Stmn1

Summary

Gene Symbol: Stmn1
Description: stathmin 1
Alias: 19k, Lag, Lap18, Op18, P18, P19, Pig, Pp17, Pp18, Pp19, Pr22, Smn, stathmin, leukemia-associated gene protein, leukemia-associated phosphoprotein p18, metablastin, oncoprotein 18, phosphoprotein p19, prosolin
Species: mouse
Products:     Stmn1

Top Publications

  1. Ghosh R, Gu G, Tillman E, Yuan J, Wang Y, Fazli L, et al. Increased expression and differential phosphorylation of stathmin may promote prostate cancer progression. Prostate. 2007;67:1038-52 pubmed
    ..b>Stathmin expression and phosphorylation patterns were analyzed in mouse and human PCa cell lines as well as in human PCa ..
  2. Giampietro C, Luzzati F, Gambarotta G, Giacobini P, Boda E, Fasolo A, et al. Stathmin expression modulates migratory properties of GN-11 neurons in vitro. Endocrinology. 2005;146:1825-34 pubmed
    Expression of stathmin, a microtubule-associated cytoplasmic protein, prominently localized in neuroproliferative zones and neuronal migration pathways in brain, was investigated in the GnRH neuroendocrine system in vivo and the function ..
  3. Beretta L, Dobransky T, Sobel A. Multiple phosphorylation of stathmin. Identification of four sites phosphorylated in intact cells and in vitro by cyclic AMP-dependent protein kinase and p34cdc2. J Biol Chem. 1993;268:20076-84 pubmed
    b>Stathmin is a ubiquitous, highly conserved phosphoprotein which most likely acts as a relay integrating various intracellular pathways regulating cell proliferation, differentiation, and functions...
  4. Belletti B, Pellizzari I, Berton S, Fabris L, Wolf K, Lovat F, et al. p27kip1 controls cell morphology and motility by regulating microtubule-dependent lipid raft recycling. Mol Cell Biol. 2010;30:2229-40 pubmed publisher
    ..When located in the cytoplasm, p27 binds Op18/stathmin (stathmin), a microtubule (MT)-destabilizing protein, and restrains its activity...
  5. Martel G, Nishi A, Shumyatsky G. Stathmin reveals dissociable roles of the basolateral amygdala in parental and social behaviors. Proc Natl Acad Sci U S A. 2008;105:14620-5 pubmed publisher
    ..We recently demonstrated that mice without an inhibitor of microtubules, stathmin, a gene enriched in BLA-associated circuitry, have deficiency in innate and learned fear...
  6. Zahedi K, Revelo M, Barone S, Wang Z, Tehrani K, Citron D, et al. Stathmin-deficient mice develop fibrosis and show delayed recovery from ischemic-reperfusion injury. Am J Physiol Renal Physiol. 2006;290:F1559-67 pubmed
    In kidneys subjected to ischemic reperfusion injury (IRI) stathmin, a tubulin-binding protein involved in the regulation of mitosis, is expressed in dedifferentiated and proliferating renal tubule cells during the recovery phase...
  7. Yoshie M, Tamura K, Hara T, Kogo H. Expression of stathmin family genes in the murine uterus during early pregnancy. Mol Reprod Dev. 2006;73:164-72 pubmed
    b>Stathmin, a cytosolic phosphoprotein that regulates microtubule dynamics during cell-cycle progression, is abundantly expressed at embryo implantation sites in rats...
  8. Liu A, Stadelmann C, Moscarello M, Bruck W, Sobel A, Mastronardi F, et al. Expression of stathmin, a developmentally controlled cytoskeleton-regulating molecule, in demyelinating disorders. J Neurosci. 2005;25:737-47 pubmed
    ..In this study, we report the increased expression of stathmin, a developmentally regulated tubulin-binding protein, in the brains of patients with multiple sclerosis (MS)...
  9. Baldassarre G, Belletti B, Nicoloso M, Schiappacassi M, Vecchione A, Spessotto P, et al. p27(Kip1)-stathmin interaction influences sarcoma cell migration and invasion. Cancer Cell. 2005;7:51-63 pubmed
    ..This p27(kip1) activity is due to its ability to bind and impair the function of the MT-destabilizing protein stathmin. Accordingly, upregulation of p27(kip1) or downregulation of stathmin expression results in the inhibition of ..

