Gene Symbol: Sycp2
Description: synaptonemal complex protein 2
Alias: 3830402K23Rik, 4930518F03Rik, synaptonemal complex protein 2, SCP-2, synaptonemal complex lateral element protein
Species: mouse
Products:     Sycp2

Top Publications

  1. Pelttari J, Hoja M, Yuan L, Liu J, Brundell E, Moens P, et al. A meiotic chromosomal core consisting of cohesin complex proteins recruits DNA recombination proteins and promotes synapsis in the absence of an axial element in mammalian meiotic cells. Mol Cell Biol. 2001;21:5667-77 pubmed
    ..A model for early meiotic chromosome pairing and synapsis is proposed. ..
  2. Shin Y, Choi Y, Erdin S, Yatsenko S, Kloc M, Yang F, et al. Hormad1 mutation disrupts synaptonemal complex formation, recombination, and chromosome segregation in mammalian meiosis. PLoS Genet. 2010;6:e1001190 pubmed publisher
    ..Hormad1 deficiency does not affect localization of other synaptonemal complex proteins, SYCP2 and SYCP3, but disrupts homologous chromosome pairing...
  3. Kouznetsova A, Novak I, Jessberger R, Hoog C. SYCP2 and SYCP3 are required for cohesin core integrity at diplotene but not for centromere cohesion at the first meiotic division. J Cell Sci. 2005;118:2271-8 pubmed
    ..of the meiotic prophase-I chromosome axis is attributed to two groups of proteins: the axial element proteins, SYCP2 and SYCP3; and the cohesin-complex proteins...
  4. Kouznetsova A, Benavente R, Pastink A, Hoog C. Meiosis in mice without a synaptonemal complex. PLoS ONE. 2011;6:e28255 pubmed publisher
  5. Yang F, Gell K, van der Heijden G, Eckardt S, Leu N, Page D, et al. Meiotic failure in male mice lacking an X-linked factor. Genes Dev. 2008;22:682-91 pubmed publisher
    ..TEX11 interacts with SYCP2, which is an integral component of the synaptonemal complex lateral elements...
  6. Yang F, Eckardt S, Leu N, McLaughlin K, Wang P. Mouse TEX15 is essential for DNA double-strand break repair and chromosomal synapsis during male meiosis. J Cell Biol. 2008;180:673-9 pubmed publisher
    ..Based on these data, we propose that TEX15 regulates the loading of DNA repair proteins onto sites of DSBs and, thus, its absence causes a failure in meiotic recombination. ..
  7. Yang F, De La Fuente R, Leu N, Baumann C, McLaughlin K, Wang P. Mouse SYCP2 is required for synaptonemal complex assembly and chromosomal synapsis during male meiosis. J Cell Biol. 2006;173:497-507 pubmed
    ..Each SC consists of two axial/lateral elements (AEs/LEs), and numerous transverse filaments. SC protein 2 (SYCP2) and SYCP3 are integral components of AEs/LEs in mammals...
  8. Kolas N, Yuan L, Hoog C, Heng H, Marcon E, Moens P. Male mouse meiotic chromosome cores deficient in structural proteins SYCP3 and SYCP2 align by homology but fail to synapse and have possible impaired specificity of chromatin loop attachment. Cytogenet Genome Res. 2004;105:182-8 pubmed
    ..To test the functions of SYCP2 and SYCP3 proteins in the cores, we determined the effect of their deletion on homology recognition by whole ..
  9. Venables J, Ruggiu M, Cooke H. The RNA-binding specificity of the mouse Dazl protein. Nucleic Acids Res. 2001;29:2479-83 pubmed
    ..CDC25C 5' UTR also interacted specifically with Dazl in vitro. The tri-hybrid screen retrieved UTRs of known genes that may be physiological substrates of Dazl. ..

