Gene Symbol: Stra6
Description: stimulated by retinoic acid gene 6
Alias: AI891933, receptor for retinol uptake STRA6, stimulated by retinoic acid gene 6 protein, retinoic acid-responsive protein, retinol-binding protein receptor STRA6
Species: mouse
Products:     Stra6

Top Publications

  1. Bouillet P, Sapin V, Chazaud C, Messaddeq N, Decimo D, Dolle P, et al. Developmental expression pattern of Stra6, a retinoic acid-responsive gene encoding a new type of membrane protein. Mech Dev. 1997;63:173-86 pubmed
    ..A new retinoic acid-inducible gene, Stra6, has been identified in P19 embryonal carcinoma cells using a subtractive hybridization cDNA cloning technique...
  2. Alapatt P, Guo F, Komanetsky S, Wang S, Cai J, Sargsyan A, et al. Liver retinol transporter and receptor for serum retinol-binding protein (RBP4). J Biol Chem. 2013;288:1250-65 pubmed publisher
    ..The only known high affinity receptor for RBP4, Stra6, is not expressed in the liver...
  3. Ruiz A, Mark M, Jacobs H, Klopfenstein M, Hu J, Lloyd M, et al. Retinoid content, visual responses, and ocular morphology are compromised in the retinas of mice lacking the retinol-binding protein receptor, STRA6. Invest Ophthalmol Vis Sci. 2012;53:3027-39 pubmed publisher
    We report generation of a mouse model in which the STRA6 gene has been disrupted functionally to facilitate the study of visual responses, changes in ocular morphology, and retinoid processing under STRA6 protein deficiency...
  4. Berry D, Jin H, Majumdar A, Noy N. Signaling by vitamin A and retinol-binding protein regulates gene expression to inhibit insulin responses. Proc Natl Acad Sci U S A. 2011;108:4340-5 pubmed publisher
    ..RBP) and is transported into cells by a membrane protein termed "stimulated by retinoic acid 6" (STRA6)...
  5. Bouillet P, Oulad Abdelghani M, Vicaire S, Garnier J, Schuhbaur B, Dolle P, et al. Efficient cloning of cDNAs of retinoic acid-responsive genes in P19 embryonal carcinoma cells and characterization of a novel mouse gene, Stra1 (mouse LERK-2/Eplg2). Dev Biol. 1995;170:420-33 pubmed
    ..We also report the sequence and expression pattern in mouse embryos and adult tissues of one of these novel RA-inducible genes, Stra1, and show that it corresponds to the mouse ligand for the Cek5 receptor protein-tyrosine kinase. ..
  6. Sapin V, Dolle P, Hindelang C, Kastner P, Chambon P. Defects of the chorioallantoic placenta in mouse RXRalpha null fetuses. Dev Biol. 1997;191:29-41 pubmed
    ..Thus, placental defects could represent an extraembryonic cause of lethality for RXRalpha null mutant fetuses, in addition to the previously described embryonic cardiac defects. ..
  7. Kim Y, Wassef L, Hamberger L, Piantedosi R, Palczewski K, Blaner W, et al. Retinyl ester formation by lecithin: retinol acyltransferase is a key regulator of retinoid homeostasis in mouse embryogenesis. J Biol Chem. 2008;283:5611-21 pubmed
    ..acts together with Cyp26A1, one of the enzymes that catalyze the degradation of retinoic acid, and possibly with STRA6, the recently identified cell surface receptor for retinol-RBP, in maintaining adequate levels of retinoids in ..
  8. Tan L, Wray A, Ross A. Oral vitamin A and retinoic acid supplementation stimulates antibody production and splenic Stra6 expression in tetanus toxoid-immunized mice. J Nutr. 2012;142:1590-5 pubmed publisher
    ..Recent studies have identified Stimulated by Retinoic Acid-6 (Stra6) as the cell membrane receptor for retinol-binding protein (RBP) in many organs, including spleen...
  9. Billings S, Pierzchalski K, Butler Tjaden N, Pang X, Trainor P, KANE M, et al. The retinaldehyde reductase DHRS3 is essential for preventing the formation of excess retinoic acid during embryonic development. FASEB J. 2013;27:4877-89 pubmed publisher
    ..These data demonstrate that the reduction of retinaldehyde by DHRS3 is critical for preventing formation of excess ATRA during embryonic development...

