enhancer is regulated by a multiprotein complex containing Ets and GATA factors. EMBO J. 2002;21:3039-50 pubmed
    ..The stem cell leukaemia (SCL) gene encodes a basic helix-loop-helix (bHLH) transcription factor with an essential role in specifying HSCs...
  21. Sanchez M, Bockamp E, Miller J, Gambardella L, Green A. Selective rescue of early haematopoietic progenitors in Scl(-/-) mice by expressing Scl under the control of a stem cell enhancer. Development. 2001;128:4815-27 pubmed
    The stem cell leukaemia gene (Scl) encodes a basic helix-loop-helix transcription factor with a pivotal role in both haematopoiesis and endothelial development...
  22. Chervinsky D, Zhao X, Lam D, Ellsworth M, Gross K, Aplan P. Disordered T-cell development and T-cell malignancies in SCL LMO1 double-transgenic mice: parallels with E2A-deficient mice. Mol Cell Biol. 1999;19:5025-35 pubmed
    ..commonly activated by chromosomal rearrangements in patients with T-cell acute lymphoblastic leukemia (T-ALL) is SCL/tal...
  23. Van Handel B, Montel Hagen A, Sasidharan R, Nakano H, Ferrari R, Boogerd C, et al. Scl represses cardiomyogenesis in prospective hemogenic endothelium and endocardium. Cell. 2012;150:590-605 pubmed publisher
    ..We show that transcription factor Scl/Tal1 is essential for both establishing the hematopoietic transcriptional program in hemogenic endothelium and ..
  24. Tang T, Arbiser J, Brandt S. Phosphorylation by mitogen-activated protein kinase mediates the hypoxia-induced turnover of the TAL1/SCL transcription factor in endothelial cells. J Biol Chem. 2002;277:18365-72 pubmed
    The basic helix-loop-helix transcription factor TAL1 (or SCL), originally identified from its involvement by a chromosomal rearrangement in T-cell acute lymphoblastic leukemia, is required for hematopoietic development...
  25. Gottgens B, Barton L, Gilbert J, Bench A, Sanchez M, Bahn S, et al. Analysis of vertebrate SCL loci identifies conserved enhancers. Nat Biotechnol. 2000;18:181-6 pubmed
    The SCL gene encodes a highly conserved bHLH transcription factor with a pivotal role in hemopoiesis and vasculogenesis. We have sequenced and analyzed 320 kb of genomic DNA composing the SCL loci from human, mouse, and chicken...
  26. Elefanty A, Begley C, Metcalf D, Barnett L, Kontgen F, Robb L. Characterization of hematopoietic progenitor cells that express the transcription factor SCL, using a lacZ "knock-in" strategy. Proc Natl Acad Sci U S A. 1998;95:11897-902 pubmed
    Gene targeting experiments have demonstrated that the transcription factor SCL is essential for primitive and definitive hematopoiesis in the mouse...
  27. Robb L, Lyons I, Li R, Hartley L, Kontgen F, Harvey R, et al. Absence of yolk sac hematopoiesis from mice with a targeted disruption of the scl gene. Proc Natl Acad Sci U S A. 1995;92:7075-9 pubmed
    The scl gene encodes a basic-helix-loop-helix transcription factor which was identified through its involvement in chromosomal translocations in T-cell leukemia...
  28. Tatarek J, Cullion K, Ashworth T, Gerstein R, Aster J, Kelliher M. Notch1 inhibition targets the leukemia-initiating cells in a Tal1/Lmo2 mouse model of T-ALL. Blood. 2011;118:1579-90 pubmed publisher
    T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive malignancy largely caused by aberrant activation of the TAL1/SCL, LMO1/2, and NOTCH1 oncogenes...
  29. Lancrin C, Sroczynska P, Stephenson C, Allen T, Kouskoff V, Lacaud G. The haemangioblast generates haematopoietic cells through a haemogenic endothelium stage. Nature. 2009;457:892-5 pubmed publisher
    ..At the molecular level, we demonstrate that the transcription factor Tal1 (also known as Scl; ref...
