Genomes and Genes
Gene Symbol: stromelysin 1
Description: matrix metallopeptidase 3
Alias: EMS-2, MMP-3, SL-1, SLN-1, SLN1, STR-1, Stmy1, Str1, stromelysin-1, matrix metalloproteinase 3, progelatinase, transin-1
Publications115 found, 100 shown here
- Expression of stromelysin-1 and TIMP-1 in the involuting mammary gland and in early invasive tumors of the mouseF Li
Laboratory for Clinical and Experimental Research, Berne, Switzerland
Int J Cancer 59:560-8. 1994..Thus, expression of stromelysin-1 and TIMP-1 is confined to the aggressively growing tumors and is induced in the earliest stages of carcinogenesis...
- Matrix metalloproteinases are expressed during ductal and alveolar mammary morphogenesis, and misregulation of stromelysin-1 in transgenic mice induces unscheduled alveolar developmentJ P Witty
Department of Cell Biology, Vanderbilt University, Nashville, Tennessee 37232, USA
Mol Biol Cell 6:1287-303. 1995....
- Urokinase-generated plasmin activates matrix metalloproteinases during aneurysm formationP Carmeliet
Centre for Transgene Technology and Gene Therapy, Flanders Interuniversity Institute for Biotechnology, University of Leuven, Belgium
Nat Genet 17:439-44. 1997....
- Blood-brain barrier disruption by stromelysin-1 facilitates neutrophil infiltration in neuroinflammationKate J Gurney
Department of Neurology, University of New Mexico Health Sciences Center, MSC10 5620, Albuquerque, NM 87131 0001, USA
Neurobiol Dis 23:87-96. 2006..Our results provide the first in vivo evidence that MMP-3 attacks the basal lamina and tight junction proteins, opening the BBB, thereby facilitating neutrophil influx...
- Genetic inactivation of IL-1 signaling enhances atherosclerotic plaque instability and reduces outward vessel remodeling in advanced atherosclerosis in miceMatthew R Alexander
Department of Molecular Physiology and Biological Physics, University of Virginia, Charlottesville, Virginia 22908, USA
J Clin Invest 122:70-9. 2012....
- Tissue-type plasminogen activator (t-PA) induces stromelysin-1 (MMP-3) in endothelial cells through activation of lipoprotein receptor-related proteinYasuhiro Suzuki
Department of Pharmacology, Hamamatsu University School of Medicine, Hamamatsu, Japan, Japan
Blood 114:3352-8. 2009..These findings indicate that t-PA deteriorates ICB via MMP-3 induction in endothelial cells, which is regulated through the LRP/nuclear factor-kappaB pathway...
- Cyclooxygenase-1 and -2 differentially modulate lipopolysaccharide-induced blood-brain barrier disruption through matrix metalloproteinase activitySaba Aid
Brain Physiology and Metabolism Section, National Institute on Aging, NIH, Bethesda, Maryland 20892, USA
J Cereb Blood Flow Metab 30:370-80. 2010..Altogether, these results indicate that COX-2 activity modulates MMP-9 and-3 activities and is necessary to maintain BBB integrity during toll-like receptor 4-dependent innate immune activation...
- General and specific host responses to bacterial infection in Peyer's patches: a role for stromelysin-1 (matrix metalloproteinase-3) during Salmonella enterica infectionScott A Handley
Department of Molecular Microbiology, Washington University School of Medicine, St Louis, MO 63110, USA
Mol Microbiol 64:94-110. 2007..We hypothesize that MMP-3 is involved in initiating an early and lethal cytokine response to S. typhimurium colonization...
- The matrix metalloproteinase stromelysin-1 acts as a natural mammary tumor promoterM D Sternlicht
Department of Anatomy, University of California, 513 Parnassus Avenue, HSW 1301, San Francisco, California, CA 94143 0452, USA
Oncogene 19:1102-13. 2000..Thus by altering the cellular microenvironment, stromelysin-1 can act as a natural tumor promoter and enhance cancer susceptibility...
- Stromelysin-1 (MMP-3) is critical for intracranial bleeding after t-PA treatment of stroke in miceY Suzuki
Center for Molecular and Vascular Biology, KU Leuven, Leuven, Belgium
J Thromb Haemost 5:1732-9. 2007..Matrix metalloproteinases (MMPs), which can be activated through the plasminogen/plasmin system, may contribute to ICB after ischemic stroke...
- ETS-1 converts endothelial cells to the angiogenic phenotype by inducing the expression of matrix metalloproteinases and integrin beta3N Oda
Department of Vascular Biology, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan
J Cell Physiol 178:121-32. 1999..These results indicate that ETS-1 is a principal regulator that converts ECs to the angiogenic phenotype...
- Identification and enzymatic characterization of two diverging murine counterparts of human interstitial collagenase (MMP-1) expressed at sites of embryo implantationM Balbin
Departamento de Bioquimica y Biologia Molecular, Instituto Universitario de Oncologia, Universidad de Oviedo, 33006 Oviedo, Spain
J Biol Chem 276:10253-62. 2001....
- Activation of p38 alpha MAPK enhances collagenase-1 (matrix metalloproteinase (MMP)-1) and stromelysin-1 (MMP-3) expression by mRNA stabilizationNiina Reunanen
Centre for Biotechnology and Department of Medicinal Biochemistry, University of Turku, FIN 20520 Turku, Finland
J Biol Chem 277:32360-8. 2002..It is conceivable that both modes of action play an important role in controlling the proteolytic phenotype of fibroblasts, e.g. in wound repair and tumor invasion...