More Information

Publications73

  1. Schubart U, Yu J, Amat J, Wang Z, Hoffmann M, Edelmann W. Normal development of mice lacking metablastin (P19), a phosphoprotein implicated in cell cycle regulation. J Biol Chem. 1996;271:14062-6 pubmed
    b>Metablastin, also called P19, stathmin, prosolin, Lap18, and oncoprotein18, is a highly conserved cytosolic protein that undergoes extracellular factor- and cell cycle-regulated serine phosphorylation and developmentally regulated ..
  2. Liedtke W, Leman E, Fyffe R, Raine C, Schubart U. Stathmin-deficient mice develop an age-dependent axonopathy of the central and peripheral nervous systems. Am J Pathol. 2002;160:469-80 pubmed
    b>Stathmin is a cytosolic protein that binds tubulin and destabilizes cellular microtubules, an activity regulated by phosphorylation...
  3. Ahn J, Murphy M, Kratowicz S, Wang A, Levine A, George D. Down-regulation of the stathmin/Op18 and FKBP25 genes following p53 induction. Oncogene. 1999;18:5954-8 pubmed
    ..Among the negative p53-response genes revealed by our screening protocols are those encoding stathmin (Op18), a tubulin-associated protein implicated in cell signaling pathways, and an FK506/rapamycin-binding ..
  4. Ozon S, Byk T, Sobel A. SCLIP: a novel SCG10-like protein of the stathmin family expressed in the nervous system. J Neurochem. 1998;70:2386-96 pubmed
    b>Stathmin is a cytosolic phosphoprotein previously described as a ubiquitous relay integrating various signaling pathways...
  5. Martel G, Hevi C, Wong A, Zushida K, Uchida S, Shumyatsky G. Murine GRPR and stathmin control in opposite directions both cued fear extinction and neural activities of the amygdala and prefrontal cortex. PLoS ONE. 2012;7:e30942 pubmed publisher
    ..These mutant mice are based on fear memory-related genes, stathmin and gastrin-releasing peptide receptor (GRPR)...
  6. Ringhoff D, Cassimeris L. Stathmin regulates centrosomal nucleation of microtubules and tubulin dimer/polymer partitioning. Mol Biol Cell. 2009;20:3451-8 pubmed publisher
    b>Stathmin is a microtubule-destabilizing protein ubiquitously expressed in vertebrates and highly expressed in many cancers...
  7. Shumyatsky G, Malleret G, Shin R, Takizawa S, Tully K, Tsvetkov E, et al. stathmin, a gene enriched in the amygdala, controls both learned and innate fear. Cell. 2005;123:697-709 pubmed
    Little is known about the molecular mechanisms of learned and innate fear. We have identified stathmin, an inhibitor of microtubule formation, as highly expressed in the lateral nucleus (LA) of the amygdala as well as in the thalamic and ..
  8. Pampfer S, Fan W, Schubart U, Pollard J. Differential mRNA expression of the phosphoprotein p19/SCG10 gene family in mouse preimplantation embryos, uterus, and placenta. Reprod Fertil Dev. 1992;4:205-11 pubmed
    The p19/SCG10 gene family encodes two structurally related cellular proteins that are implicated in signal transduction during differentiation of mammalian cells...
  9. Inman M, Levy S, Mock B, Owens G. Gene organization and chromosome location of the neural-specific RNA binding protein Elavl4. Gene. 1998;208:139-45 pubmed
    ..The high degree of sequence conservation between the Hu proteins suggests that the exon organization of all the Hu protein genes will be similar, if not identical, to the Elavl4 gene. ..
  10. Rubin C, French D, Atweh G. Stathmin expression and megakaryocyte differentiation: a potential role in polyploidy. Exp Hematol. 2003;31:389-97 pubmed
    ..b>Stathmin is a major microtubule-regulatory protein that plays an important role in the regulation of the mitotic spindle...
  11. Petry F, McClive P, Botto M, Morley B, Morahan G, Loos M. The mouse C1q genes are clustered on chromosome 4 and show conservation of gene organization. Immunogenetics. 1996;43:370-6 pubmed
    ..Southern blot analysis of chromosomal DNA from 14 vertebrate species demonstrated highest similarity between the C1qB genes, followed by C1qC and finally C1qA. ..