  30. Kataoka H, Hayashi M, Nakagawa R, Tanaka Y, Izumi N, Nishikawa S, et al. Etv2/ER71 induces vascular mesoderm from Flk1+PDGFR?+ primitive mesoderm. Blood. 2011;118:6975-86 pubmed publisher
    ..Critical hemato-endothelial genes were severely down-regulated in Etv2-null Flk-1(+) cells. Among those genes Scl, Fli1, and GATA2 were expressed simultaneously with Etv2 in early embryos and seemed to be critical targets...
  31. O Neil J, Shank J, Cusson N, Murre C, Kelliher M. TAL1/SCL induces leukemia by inhibiting the transcriptional activity of E47/HEB. Cancer Cell. 2004;5:587-96 pubmed
    Activation of the basic-helix-loop-helix (bHLH) gene TAL1 (or SCL) is a frequent gain-of-function mutation in T cell acute lymphoblastic leukemia (T-ALL)...
  32. Bradley C, Takano E, Hall M, Gothert J, Harvey A, Begley C, et al. The essential haematopoietic transcription factor Scl is also critical for neuronal development. Eur J Neurosci. 2006;23:1677-89 pubmed
    Abstract The basic helix-loop-helix (bHLH) transcription factor Scl displays tissue-restricted expression and is critical for the establishment of the haematopoietic system; loss of Scl results in embryonic death due to absolute anaemia...
  33. Brunet de la Grange P, Armstrong F, Duval V, Rouyez M, Goardon N, Romeo P, et al. Low SCL/TAL1 expression reveals its major role in adult hematopoietic myeloid progenitors and stem cells. Blood. 2006;108:2998-3004 pubmed
    Stem cell leukemia/T cell acute leukemia 1 (SCL/TAL1) plays a key role in the development of murine primitive hematopoiesis but its functions in adult definitive hematopoiesis are still unclear...
  34. Schuh A, Tipping A, Clark A, Hamlett I, Guyot B, Iborra F, et al. ETO-2 associates with SCL in erythroid cells and megakaryocytes and provides repressor functions in erythropoiesis. Mol Cell Biol. 2005;25:10235-50 pubmed
    ..we have used a proteomic approach to characterize multiprotein complexes containing the key hematopoietic regulator SCL in erythroid and megakaryocytic cell lines...
  35. Warren A, Colledge W, Carlton M, Evans M, Smith A, Rabbitts T. The oncogenic cysteine-rich LIM domain protein rbtn2 is essential for erythroid development. Cell. 1994;78:45-57 pubmed
    ..This shows a pivotal role for a LIM domain protein in lineage specification during mammalian development and suggests that RBTN2 and GATA-1 are critical at similar stages of erythroid differentiation. ..
  36. Lecuyer E, Larivière S, Sincennes M, Haman A, Lahlil R, Todorova M, et al. Protein stability and transcription factor complex assembly determined by the SCL-LMO2 interaction. J Biol Chem. 2007;282:33649-58 pubmed
    ..The basic helix-loop-helix factor SCL and the LIM-only protein LMO2 are components of transcription factor complexes that are essential for hematopoiesis...
  37. Pimanda J, Ottersbach K, Knezevic K, Kinston S, Chan W, Wilson N, et al. Gata2, Fli1, and Scl form a recursively wired gene-regulatory circuit during early hematopoietic development. Proc Natl Acad Sci U S A. 2007;104:17692-7 pubmed
    ..We describe a regulatory circuit made up of Gata2, Fli1, and Scl/Tal1 and their enhancers, Gata2-3, Fli1+12, and Scl+19, that operates during specification of hematopoiesis in the mouse ..
