Sun1

Summary

Gene Symbol: Sun1
Description: Sad1 and UNC84 domain containing 1
Alias: 4632417G13Rik, 5730434D03Rik, Unc84a, mKIAA0810, SUN domain-containing protein 1, protein unc-84 homolog A, sad1/unc-84 protein-like 1, unc-84 homolog A
Species: mouse
Products:     Sun1

Top Publications

  1. Wang Q, Du X, Cai Z, Greene M. Characterization of the structures involved in localization of the SUN proteins to the nuclear envelope and the centrosome. DNA Cell Biol. 2006;25:554-62 pubmed
    ..We found that a structurally related protein, SUN1, may be localized to the nuclear envelope through a different mechanism...
  2. Chen C, Chi Y, Mutalif R, Starost M, Myers T, Anderson S, et al. Accumulation of the inner nuclear envelope protein Sun1 is pathogenic in progeric and dystrophic laminopathies. Cell. 2012;149:565-77 pubmed publisher
    ..Unexpectedly, Lmna(-/-) or LmnaΔ9 mice that are also deficient for the inner nuclear membrane protein Sun1 show markedly reduced tissue pathologies and enhanced longevity...
  3. Ostlund C, Folker E, Choi J, Gomes E, Gundersen G, Worman H. Dynamics and molecular interactions of linker of nucleoskeleton and cytoskeleton (LINC) complex proteins. J Cell Sci. 2009;122:4099-108 pubmed publisher
    ..b>Sun1, Sun2 and nesprin-2 are important components of the LINC complex...
  4. Padmakumar V, Libotte T, Lu W, Zaim H, Abraham S, Noegel A, et al. The inner nuclear membrane protein Sun1 mediates the anchorage of Nesprin-2 to the nuclear envelope. J Cell Sci. 2005;118:3419-30 pubmed
    ..a direct association of their highly conserved C-terminal luminal domain with the inner nuclear membrane protein Sun1 mediates their nuclear envelope localisation...
  5. Morimoto A, Shibuya H, Zhu X, Kim J, Ishiguro K, Han M, et al. A conserved KASH domain protein associates with telomeres, SUN1, and dynactin during mammalian meiosis. J Cell Biol. 2012;198:165-72 pubmed publisher
    ..However, although the vertebrate SUN domain protein SUN1 is involved in these processes, its partner has remained identified...
  6. Ding X, Xu R, Yu J, Xu T, Zhuang Y, Han M. SUN1 is required for telomere attachment to nuclear envelope and gametogenesis in mice. Dev Cell. 2007;12:863-72 pubmed
    ..Here we show that the inner nuclear membrane protein SUN1 specifically associates with telomeres between the leptotene and diplotene stages during meiotic prophase I...
  7. Lu W, Gotzmann J, Sironi L, Jaeger V, Schneider M, Lüke Y, et al. Sun1 forms immobile macromolecular assemblies at the nuclear envelope. Biochim Biophys Acta. 2008;1783:2415-26 pubmed publisher
    ..In the current study, we provide evidence that within the nuclear envelope (NE) Sun1 proteins form highly immobile oligomeric complexes in interphase cells...
  8. Chi Y, Cheng L, Myers T, Ward J, Williams E, Su Q, et al. Requirement for Sun1 in the expression of meiotic reproductive genes and piRNA. Development. 2009;136:965-73 pubmed publisher
    ..b>Sun1 is an inner nuclear membrane (INM) protein that locates to telomeres and anchors chromosome movement in the ..
  9. Randles K, Lam L, Sewry C, Puckelwartz M, Furling D, Wehnert M, et al. Nesprins, but not sun proteins, switch isoforms at the nuclear envelope during muscle development. Dev Dyn. 2010;239:998-1009 pubmed publisher
    ..b>Sun1 and Sun2 proteins remained unchanged during this fibre maturation...

