Gene Symbol: Tacr3
Description: tachykinin receptor 3
Alias: Nk3r, Nkr, Tac3r, neuromedin-K receptor, NK-3 receptor, Nk3 receptor, neurokinin 3 receptor, neurokinin B receptor, neuromedin K receptor
Species: mouse
Products:     Tacr3

Top Publications

  1. Pintado C, Pinto F, Pennefather J, Hidalgo A, Baamonde A, Sanchez T, et al. A role for tachykinins in female mouse and rat reproductive function. Biol Reprod. 2003;69:940-6 pubmed
    ..A reduction in litter size was observed in female rats treated in vivo with the tachykinin NK3 receptor antagonist SR 142801...
  2. Naillat F, Yan W, Karjalainen R, Liakhovitskaia A, Samoylenko A, Xu Q, et al. Identification of the genes regulated by Wnt-4, a critical signal for commitment of the ovary. Exp Cell Res. 2015;332:163-78 pubmed publisher
    ..that the Notum, Phlda2, Runx-1 and Msx1 genes are typical of the wild-type ovary and the Osr2, Dach2, Pitx2 and Tacr3 genes of the testis...
  3. Dacks P, Krajewski S, Rance N. Activation of neurokinin 3 receptors in the median preoptic nucleus decreases core temperature in the rat. Endocrinology. 2011;152:4894-905 pubmed publisher
    ..There is no information, however, on whether the primary NKB receptor [neurokinin 3 receptor (NK(3)R)] modulates body temperature in any species...
  4. Navarro V, Ruiz Pino F, Sánchez Garrido M, García Galiano D, Hobbs S, Manfredi Lozano M, et al. Role of neurokinin B in the control of female puberty and its modulation by metabolic status. J Neurosci. 2012;32:2388-97 pubmed publisher
    ..We investigated here the regulation of Tac2 and Tacr3 mRNAs (encoding NKB and NK3R, respectively) in female rats and demonstrated that their hypothalamic expression is ..
  5. Sarau H, Feild J, Ames R, Foley J, Nuthulaganti P, Schmidt D, et al. Molecular and pharmacological characterization of the murine tachykinin NK(3) receptor. Eur J Pharmacol. 2001;413:143-50 pubmed
  6. McClelland K, Bell K, Larney C, Harley V, Sinclair A, Oshlack A, et al. Purification and Transcriptomic Analysis of Mouse Fetal Leydig Cells Reveals Candidate Genes for Specification of Gonadal Steroidogenic Cells. Biol Reprod. 2015;92:145 pubmed publisher
    ..In addition, it provides a basis for targeted studies designed to identify causes of idiopathic XY DSD. ..
  7. Wang Y, Hu H, Cao R, Chen L. Differential co-localization of neurokinin-3 receptor and NMDA/AMPA receptor subunits in neurons of the substantia nigra of C57/BL mice. Brain Res. 2005;1053:207-12 pubmed
  8. Catalani E, Dal Monte M, Gangitano C, Lucattelli M, Fineschi S, Bosco L, et al. Expression of substance P, neurokinin 1 receptors (NK1) and neurokinin 3 receptors in the developing mouse retina and in the retina of NK1 knockout mice. Neuroscience. 2006;138:487-99 pubmed
    ..Neurokinin 1 receptor and neurokinin 3 receptor mRNAs were also detected at postnatal day 4...
  9. Nordquist R, Delenclos M, Ballard T, Savignac H, Pauly Evers M, Ozmen L, et al. Cognitive performance in neurokinin 3 receptor knockout mice. Psychopharmacology (Berl). 2008;198:211-20 pubmed publisher
    ..Collectively, these results support a role for the NK(3) receptor in performance of operant tasks and in spatial learning but not in working memory. ..