  38. D Souza S, Elefanty A, Keller G. SCL/Tal-1 is essential for hematopoietic commitment of the hemangioblast but not for its development. Blood. 2005;105:3862-70 pubmed
    In this report, we have defined the stage at which Scl functions in the establishment of the hematopoietic system and provide evidence that its primary role is in the generation of the hematopoietic lineages from a progenitor called the ..
  39. Aplan P, Begley C, Bertness V, Nussmeier M, Ezquerra A, Coligan J, et al. The SCL gene is formed from a transcriptionally complex locus. Mol Cell Biol. 1990;10:6426-35 pubmed
    We describe the structural organization of the human SCL gene, a helix-loop-helix family member which we believe plays a fundamental role in hematopoietic differentiation. The SCL locus is composed of eight exons distributed over 16 kb...
  40. Elefanty A, Begley C, Hartley L, Papaevangeliou B, Robb L. SCL expression in the mouse embryo detected with a targeted lacZ reporter gene demonstrates its localization to hematopoietic, vascular, and neural tissues. Blood. 1999;94:3754-63 pubmed
    The helix-loop-helix transcription factor SCL (TAL1) is indispensable for blood cell formation in the mouse embryo...
  41. Sinclair A, Bench A, Bloor A, Li J, Gottgens B, Stanley M, et al. Rescue of the lethal scl(-/-) phenotype by the human SCL locus. Blood. 2002;99:3931-8 pubmed
    The stem cell leukemia (SCL) gene encodes a basic helix-loop-helix transcription factor with a critical role in the development of both blood and endothelium...
  42. Tremblay M, Tremblay C, Herblot S, Aplan P, Hébert J, Perreault C, et al. Modeling T-cell acute lymphoblastic leukemia induced by the SCL and LMO1 oncogenes. Genes Dev. 2010;24:1093-105 pubmed publisher
    ..In T-cell acute lymphoblastic leukemia (T-ALL), the genes encoding the TAL1/SCL and LMO1/2 transcription factors are recurring targets of chromosomal translocations, whereas NOTCH1 is ..
  43. Bockamp E, Antunes C, Maringer M, Heck R, Presser K, Beilke S, et al. Tetracycline-controlled transgenic targeting from the SCL locus directs conditional expression to erythrocytes, megakaryocytes, granulocytes, and c-kit-expressing lineage-negative hematopoietic cells. Blood. 2006;108:1533-41 pubmed
    The stem cell leukemia gene SCL, also known as TAL-1, encodes a basic helix-loop-helix transcription factor expressed in erythroid, myeloid, megakaryocytic, and hematopoietic stem cells...
  44. Shivdasani R, Mayer E, Orkin S. Absence of blood formation in mice lacking the T-cell leukaemia oncoprotein tal-1/SCL. Nature. 1995;373:432-4 pubmed
    ..system (for example, Hox11), or specifically in haematopoietic cells and other selected sites (for example, tal-1/SCL, lyl-1). Aberrant expression within T cells is though to interfere with programmes of normal maturation...
  45. Sanchez M, Gottgens B, Sinclair A, Stanley M, Begley C, Hunter S, et al. An SCL 3' enhancer targets developing endothelium together with embryonic and adult haematopoietic progenitors. Development. 1999;126:3891-904 pubmed
    The SCL gene encodes a basic helix-loop-helix transcription factor which is expressed in early haematopoietic progenitors throughout ontogeny and is essential for the normal development of blood and blood vessels...
  46. Gottgens B, Gilbert J, Barton L, Grafham D, Rogers J, Bentley D, et al. Long-range comparison of human and mouse SCL loci: localized regions of sensitivity to restriction endonucleases correspond precisely with peaks of conserved noncoding sequences. Genome Res. 2001;11:87-97 pubmed
    ..The stem cell leukemia (SCL) gene encodes a bHLH transcription factor with a pivotal role in hemopoiesis and vasculogenesis, and it displays a ..