- Enhanced nutritionally induced adipose tissue development in mice with stromelysin-1 gene inactivationErik Maquoi
Center for Molecular and Vascular Biology, University of Leuven, Campus Gasthuisberg, O and N, Herestraat 49, B 3000 Leuven, Belgium
Thromb Haemost 89:696-704. 2003..Thus, in a murine model of nutritionally induced obesity, MMP-3 impairs adipose tissue development, possibly by affecting food intake and/or adipose tissue-related angiogenesis...
- Gene deletion of either interleukin-1beta, interleukin-1beta-converting enzyme, inducible nitric oxide synthase, or stromelysin 1 accelerates the development of knee osteoarthritis in mice after surgical transection of the medial collateral ligament and pKristen M Clements
Imperial College London, London, UK
Arthritis Rheum 48:3452-63. 2003..the medial collateral ligament and partial medial meniscectomy in mice in which genes encoding either interleukin-1beta (IL-1beta), IL-1beta-converting enzyme (ICE), stromelysin 1, or inducible nitric oxide synthase (iNOS) were deleted.
- Tissue inhibitor of metalloproteinase 1 regulates resistance to infectionMarie Mei Lee
Division of Nutritional Sciences, Cornell University, Ithaca, NY 14853, USA
Infect Immun 73:661-5. 2005..Increased resistance was also seen during pulmonary infections. These results identify a novel pathway regulating infection resistance...
- Matrix metalloproteinase-3 (stromelysin-1) in acute inflammatory tissue injuryKamalakar C Nerusu
Department of Pathology, The University of Michigan Medical School, 1301 Catherine Road Box 0602, Ann Arbor, MI 48109, USA
Exp Mol Pathol 83:169-76. 2007..There was also a relationship between tissue injury and influx of neutrophils into the BAL or PL fluid. Taken together, these data demonstrate an important role for MMP-3 in acute inflammatory tissue injury...
- Targeted expression of stromelysin-1 in mammary gland provides evidence for a role of proteinases in branching morphogenesis and the requirement for an intact basement membrane for tissue-specific gene expressionC J Sympson
Life Sciences Division, Lawrence Berkeley Laboratory, Berkeley, California 94720
J Cell Biol 125:681-93. 1994..We conclude that the balance of ECM-degrading enzymes with their inhibitors, and the associated regulation of ECM structure, is crucial for tissue-specific gene expression and morphogenesis in vivo...
- Coordinate expression of matrix metalloproteinase family members in the uterus of normal, matrilysin-deficient, and stromelysin-1-deficient miceL A Rudolph-Owen
Department of Cell Biology, Vanderbilt University Medical School, Nashville, Tennessee 37232, USA
Endocrinology 138:4902-11. 1997..We conclude that the concerted action of several MMPs is likely to play an important role in the remodeling of the postpartum uterus, and that mechanisms that compensate for the loss of a specific MMP during this process appear to exist...
- Susceptibility of stromelysin 1-deficient mice to collagen-induced arthritis and cartilage destructionJ S Mudgett
Merck Research Laboratories, Rahway, New Jersey 07065, USA
Arthritis Rheum 41:110-21. 1998..This hypothesis was tested by examining the arthritic paws of stromelysin 1 (SLN1)-deficient mice for loss of cartilage and for generation of neoepitopes that would be indicative of ..
- Expression of autoactivated stromelysin-1 in mammary glands of transgenic mice leads to a reactive stroma during early developmentN Thomasset
Life Sciences Division, Ernest Orlando Lawrence Berkeley National Laboratory, Berkeley, California 94720, USA
Am J Pathol 153:457-67. 1998..This, together with increased transgene expression, led to basement membrane disruption starting by day 15 of pregnancy. We propose that the highly reactive stroma provides a prelude to breast epithelial tumors observed in these animals...
- The stromal proteinase MMP3/stromelysin-1 promotes mammary carcinogenesisM D Sternlicht
Department of Anatomy, University of California, San Francisco 94143 0452, USA
Cell 98:137-46. 1999..that phenotypically normal mammary epithelial cells with tetracycline-regulated expression of MMP3/stromelysin-1 (Str1) form epithelial glandular structures in vivo without Str1 but form invasive mesenchymal-like tumors with Str1...
- Impaired wound contraction in stromelysin-1-deficient miceK M Bullard
Department of Surgery, University of California, San Francisco 94143 0570, USA
Ann Surg 230:260-5. 1999..To determine whether the deletion of stromelysin-1, a single metalloproteinase gene product, will alter the time course and quality of dermal wound repair in mice...
- Signaling through the EGF receptor controls lung morphogenesis in part by regulating MT1-MMP-mediated activation of gelatinase A/MMP2Farrah Kheradmand
Department of Medicine, Baylor College of Medicine, Houston, TX 77030, USA
J Cell Sci 115:839-48. 2002..MT1-MMP is, in turn, necessary for activation of MMP-2, a mesenchymal enzyme that is required for normal lung morphogenesis...
- Impaired immunity to intestinal bacterial infection in stromelysin-1 (matrix metalloproteinase-3)-deficient miceChris K F Li
Division of Infection, Inflammation and Repair, University of Southampton School of Medicine, UK
J Immunol 173:5171-9. 2004..These studies show that mucosal remodeling can occur in the absence of MMP3, but that MMP3 plays a role in the migration of CD4+ T lymphocytes to the intestinal mucosa...
- Functional interaction between matrix metalloproteinase-3 and semaphorin-3C during cortical axonal growth and guidanceB Gonthier
INSERM U575, Physiopathologie du Système Nerveux, Centre de Neurochimie, 67084 Strasbourg, France
Cereb Cortex 17:1712-21. 2007....
