Stk11

Summary

Gene Symbol: Stk11
Description: serine/threonine kinase 11
Alias: AA408040, Lkb1, Par-4, R75140, serine/threonine-protein kinase STK11, liver kinase B1 homolog, serine/threonine-protein kinase 11, serine/threonine-protein kinase LKB1, stk11
Species: mouse
Products:     Stk11

Top Publications

  1. Smith D, Spicer J, Smith A, Swift S, Ashworth A. The mouse Peutz-Jeghers syndrome gene Lkb1 encodes a nuclear protein kinase. Hum Mol Genet. 1999;8:1479-85 pubmed
    The protein kinase gene LKB1 has recently been identified as the gene mutated in the Peutz-Jeghers cancer predisposition syndrome...
  2. Koh H, Toyoda T, Fujii N, Jung M, Rathod A, Middelbeek R, et al. Sucrose nonfermenting AMPK-related kinase (SNARK) mediates contraction-stimulated glucose transport in mouse skeletal muscle. Proc Natl Acad Sci U S A. 2010;107:15541-6 pubmed publisher
    ..Muscle-specific knockout of LKB1, an upstream kinase for AMPK and AMPK-related protein kinases, significantly inhibited contraction-stimulated ..
  3. Contreras C, Gurumurthy S, Haynie J, Shirley L, Akbay E, Wingo S, et al. Loss of Lkb1 provokes highly invasive endometrial adenocarcinomas. Cancer Res. 2008;68:759-66 pubmed publisher
    Mutations in the LKB1 tumor suppressor gene result in the Peutz-Jeghers syndrome, an autosomal dominant condition characterized by hamartomatous polyps of the gastrointestinal tract and a dramatically increased risk of epithelial ..
  4. Mian I, Pierre Louis W, Dole N, Gilberti R, Dodge Kafka K, Tirnauer J. LKB1 destabilizes microtubules in myoblasts and contributes to myoblast differentiation. PLoS ONE. 2012;7:e31583 pubmed publisher
    ..We find that microtubules in differentiated myotubes are highly stabilized, but premature microtubule stabilization blocks differentiation. Factors responsible for microtubule destabilization in myoblasts have not been identified...
  5. Thomson D, Hancock C, Evanson B, Kenney S, Malan B, Mongillo A, et al. Skeletal muscle dysfunction in muscle-specific LKB1 knockout mice. J Appl Physiol (1985). 2010;108:1775-85 pubmed publisher
    Liver kinase B1 (LKB1) is a tumor-suppressing protein that is involved in the regulation of muscle metabolism and growth by phosphorylating and activating AMP-activated protein kinase (AMPK) family members...
  6. Gao Y, Xiao Q, Ma H, Li L, Liu J, Feng Y, et al. LKB1 inhibits lung cancer progression through lysyl oxidase and extracellular matrix remodeling. Proc Natl Acad Sci U S A. 2010;107:18892-7 pubmed publisher
    b>LKB1 loss-of-function mutations, observed in ∼30% of human lung adenocarcinomas, contribute significantly to lung cancer malignancy progression...
  7. Sapkota G, Kieloch A, Lizcano J, Lain S, Arthur J, Williams M, et al. Phosphorylation of the protein kinase mutated in Peutz-Jeghers cancer syndrome, LKB1/STK11, at Ser431 by p90(RSK) and cAMP-dependent protein kinase, but not its farnesylation at Cys(433), is essential for LKB1 to suppress cell vrowth. J Biol Chem. 2001;276:19469-82 pubmed
    ..The causative gene is a protein kinase termed LKB1, predicted to function as a tumor suppressor. The mechanism by which LKB1 is regulated in cells is not known...
  8. González Sánchez E, Martin Caballero J, Flores J, Hernandez Losa J, Cortes J, Mares R, et al. Lkb1 loss promotes tumor progression of BRAF(V600E)-induced lung adenomas. PLoS ONE. 2013;8:e66933 pubmed publisher
    Aberrant activation of MAP kinase signaling pathway and loss of tumor suppressor LKB1 have been implicated in lung cancer development and progression...
