Gene Symbol: Stim2
Description: stromal interaction molecule 2
Alias: stromal interaction molecule 2
Species: mouse
Products:     Stim2

Top Publications

  1. Oh Hora M, Yamashita M, Hogan P, Sharma S, Lamperti E, Chung W, et al. Dual functions for the endoplasmic reticulum calcium sensors STIM1 and STIM2 in T cell activation and tolerance. Nat Immunol. 2008;9:432-43 pubmed publisher
    ..calcium sensor STIM1 had severely impaired store-operated Ca2+ influx, whereas deficiency in the calcium sensor STIM2 had a smaller effect...
  2. Berna Erro A, Braun A, Kraft R, Kleinschnitz C, Schuhmann M, Stegner D, et al. STIM2 regulates capacitive Ca2+ entry in neurons and plays a key role in hypoxic neuronal cell death. Sci Signal. 2009;2:ra67 pubmed publisher controlled by the endoplasmic reticulum (ER)-resident Ca(2+) sensor STIM1, whereas the closely related protein STIM2 has been proposed to regulate basal cytosolic and ER Ca(2+) concentrations and make only a minor contribution to ..
  3. Schuhmann M, Stegner D, Berna Erro A, Bittner S, Braun A, Kleinschnitz C, et al. Stromal interaction molecules 1 and 2 are key regulators of autoreactive T cell activation in murine autoimmune central nervous system inflammation. J Immunol. 2010;184:1536-42 pubmed publisher
    ..1 is the Ca(2+) sensor in the endoplasmic reticulum, which controls this process, whereas the other STIM isoform, STIM2, coregulates SOCE...
  4. Ma J, McCarl C, Khalil S, Lüthy K, Feske S. T-cell-specific deletion of STIM1 and STIM2 protects mice from EAE by impairing the effector functions of Th1 and Th17 cells. Eur J Immunol. 2010;40:3028-42 pubmed publisher
    ..We show that mice with T-cell-specific deletion of STIM1 or STIM2 are protected from EAE, a mouse model of multiple sclerosis (MS)...
  5. Shanmughapriya S, Rajan S, Hoffman N, Zhang X, Guo S, Kolesar J, et al. Ca2+ signals regulate mitochondrial metabolism by stimulating CREB-mediated expression of the mitochondrial Ca2+ uniporter gene MCU. Sci Signal. 2015;8:ra23 pubmed publisher
    ..Thus, our results showed that a transcriptional regulatory circuit involving Ca2+ -dependent activation of CREB controls the Ca2+ uptake capability of mitochondria and hence regulates mitochondrial metabolism. ..
  6. Sun S, Zhang H, Liu J, Popugaeva E, Xu N, Feske S, et al. Reduced synaptic STIM2 expression and impaired store-operated calcium entry cause destabilization of mature spines in mutant presenilin mice. Neuron. 2014;82:79-93 pubmed publisher
    ..The stabilization of mushroom spines depends on STIM2-mediated neuronal store-operated calcium influx (nSOC) and continuous activity of Ca(2+)/calmodulin-dependent ..
  7. Weidinger C, Shaw P, Feske S. STIM1 and STIM2-mediated Ca(2+) influx regulates antitumour immunity by CD8(+) T cells. EMBO Mol Med. 2013;5:1311-21 pubmed publisher
    ..Using conditional knock out mice lacking STIM1 and its homologue STIM2, we find that SOCE in CD8(+) T cells is required to prevent the engraftment of melanoma and colon carcinoma cells ..
  8. Wissenbach U, Philipp S, Gross S, Cavalié A, Flockerzi V. Primary structure, chromosomal localization and expression in immune cells of the murine ORAI and STIM genes. Cell Calcium. 2007;42:439-46 pubmed
    ..the ORAI1, ORAI2 and ORAI3 proteins and two genes which encode the type I single-pass transmembrane STIM1 and STIM2 proteins...
  9. Shaw P, Weidinger C, Vaeth M, Luethy K, Kaech S, Feske S. CD4⁺ and CD8⁺ T cell-dependent antiviral immunity requires STIM1 and STIM2. J Clin Invest. 2014;124:4549-63 pubmed publisher
    ..Here, using mice with conditional deletion of Stim1 and its homolog Stim2 in T cells, we determined that both components are required for the maintenance of virus-specific memory CD8+ T ..

More Information


  1. Yap K, Shetty M, Garcia Alvarez G, Lu B, Alagappan D, Oh Hora M, et al. STIM2 regulates AMPA receptor trafficking and plasticity at hippocampal synapses. Neurobiol Learn Mem. 2017;138:54-61 pubmed publisher
    b>STIM2 is an integral membrane protein of the endoplasmic reticulum (ER) that regulates the activity of plasma membrane (PM) channels at ER-PM contact sites...
  2. Cheng K, Alevizos I, Liu X, Swaim W, Yin H, Feske S, et al. STIM1 and STIM2 protein deficiency in T lymphocytes underlies development of the exocrine gland autoimmune disease, Sjogren's syndrome. Proc Natl Acad Sci U S A. 2012;109:14544-9 pubmed publisher
    ..Here we report that mice with T-cell-targeted deletion of Stromal Interaction Molecule (STIM) 1 and STIM2 [double-knockout (DKO)] mice develop spontaneous and severe pSS-like autoimmune disease, displaying major ..
  3. Zeiger W, Ito D, Swetlik C, Oh Hora M, Villereal M, Thinakaran G. Stanniocalcin 2 is a negative modulator of store-operated calcium entry. Mol Cell Biol. 2011;31:3710-22 pubmed publisher
    ..Furthermore, our findings implicate the modulation of SOCE through STC2 expression as one of the prosurvival measures of the unfolded protein response. ..
  4. Sodero A, Vriens J, Ghosh D, Stegner D, Brachet A, Pallotto M, et al. Cholesterol loss during glutamate-mediated excitotoxicity. EMBO J. 2012;31:1764-73 pubmed publisher
    ..glutamate-induced cholesterol loss requires high levels of intracellular Ca(2+), a functional stromal interaction molecule 2 (STIM2) and mobilization of CYP46A1 towards the plasma membrane...
  5. Seth M, Li T, Graham V, Burch J, Finch E, Stiber J, et al. Dynamic regulation of sarcoplasmic reticulum Ca(2+) stores by stromal interaction molecule 1 and sarcolipin during muscle differentiation. Dev Dyn. 2012;241:639-47 pubmed publisher
    ..These results suggest that SOCE regulates SR/ER specialization and that SLN and STIM1 act in opposing fashions to govern SOCE during myogenesis. ..
  6. Mao X, Zhang J, Han Y, Luan C, Hu Y, Hao Z, et al. Deficient for endoplasmic reticulum calcium sensors Stim1 and Stim2 affects aberrant antibody affinity maturation in B cells. Oncotarget. 2016;7:60885-60895 pubmed publisher
    ..In our studies, mice deficient for both endoplasmic reticulum calciumsensor Stim1 and Stim2 was immunized with T-cell dependent and independent antigens. Antibody affinity was measured by ELISA...
  7. Michaelis M, Nieswandt B, Stegner D, Eilers J, Kraft R. STIM1, STIM2, and Orai1 regulate store-operated calcium entry and purinergic activation of microglia. Glia. 2015;63:652-63 pubmed publisher
    ..and Orai Ca(2+) channel subunits, that comprise the molecular machinery of SOCE, showed relevant levels of STIM1, STIM2, and Orai1 in cultured mouse microglia...
  8. McDonald B, Bunker J, Erickson S, Oh Hora M, Bendelac A. