Gene Symbol: Sun2
Description: Sad1 and UNC84 domain containing 2
Alias: B230369L08Rik, C030011B15, Unc84b, SUN domain-containing protein 2, protein unc-84 homolog B, sad1/unc-84 protein-like 2
Species: mouse
Products:     Sun2

Top Publications

  1. Haque F, Mazzeo D, Patel J, Smallwood D, Ellis J, Shanahan C, et al. Mammalian SUN protein interaction networks at the inner nuclear membrane and their role in laminopathy disease processes. J Biol Chem. 2010;285:3487-98 pubmed publisher
    ..SUN1 and SUN2 interact with lamin A, but lamin A is only required for NE localization of SUN2, and it remains unclear how SUN1 is ..
  2. Ostlund C, Folker E, Choi J, Gomes E, Gundersen G, Worman H. Dynamics and molecular interactions of linker of nucleoskeleton and cytoskeleton (LINC) complex proteins. J Cell Sci. 2009;122:4099-108 pubmed publisher
    ..Sun1, Sun2 and nesprin-2 are important components of the LINC complex...
  3. Randles K, Lam L, Sewry C, Puckelwartz M, Furling D, Wehnert M, et al. Nesprins, but not sun proteins, switch isoforms at the nuclear envelope during muscle development. Dev Dyn. 2010;239:998-1009 pubmed publisher
    ..Sun1 and Sun2 proteins remained unchanged during this fibre maturation...
  4. Yu J, Lei K, Zhou M, Craft C, Xu G, Xu T, et al. KASH protein Syne-2/Nesprin-2 and SUN proteins SUN1/2 mediate nuclear migration during mammalian retinal development. Hum Mol Genet. 2011;20:1061-73 pubmed publisher
    ..that a KASH domain-containing protein, Syne-2/Nesprin-2, as well as SUN domain-containing proteins, SUN1 and SUN2, play critical roles during INM and photoreceptor cell migration in the mouse retina...
  5. Crisp M, Liu Q, Roux K, Rattner J, Shanahan C, Burke B, et al. Coupling of the nucleus and cytoplasm: role of the LINC complex. J Cell Biol. 2006;172:41-53 pubmed
    ..The inner nuclear membrane contains specific integral proteins that include Sun1 and Sun2. Although the outer nuclear membrane (ONM) is continuous with the endoplasmic reticulum, it is nevertheless ..
  6. Wang Q, Du X, Cai Z, Greene M. Characterization of the structures involved in localization of the SUN proteins to the nuclear envelope and the centrosome. DNA Cell Biol. 2006;25:554-62 pubmed
    ..In the current study we characterized a nuclear envelope protein SUN2 and identified a substructure involved in its localization to the nuclear envelope...
  7. Schmitt J, Benavente R, Hodzic D, Hoog C, Stewart C, Alsheimer M. Transmembrane protein Sun2 is involved in tethering mammalian meiotic telomeres to the nuclear envelope. Proc Natl Acad Sci U S A. 2007;104:7426-31 pubmed
    ..Here we report that mammalian SUN-domain protein Sun2 specifically localizes to the nuclear envelope attachment sites of meiotic telomeres...
  8. Lei K, Zhang X, Ding X, Guo X, Chen M, Zhu B, et al. SUN1 and SUN2 play critical but partially redundant roles in anchoring nuclei in skeletal muscle cells in mice. Proc Natl Acad Sci U S A. 2009;106:10207-12 pubmed publisher
    ..Here we show that the synaptic nuclear anchorage is partially perturbed in Sun1, but not in Sun2, knockout mice...
  9. Zhang X, Lei K, Yuan X, Wu X, Zhuang Y, Xu T, et al. SUN1/2 and Syne/Nesprin-1/2 complexes connect centrosome to the nucleus during neurogenesis and neuronal migration in mice. Neuron. 2009;64:173-87 pubmed publisher
    ..We report here that the SUN-domain proteins SUN1 and SUN2 and the KASH-domain proteins Syne-1/Nesprin-1 and Syne-2/Nesprin-2 play critical roles in neurogenesis and neuronal ..

