Gene Symbol: Syt3
Description: synaptotagmin III
Alias: AI385753, sytIII, synaptotagmin-3
Species: mouse
Products:     Syt3

Top Publications

  1. Jones J, Popma S, Mizuta M, Seino S, Meisler M. Synaptotagmin genes on mouse chromosomes 1, 7, and 10 and human chromosome 19. Mamm Genome. 1995;6:212-3 pubmed
  2. Willison K. The mouse Brachyury gene and mesoderm formation. Trends Genet. 1990;6:104-5 pubmed
  3. Masztalerz A, Zeelenberg I, Wijnands Y, de Bruijn R, Drager A, Janssen H, et al. Synaptotagmin 3 deficiency in T cells impairs recycling of the chemokine receptor CXCR4 and thereby inhibits CXCL12 chemokine-induced migration. J Cell Sci. 2007;120:219-28 pubmed
    ..Amongst synaptotagmins 1-11, we found synaptotagmin 3 (SYT3) to be the only one that is expressed in T cells...
  4. Lee B, Min X, Heise C, Xu B, Chen S, Shu H, et al. WNK1 phosphorylates synaptotagmin 2 and modulates its membrane binding. Mol Cell. 2004;15:741-51 pubmed
    ..These findings provide a biochemical mechanism that could lead to the retention or insertion of proteins in the plasma membrane. Interruption of this regulatory pathway may disturb membrane events that regulate ion balance. ..
  5. Fukuda M, Kanno E, Mikoshiba K. Conserved N-terminal cysteine motif is essential for homo- and heterodimer formation of synaptotagmins III, V, VI, and X. J Biol Chem. 1999;274:31421-7 pubmed
  6. Lang J. Molecular mechanisms and regulation of insulin exocytosis as a paradigm of endocrine secretion. Eur J Biochem. 1999;259:3-17 pubmed
    ..Insights into the progression of the exocytotic vesicle from docking to fusion and how these processes are precisely regulated by proteins and second messengers may provide the basis for new therapeutic principles. ..
  7. Ben Porath I, Kozak C, Benvenisty N. Chromosomal mapping of Tmp (Emp1), Xmp (Emp2), and Ymp (Emp3), genes encoding membrane proteins related to Pmp22. Genomics. 1998;49:443-7 pubmed
    ..These data suggest that this family of membrane glycoproteins evolved as a result of chromosomal duplications. ..
  8. Fukuda M, Kojima T, Mikoshiba K. Phospholipid composition dependence of Ca2+-dependent phospholipid binding to the C2A domain of synaptotagmin IV. J Biol Chem. 1996;271:8430-4 pubmed
    ..However, it binds PS with a positive cooperativity and an affinity similar to those of the C2A domains of other isoforms. Our results suggest that synaptotagmin IV is also a potential Ca2+ sensor for neurotransmitter release. ..
  9. Fukuda M, Kojima T, Aruga J, Niinobe M, Mikoshiba K. Functional diversity of C2 domains of synaptotagmin family. Mutational analysis of inositol high polyphosphate binding domain. J Biol Chem. 1995;270:26523-7 pubmed
    ..These functional diversities of C2B domains suggest that not all synaptotagmins function as inositol high polyphosphate sensors at the synaptic vesicle. ..

More Information


  1. Gautam M, Noakes P, Moscoso L, Rupp F, Scheller R, Merlie J, et al. Defective neuromuscular synaptogenesis in agrin-deficient mutant mice. Cell. 1996;85:525-35 pubmed
  2. Kwon O, Adamson M, Chin H, Kozak C. Genetic mapping of five mouse genes encoding synaptotagmins. Mamm Genome. 1995;6:880-1 pubmed
  3. White R, Dowler L, Angeloni S, Koeller D. Assignment of Etfdh, Etfb, and Etfa to chromosomes 3, 7, and 13: the mouse homologs of genes responsible for glutaric acidemia type II in human. Genomics. 1996;33:131-4 pubmed
    ..We used cDNA probes for the Etfdh, Etfb, and Etfa genes to determine localization of these mouse genes to chromosomes 3, 7, and 13. ..
  4. Hilbush B, Morgan J. A third synaptotagmin gene, Syt3, in the mouse. Proc Natl Acad Sci U S A. 1994;91:8195-9 pubmed
    ..Here we report the isolation of a third member of the synaptotagmin family (Syt3) from mouse brain...
  5. Krass K, Colinayo V, Ghazalpour A, Vinters H, Lusis A, Drake T. Genetic loci contributing to age-related hippocampal lesions in mice. Neurobiol Dis. 2003;13:102-8 pubmed
    ..The genomic data indicate that the genetic basis is complex, but with one locus playing a major role in lesion formation. These lesions may represent a useful model for investigating dysregulation of tau protein in the hippocampus. ..
  6. Fukuda M. Distinct developmental expression of synaptotagmin I and IX in the mouse brain. Neuroreport. 2006;17:179-82 pubmed
    ..These findings suggest that synaptotagmin IX regulates the transport of certain vesicles in the brain other than synaptic vesicles. ..
  7. Morita T, Kubota H, Murata K, Nozaki M, Delarbre C, Willison K, et al. Evolution of the mouse t haplotype: recent and worldwide introgression to Mus musculus. Proc Natl Acad Sci U S A. 1992;89:6851-5 pubmed
    ..Hence, polymorphisms among t haplotypes including lethality factors have accumulated during this short time period independently in each M. musculus subspecies. ..
  8. Jensen J, Ulhøi B, Jensen K. Lymph node mapping in patients with bladder cancer undergoing radical cystectomy and lymph node dissection to the level of the inferior mesenteric artery. BJU Int. 2010;106:199-205 pubmed publisher
    ..Extending the limits above the aortic bifurcation is not necessary from a staging perspective. ..
  9. Tremblay M, Moss T. Loss of all 3 Extended Synaptotagmins does not affect normal mouse development, viability or fertility. Cell Cycle. 2016;15:2360-6 pubmed publisher
    ..Given the multiple functions suggested for the E-Syts and their evolutionary conservation, our unexpected findings suggest that they may only provide a survival advantage under specific conditions that have as yet to be identified. ..
  10. Peters L, Ciciotte S, Su G, Simon M. The gene encoding the transcription factor Spi-B maps to mouse chromosome 7. Mamm Genome. 1997;8:452-3 pubmed
  11. Fukuda M, Mikoshiba K. Genomic structures of synaptotagmin II protein: comparison of exon-intron organization of the synaptotagmin gene family. Biochem Biophys Res Commun. 2000;270:528-32 pubmed
    ..The only conserved feature among the synaptotagmin gene family seems to have a single exon that encodes the whole transmembrane domain. ..