More Information


  1. Nordquist R, Savignac H, Pauly Evers M, Walker G, Knoflach F, Borroni E, et al. Characterization of behavioral response to amphetamine, tyrosine hydroxylase levels, and dopamine receptor levels in neurokinin 3 receptor knockout mice. Behav Pharmacol. 2008;19:518-29 pubmed publisher
    ..receptor, sensitivity to dopaminergic stimuli and levels of dopaminergic receptors and tyrosine hydroxylase in NK3 receptor knockout mice were studied...
  2. True C, Nasrin Alam S, Cox K, Chan Y, Seminara S. Neurokinin B is critical for normal timing of sexual maturation but dispensable for adult reproductive function in female mice. Endocrinology. 2015;156:1386-97 pubmed publisher
  3. Pinto F, Pintado C, Pennefather J, Patak E, Candenas L. Ovarian steroids regulate tachykinin and tachykinin receptor gene expression in the mouse uterus. Reprod Biol Endocrinol. 2009;7:77 pubmed publisher
    ..All genes encoding tachykinins (Tac1, Tac2 and Tac4) and tachykinin receptors (Tacr1, Tacr2 and Tacr3) were expressed in uteri from ovariectomized mice...
  4. Wang T, Chen S, Wang S, Shi L, Wang C, Zhang J, et al. Targeting neurokinin-3 receptor: a novel anti-angiogenesis strategy for cancer treatment. Oncotarget. 2017;8:40713-40723 pubmed publisher
    ..the tumor angiogenesis homing sequence (NGR), we designed and synthesized two novel agonist analogues of NK3R, NK3R-A1 and NK3R-A2...
  5. Ruka K, Burger L, Moenter S. Regulation of arcuate neurons coexpressing kisspeptin, neurokinin B, and dynorphin by modulators of neurokinin 3 and ?-opioid receptors in adult male mice. Endocrinology. 2013;154:2761-71 pubmed publisher
    ..Single-cell PCR confirmed most of these cells had a KNDy phenotype. The neurokinin 3 receptor (NK3R) agonist senktide increased action potential firing activity of KNDy neurons...
  6. Siuciak J, McCarthy S, Martin A, Chapin D, Stock J, Nadeau D, et al. Disruption of the neurokinin-3 receptor (NK3) in mice leads to cognitive deficits. Psychopharmacology (Berl). 2007;194:185-95 pubmed
    ..These studies suggest a role for NK3 in learning and memory in mice. ..
  7. Cook G, Elliott D, Metwali A, Blum A, Sandor M, Lynch R, et al. Molecular evidence that granuloma T lymphocytes in murine schistosomiasis mansoni express an authentic substance P (NK-1) receptor. J Immunol. 1994;152:1830-5 pubmed
    ..CD4+ granuloma T lymphocytes, purified by FACS, express NK-1 receptor mRNA. Normal liver devoid of granulomas exhibited none of the three tachykinin receptor subclasses. ..
  8. Yang J, Caligioni C, Chan Y, Seminara S. Uncovering novel reproductive defects in neurokinin B receptor null mice: closing the gap between mice and men. Endocrinology. 2012;153:1498-508 pubmed publisher
    Patients bearing mutations in TAC3 and TACR3 (which encode neurokinin B and its receptor, respectively) have sexual infantilism and infertility due to GnRH deficiency...
  9. Star E, Zhu M, Shi Z, Liu H, Pashmforoush M, Sauve Y, et al. Regulation of retinal interneuron subtype identity by the Iroquois homeobox gene Irx6. Development. 2012;139:4644-55 pubmed publisher
    ..adopt molecular features of both type 2 and 3a bipolar cells, highlighted by the ectopic upregulation of neurokinin 3 receptor (Nk3r) and Vsx1...
  10. Matsuoka R, Chivatakarn O, Badea T, SAMUELS I, Cahill H, Katayama K, et al. Class 5 transmembrane semaphorins control selective Mammalian retinal lamination and function. Neuron. 2011;71:460-73 pubmed publisher
    ..These findings define a set of ligands and receptors required for the establishment of inner retinal lamination and function. ..
  11. Sundelin J, Provvedini D, Wahlestedt C, Laurell H, Pohl J, Peterson P. Molecular cloning of the murine substance K and substance P receptor genes. Eur J Biochem. 1992;203:625-31 pubmed
    ..The cloning of the murine substance K and substance P receptor genes should contribute substantially to the generation of in vivo models for the detailed analysis of the functional significance of these receptors. ..
  12. Kung T, Crawley Y, Jones H, Luo B, Gilchrest H, Greenfeder S, et al. Tachykinin NK3-receptor deficiency does not inhibit pulmonary eosinophilia in allergic mice. Pharmacol Res. 2004;50:611-5 pubmed
    ..These results find no role for tachykinin NK3-receptors on the pulmonary eosinophilia and lung damage after antigen challenge in mice. ..