- A pivotal role of matrix metalloproteinase-3 activity in dopaminergic neuronal degeneration via microglial activationYoon Seong Kim
Burke Medical Research Institute, and Department of Neurology and Neuroscience, Weill Medical College of Cornell University, 1300 York Ave, New York, NY 10021, USA
FASEB J 21:179-87. 2007..Our results could lead to a novel therapeutic approach to PD...
- Novel transcription-factor-like function of human matrix metalloproteinase 3 regulating the CTGF/CCN2 geneTakanori Eguchi
Department of Biochemistry and Molecular Dentistry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2 5 1, Shikata cho, Okayama City, Okayama, Japan
Mol Cell Biol 28:2391-413. 2008b>Matrix metalloproteinase 3 (MMP3) is well known as a secretory endopeptidase that degrades extracellular matrices. Recent reports indicated the presence of MMPs in the nucleus (A. J. Kwon et al., FASEB J...
- A novel intracellular role of matrix metalloproteinase-3 during apoptosis of dopaminergic cellsDong Hee Choi
Department of Biochemistry and Molecular Biology, University of Ulsan College of Medicine, Seoul, Korea
J Neurochem 106:405-15. 2008..Thus, actMMP-3 seems to have a novel intracellular role in apoptotic DArgic cells and this finding provides an insight into the pathogenesis of Parkinson's disease...
- TIMP-3 and MMP-3 contribute to delayed inflammation and hippocampal neuronal death following global ischemiaEspen J Walker
Department of Neurology, University of New Mexico Health Sciences Center, Albuquerque, NM 87131, USA
Exp Neurol 216:122-31. 2009..Our results indicate a novel additive role for TIMP-3 and MMP-3 in delayed neuronal death, and show that delayed treatment with MMP inhibitors can be used to reduce hippocampal death...
- Matrix metalloproteinase-3 contributes to vulnerability of the nigral dopaminergic neuronsSung Tae Kim
Department of Biochemistry and Molecular Biology, University of Ulsan College of Medicine, Seoul, South Korea
Neurochem Int 56:161-7. 2010..These results further indicate a role of MMP-3 in the demise of DArgic neurons and suggest MMP-3 as a candidate cellular target for neuroprotective therapy...
- Allele-specific regulation of matrix metalloproteinase-3 gene by transcription factor NFkappaBVeronika Souslova
William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom
PLoS ONE 5:e9902. 2010..In the present study, we sought to investigate whether MMP3 and NFkappaB were co-localized in atherosclerotic lesions and whether NFkappaB had differential effects on the two alleles of the MMP3 5A/6A polymorphism...
- Matrix metalloproteinase-3 is increased and participates in neuronal apoptotic signaling downstream of caspase-12 during endoplasmic reticulum stressEun Mee Kim
Department of Biochemistry and Molecular Biology, University of Ulsan College of Medicine, Asan Institute for Life Science, Seoul 138 736, Korea
J Biol Chem 285:16444-52. 2010..MMP-3 and TIMP-1 may therefore serve as cellular targets for therapy against neurodegenerative diseases...
- DJ-1 cleavage by matrix metalloproteinase 3 mediates oxidative stress-induced dopaminergic cell deathDong Hee Choi
Neurology Neuroscience Department, Weill Medical College of Cornell University, New York, New York, USA
Antioxid Redox Signal 14:2137-50. 2011..Our data suggest that DJ-1 is fragmented by the intracellular MMP3 in response to cell stress, abolishing the protective role of DJ-1 against oxidative damage, and this contributes to the pathogenesis of PD...
- An aberrant cerebellar development in mice lacking matrix metalloproteinase-3Inge Van Hove
Laboratory of Neural Circuit Development and Regeneration, Animal Physiology and Neurobiology Section, Department of Biology, K U Leuven, Naamsestraat 61, Box 2464, 3000 Leuven, Belgium
Mol Neurobiol 45:17-29. 2012..Of note, these developmental and adult cerebellar defects might contribute to the aberrant motor phenotype observed in MMP-3(-/-) mice and suggest an involvement of MMP-3 in mouse cerebellar development...
- Matrix metalloproteinase-3 in the central nervous system: a look on the bright sideInge Van Hove
Laboratory of Neural Circuit Development and Regeneration, Animal Physiology and Neurobiology Section, Department of Biology, KU Leuven, Leuven, Belgium
J Neurochem 123:203-16. 2012..Moreover, a strict spatiotemporal MMP-3 up-regulation in the injured or diseased CNS might support remyelination and neuroprotection, as well as genesis and migration of stem cells in the damaged brain...
- MMP-3 contributes to nigrostriatal dopaminergic neuronal loss, BBB damage, and neuroinflammation in an MPTP mouse model of Parkinson's diseaseYoung Cheul Chung
Department of Biochemistry and Molecular Biology, School of Medicine, Kyung Hee University, Seoul 130 701, Republic of Korea
Mediators Inflamm 2013:370526. 2013..These data suggest that MMP-3 could play a crucial role in neurodegenerative diseases such as PD in which BBB damage and neuroinflammation are implicated. ..
- A role for matrix metalloproteinases in regulating mammary stem cell function via the Wnt signaling pathwayKai Kessenbrock
Department of Anatomy and Biomedical Sciences Program, University of California, San Francisco, San Francisco, CA 94143, USA
Cell Stem Cell 13:300-13. 2013..Our study reveals a mechanism by a microenvironmental protease that regulates Wnt signaling and impacts adult epithelial stem cell function. ..
- Misregulation of stromelysin-1 expression in mouse mammary tumor cells accompanies acquisition of stromelysin-1-dependent invasive propertiesA Lochter
Life Sciences Division, Lawrence Berkeley National Laboratory, University of California, Berkeley, California 94720, USA
J Biol Chem 272:5007-15. 1997..Thus misregulation of stromelysin-1 expression appears to be an important aspect of mammary tumor cell progression to an invasive phenotype...