More Information


  1. Sapin V, Bouillet P, Oulad Abdelghani M, Dastugue B, Chambon P, Dolle P. Differential expression of retinoic acid-inducible (Stra) genes during mouse placentation. Mech Dev. 2000;92:295-9 pubmed
    ..Three other Stra genes, including the AP-2-related gene AP-2gamma, are differentially expressed in the trophoblastic cell lineage. Thus, retinoids may regulate various signaling pathways in specific placental cell-types. ..
  2. Chen C, Ke L, Chan H, Lee A, Lin K, Chu C, et al. Electronegative low density lipoprotein induces renal apoptosis and fibrosis: STRA6 signaling involved. J Lipid Res. 2016;57:1435-46 pubmed publisher
    ..Stimulated by retinoic acid 6" (STRA6), one retinol-binding protein 4 receptor, was recently identified to regulate retinoid homeostasis...
  3. Amengual J, Zhang N, Kemerer M, Maeda T, Palczewski K, von Lintig J. STRA6 is critical for cellular vitamin A uptake and homeostasis. Hum Mol Genet. 2014;23:5402-17 pubmed publisher
    ..This receptor, identified as the Stimulated by retinoic acid gene 6 (Stra6) gene product, is highly expressed in epithelia that constitute blood-tissue barriers...
  4. Gliniak C, Brown J, Noy N. The retinol-binding protein receptor STRA6 regulates diurnal insulin responses. J Biol Chem. 2017;292:15080-15093 pubmed publisher
    ..can be recognized by a cell-surface receptor known as stimulated by retinoic acid 6 (STRA6), which transports retinol into cells...
  5. Kelly M, Widjaja Adhi M, Palczewski G, von Lintig J. Transport of vitamin A across blood-tissue barriers is facilitated by STRA6. FASEB J. 2016;30:2985-95 pubmed publisher
    ..Emerging evidence suggests that membrane protein, STRA6 (stimulated by retinoic acid 6), is the RBP4 receptor and vitamin A channel; however, the role of STRA6 in vitamin ..
  6. Zemany L, Kraus B, Norseen J, Saito T, Peroni O, Johnson R, et al. Downregulation of STRA6 in adipocytes and adipose stromovascular fraction in obesity and effects of adipocyte-specific STRA6 knockdown in vivo. Mol Cell Biol. 2014;34:1170-86 pubmed publisher
    ..protein 4 (RBP4) causes insulin resistance, we studied the role of the high-affinity receptor for RBP4, STRA6 (stimulated by retinoic acid), in insulin resistance and obesity...
  7. Terra R, Wang X, Hu Y, Charpentier T, Lamarre A, Zhong M, et al. To investigate the necessity of STRA6 upregulation in T cells during T cell immune responses. PLoS ONE. 2013;8:e82808 pubmed publisher
    Our earlier study revealed that STRA6 (stimulated by retinoic acid gene 6) was up-regulated within 3 h of TCR stimulation...
  8. Berry D, Jacobs H, Marwarha G, Gely Pernot A, O Byrne S, DeSantis D, et al. The STRA6 receptor is essential for retinol-binding protein-induced insulin resistance but not for maintaining vitamin A homeostasis in tissues other than the eye. J Biol Chem. 2013;288:24528-39 pubmed publisher
    The plasma membrane protein STRA6 is thought to mediate uptake of retinol from its blood carrier retinol-binding protein (RBP) into cells and to function as a surface receptor that, upon binding of holo-RBP, activates a JAK/STAT cascade...
  9. Carrera S, Cuadrado Castano S, Samuel J, Jones G, Villar E, Lee S, et al. Stra6, a retinoic acid-responsive gene, participates in p53-induced apoptosis after DNA damage. Cell Death Differ. 2013;20:910-9 pubmed publisher
    b>Stra6 is the retinoic acid (RA)-inducible gene encoding the cellular receptor for holo-retinol binding protein...
  10. Berry D, Croniger C, Ghyselinck N, Noy N. Transthyretin blocks retinol uptake and cell signaling by the holo-retinol-binding protein receptor STRA6. Mol Cell Biol. 2012;32:3851-9 pubmed publisher
    ..At target cells, holo-RBP is recognized by STRA6, a plasma membrane protein that serves a dual role: it mediates uptake of retinol from extracellular RBP into ..
  11. Muenzner M, Tuvia N, Deutschmann C, Witte N, Tolkachov A, Valai A, et al. Retinol-binding protein 4 and its membrane receptor STRA6 control adipogenesis by regulating cellular retinoid homeostasis and retinoic acid receptor ? activity. Mol Cell Biol. 2013;33:4068-82 pubmed publisher
    ..Circulating retinol-binding protein 4 (RBP4) and its membrane receptor STRA6 coordinate cellular retinol uptake...
  12. Adams M, Belyaeva O, Wu L, Kedishvili N. The retinaldehyde reductase activity of DHRS3 is reciprocally activated by retinol dehydrogenase 10 to control retinoid homeostasis. J Biol Chem. 2014;289:14868-80 pubmed publisher
    ..The mutually activating interaction between the two related proteins may represent a highly sensitive and conserved mechanism for precise control over the rate of retinoic acid biosynthesis. ..
  13. Cobb J, Duboule D. Comparative analysis of genes downstream of the Hoxd cluster in developing digits and external genitalia. Development. 2005;132:3055-67 pubmed
    ..e. the digits and the penis/clitoris. ..
  14. Chazaud C, Bouillet P, Oulad Abdelghani M, Dolle P. Restricted expression of a novel retinoic acid responsive gene during limb bud dorsoventral patterning and endochondral ossification. Dev Genet. 1996;19:66-73 pubmed
    Using a differential substractive hybridization cloning procedure we have recently identified Stra6 as a novel retinoic acid-induced gene in murine P19 embryonal carcinoma cells...