  12. Fabris L, Berton S, Pellizzari I, Segatto I, D Andrea S, Armenia J, et al. p27kip1 controls H-Ras/MAPK activation and cell cycle entry via modulation of MT stability. Proc Natl Acad Sci U S A. 2015;112:13916-21 pubmed publisher
    ..This latter function is exerted by modulating the activity of stathmin, an MT-destabilizing protein, and by direct binding to MTs...
  13. Calvo A, Perez Stable C, Segura V, Catena R, Guruceaga E, Nguewa P, et al. Molecular characterization of the Ggamma-globin-Tag transgenic mouse model of hormone refractory prostate cancer: comparison to human prostate cancer. Prostate. 2010;70:630-45 pubmed publisher
    ..Overexpression of stathmin-1, whose expression was increased in human metastatic prostate tumors, was validated in Ggamma-globin-Tag tumors ..
  14. Langenickel T, Olive M, Boehm M, San H, Crook M, Nabel E. KIS protects against adverse vascular remodeling by opposing stathmin-mediated VSMC migration in mice. J Clin Invest. 2008;118:3848-59 pubmed publisher
    Vascular proliferative diseases are characterized by VSMC proliferation and migration. Kinase interacting with stathmin (KIS) targets 2 key regulators of cell proliferation and migration, the cyclin-dependent kinase inhibitor p27Kip1 and ..
  15. Ganguly K, Favor J, Neuhäuser Klaus A, Sandulache R, Puk O, Beckers J, et al. Novel allele of crybb2 in the mouse and its expression in the brain. Invest Ophthalmol Vis Sci. 2008;49:1533-41 pubmed publisher
    ..Moreover, expression analysis of Crybb2 identified for the first time distinct regions of expression in the brain, and the differential expression analysis points to the participation of Ca2+ in the corresponding pathologic processes. ..
  16. Yamada K, Matsuzaki S, Hattori T, Kuwahara R, Taniguchi M, Hashimoto H, et al. Increased stathmin1 expression in the dentate gyrus of mice causes abnormal axonal arborizations. PLoS ONE. 2010;5:e8596 pubmed publisher
    ..These results suggest that up-regulation of stathmin1 in the dentate gyrus, secondary to PACAP deficiency, may create abnormal neuronal circuits that cause abnormal behavior. ..
  17. Santamaria E, Mora M, Munoz J, Sánchez Quiles V, Fernández Irigoyen J, Prieto J, et al. Regulation of stathmin phosphorylation in mouse liver progenitor-29 cells during proteasome inhibition. Proteomics. 2009;9:4495-506 pubmed publisher
    ..Alterations in NDRG1 and stathmin suggest new mechanisms associated to proteasome inhibitor-induced apoptosis in MLP-29 cells...
  18. Liang X, Choi Y, Sackett D, Park J. Nitrosoureas inhibit the stathmin-mediated migration and invasion of malignant glioma cells. Cancer Res. 2008;68:5267-72 pubmed publisher
    ..b>Stathmin, a microtubule-destabilizing protein that mediates cell cycle progression, can also regulate directed cell ..
  19. Dou Y, Zhao H, Huang T, Zhao S, Liu X, Yu X, et al. STMN1 Promotes Progesterone Production Via StAR Up-regulation in Mouse Granulosa Cells. Sci Rep. 2016;6:26691 pubmed publisher
    b>Stathmin 1 (STMN1) is a biomarker in several types of neoplasms. It plays an important role in cell cycle progression, mitosis, signal transduction and cell migration. In ovaries, STMN1 is predominantly expressed in granulosa cells (GCs)...
  20. Gin D, Kim H, Lee D, Lee S, Seong A, Hwang J, et al. 2,3,7,8-Tetrachlorodibenzo-p-dioxin up-regulates stathmin 1 in the eye: suggestive evidence for the involvement of stathmin 1 in accelerated eye opening in mice induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin. Toxicol Lett. 2010;196:87-94 pubmed publisher
    ..translationally controlled tumor protein (TCTP) and 60S acidic ribosomal protein p2 (RLA2) were reduced, while stathmin 1(STMN1) was increased, at both protein and mRNA levels...
  21. Chen H, Thalmann I, Adams J, Avraham K, Copeland N, Jenkins N, et al. cDNA cloning, tissue distribution, and chromosomal localization of Ocp2, a gene encoding a putative transcription-associated factor predominantly expressed in the auditory organs. Genomics. 1995;27:389-98 pubmed publisher
    We report the cloning of the Ocp2 gene encoding OCP-II from a guinea pig organ-of-Corti cDNA library. The predicted open reading frame encodes a protein of 163 amino acids with an estimated molecular mass of 18.6 kDa...