  9. Chen Z, Cheng K, Walton Z, Wang Y, Ebi H, Shimamura T, et al. A murine lung cancer co-clinical trial identifies genetic modifiers of therapeutic response. Nature. 2012;483:613-7 pubmed publisher
    ..Our studies demonstrate that concomitant loss of either p53 (also known as Tp53) or Lkb1 (also known as Stk11), two clinically relevant tumour suppressors, markedly impaired the response of Kras-mutant cancers to docetaxel ..

More Information

Publications62

  1. Sun G, Tarasov A, McGinty J, French P, McDonald A, Leclerc I, et al. LKB1 deletion with the RIP2.Cre transgene modifies pancreatic beta-cell morphology and enhances insulin secretion in vivo. Am J Physiol Endocrinol Metab. 2010;298:E1261-73 pubmed publisher
    The tumor suppressor liver kinase B1 (LKB1), also called STK11, is a protein kinase mutated in Peutz-Jeghers syndrome. LKB1 phosphorylates AMP-activated protein kinase (AMPK) and several related protein kinases...
  2. McGee S, Mustard K, Hardie D, Baar K. Normal hypertrophy accompanied by phosphoryation and activation of AMP-activated protein kinase alpha1 following overload in LKB1 knockout mice. J Physiol. 2008;586:1731-41 pubmed publisher
    ..capacity for muscle growth was determined in mice lacking the primary upstream kinase for AMPK in skeletal muscle, LKB1. Following either 1 or 4 weeks of overload, there was no difference in muscle growth between the wild type (wt) and ..
  3. Jishage K, Nezu J, Kawase Y, Iwata T, Watanabe M, Miyoshi A, et al. Role of Lkb1, the causative gene of Peutz-Jegher's syndrome, in embryogenesis and polyposis. Proc Natl Acad Sci U S A. 2002;99:8903-8 pubmed
    ..LKB1 (STK11) serine/threonine kinase is the product of the causative gene of PJS, which has been mapped to chromosome 19p13.3...
  4. Shaw R, Lamia K, Vasquez D, Koo S, Bardeesy N, Depinho R, et al. The kinase LKB1 mediates glucose homeostasis in liver and therapeutic effects of metformin. Science. 2005;310:1642-6 pubmed
    The Peutz-Jegher syndrome tumor-suppressor gene encodes a protein-threonine kinase, LKB1, which phosphorylates and activates AMPK [adenosine monophosphate (AMP)-activated protein kinase]...
  5. Asada N, Sanada K, Fukada Y. LKB1 regulates neuronal migration and neuronal differentiation in the developing neocortex through centrosomal positioning. J Neurosci. 2007;27:11769-75 pubmed
    ..Here we find that LKB1, the closest homolog of the Caenorhabditis elegans polarity protein Par4, is expressed in the developing neocortex...
  6. Granot Z, Swisa A, Magenheim J, Stolovich Rain M, Fujimoto W, Manduchi E, et al. LKB1 regulates pancreatic beta cell size, polarity, and function. Cell Metab. 2009;10:296-308 pubmed publisher
    ..We have studied the roles of LKB1, a conserved kinase implicated in the control of cell polarity and energy metabolism, in adult beta cells...
  7. Sakamoto K, Zarrinpashneh E, Budas G, Pouleur A, Dutta A, Prescott A, et al. Deficiency of LKB1 in heart prevents ischemia-mediated activation of AMPKalpha2 but not AMPKalpha1. Am J Physiol Endocrinol Metab. 2006;290:E780-8 pubmed
    Recent studies indicate that the LKB1 is a key regulator of the AMP-activated protein kinase (AMPK), which plays a crucial role in protecting cardiac muscle from damage during ischemia...
  8. Woods A, Heslegrave A, Muckett P, Levene A, Clements M, Mobberley M, et al. LKB1 is required for hepatic bile acid transport and canalicular membrane integrity in mice. Biochem J. 2011;434:49-60 pubmed publisher
    b>LKB1 is a 'master' protein kinase implicated in the regulation of metabolism, cell proliferation, cell polarity and tumorigenesis. However, the long-term role of LKB1 in hepatic function is unknown...
  9. Nakada D, Saunders T, Morrison S. Lkb1 regulates cell cycle and energy metabolism in haematopoietic stem cells. Nature. 2010;468:653-8 pubmed publisher
    ..Deletion of the Lkb1 (also called Stk11) gene in mice caused increased haematopoietic stem cell (HSC) division, rapid HSC depletion and pancytopenia...
  10. Thomson D, Porter B, Tall J, Kim H, Barrow J, Winder W. Skeletal muscle and heart LKB1 deficiency causes decreased voluntary running and reduced muscle mitochondrial marker enzyme expression in mice. Am J Physiol Endocrinol Metab. 2007;292:E196-202 pubmed
    b>LKB1 has been identified as a component of the major upstream kinase of AMP-activated protein kinase (AMPK) in skeletal muscle...
  11. Andrade Vieira R, Xu Z, Colp P, Marignani P. Loss of LKB1 expression reduces the latency of ErbB2-mediated mammary gland tumorigenesis, promoting changes in metabolic pathways. PLoS ONE. 2013;8:e56567 pubmed publisher
    ..To expand on these observations, we crossed STK11 (fl/fl) mice with mice genetically engineered to express activated Neu/HER2-MMTV-Cre (NIC) under the endogenous ..
  12. Nakada Y, Stewart T, Peña C, Zhang S, Zhao N, Bardeesy N, et al. The LKB1 tumor suppressor as a biomarker in mouse and human tissues. PLoS ONE. 2013;8:e73449 pubmed publisher
    Germline mutations in the LKB1 gene (also known as STK11) cause the Peutz-Jeghers Syndrome, and somatic loss of LKB1 has emerged as causal event in a wide range of human malignancies, including melanoma, lung cancer, and cervical cancer...
  13. Foretz M, Hebrard S, Leclerc J, Zarrinpashneh E, Soty M, Mithieux G, et al. Metformin inhibits hepatic gluconeogenesis in mice independently of the LKB1/AMPK pathway via a decrease in hepatic energy state. J Clin Invest. 2010;120:2355-69 pubmed publisher
    Metformin is widely used to treat hyperglycemia in individuals with type 2 diabetes. Recently the LKB1/AMP-activated protein kinase (LKB1/AMPK) pathway was proposed to mediate the action of metformin on hepatic gluconeogenesis...
  14. Shorning B, Zabkiewicz J, McCarthy A, Pearson H, Winton D, Sansom O, et al. Lkb1 deficiency alters goblet and paneth cell differentiation in the small intestine. PLoS ONE. 2009;4:e4264 pubmed publisher
    The Lkb1 tumour suppressor is a multitasking kinase participating in a range of physiological processes...
  15. Sun G, Reynolds R, Leclerc I, Rutter G. RIP2-mediated LKB1 deletion causes axon degeneration in the spinal cord and hind-limb paralysis. Dis Model Mech. 2011;4:193-202 pubmed publisher
    ..Here, we show that mice deleted for the tumour suppressor LKB1 (also called STK11) in the spinal cord, some parts of the brain and in the endocrine pancreas (?LKB1KO mice) develop hind-limb ..
  16. Liu W, Monahan K, Pfefferle A, Shimamura T, Sorrentino J, Chan K, et al. LKB1/STK11 inactivation leads to expansion of a prometastatic tumor subpopulation in melanoma. Cancer Cell. 2012;21:751-64 pubmed publisher
    Germline mutations in LKB1 (STK11) are associated with the Peutz-Jeghers syndrome (PJS), which includes aberrant mucocutaneous pigmentation, and somatic LKB1 mutations occur in 10% of cutaneous melanoma...
  17. Mehenni H, Lin Marq N, Buchet Poyau K, Reymond A, Collart M, Picard D, et al. LKB1 interacts with and phosphorylates PTEN: a functional link between two proteins involved in cancer predisposing syndromes. Hum Mol Genet. 2005;14:2209-19 pubmed
    Germline mutations of the LKB1 (STK11) tumor suppressor gene lead to Peutz-Jeghers syndrome (PJS) and predisposition to cancer. LKB1 encodes a serine/threonine kinase generally inactivated in PJS patients...
  18. Sapkota G, Boudeau J, Deak M, Kieloch A, Morrice N, Alessi D. Identification and characterization of four novel phosphorylation sites (Ser31, Ser325, Thr336 and Thr366) on LKB1/STK11, the protein kinase mutated in Peutz-Jeghers cancer syndrome. Biochem J. 2002;362:481-90 pubmed
    ..The causative gene encodes a nuclear-localized protein kinase, termed LKB1, which is predicted to function as a tumour suppressor...
  19. Thomson D, Brown J, Fillmore N, Condon B, Kim H, Barrow J, et al. LKB1 and the regulation of malonyl-CoA and fatty acid oxidation in muscle. Am J Physiol Endocrinol Metab. 2007;293:E1572-9 pubmed
    ..In these tissues, LKB1 is the major AMPK kinase and is therefore critical for AMPK activation...
  20. Boudeau J, Deak M, Lawlor M, Morrice N, Alessi D. Heat-shock protein 90 and Cdc37 interact with LKB1 and regulate its stability. Biochem J. 2003;370:849-57 pubmed
    b>LKB1 is a widely expressed serine/threonine protein kinase that is mutated in the inherited Peutz-Jeghers cancer syndrome...
  21. Ylikorkala A, Rossi D, Korsisaari N, Luukko K, Alitalo K, Henkemeyer M, et al. Vascular abnormalities and deregulation of VEGF in Lkb1-deficient mice. Science. 2001;293:1323-6 pubmed
    The LKB1 tumor suppressor gene, mutated in Peutz-Jeghers syndrome, encodes a serine/threonine kinase of unknown function...
  22. Shelly M, Cancedda L, Heilshorn S, Sumbre G, Poo M. LKB1/STRAD promotes axon initiation during neuronal polarization. Cell. 2007;129:565-77 pubmed
    ..In cultured hippocampal neurons, the accumulation of LKB1 and STRAD, two interacting proteins critical for establishing epithelial polarity, in an undifferentiated neurite ..
  23. Sakamoto K, McCarthy A, Smith D, Green K, Grahame Hardie D, Ashworth A, et al. Deficiency of LKB1 in skeletal muscle prevents AMPK activation and glucose uptake during contraction. EMBO J. 2005;24:1810-20 pubmed
    Recent studies indicate that the LKB1 tumour suppressor protein kinase is the major "upstream" activator of the energy sensor AMP-activated protein kinase (AMPK)...
  24. Cao Y, Li H, Liu H, Zheng C, Ji H, Liu X. The serine/threonine kinase LKB1 controls thymocyte survival through regulation of AMPK activation and Bcl-XL expression. Cell Res. 2010;20:99-108 pubmed publisher
    b>LKB1 is a serine/threonine kinase that directly activates the energy sensor AMP-activated protein kinase (AMPK) in response to bioenergetic stress, and mainly acts as a tumor suppressor that controls cell polarity and proliferation...
  25. Ji H, Ramsey M, Hayes D, Fan C, McNamara K, Kozlowski P, et al. LKB1 modulates lung cancer differentiation and metastasis. Nature. 2007;448:807-10 pubmed
    Germline mutation in serine/threonine kinase 11 (STK11, also called LKB1) results in Peutz-Jeghers syndrome, characterized by intestinal hamartomas and increased incidence of epithelial cancers...
  26. Fu A, Ng A, Depatie C, Wijesekara N, He Y, Wang G, et al. Loss of Lkb1 in adult beta cells increases beta cell mass and enhances glucose tolerance in mice. Cell Metab. 2009;10:285-95 pubmed publisher
    The Lkb1 tumor suppressor exerts its biological effects through phosphorylation and consequent activation of the AMP kinase (AMPK) family...
  27. Shackelford D, Abt E, Gerken L, Vasquez D, Seki A, Leblanc M, et al. LKB1 inactivation dictates therapeutic response of non-small cell lung cancer to the metabolism drug phenformin. Cancer Cell. 2013;23:143-58 pubmed publisher
    The LKB1 (also called STK11) tumor suppressor is mutationally inactivated in ?20% of non-small cell lung cancers (NSCLC)...
  28. Shah U, Sharpless N, Hayes D. LKB1 and lung cancer: more than the usual suspects. Cancer Res. 2008;68:3562-5 pubmed publisher
    ..For LKB1, a more recently identified human tumor suppressor gene, however, the problem is different...
  29. Barnes A, Lilley B, Pan Y, Plummer L, Powell A, Raines A, et al. LKB1 and SAD kinases define a pathway required for the polarization of cortical neurons. Cell. 2007;129:549-63 pubmed
    ..We show here that the serine/threonine kinase LKB1, previously implicated in the establishment of epithelial polarity and control of cell growth, is required for axon ..
  30. Wei C, Amos C, Stephens L, Campos I, Deng J, Behringer R, et al. Mutation of Lkb1 and p53 genes exert a cooperative effect on tumorigenesis. Cancer Res. 2005;65:11297-303 pubmed
    ..Germ line mutations in LKB1 cause PJS. We have generated mice carrying an Lkb1 exon 2 to 8 deletion by gene targeting in embryonic stem cells...
  31. Ollila S, Makela T. The tumor suppressor kinase LKB1: lessons from mouse models. J Mol Cell Biol. 2011;3:330-40 pubmed publisher
    Mutations in the tumor suppressor gene LKB1 are important in hereditary Peutz-Jeghers syndrome, as well as in sporadic cancers including lung and cervical cancer...
  32. Miyoshi H, Nakau M, Ishikawa T, Seldin M, Oshima M, Taketo M. Gastrointestinal hamartomatous polyposis in Lkb1 heterozygous knockout mice. Cancer Res. 2002;62:2261-6 pubmed
    ..Germ-line mutations of the gene encoding LKB1 (STK11), a serine/threonine kinase, are identified in most PJS patients...
  33. Gurumurthy S, Xie S, Alagesan B, Kim J, Yusuf R, Saez B, et al. The Lkb1 metabolic sensor maintains haematopoietic stem cell survival. Nature. 2010;468:659-63 pubmed publisher
    ..Here we show that the Lkb1 tumour suppressor is critical for the maintenance of energy homeostasis in haematopoietic cells...
  34. Katajisto P, Vaahtomeri K, Ekman N, Ventelä E, Ristimaki A, Bardeesy N, et al. LKB1 signaling in mesenchymal cells required for suppression of gastrointestinal polyposis. Nat Genet. 2008;40:455-9 pubmed publisher
    Germline mutations in STK11 (also known as LKB1) are found in individuals with Peutz-Jeghers syndrome (PJS) manifesting with gastrointestinal polyps that contain a prominent stromal component...
  35. McCarthy A, Lord C, Savage K, Grigoriadis A, Smith D, Weigelt B, et al. Conditional deletion of the Lkb1 gene in the mouse mammary gland induces tumour formation. J Pathol. 2009;219:306-16 pubmed publisher
    Heterozygous germline mutations in the LKB1 (STK11) gene cause Peutz-Jeghers syndrome (PJS), an autosomal dominant disorder characterized by hamartomatous polyposis of the gastrointestinal tract and an increased risk of colorectal, ..
