Gene Symbol: Tagap
Description: T cell activation Rho GTPase activating protein
Alias: 2610315E15Rik, TRD, Tcd-1, Tcd1, Tcd1a, tcs-1, tcs1, T-cell activation Rho GTPase-activating protein, T-cell activation GTPase-activating protein 1, t-complex distorter 1A
Species: mouse
Products:     Tagap

Top Publications

  1. Bauer H, Willert J, Koschorz B, Herrmann B. The t complex-encoded GTPase-activating protein Tagap1 acts as a transmission ratio distorter in mice. Nat Genet. 2005;37:969-73 pubmed
    ..The combined data strongly suggest that the t loci of Tagap1 produce Tcd1a. Our results unravel the molecular nature of a Tcd and demonstrate the importance of small G proteins in ..
  2. Lyon M. Male sterility of the mouse t-complex is due to homozygosity of the distorter genes. Cell. 1986;44:357-63 pubmed
    ..Thus, the relationship between the various properties of the t-complex can now be understood. ..
  3. Ogawa K, Inaba K. Sperm motility-activating complex formed by t-complex distorters. Biochem Biophys Res Commun. 2003;310:1155-9 pubmed
    ..Thus, we designate it as Smoac (sperm motility activating complex). ..
  4. Ott M, Rey Campos J, Cereghini S, Yaniv M. vHNF1 is expressed in epithelial cells of distinct embryonic origin during development and precedes HNF1 expression. Mech Dev. 1991;36:47-58 pubmed
    ..vHNF1 expression seems particularly prevalent with morphogenetic events in the kidney and may be a marker for certain polarized epithelium. ..
  5. Lyon M. Transmission ratio distortion in mouse t-haplotypes is due to multiple distorter genes acting on a responder locus. Cell. 1984;37:621-8 pubmed
    ..In the absence of Tcr the distorters are transmitted normally. The system is compared with the SD system of Drosophila. ..
  6. Willison K. Distorting sex ratios. Nature. 1999;402:131-2 pubmed
  7. Lyon M, Schimenti J, Evans E. Narrowing the critical regions for mouse t complex transmission ratio distortion factors by use of deletions. Genetics. 2000;155:793-801 pubmed
    ..It is suggested that the original distorter Tcd1 in fact consists of two loci: Tcd1a, lying between D17Mit164 and D17Leh48, and Tcd1b, lying between T and D17Leh66E.
  8. Planchart A, You Y, Schimenti J. Physical mapping of male fertility and meiotic drive quantitative trait loci in the mouse t complex using chromosome deficiencies. Genetics. 2000;155:803-12 pubmed
    ..One factor, Tcd1, was previously shown to be amorphic using a chromosome deletion...
  9. Planchart A, Schimenti J. Experimental and computational approaches yield a high-resolution, 1-Mb physical map of the region harboring the mouse t haplotype sterility factor, tcs1. Mamm Genome. 2001;12:668-70 pubmed

More Information


  1. Himmelbauer H, Artzt K, Barlow D, Fischer Lindahl K, Lyon M, Klein J, et al. Encyclopedia of the mouse genome III. October 1993. Mouse chromosome 17. Mamm Genome. 1993;4 Spec No:S230-52 pubmed
  2. Schimenti J. Segregation distortion of mouse t haplotypes the molecular basis emerges. Trends Genet. 2000;16:240-3 pubmed
    ..contain mutations that affect embryonic development, male fertility and male transmission ratio distortion (TRD)...
  3. Liao J, Jijon H, Kim I, Goel G, Doan A, Sokol H, et al. An image-based genetic assay identifies genes in T1D susceptibility loci controlling cellular antiviral immunity in mouse. PLoS ONE. 2014;9:e108777 pubmed publisher
    ..14 candidates identified with high confidence, two candidates were selected for further investigation, Il27 and Tagap. Administration of recombinant IL-27 during viral infection was found to act synergistically with interferon gamma ..