  22. Hosoya H, Ishikawa K, Dohi N, Marunouchi T. Transcriptional and post-transcriptional regulation of pr22 (Op18) with proliferation control. Cell Struct Funct. 1996;21:237-43 pubmed
    The pr22 gene was isolated as a gene which is expressed in proliferating cells but not in cells which are differentiated or growth-arrested...
  23. Filbert E, Le Borgne M, Lin J, Heuser J, Shaw A. Stathmin regulates microtubule dynamics and microtubule organizing center polarization in activated T cells. J Immunol. 2012;188:5421-7 pubmed publisher
    ..Suspecting that ERK phosphorylates a regulator of microtubules, we next focused on stathmin, a known ERK substrate...
  24. Camoletto P, Colesanti A, Ozon S, Sobel A, Fasolo A. Expression of stathmin and SCG10 proteins in the olfactory neurogenesis during development and after lesion in the adulthood. Brain Res Bull. 2001;54:19-28 pubmed
    b>Stathmin and SCG10 belong to a family of phosphoproteins associated to cell proliferation and differentiation...
  25. Graef I, Wang F, Charron F, Chen L, Neilson J, Tessier Lavigne M, et al. Neurotrophins and netrins require calcineurin/NFAT signaling to stimulate outgrowth of embryonic axons. Cell. 2003;113:657-70 pubmed
    ..The precise parsing of signals for elongation turning and survival could allow independent control of these processes during development. ..
  26. Wen H, Lin Y, Ting C, Lin Chao S, Li H, Hsieh Li H. Stathmin, a microtubule-destabilizing protein, is dysregulated in spinal muscular atrophy. Hum Mol Genet. 2010;19:1766-78 pubmed publisher
    ..Here, we describe a potential link between stathmin and microtubule defects in SMA...
  27. Lin Y, Li C, Shan B, Wang W, Saito S, Xu J, et al. Reduced stathmin-1 expression in natural killer cells associated with spontaneous abortion. Am J Pathol. 2011;178:506-14 pubmed publisher
    ..In this study, the stathmin-1 expression pattern was evaluated in uterine natural killer (uNK) cells purified from CBA/J×DBA/2J matings...
  28. Avraham K, Levanon D, Negreanu V, Bernstein Y, Groner Y, Copeland N, et al. Mapping of the mouse homolog of the human runt domain gene, AML2, to the distal region of mouse chromosome 4. Genomics. 1995;25:603-5 pubmed
  29. Okazaki T, Yoshida B, Avraham K, Wang H, Wuenschell C, Jenkins N, et al. Molecular diversity of the SCG10/stathmin gene family in the mouse. Genomics. 1993;18:360-73 pubmed
    ..protein that shares an amino acid sequence similarity with an 18- to 19-kDa phosphoprotein named stathmin (also called p19, p18, Op18, pp17, prosolin, pp20, 19K, and leukemia-associated phosphoprotein, Lap18), which is ..
  30. Gou J, Jia J, Zhao X, Yi T, Li Z. Identification of stathmin 1 during peri-implantation period in mouse endometrium by a proteomics-based analysis. Biochem Biophys Res Commun. 2015;461:211-6 pubmed publisher
    ..15 proteins were identified, of which stathmin 1, Apo-A1, hnRNP H3, transgelin 2 and arginase 1 were validated by western blotting...
  31. Bichsel K, Hammiller B, Trempus C, Li Y, Hansen L. The epidermal growth factor receptor decreases Stathmin 1 and triggers catagen entry in the mouse. Exp Dermatol. 2016;25:275-81 pubmed publisher
    ..Similarly, Rcc2-regulated mitotic regulator Stathmin 1 was strikingly reduced in control but not Egfr mutant follicles between P17 and P19...
  32. Thorey I, Muth K, Russ A, Otte J, Reffelmann A, von Melchner H. Selective disruption of genes transiently induced in differentiating mouse embryonic stem cells by using gene trap mutagenesis and site-specific recombination. Mol Cell Biol. 1998;18:3081-8 pubmed
    ..Thus, when two of the clones with inducible U3Cre integrations were passaged in the germ line, they generated spatial patterns of beta-Gal expression. ..