  36. Esteve Puig R, Canals F, Colome N, Merlino G, Recio J. Uncoupling of the LKB1-AMPKalpha energy sensor pathway by growth factors and oncogenic BRAF. PLoS ONE. 2009;4:e4771 pubmed publisher
    ..b>LKB1 is a multi-task Ser/Thr kinase that phosphorylates AMPK controlling cell growth and apoptosis under metabolic ..
  37. Gurumurthy S, Hezel A, Sahin E, Berger J, Bosenberg M, Bardeesy N. LKB1 deficiency sensitizes mice to carcinogen-induced tumorigenesis. Cancer Res. 2008;68:55-63 pubmed publisher
    b>Lkb1 is a central regulator of cell polarity and energy metabolism through its capacity to activate the AMP-activated protein kinase (AMPK)-related family of protein kinases...
  38. Koh H, Arnolds D, Fujii N, Tran T, Rogers M, Jessen N, et al. Skeletal muscle-selective knockout of LKB1 increases insulin sensitivity, improves glucose homeostasis, and decreases TRB3. Mol Cell Biol. 2006;26:8217-27 pubmed
    b>LKB1 is a tumor suppressor that may also be fundamental to cell metabolism, since LKB1 phosphorylates and activates the energy sensing enzyme AMPK...
  39. Kojima Y, Miyoshi H, Clevers H, Oshima M, Aoki M, Taketo M. Suppression of tubulin polymerization by the LKB1-microtubule-associated protein/microtubule affinity-regulating kinase signaling. J Biol Chem. 2007;282:23532-40 pubmed
    b>LKB1, a tumor suppressor gene mutated in the Peutz-Jeghers syndrome, encodes a serine/threonine protein kinase...
  40. Gan B, Hu J, Jiang S, Liu Y, Sahin E, Zhuang L, et al. Lkb1 regulates quiescence and metabolic homeostasis of haematopoietic stem cells. Nature. 2010;468:701-4 pubmed publisher
    ..How energy metabolism and stem-cell homeostatic processes are coordinated is not well understood. Lkb1 acts as an evolutionarily conserved regulator of cellular energy metabolism in eukaryotic cells and functions as ..
  41. Jaleel M, McBride A, Lizcano J, Deak M, Toth R, Morrice N, et al. Identification of the sucrose non-fermenting related kinase SNRK, as a novel LKB1 substrate. FEBS Lett. 2005;579:1417-23 pubmed
    Recent work has shown that the LKB1 tumour suppressor protein kinase phosphorylates and activates protein kinases belonging to the AMP activated kinase (AMPK) subfamily...
  42. Jacob L, Wu X, Dodge M, Fan C, Kulak O, Chen B, et al. Genome-wide RNAi screen reveals disease-associated genes that are common to Hedgehog and Wnt signaling. Sci Signal. 2011;4:ra4 pubmed publisher
    ..We identified functions in both pathways for the multitasking kinase Stk11 (also known as Lkb1), a tumor suppressor implicated in lung and cervical cancers...
  43. Sapkota G, Deak M, Kieloch A, Morrice N, Goodarzi A, Smythe C, et al. Ionizing radiation induces ataxia telangiectasia mutated kinase (ATM)-mediated phosphorylation of LKB1/STK11 at Thr-366. Biochem J. 2002;368:507-16 pubmed
    The serine/threonine protein kinase LKB1 functions as a tumour suppressor, and mutations in this enzyme lead to the inherited Peutz-Jeghers cancer syndrome...
  44. Courchet J, Lewis T, Lee S, Courchet V, Liou D, Aizawa S, et al. Terminal axon branching is regulated by the LKB1-NUAK1 kinase pathway via presynaptic mitochondrial capture. Cell. 2013;153:1510-25 pubmed publisher
    ..We identified a pathway defined by two kinases, LKB1 and NUAK1, required for cortical axon branching in vivo...
  45. Algire C, Amrein L, Bazile M, David S, Zakikhani M, Pollak M. Diet and tumor LKB1 expression interact to determine sensitivity to anti-neoplastic effects of metformin in vivo. Oncogene. 2011;30:1174-82 pubmed publisher
    ..We treated both tumor LKB1 expression and host diet as variables, and observed that metformin inhibited tumor growth and reduced insulin ..
  46. Contreras C, Akbay E, Gallardo T, Haynie J, Sharma S, Tagao O, et al. Lkb1 inactivation is sufficient to drive endometrial cancers that are aggressive yet highly responsive to mTOR inhibitor monotherapy. Dis Model Mech. 2010;3:181-93 pubmed publisher
    ..We then used this tool to generate a completely penetrant Lkb1 (also known as Stk11)-based mouse model of invasive endometrial cancer...
  47. Huang X, Wullschleger S, Shpiro N, McGuire V, Sakamoto K, Woods Y, et al. Important role of the LKB1-AMPK pathway in suppressing tumorigenesis in PTEN-deficient mice. Biochem J. 2008;412:211-21 pubmed publisher
    The LKB1 tumour suppressor phosphorylates and activates AMPK (AMP-activated protein kinase) when cellular energy levels are low, thereby suppressing growth through multiple pathways, including inhibiting the mTORC1 (mammalian target of ..
  48. Udd L, Katajisto P, Kyyrönen M, Ristimaki A, Makela T. Impaired gastric gland differentiation in Peutz-Jeghers syndrome. Am J Pathol. 2010;176:2467-76 pubmed publisher
    Gastrointestinal hamartomatous polyps in the Peutz-Jeghers cancer predisposition syndrome and its mouse model (Lkb1(+/-)) are presumed to contain all cell types native to the site of their occurrence...
  49. Lo B, Strasser G, Sagolla M, Austin C, Junttila M, Mellman I. Lkb1 regulates organogenesis and early oncogenesis along AMPK-dependent and -independent pathways. J Cell Biol. 2012;199:1117-30 pubmed publisher
    The tumor suppressor Lkb1/STK11/Par-4 is a key regulator of cellular energy, proliferation, and polarity, yet its mechanisms of action remain poorly defined...
  50. Collins S, Reoma J, Gamm D, Uhler M. LKB1, a novel serine/threonine protein kinase and potential tumour suppressor, is phosphorylated by cAMP-dependent protein kinase (PKA) and prenylated in vivo. Biochem J. 2000;345 Pt 3:673-80 pubmed
    ..The human LKB1 (hLKB1) gene encodes a serine/threonine protein kinase that is deficient in the majority of patients with PJS...
  51. Towler M, Fogarty S, Hawley S, Pan D, Martin D, Morrice N, et al. A novel short splice variant of the tumour suppressor LKB1 is required for spermiogenesis. Biochem J. 2008;416:1-14 pubmed publisher
    b>LKB1 was discovered as a tumour suppressor mutated in Peutz-Jeghers syndrome, and is a gene involved in cell polarity as well as an upstream protein kinase for members of the AMP-activated protein kinase family...
  52. Vaahtomeri K, Ventelä E, Laajanen K, Katajisto P, Wipff P, Hinz B, et al. Lkb1 is required for TGFbeta-mediated myofibroblast differentiation. J Cell Sci. 2008;121:3531-40 pubmed publisher
    Inactivating mutations of the tumor-suppressor kinase gene LKB1 underlie Peutz-Jeghers syndrome (PJS), which is characterized by gastrointestinal hamartomatous polyps with a prominent smooth-muscle and stromal component...
  53. Morén A, Raja E, Heldin C, Moustakas A. Negative regulation of TGF? signaling by the kinase LKB1 and the scaffolding protein LIP1. J Biol Chem. 2011;286:341-53 pubmed publisher
    ..Previous work established a protein complex between Smad4 and the scaffolding protein LKB1-interacting protein 1 (LIP1)...