More Information

Publications34

  1. Zhang X, Lei K, Yuan X, Wu X, Zhuang Y, Xu T, et al. SUN1/2 and Syne/Nesprin-1/2 complexes connect centrosome to the nucleus during neurogenesis and neuronal migration in mice. Neuron. 2009;64:173-87 pubmed publisher
    ..We report here that the SUN-domain proteins SUN1 and SUN2 and the KASH-domain proteins Syne-1/Nesprin-1 and Syne-2/Nesprin-2 play critical roles in neurogenesis and ..
  2. Horn H, Brownstein Z, Lenz D, Shivatzki S, Dror A, Dagan Rosenfeld O, et al. The LINC complex is essential for hearing. J Clin Invest. 2013;123:740-50 pubmed publisher
    ..NESP4 and SUN domain-containing protein 1 (SUN1), which localizes to the inner nuclear membrane (INM), are part of the linker of nucleoskeleton and cytoskeleton (..
  3. Horn H, Kim D, Wright G, Wong E, Stewart C, Burke B, et al. A mammalian KASH domain protein coupling meiotic chromosomes to the cytoskeleton. J Cell Biol. 2013;202:1023-39 pubmed publisher
    ..In metazoans, telomere clustering is dynein and microtubule dependent and requires Sun1, an inner nuclear membrane protein...
  4. Göb E, Schmitt J, Benavente R, Alsheimer M. Mammalian sperm head formation involves different polarization of two novel LINC complexes. PLoS ONE. 2010;5:e12072 pubmed publisher
    ..Moreover, they are shown to be essential for maintaining nuclear shape...
  5. Haque F, Lloyd D, Smallwood D, Dent C, Shanahan C, Fry A, et al. SUN1 interacts with nuclear lamin A and cytoplasmic nesprins to provide a physical connection between the nuclear lamina and the cytoskeleton. Mol Cell Biol. 2006;26:3738-51 pubmed
    ..Here, we report the identification of SUN1 as a lamin A-binding protein in a yeast two-hybrid screen...
  6. Crisp M, Liu Q, Roux K, Rattner J, Shanahan C, Burke B, et al. Coupling of the nucleus and cytoplasm: role of the LINC complex. J Cell Biol. 2006;172:41-53 pubmed
    ..The inner nuclear membrane contains specific integral proteins that include Sun1 and Sun2...
  7. Boateng K, Bellani M, Gregoretti I, Pratto F, Camerini Otero R. Homologous pairing preceding SPO11-mediated double-strand breaks in mice. Dev Cell. 2013;24:196-205 pubmed publisher
    ..Intriguingly, SUN1, a protein required for telomere attachment to the nuclear envelope and for post-DSB synapsis, is also required for ..
  8. Haque F, Mazzeo D, Patel J, Smallwood D, Ellis J, Shanahan C, et al. Mammalian SUN protein interaction networks at the inner nuclear membrane and their role in laminopathy disease processes. J Biol Chem. 2010;285:3487-98 pubmed publisher
    ..b>SUN1 and SUN2 interact with lamin A, but lamin A is only required for NE localization of SUN2, and it remains unclear ..
  9. Yu J, Lei K, Zhou M, Craft C, Xu G, Xu T, et al. KASH protein Syne-2/Nesprin-2 and SUN proteins SUN1/2 mediate nuclear migration during mammalian retinal development. Hum Mol Genet. 2011;20:1061-73 pubmed publisher
    ..we demonstrated that a KASH domain-containing protein, Syne-2/Nesprin-2, as well as SUN domain-containing proteins, SUN1 and SUN2, play critical roles during INM and photoreceptor cell migration in the mouse retina...
  10. Lei K, Zhang X, Ding X, Guo X, Chen M, Zhu B, et al. SUN1 and SUN2 play critical but partially redundant roles in anchoring nuclei in skeletal muscle cells in mice. Proc Natl Acad Sci U S A. 2009;106:10207-12 pubmed publisher
    ..Here we show that the synaptic nuclear anchorage is partially perturbed in Sun1, but not in Sun2, knockout mice...
  11. Shibuya H, Ishiguro K, Watanabe Y. The TRF1-binding protein TERB1 promotes chromosome movement and telomere rigidity in meiosis. Nat Cell Biol. 2014;16:145-56 pubmed publisher
    ..Our study suggests that TERB1 acts as a central hub for the assembly of a conserved meiotic telomere complex required for chromosome movements. ..
  12. Bray J, Chennathukuzhi V, Hecht N. Identification and characterization of cDNAs encoding four novel proteins that interact with translin associated factor-X. Genomics. 2002;79:799-808 pubmed
    ..429 amino acids with 73% homology to centrosomal Akap9; and a cDNA encoding 346 amino acids with 75% homology to SUN1, a predicted human protein that contains a SUN domain (which is present in some perinuclear proteins)...
  13. Liu W, Wang L, Zhao W, Song G, Xu R, Wang G, et al. Phosphorylation of CDK2 at threonine 160 regulates meiotic pachytene and diplotene progression in mice. Dev Biol. 2014;392:108-16 pubmed publisher
    ..Here, we show that CDK2, especially p39(cdk2), as a potential meiosis-specific connector interaction with SUN1 mediates formation of telomere clustering during mouse meiosis...