- Matrix metalloproteinase deficiencies affect contact hypersensitivity: stromelysin-1 deficiency prevents the response and gelatinase B deficiency prolongs the responseM Wang
Division of Dermatology, Department of Medicine, Barnes Jewish Hospital at Washington University Medical Center, St Louis, MO 63110, USA
Proc Natl Acad Sci U S A 96:6885-9. 1999..These results indicate that stromelysin-1 and gelatinase B serve important functions in CHS. Stromelysin-1 is required for initiation of the response, whereas gelatinase B plays a critical role in its resolution...
- Active matrix metalloproteinases are present in cartilage during immune complex-mediated arthritis: a pivotal role for stromelysin-1 in cartilage destructionJ Van Meurs
Department of Rheumatology, University Hospital Nijmegen, The Netherlands
J Immunol 163:5633-9. 1999..SLN-1 is a pivotal enzyme in overall MMP-activity in cartilage during immune complex-mediated arthritis...
- Role of stromelysin 1 and gelatinase B in experimental acute lung injuryR L Warner
Department of Pathology, University of Michigan Medical School, Ann Arbor, Michigan 48109 0602, USA
Am J Respir Cell Mol Biol 24:537-44. 2001..of individual MMPs in the development of lung injury, mice genetically deficient in gelatinase B (MMP-9) and stromelysin 1 (MMP-3) were acutely injured with immunoglobulin G immune complexes and the intensity of the lung injury was ..
- Differential expression of tissue inhibitor of metalloproteinases type 1 (TIMP-1) during mouse gonad developmentRomain Guyot
INSERM U329, Hopital Debrousse, Lyon, France
Dev Dyn 227:357-66. 2003..Experiments are now under way to determine to what extent TIMP-1 is a morphogenic gene involved in seminiferous cord formation and development...
- Mechanism of signal transduction in tumor necrosis factor-like weak inducer of apoptosis-induced matrix degradation by MMP-3 upregulation in disc tissuesMasanori Wako
Department of Orthopaedic Surgery, Graduate School of Medicine and Engineering, University of Yamanashi, Yamanashi, Japan
Spine (Phila Pa 1976) 33:2489-94. 2008..Molecular biologic and immuno-histologic analyses using in vitro murine intervertebral disc tissue culture...
- Importance of protein-tyrosine phosphatase-alpha catalytic domains for interactions with SHP-2 and interleukin-1-induced matrix metalloproteinase-3 expressionQin Wang
Matrix Dynamics Group, University of Toronto, Toronto, Ontario M5S 3E2, Canada
J Biol Chem 285:22308-17. 2010..These data indicate that IL-1-induced signaling through focal adhesions leading to MMP3 release and interactions between SHP-2 and PTPalpha are dependent on the integrity of the catalytic domains of PTPalpha...
- Matrix metalloproteinase 3 is a mediator of pulmonary fibrosisCory M Yamashita
Department of Medicine, University of Western Ontario, London, Ontario, Canada
Am J Pathol 179:1733-45. 2011..These observations support a novel role for MMP-3 in the pathogenesis of IPF, through activation of β-catenin signaling and induction of epithelial-mesenchymal transition...
- Age-related expression of MCP-1 and MMP-3 in mouse intervertebral disc in relation to TWEAK and TNF-α stimulationKoji Fujita
Department of Orthopaedic Surgery, University of Yamanashi, 1110 Shimokato, Chuo, Yamanashi 409 3898, Japan
J Orthop Res 30:599-605. 2012..The response to inflammation in IVD also displayed age-related changes. Therefore, disc degeneration may vary with the patients' age and targeting MMP-3 may be a possible future therapeutic strategy for disc degeneration...
- West Nile virus-induced disruption of the blood-brain barrier in mice is characterized by the degradation of the junctional complex proteins and increase in multiple matrix metalloproteinasesKelsey Roe
Department of Tropical Medicine, Medical Microbiology and Pharmacology, Pacific Center for Emerging Infectious Diseases Research, John A Burns School of Medicine, University of Hawaii at Manoa, Honolulu, Hawaii 96813, USA
J Gen Virol 93:1193-203. 2012..These data further implicate roles of multiple MMPs in the BBB disruption and strategies to interrupt this process may influence the WNV disease outcome...
- Epidermal inactivation of the glucocorticoid receptor triggers skin barrier defects and cutaneous inflammationLisa M Sevilla
Instituto de Biomedicina de Valencia Consejo Superior de Investigaciones Científicas IBV CSIC, Jaime Roig, Valencia, Spain
J Invest Dermatol 133:361-70. 2013..Together, our results show that epidermal loss of GR provokes skin barrier defects and cutaneous inflammation...
- Ras-guanine-nucleotide-releasing factors 1 and 2 interact with PLCγ at focal adhesions to enable IL-1-induced Ca(2+) signalling, ERK activation and MMP-3 expressionQin Wang
Matrix Dynamics Group, Faculty of Dentistry, University of Toronto, Toronto, ON, Canada, M5S 3E2
Biochem J 449:771-82. 2013....
- Functional interactions between matrix metalloproteinases and glycosaminoglycansAutumn Tocchi
Department of Medicine Pulmonary and Critical Care Medicine, Center for Lung Biology, University of Washington, Seattle, WA 98109, USA
FEBS J 280:2332-41. 2013....
- Matrix metalloproteinase 3 promotes cellular anti-dengue virus response via interaction with transcription factor NFκB in cell nucleusXiangyang Zuo
Institute of Biology and Medical Sciences, Jiangsu Key Laboratory of Infection and Immunity, Soochow University, Suzhou City, Jiangsu Province, People s Republic of China
PLoS ONE 9:e84748. 2014..This study suggested a novel role of MMP3 in nucleus during viral infection and provided new evidence for MMPs in immunomodulation. ..