  33. Uchida S, Martel G, Pavlowsky A, Takizawa S, Hevi C, Watanabe Y, et al. Learning-induced and stathmin-dependent changes in microtubule stability are critical for memory and disrupted in ageing. Nat Commun. 2014;5:4389 pubmed publisher
    ..In the early phase, stathmin is dephosphorylated, enhancing its microtubule-destabilizing activity by promoting stathmin-tubulin binding, ..
  34. Boekhoorn K, van Dis V, Goedknegt E, Sobel A, Lucassen P, Hoogenraad C. The microtubule destabilizing protein stathmin controls the transition from dividing neuronal precursors to postmitotic neurons during adult hippocampal neurogenesis. Dev Neurobiol. 2014;74:1226-42 pubmed publisher
    ..b>Stathmin is such a MT-destabilizing protein largely restricted to the CNS, and in contrast to its developmental family ..
  35. Koppel J, Rehak P, Baran V, Vesela J, Hlinka D, Manceau V, et al. Cellular and subcellular localization of stathmin during oocyte and preimplantation embryo development. Mol Reprod Dev. 1999;53:306-17 pubmed
    b>Stathmin is a 19 kDa cytosolic phosphoprotein, proposed to act as a relay integrating diverse intracellular signaling pathways involved in regulation of cell proliferation, differentiation, and function...
  36. Schubart U, Xu J, Fan W, Cheng G, Goldstein H, Alpini G, et al. Widespread differentiation stage-specific expression of the gene encoding phosphoprotein p19 (metablastin) in mammalian cells. Differentiation. 1992;51:21-32 pubmed
    b>p19 is a highly conserved 19 kD cytosolic protein that undergoes phosphorylation in response to diverse extracellular factors in mammalian cells. Its expression is abundant in brain and testis and is developmentally regulated...
  37. Berton S, Pellizzari I, Fabris L, D Andrea S, Segatto I, Canzonieri V, et al. Genetic characterization of p27(kip1) and stathmin in controlling cell proliferation in vivo. Cell Cycle. 2014;13:3100-11 pubmed publisher
    ..We recently demonstrated that the microtubule destabilizing protein stathmin is a relevant p27(kip1) binding partner...
  38. Jiang X, Wassif C, Backlund P, Song L, Holtzclaw L, Li Z, et al. Activation of Rho GTPases in Smith-Lemli-Opitz syndrome: pathophysiological and clinical implications. Hum Mol Genet. 2010;19:1347-57 pubmed publisher
    ..Developmental abnormalities of neuronal process formation may contribute to the neurocognitive deficits found in SLOS and may represent a potential target for therapeutic intervention. ..
  39. Xu K, Harrison R. Down-regulation of Stathmin Is Required for the Phenotypic Changes and Classical Activation of Macrophages. J Biol Chem. 2015;290:19245-60 pubmed publisher
    ..Our previous microtubule (MT) proteomic work revealed that the stathmin association with MTs is considerably reduced in activated macrophages, which contain significantly more ..
  40. Strey C, Spellman D, Stieber A, Gonatas J, Wang X, Lambris J, et al. Dysregulation of stathmin, a microtubule-destabilizing protein, and up-regulation of Hsp25, Hsp27, and the antioxidant peroxiredoxin 6 in a mouse model of familial amyotrophic lateral sclerosis. Am J Pathol. 2004;165:1701-18 pubmed
    ..Protein profiling showed dysregulation of Stathmin with a marked decrease of its most acidic and phosphorylated isoform, and up-regulation of heat shock proteins 25 ..
  41. Maucuer A, Camonis J, Sobel A. Stathmin interaction with a putative kinase and coiled-coil-forming protein domains. Proc Natl Acad Sci U S A. 1995;92:3100-4 pubmed
    b>Stathmin is a ubiquitous, cytosolic 19-kDa protein, which is phosphorylated on up to four sites in response to many regulatory signals within cells...
  42. Southwood C, He C, Garbern J, Kamholz J, Arroyo E, Gow A. CNS myelin paranodes require Nkx6-2 homeoprotein transcriptional activity for normal structure. J Neurosci. 2004;24:11215-25 pubmed
    ..CNS white matter and aberrant expression of three genes encoding a paranodal microtubule destabilizing protein, stathmin 1, and the paranodal cell adhesion molecules neurofascin and contactin...