  14. Daniel K, Tränkner D, Wojtasz L, Shibuya H, Watanabe Y, Alsheimer M, et al. Mouse CCDC79 (TERB1) is a meiosis-specific telomere associated protein. BMC Cell Biol. 2014;15:17 pubmed publisher
    ..Although inner-nuclear envelope proteins, such as SUN1 and potentially SUN2, are known to bind and recruit meiotic telomeres, these proteins are not meiosis-specific, ..
  15. Viera A, Alsheimer M, Gómez R, Berenguer I, Ortega S, Symonds C, et al. CDK2 regulates nuclear envelope protein dynamics and telomere attachment in mouse meiotic prophase. J Cell Sci. 2015;128:88-99 pubmed publisher
    ..that the ablation of the kinase CDK2 alters the nuclear envelope in mouse spermatocytes, and that the proteins SUN1, KASH5 (also known as CCDC155) and lamin C2 show an abnormal cap-like distribution facing the centrosome...
  16. Shibuya H, Hernández Hernández A, Morimoto A, Negishi L, Höög C, Watanabe Y. MAJIN Links Telomeric DNA to the Nuclear Membrane by Exchanging Telomere Cap. Cell. 2015;163:1252-1266 pubmed publisher
    ..Further, we uncover a positive feedback between telomere attachment and chromosome movement, revealing a comprehensive regulatory network underlying meiosis-specific telomere function in mammals. ..
  17. Link J, Leubner M, Schmitt J, Göb E, Benavente R, Jeang K, et al. Analysis of meiosis in SUN1 deficient mice reveals a distinct role of SUN2 in mammalian meiotic LINC complex formation and function. PLoS Genet. 2014;10:e1004099 pubmed publisher
    ..In mice, SUN1 and SUN2 are the only SUN domain proteins expressed during meiosis, sharing their localization with meiosis-..
  18. Ishiguro K, Kim J, Shibuya H, Hern ndez Hern ndez A, Suzuki A, Fukagawa T, et al. Meiosis-specific cohesin mediates homolog recognition in mouse spermatocytes. Genes Dev. 2014;28:594-607 pubmed publisher
    ..Intriguingly, the ability to recognize homologs is retained in Sun1 knockout spermatocytes, in which telomere-directed chromosome movement is abolished, and this is the case even in ..
  19. Lee C, Horn H, Stewart C, Burke B, Bolcun Filas E, Schimenti J, et al. Mechanism and regulation of rapid telomere prophase movements in mouse meiotic chromosomes. Cell Rep. 2015;11:551-63 pubmed publisher
    ..Studies in mice suggested that dynein movement along microtubules is transmitted to telomeres through SUN1/KASH5 nuclear envelope bridges to generate RPMs...
  20. Luo Y, Lee I, Jo Y, Namgoong S, Kim N. Depletion of the LINC complex disrupts cytoskeleton dynamics and meiotic resumption in mouse oocytes. Sci Rep. 2016;6:20408 pubmed publisher
    ..To date, the SUN1/KASH5 complex is known to function as meiotic-specific factors...
  21. Stroud M, Feng W, Zhang J, Veevers J, Fang X, Gerace L, et al. Nesprin 1α2 is essential for mouse postnatal viability and nuclear positioning in skeletal muscle. J Cell Biol. 2017;216:1915-1924 pubmed publisher
    ..Furthermore, we revealed that kinesin 1 was displaced in fibers of nesprin 1α2-knockout mice, suggesting that this interaction may play an important role in positioning of myonuclei and functional skeletal muscle. ..
  22. Razafsky D, Blecher N, Markov A, Stewart Hutchinson P, Hodzic D. LINC complexes mediate the positioning of cone photoreceptor nuclei in mouse retina. PLoS ONE. 2012;7:e47180 pubmed publisher
    ..We further show that Sun1, a component of LINC complexes, but not A-type lamins, which interact with LINC complexes at the nuclear envelope, ..
  23. Lei K, Zhu X, Xu R, Shao C, Xu T, Zhuang Y, et al. Inner nuclear envelope proteins SUN1 and SUN2 play a prominent role in the DNA damage response. Curr Biol. 2012;22:1609-15 pubmed publisher
    ..Recent findings indicate that accumulation of SUN1, a nuclear envelope (NE) protein, is a significant pathogenic event in Emery-Dreifuss muscular dystrophy and ..
  24. Dreger M, Bengtsson L, Schoneberg T, Otto H, Hucho F. Nuclear envelope proteomics: novel integral membrane proteins of the inner nuclear membrane. Proc Natl Acad Sci U S A. 2001;98:11943-8 pubmed
    ..The utility of our approach is not restricted to the investigation of the NE. Our approach should be applicable to the analysis of other complex membrane structures of the cell as well. ..
  25. Wang J, Yu I, Huang C, Chen C, Wang W, Lin S, et al. Sun1 deficiency leads to cerebellar ataxia in mice. Dis Model Mech. 2015;8:957-67 pubmed publisher
    ..Here, we report an unrecognized contribution of Sun1 and Sun2 to the postnatal development of murine cerebellum...