- Matrix metalloproteinase-3 promotes early blood-spinal cord barrier disruption and hemorrhage and impairs long-term neurological recovery after spinal cord injuryJee Youn Lee
Age Related and Brain Diseases Research Center, School of Medicine, Kyung Hee University, Seoul, Republic of Korea Neurodegeneration Control Research Center, School of Medicine, Kyung Hee University, Seoul, Republic of Korea
Am J Pathol 184:2985-3000. 2014....
- Matrix metalloproteinase-3 causes dopaminergic neuronal death through Nox1-regenerated oxidative stressDong Hee Choi
Center for Neuroscience Research, Institute of Biomedical Science and Technology, Konkuk University, Seoul, 143 701, Korea Department of Medical Science, Konkuk University School of Medicine, Seoul, 143 701, Korea
PLoS ONE 9:e115954. 2014In the present study we investigated the interplay between matrix metalloproteinase 3 (MMP3) and NADPH oxidase 1 (Nox1) in the process of dopamine (DA) neuronal death...
- A proteomic approach to understand MMP-3-driven developmental processes in the postnatal cerebellum: Chaperonin CCT6A and MAP kinase as contributing factorsInge Van Hove
Laboratory of Neural Circuit Development and Regeneration, Animal Physiology and Neurobiology Section, Department of Biology, KU Leuven, Leuven, Belgium
Dev Neurobiol 75:1033-48. 2015....
- Up-regulation of matrix metalloproteinases in a mouse model of chemically induced colitis-associated cancer: the role of microRNAsFeiyan Ai
Department of Gastroenterology, The Third Xiangya Hospital of Central South University, Changsha, Hunan, China
Oncotarget 6:5412-25. 2015..Our results suggest that microRNAs modulate the production of key inflammatory mediators and that microRNA dysfunction may contribute to the non-resolving inflammation associated with cancer. ..
- Pleiotropic functions of the tumor- and metastasis-suppressing matrix metalloproteinase-8 in mammary cancer in MMTV-PyMT transgenic miceJulie Decock
Breast Cancer Res 17:38. 2015..Matrix metalloproteinase-8 (MMP-8; neutrophil collagenase) is an important regulator of innate immunity that has oncosuppressive actions in numerous tumor types...
- Repeated exposure to high-frequency low-amplitude vibration induces degeneration of murine intervertebral discs and knee jointsMatthew R McCann
University of Western Ontario Schulich School of Medicine and Dentistry, London, Ontario, Canada
Arthritis Rheumatol 67:2164-75. 2015..This study was undertaken to examine the effects of repeated exposure to WBV on bone and joint tissues in an in vivo mouse model...
- Mice Deficient in CIZ/NMP4 Develop an Attenuated Form of K/BxN-Serum Induced ArthritisTetsuya Nakamoto
Department of Molecular Pharmacology, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, 113 8510, Japan
J Cell Biochem 117:970-7. 2016..Thus, CIZ/NMP4 plays a role in the development of arthritis at least in part through regulation of key molecules related to the arthritis...
- MMP9 deficiency does not decrease blood-brain barrier disruption, but increases astrocyte MMP3 expression during viral encephalomyelitisCarine Savarin
Department of Neurosciences, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, Ohio, USA
Glia 59:1770-81. 2011..Overall, these results highlight the complexity of targeting individual MMPs as a strategy to regulate inflammation...
- Epinephrine-induced MMP expression is different between skeletal fibroblasts and myoblastsM C Cha
Department of Food Science, University of Guelph, Guelph, Ontario, Canada
Cell Biochem Funct 29:603-9. 2011....
- Chronic gastric ulceration causes matrix metalloproteinases-9 and -3 augmentation: alleviation by melatoninKrishnendu Ganguly
Department of Physiology, Drug Development Diagnostics and Biotechnology Division, CSIR Indian Institute of Chemical Biology, 4, Raja SC Mullick Road, Jadavpur, Kolkata 700032, India
Biochimie 94:2687-98. 2012..In summary, oxidative stress is preceded by chronic inflammation that enhances the expression of MMP-9 and -3, while melatonin arrests both of them via reduction of AP-1 activity during protection of ulcer...
- Overcoming neurite-inhibitory chondroitin sulfate proteoglycans in the astrocyte matrixRowena C Cua
Hotchkiss Brain Institute and the Department of Clinical Neurosciences, University of Calgary, Calgary, Alberta, Canada
Glia 61:972-84. 2013..These findings highlight ADAMTS-4 as a superior protease for overcoming CSPG inhibition of axonal regeneration in the CNS...
- Heterogeneous nuclear ribonucleoprotein K (hnRNP-K) promotes tumor metastasis by induction of genes involved in extracellular matrix, cell movement, and angiogenesisRan Gao
National Institute of Advanced Industrial Science and Technology, Central 4, 1 1 1 Higashi, Tsukuba Science City 305 8562, Japan
J Biol Chem 288:15046-56. 2013..Involvement of the selected genes (Cck, Mmp-3, Ptgs2, and Ctgf) and pathways was validated by gene-specific expression analysis. Our results demonstrated that the hnRNP-K is a potential target for metastasis therapy...
- Cloning and sequencing of a cDNA encoding mouse stromelysin 1K Hammani
Laboratoire de Chimie Physiologique Connective Tissue Group, Universite de Louvain, Bruxelles, Belgium
Gene 120:321-2. 1992A cDNA encoding mouse stromelysin 1 was cloned and the 1740-bp sequence was determined. The deduced amino acid (aa) sequence was compared with stromelysin 1 sequences of other mammals...
- Molecular characterization of a novel transcription factor that controls stromelysin expressionL Sanz
Centro de Biología Molecular Severo Ochoa Consejo Superior de Investigaciones Científicas Universidad Autónoma de Madrid, Spain
Mol Cell Biol 15:3164-70. 1995..Therefore, the results presented here identify a novel transcription factor critically involved in the control of stromelysin expression...
- Matrix metalloproteinases and TIMPS in cultured C57BL/6J-cpk kidney tubulesC A Rankin
Department of Biochemistry and Molecular Biology, University of Kansas Medical Center, Kansas City, USA
Kidney Int 50:835-44. 1996..These data suggest that cystic kidney tubules synthesize and secrete high levels of MMPs which may then participate in the restructuring of the tubular basement membrane...
- Matrix metalloproteinases regulate morphogenesis, migration and remodeling of epithelium, tongue skeletal muscle and cartilage in the mandibular archJ R Chin
Department of Anatomy, University of California, San Francisco 94143 0750, USA
Development 124:1519-30. 1997..Our data suggest that matrix metalloproteinases play a pivotal role in the morphogenesis of structures derived from epithelium (oral sulcus), cranial paraxial mesoderm (tongue) and cranial neural crest (Meckel's cartilage)...
- Expression of matrix metalloproteinases and tissue inhibitors of metalloproteinases in the mouse uterus during the peri-implantation periodS K Das
Department of Molecular and Integrative Physiology, University of Kansas Medical Center, Kansas City 66160, USA
Dev Genet 21:44-54. 1997..and spatial expression of mRNAs for four matrix metalloproteinases (MMPs; MMP-2 [gelatinase A], MMP-3 [stromelysin 1], MMPs; MMP-2 [gelatinase B], and MMP-13 [collagenase 3]) and tissue inhibitors of metalloproteinases (TIMPs; ..
- Inhibition of plasminogen activators or matrix metalloproteinases prevents cardiac rupture but impairs therapeutic angiogenesis and causes cardiac failureS Heymans
Center for Transgene Technology, Flanders Interuniversity, Leuven, Belgium
Nat Med 5:1135-42. 1999....
- Stromelysin-1 (MMP-3) expression driven by a macrophage-specific promoter results in reduced viability in transgenic miceR P Fabunmi
Lipid Metabolism Unit, Massachusetts General Hospital, GRJ 1328, 55 Fruit Street, Boston, MA 02114, USA
Atherosclerosis 148:375-86. 2000....
- The up-regulation of stromelysin-1 (MMP-3) in a spontaneously demyelinating transgenic mouse precedes onset of diseaseCheryl A D'Souza
Department of Structural Biology, The Hospital for Sick Children, Toronto, Canada
J Biol Chem 277:13589-96. 2002..Thus, in this transgenic model of demyelinating disease up-regulation of DM20, MMP-3, and TIMP-1 represent important changes in the chemical pathogenesis in brain, which precede the onset of disease...
- Matrix metalloproteinases regulate mesonephric cell migration in developing XY gonads which correlates with the inhibition of tissue inhibitor of metalloproteinase-3 by SryKoichiro Nishino
Laboratory of Applied Genetics, Graduate School of Agricultural and Life Sciences, University of Tokyo, 1 1 1, Yayoi, Bunkyo ku, Tokyo 113 8657, Japan
Dev Growth Differ 44:35-43. 2002..These findings are an important clue for the elucidation of testicular formation in developing gonads...
- Site-specific inductive and inhibitory activities of MMP-2 and MMP-3 orchestrate mammary gland branching morphogenesisBryony S Wiseman
Department of Anatomy, University of California, San Francisco, CA 94143 0452, USA
J Cell Biol 162:1123-33. 2003..Nevertheless, the mammary gland is able to develop lactational competence in MMP mutant mice. Thus, specific MMPs refine the mammary branching pattern by distinct mechanisms during mammary gland branching morphogenesis...
- Structural alterations at the neuromuscular junctions of matrix metalloproteinase 3 null mutant miceM VanSaun
Department of Anatomy and Cell Biology, University of Kansas Medical Center, Kansas City, KS 66160, USA
J Neurocytol 32:1129-42. 2003..Antibodies to matrix metalloproteinase 3 (MMP3) recognize molecules at the frog neuromuscular junction, and MMP3 can remove agrin from synaptic ..
- Expression analysis of the entire MMP and TIMP gene families during mouse tissue developmentRobert K Nuttall
School of Biological Sciences, University of East Anglia, Norwich NR4 7TJ, UK
FEBS Lett 563:129-34. 2004....
- A protective role for matrix metalloproteinase-3 in squamous cell carcinomaLisa J McCawley
Department of Cancer Biology, Division of Dermatology, Vanderbilt University, Nashville, Tennessee 37232 6840, USA
Cancer Res 64:6965-72. 2004..We propose that MMP-3 is expressed as a protective response and plays an important role in host defense during SCC tumorigenesis...
- Lhx2-/- mice develop liver fibrosisEwa Wandzioch
Umeå Center for Molecular Medicine, Umea University, 901 87 Umea, Sweden
Proc Natl Acad Sci U S A 101:16549-54. 2004..This study establishes a spontaneous and reproducible animal model for hepatic fibrosis and reveals that Lhx2 expression in HSCs is important for proper cellular organization and differentiation of the liver...
- Matrix metalloproteinases 2 and 9 are dispensable for pancreatic islet formation and function in vivoSabina E Perez
Diabetes Center, Department of Medicine, University of California, San Francisco, California, 94143 0573, USA
Diabetes 54:694-701. 2005..However, islet formation is unaffected in transgenic mice with modified tissue inhibitor of metalloproteinase-1 (TIMP1) levels, suggesting that MMP activity may contribute little to islet morphogenesis in vivo...