More Information


  1. Llano E, Herrán Y, García Tuñón I, Gutiérrez Caballero C, de Alava E, Barbero J, et al. Meiotic cohesin complexes are essential for the formation of the axial element in mice. J Cell Biol. 2012;197:877-85 pubmed publisher
  2. Berkowitz K, Sowash A, Koenig L, Urcuyo D, Khan F, Yang F, et al. Disruption of CHTF18 causes defective meiotic recombination in male mice. PLoS Genet. 2012;8:e1002996 pubmed publisher
    ..These findings demonstrate essential roles for CHTF18 in mammalian spermatogenesis and meiosis, and suggest that CHTF18 may function during the double-strand break repair pathway to promote the formation of crossovers. ..
  3. Park C, Rehrauer H, Mansuy I. Genome-wide analysis of H4K5 acetylation associated with fear memory in mice. BMC Genomics. 2013;14:539 pubmed publisher
    ..More broadly, this study strengthens the importance of histone posttranslational modifications for the differential regulation of transcriptional programs in cognitive processes. ..
  4. Fukuda T, Fukuda N, Agostinho A, Hernández Hernández A, Kouznetsova A, Hoog C. STAG3-mediated stabilization of REC8 cohesin complexes promotes chromosome synapsis during meiosis. EMBO J. 2014;33:1243-55 pubmed publisher
  5. Schücker K, Holm T, Franke C, Sauer M, Benavente R. Elucidation of synaptonemal complex organization by super-resolution imaging with isotropic resolution. Proc Natl Acad Sci U S A. 2015;112:2029-33 pubmed publisher
    ..A single-cell preparation generates sufficient localizations to compile a 3D model of the SC with nanometer precision. ..
  6. Kouznetsova A, Wang H, Bellani M, Camerini Otero R, Jessberger R, Hoog C. BRCA1-mediated chromatin silencing is limited to oocytes with a small number of asynapsed chromosomes. J Cell Sci. 2009;122:2446-52 pubmed publisher
  7. La Salle S, Palmer K, O Brien M, Schimenti J, Eppig J, Handel M. Spata22, a novel vertebrate-specific gene, is required for meiotic progress in mouse germ cells. Biol Reprod. 2012;86:45 pubmed publisher
    ..The repro42 mutation thus identifies a novel mammalian germ cell-specific gene required for meiotic progression. ..
  8. Fukuda T, Pratto F, Schimenti J, Turner J, Camerini Otero R, Hoog C. Phosphorylation of chromosome core components may serve as axis marks for the status of chromosomal events during mammalian meiosis. PLoS Genet. 2012;8:e1002485 pubmed publisher
    ..We show here that many protein components of the meiotic chromosome axis, including SYCP2, SYCP3, HORMAD1, HORMAD2, SMC3, STAG3, and REC8, become post-translationally modified by phosphorylation during ..
  9. Shin Y, McGuire M, Rajkovic A. Mouse HORMAD1 is a meiosis i checkpoint protein that modulates DNA double- strand break repair during female meiosis. Biol Reprod. 2013;89:29 pubmed
    ..Moreover, Hormad1 deficiency rescued Dmc1(?/?) oocytes. These results indicate that Hormad1 deficiency promotes DMC1-independent DSB repairs, which in turn helps asynaptic Hormad1(?/?) oocytes resist perinatal loss. ..
  10. Malki S, van der Heijden G, O Donnell K, Martin S, Bortvin A. A role for retrotransposon LINE-1 in fetal oocyte attrition in mice. Dev Cell. 2014;29:521-533 pubmed publisher
    ..We propose that FOA serves to select oocytes with limited L1 activity that are therefore best suited for the next generation...
  11. Luo M, Zhou J, Leu N, Abreu C, Wang J, Anguera M, et al. Polycomb protein SCML2 associates with USP7 and counteracts histone H2A ubiquitination in the XY chromatin during male meiosis. PLoS Genet. 2015;11:e1004954 pubmed publisher
    ..Our results demonstrate that the SCML2/USP7 complex constitutes a novel molecular pathway in modulating the epigenetic state of sex chromosomes during male meiosis. ..
  12. Zhou J, Stein P, Leu N, Chmatal L, Xue J, Ma J, et al. Accelerated reproductive aging in females lacking a novel centromere protein SYCP2L. Hum Mol Genet. 2015;24:6505-14 pubmed publisher
    ..SYCP2L is a paralogue of the synaptonemal complex protein SYCP2 and is expressed exclusively in oocytes...