  47. Mikkola H, Klintman J, Yang H, Hock H, Schlaeger T, Fujiwara Y, et al. Haematopoietic stem cells retain long-term repopulating activity and multipotency in the absence of stem-cell leukaemia SCL/tal-1 gene. Nature. 2003;421:547-51 pubmed
    ..Specification of HSCs from mesoderm during embryonic development requires the stem cell leukaemia SCL/tal-1 gene product...
  48. LaCombe J, Herblot S, Rojas Sutterlin S, Haman A, Barakat S, Iscove N, et al. Scl regulates the quiescence and the long-term competence of hematopoietic stem cells. Blood. 2010;115:792-803 pubmed publisher
    ..We show here that the SCL/TAL1 transcription factor is highly expressed in LT-HSCs compared with short-term reconstituting HSCs and progenitors ..
  49. Joshi K, Lee S, Lee B, Lee J, Lee S. LMO4 controls the balance between excitatory and inhibitory spinal V2 interneurons. Neuron. 2009;61:839-51 pubmed publisher
    ..In the spinal cord, LMO4 induces GABAergic V2b-interneurons in collaboration with SCL and inhibits Lhx3 from generating glutamatergic V2a-interneuons...
  50. Hall M, Curtis D, Metcalf D, Elefanty A, Sourris K, Robb L, et al. The critical regulator of embryonic hematopoiesis, SCL, is vital in the adult for megakaryopoiesis, erythropoiesis, and lineage choice in CFU-S12. Proc Natl Acad Sci U S A. 2003;100:992-7 pubmed
    Gene targeting studies have shown that the transcription factor SCL is critically important for embryonic hematopoiesis, but the early lethality of SCL null mice has precluded the genetic analysis of its function in the adult...
  51. Ogilvy S, Ferreira R, Piltz S, Bowen J, Gottgens B, Green A. The SCL +40 enhancer targets the midbrain together with primitive and definitive hematopoiesis and is regulated by SCL and GATA proteins. Mol Cell Biol. 2007;27:7206-19 pubmed
    The SCL/Tal-1 gene encodes a basic helix-loop-helix transcription factor with key roles in hematopoietic and neural development. SCL is expressed in, and required for, both primitive and definitive erythropoiesis...
  52. Song H, Lee B, Pyun D, Guimera J, Son Y, Yoon J, et al. Ascl1 and Helt act combinatorially to specify thalamic neuronal identity by repressing Dlxs activation. Dev Biol. 2015;398:280-91 pubmed publisher
    ..Taken together, our results suggest a model whereby the combined activity of two distinct bHLH factors plays a key role in the development of discrete classes of thalamic interneurons. ..
  53. Brooke Bisschop T, Savory J, Foley T, Ringuette R, Lohnes D. Essential roles for Cdx in murine primitive hematopoiesis. Dev Biol. 2017;422:115-124 pubmed publisher
    ..concomitant with reduced expression of several genes encoding hematopoietic transcription factors including Scl/Tal1. Chromatin immunoprecipitation analysis revealed that Scl was occupied by Cdx2 in vivo, and Cdx mutant ..
  54. Robert Moreno A, Espinosa L, de la Pompa J, Bigas A. RBPjkappa-dependent Notch function regulates Gata2 and is essential for the formation of intra-embryonic hematopoietic cells. Development. 2005;132:1117-26 pubmed
    ..accompanied by the lack of expression of the hematopoietic transcription factors Aml1/Runx1, Gata2 and Scl/Tal1. We show that in wild-type embryos, a few cells lining the aorta endothelium at E9...
  55. Nottingham W, Jarratt A, Burgess M, Speck C, Cheng J, Prabhakar S, et al. Runx1-mediated hematopoietic stem-cell emergence is controlled by a Gata/Ets/SCL-regulated enhancer. Blood. 2007;110:4188-97 pubmed
    ..We also show that the SCL/Lmo2/Ldb-1 complex is recruited to the enhancer in vivo...