- Divergent effects of matrix metalloproteinases 3, 7, 9, and 12 on atherosclerotic plaque stability in mouse brachiocephalic arteriesJason L Johnson
Bristol Heart Institute, University of Bristol, Bristol BS2 8HW, United Kingdom
Proc Natl Acad Sci U S A 102:15575-80. 2005..These data demonstrate that MMPs are directly involved in atherosclerotic plaque destabilization and clearly show that members of the MMP family have widely differing effects on atherogenesis...
- Stage-specific action of matrix metalloproteinases influences progressive hereditary kidney diseaseMichael Zeisberg
Center for Matrix Biology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts, USA
PLoS Med 3:e100. 2006..The pathological mechanisms by which such mutations lead to eventual kidney failure are not completely understood...
- Microarray analysis reveals the role of matrix metalloproteinases in mouse experimental autoimmune myocarditis induced by cardiac myosin peptidesQizhu Tang
Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan, PR China
Cell Mol Biol Lett 12:176-91. 2007..This indicates that MMPs may act as major regulators of the cytokine profile. Together, these findings provide new insight into the molecular events associated with the mechanism of the autoimmune genesis of myocarditis...
- Osteoactivin fragments produced by ectodomain shedding induce MMP-3 expression via ERK pathway in mouse NIH-3T3 fibroblastsHarumi Furochi
Department of Nutritional Physiology, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, Japan
FEBS Lett 581:5743-50. 2007..Our results suggest that the extracellular fragments of osteoactivin produced by shedding act as a growth factor to induce MMP-3 expression via the ERK pathway in fibroblasts...
- Articular cartilage and biomechanical properties of the long bones in Frzb-knockout miceRik J U Lories
Laboratory for Skeletal Development and Joint Disorders, Department of Rheumatology, University Hospitals Leuven, Katholieke Universiteit Leuven, Herestraat 49, Leuven, Belgium
Arthritis Rheum 56:4095-103. 2007..In particular, polymorphisms in the FRZB gene, a secreted WNT antagonist, have been associated with osteoarthritis. The aim of this study was to examine cartilage and bone in Frzb(-/-) mice...
- Profibrinolytic effects of metalloproteinases during skin wound healing in the absence of plasminogenKirsty A Green
Finsen Laboratory, Rigshospitalet, Copenhagen Biocenter, Copenhagen, Denmark
J Invest Dermatol 128:2092-101. 2008..Furthermore, these in vivo data reveal that galardin-sensitive metalloproteinases mediate compensatory fibrinolysis to facilitate wound healing in the absence of plasmin...
- uPARAP expression during murine lung developmentLeah Smith
Division of Pulmonary and Critical Care Medicine, Department of Medicine, Harborview Medical Center, University of Washington, Box 359640, 325 9th Ave, Seattle, WA 98104, USA
Gene Expr Patterns 8:486-93. 2008..Finally, we compared lung development between wild-type and uPARAP(-/-) mice, and found no significant histologic differences, indicating the presence of alternative collagen degradation pathways during murine lung development...
- Scleraxis is required for cell lineage differentiation and extracellular matrix remodeling during murine heart valve formation in vivoAgata K Levay
Department of Molecular and Cellular Pharmacology, Leonard M Miller School of Medicine, University of Miami, Miami, FL 33101, USA
Circ Res 103:948-56. 2008..Collectively, our studies have identified an in vivo requirement for scx during valvulogenesis and demonstrate its role in cell lineage differentiation and matrix distribution in remodeling valve structures...
- Endogenous matrix metalloproteinase (MMP)-3 and MMP-9 promote the differentiation and migration of adult neural progenitor cells in response to chemokinesBasam Z Barkho
Department of Neurosciences, University of New Mexico School of Medicine, Albuquerque, New Mexico 87131, USA
Stem Cells 26:3139-49. 2008..Thus, endogenous MMPs expressed by aNPCs are important for mediating their neurogenic response to extrinsic signals...
- Aging-related loss of the chromatin protein HMGB2 in articular cartilage is linked to reduced cellularity and osteoarthritisNoboru Taniguchi
Division of Arthritis Research, The Scripps Research Institute, La Jolla, CA 92037, USA
Proc Natl Acad Sci U S A 106:1181-6. 2009..Aging is associated with a loss of HMGB2 expression and reduced cellularity, and this contributes to the development of OA...
- Roles of a prostaglandin E-type receptor, EP3, in upregulation of matrix metalloproteinase-9 and vascular endothelial growth factor during enhancement of tumor metastasisHideki Amano
Department of Pharmacology, Kitasato University School of Medicine, Kanagawa, Japan
Cancer Sci 100:2318-24. 2009..An EP3 receptor antagonist may be useful to protect against tumor metastasis...
- Isolation and characterization of human monoclonal antibodies specific to MMP-1A, MMP-2 and MMP-3Stefanie Pfaffen
ETH Zürich HCI G396, Institute of Pharmaceutical Sciences, Department of Chemistry and Applied Biosciences, Wolfgang Pauli Strasse 10, CH 8093 Zurich, Switzerland
Exp Cell Res 316:836-47. 2010..g., liver). The new antibodies may serve as building blocks for the development of antibody-based therapy strategies in mouse models of pathology...
- Transcriptional regulation of endochondral ossification by HIF-2alpha during skeletal growth and osteoarthritis developmentTaku Saito
Sensory and Motor System Medicine, University of Tokyo, Hongo, Bunkyo ku, Tokyo, Japan
Nat Med 16:678-86. 2010..Hence, HIF-2alpha is a central transactivator that targets several crucial genes for endochondral ossification and may represent a therapeutic target for osteoarthritis...