  43. Herron B, Liddell R, Parker A, Grant S, Kinne J, Fisher J, et al. A mutation in stratifin is responsible for the repeated epilation (Er) phenotype in mice. Nat Genet. 2005;37:1210-2 pubmed
    ..Er/+ mice expressed a truncated Sfn protein, which probably contributes to the defects in Er/Er and Er/+ epidermis and to cancer development in Er/+ mice. ..
  44. Ringhoff D, Cassimeris L. Gene expression profiles in mouse embryo fibroblasts lacking stathmin, a microtubule regulatory protein, reveal changes in the expression of genes contributing to cell motility. BMC Genomics. 2009;10:343 pubmed publisher
    b>Stathmin (STMN1) protein functions to regulate assembly of the microtubule cytoskeleton by destabilizing microtubule polymers...
  45. Li Y, Chan P. Identification of the pro-oncogene stathmin/op18 mRNA in the brain of mitochondrial Mn-superoxide dismutase-deficient mice by a modified differential display PCR. Brain Res Mol Brain Res. 1998;55:277-84 pubmed
    ..hybridization and sequencing, and was confirmed to be induced only in the brain of MnSOD-deficient mice, encoded stathmin/op18. The MnSOD deficiency causes oxidative stress and mitochondrial dysfunction...
  46. Lipoldová M, Havelková H, Badalova J, Demant P. Novel loci controlling lymphocyte proliferative response to cytokines and their clustering with loci controlling autoimmune reactions, macrophage function and lung tumor susceptibility. Int J Cancer. 2005;114:394-9 pubmed
    ..The possible relevance of these QTL associations in several different sites of the genome for the immune response, inflammation and tumorigenesis has to be elucidated. ..
  47. Polager S, Ginsberg D. E2F mediates sustained G2 arrest and down-regulation of Stathmin and AIM-1 expression in response to genotoxic stress. J Biol Chem. 2003;278:1443-9 pubmed
    ..the genotoxic agent doxorubicin is E2F-dependent and involves a decrease in expression of two mitotic regulators, Stathmin and AIM-1...
  48. Menon M, Sawada A, Chaturvedi A, Mishra P, Schuster Gossler K, Galla M, et al. Genetic deletion of SEPT7 reveals a cell type-specific role of septins in microtubule destabilization for the completion of cytokinesis. PLoS Genet. 2014;10:e1004558 pubmed publisher
    ..We identified the microtubule depolymerizing protein stathmin as a key molecule aiding in septin-independent cytokinesis, demonstrated that stathmin supplementation is ..
  49. Mock B, Krall M, Padlan C, Dosik J, Schubart U. The gene for Lap18, leukemia-associated phosphoprotein p18 (metablastin), maps to distal mouse chromosome 4. Mamm Genome. 1993;4:461-2 pubmed
  50. Tian X, Tian Y, Sarich N, Wu T, Birukova A. Novel role of stathmin in microtubule-dependent control of endothelial permeability. FASEB J. 2012;26:3862-74 pubmed publisher
    ..This study investigated the involvement of the MT-associated protein stathmin in the mediation of agonist-induced permeability in EC cultures and vascular leak in vivo...
  51. McClive P, Huang D, Morahan G. C57BL/6 and C57BL/10 inbred mouse strains differ at multiple loci on chromosome 4. Immunogenetics. 1994;39:286-8 pubmed
  52. Liu H, Zhang R, Ko S, Oyajobi B, Papasian C, Deng H, et al. Microtubule assembly affects bone mass by regulating both osteoblast and osteoclast functions: stathmin deficiency produces an osteopenic phenotype in mice. J Bone Miner Res. 2011;26:2052-67 pubmed publisher
    ..elucidate the role of microtubules in bone homeostasis, we characterized the skeletal phenotype of mice null for stathmin, an endogenous protein that inhibits microtubule assembly...
  53. Benlhabib H, Herrera J. Expression of the Op18 gene is maintained by the CCAAT-binding transcription factor NF-Y. Gene. 2006;377:177-85 pubmed
    Op18 (Oncoprotein 18, Stathmin) is a mitotic regulator that is highly expressed in many cancers...