More Information


  1. Horn H, Brownstein Z, Lenz D, Shivatzki S, Dror A, Dagan Rosenfeld O, et al. The LINC complex is essential for hearing. J Clin Invest. 2013;123:740-50 pubmed publisher
    ..These results demonstrate that the LINC complex is essential for viability and normal morphology of OHCs and suggest that the position of the nucleus in sensory epithelial cells is critical for maintenance of normal hearing...
  2. Turgay Y, Ungricht R, Rothballer A, Kiss A, Csucs G, Horvath P, et al. A classical NLS and the SUN domain contribute to the targeting of SUN2 to the inner nuclear membrane. EMBO J. 2010;29:2262-75 pubmed publisher
    ..We have used human SUN2 to delineate features that are required for INM targeting and have identified multiple elements that collectively ..
  3. Nie S, Ke H, Gao F, Ren J, Wang M, Huo L, et al. Coiled-Coil Domains of SUN Proteins as Intrinsic Dynamic Regulators. Structure. 2016;24:80-91 pubmed publisher
    ..Here, we found that the two coiled-coil domains (CC1 and CC2) of SUN2 exhibit distinct oligomeric states. CC2 is a monomer in solution...
  4. Wang J, Yu I, Huang C, Chen C, Wang W, Lin S, et al. Sun1 deficiency leads to cerebellar ataxia in mice. Dis Model Mech. 2015;8:957-67 pubmed publisher
    ..Here, we report an unrecognized contribution of Sun1 and Sun2 to the postnatal development of murine cerebellum...
  5. Lei K, Zhu X, Xu R, Shao C, Xu T, Zhuang Y, et al. Inner nuclear envelope proteins SUN1 and SUN2 play a prominent role in the DNA damage response. Curr Biol. 2012;22:1609-15 pubmed publisher
    ..Here we report that the inner NE proteins SUN1 and SUN2 may play a redundant role in DDR...
  6. Sun G, Yuen Chan S, Yuan Y, Wang Chan K, Qiu G, Sun K, et al. Isolation of differentially expressed genes in human heart tissues. Biochim Biophys Acta. 2002;1588:241-6 pubmed
    ..of unknown function in humans: hCALO (human homologue of calossin), NP79 (coding for a nuclear protein of 79KD) and SUN2 (Sad-1 unc-84 domain protein 2)...
  7. Borrego Pinto J, Jegou T, Osorio D, Aurade F, Gorjanacz M, Koch B, et al. Samp1 is a component of TAN lines and is required for nuclear movement. J Cell Sci. 2012;125:1099-105 pubmed publisher
    ..Nuclear movement requires the LINC complex components nesprin-2G and SUN2, which form transmembrane actin-associated nuclear (TAN) lines at the nuclear envelope...
  8. Link J, Leubner M, Schmitt J, Göb E, Benavente R, Jeang K, et al. Analysis of meiosis in SUN1 deficient mice reveals a distinct role of SUN2 in mammalian meiotic LINC complex formation and function. PLoS Genet. 2014;10:e1004099 pubmed publisher
    ..In mice, SUN1 and SUN2 are the only SUN domain proteins expressed during meiosis, sharing their localization with meiosis-specific KASH5...
  9. Luxton G, Gomes E, Folker E, Vintinner E, Gundersen G. Linear arrays of nuclear envelope proteins harness retrograde actin flow for nuclear movement. Science. 2010;329:956-9 pubmed publisher
    ..We found that linear arrays of outer (nesprin2G) and inner (SUN2) nuclear membrane proteins assembled on and moved with retrogradely moving dorsal actin cables during nuclear ..
  10. Stroud M, Feng W, Zhang J, Veevers J, Fang X, Gerace L, et al. Nesprin 1α2 is essential for mouse postnatal viability and nuclear positioning in skeletal muscle. J Cell Biol. 2017;216:1915-1924 pubmed publisher
    ..Furthermore, we revealed that kinesin 1 was displaced in fibers of nesprin 1α2-knockout mice, suggesting that this interaction may play an important role in positioning of myonuclei and functional skeletal muscle. ..