- Stromelysin-1 (MMP-3) is a target and a regulator of Wnt1-induced epithelial-mesenchymal transition (EMT)Laurence Blavier
Division of Hematology Oncology, Department of Pediatrics, USC Keck School of Medicine, Los Angeles, CA, USA
Cancer Biol Ther 10:198-208. 2010..These results suggest that MMP-3 is both a direct transcriptional target and a necessary contributor of the Wnt/β-catenin signaling pathway...
- Melatonin protects against endometriosis via regulation of matrix metalloproteinase-3 and an apoptotic pathwaySumit Paul
Department of Physiology, Indian Institute of Chemical Biology, Kolkata, India
J Pineal Res 49:156-68. 2010..Melatonin suppressed MMP-3 activity and amplified apoptosis while regressing endometriosis through a caspase-3 mediated pathway. Thus, melatonin may be a therapeutic agent for resolving endometriosis...
- Altered spatiotemporal expression of collagen types I, III, IV, and VI in Lpar3-deficient peri-implantation mouse uterusHonglu Diao
Department of Physiology and Pharmacology, College of Veterinary Medicine, University of Georgia, Athens, Georgia 30602, USA
Biol Reprod 84:255-65. 2011..These results demonstrate that pathways downstream of LPA3 are involved in the dynamic remodeling of ECM in the peri-implantation uterus...
- Matrix metalloproteinase (MMP)-3 activates MMP-9 mediated vascular smooth muscle cell migration and neointima formation in miceJason L Johnson
Bristol Heart Institute, University of Bristol, Bristol, United Kingdom
Arterioscler Thromb Vasc Biol 31:e35-44. 2011..We therefore investigated the effect of MMP-3 knockout on neointima formation after carotid ligation in vivo and VSMC migration in vitro...
- Barx2 and Fgf10 regulate ocular glands branching morphogenesis by controlling extracellular matrix remodelingCindy Tsau
The Neurosciences Institute, San Diego, CA 92121, USA
Development 138:3307-17. 2011..Based on our data, we propose a functional network involving Barx2, Fgf10 and MMPs that plays an essential role in regulating branching morphogenesis of the ocular glands...
- Phenotypic alterations in fos-transgenic mice correlate with changes in Fos/Jun-dependent collagenase type I expression. Regulation of mouse metalloproteinases by carcinogens, tumor promoters, cAMP, and Fos oncoproteinS Gack
Kernforschungszentrum Karlsruhe, Institut fur Genetik, Federal Republic of Germany
J Biol Chem 269:10363-9. 1994..These results identify collagenase I as a Fos-regulated gene in vivo and suggest a possible role for Fos/Jun heterodimers in establishing the pathological phenotype of c-fos transgenic mice...
- Assignment of the mouse ataxia-telangiectasia gene (Atm) to mouse chromosome 9Y Xia
Department of Medicine, 47 123 Center for the Health Sciences, UCLA, Los Angeles, California 90095 1679, USA
Mamm Genome 7:554-5. 1996
- Temporospatial distribution of matrix metalloproteinase and tissue inhibitors of matrix metalloproteinases during murine secondary palate morphogenesisJ Morris-Wiman
Department of Orthodontics, College of Dentistry, University of Florida, Gainesville 32610 0444, USA
Anat Embryol (Berl) 202:129-41. 2000..These results provide support for the idea that temporospatially controlled interactions between MMPs and their substrates may be pivotal in modulating events in palatal morphogenesis...
- TGF-beta3-induced palatogenesis requires matrix metalloproteinasesL Blavier
Division of Hematology Oncology, Department of Pediatrics, Childrens Hospital Los Angeles and the Keck School of Medicine of the University of Southern California, Los Angeles, California 90027, USA
Mol Biol Cell 12:1457-66. 2001..Our observations indicate for the first time that the proteolytic degradation of the ECM by MMPs is a necessary step for palatal fusion...
- EPITHELIAL/MESENCHYMAL INTERACTIONS IN LUNG DEVELOPMENTFarrah Kheradmand; Fiscal Year: 2002..Michael Mafthay, Carol Basbaum, and Gerald Cunha, all senior faculty members of Division of Pulmonary and Department of Anatomy at UCSF. (End of Abstract) ..
- Mechanisms of Myocardial Radiofrequency Scar ExpansionRupak Mukherjee; Fiscal Year: 2004..abstract_text> ..
- Mast Cell Role in Masseter Muscle RepairJOYCE MORRIS WIMAN; Fiscal Year: 2005....
- The Mechanism of IVIG Action in PemphigusZhi Liu; Fiscal Year: 2006..The overall goal of this project is to study the mechanisms of WIG action in autoantibody-mediated diseases and develop novel therapies to replace current immunosuppressive treatments, which confer severe side effects. ..
- The Role of Proteinases in Experimental AsthmaFarrah Kheradmand; Fiscal Year: 2006..Together these findings will substantially contribute to the understanding of regulation of Th2 immunity and will provide new approaches for the treatment of asthma. [unreadable] [unreadable] [unreadable]..
- The Role of Proteases in Lung Inflammation & RemodelingFarrah Kheradmand; Fiscal Year: 2007..This work may serve as the foundation for future therapeutic studies that target a broad range of asthmatic patients. ..
- Viral-induced T Cell Responses in COPD ExacerbationFarrah Kheradmand; Fiscal Year: 2009....
- Immune modulators of inflammation in servere COPDFarrah Kheradmand; Fiscal Year: 2010..In this application, we will study the role of a subset of cells in the immune system called T helper cells to determine if they could be responsible for the destruction of lung in subjects with COPD and emphysema. ..