  54. Pellet J, Haefliger J, Staple J, Widmann C, Welker E, Hirling H, et al. Spatial, temporal and subcellular localization of islet-brain 1 (IB1), a homologue of JIP-1, in mouse brain. Eur J Neurosci. 2000;12:621-32 pubmed
  55. McClive P, Morahan G. Assignment of the mouse homologues of 6 loci from HSA1p to chromosomes 3 and 4. Genomics. 1994;23:243-6 pubmed
    ..were assigned to distal mouse chromosome 4 in the following order (including MIT microsatellites): (cen)-D4Mit71-Lap18-D4Mit69-C1qB-Plod/T nfr2-Cd30-(tel)...
  56. D Andrea S, Berton S, Segatto I, Fabris L, Canzonieri V, Colombatti A, et al. Stathmin is dispensable for tumor onset in mice. PLoS ONE. 2012;7:e45561 pubmed publisher
    ..protein stathmin is highly expressed in several types of tumor, thus deserving the name of oncoprotein 18. High levels of stathmin expression and/or activity favor the metastatic spreading and mark the most ..
  57. Wen H, Ting C, Liu H, Li H, Lin Chao S. Decreased stathmin expression ameliorates neuromuscular defects but fails to prolong survival in a mouse model of spinal muscular atrophy. Neurobiol Dis. 2013;52:94-103 pubmed publisher
    ..Microtubule defects can be restored by knockdown of the stathmin gene (Stmn), which is upregulated in SMA...
  58. Yeap Y, Ng I, Badrian B, Nguyen T, Yip Y, Dhillon A, et al. c-Jun N-terminal kinase/c-Jun inhibits fibroblast proliferation by negatively regulating the levels of stathmin/oncoprotein 18. Biochem J. 2010;430:345-54 pubmed publisher
    ..actions to regulate cell proliferation, we evaluated a role for the cytosolic protein, STMN (stathmin)/Op18 (oncoprotein 18)...
  59. Zimmerman J, Bui Q, Steingrimsson E, Nagle D, Fu W, Genin A, et al. Cloning and characterization of two vertebrate homologs of the Drosophila eyes absent gene. Genome Res. 1997;7:128-41 pubmed
    ..Our findings support the notion that several families of genes (Pax-6/eyeless, Six-3/sine oculis, and Eya) play related and critical roles in the eye for both files and vertebrates. ..
  60. Zhu X, Kozarsky K, Strahler J, Eckerskorn C, Lottspeich F, Melhem R, et al. Molecular cloning of a novel human leukemia-associated gene. Evidence of conservation in animal species. J Biol Chem. 1989;264:14556-60 pubmed
    We have recently described an 18-kilodalton polypeptide (p18) that is present in much greater abundance in acute leukemic blast cells (myeloid and lymphoid) than in resting or proliferating nonleukemic lymphoid cells or chronic lymphoid ..
  61. Pathak B, Shull G, Jenkins N, Copeland N. Mouse chromosomal location of four Na/H exchanger isoform genes. Genomics. 1996;31:261-3 pubmed
    ..These loci map to previously defined homologous regions between human and mouse chromosomes and provide additional information regarding human/mouse comparative mapping. ..
  62. Akilesh S, Dudley M, Eden P, Roopenian D. Efficient chromosomal mapping of a methylcholanthrene-induced tumor antigen by CTL immunoselection. J Immunol. 2001;167:5143-9 pubmed
    ..1 cM interval on chromosome 4. This region of the mouse genome is rich in tumor-modifier genes and this positioning of Ram1 may thus provide insight into the genetic basis of 3-methycholanthrene-induced tumor Ags. ..
  63. Valle C, Festucci A, Calogero A, Macri P, Mecozzi B, Liberti P, et al. Stage-specific expression of a Schistosoma mansoni polypeptide similar to the vertebrate regulatory protein stathmin. J Biol Chem. 1999;274:33869-74 pubmed
    The ubiquitous vertebrate protein stathmin is expressed and phosphorylated in response to a variety of external and internal signals...
  64. Miyashita H, Kanemura M, Yamazaki T, Abe M, Sato Y. Vascular endothelial zinc finger 1 is involved in the regulation of angiogenesis: possible contribution of stathmin/OP18 as a downstream target gene. Arterioscler Thromb Vasc Biol. 2004;24:878-84 pubmed
    ..Vezf1 AS-ODN downregulated the expression of stathmin/oncoprotein18 (OP18), a microtubule-destabilizing protein, in ECs, whereas transient transfection of Vezf1 cDNA ..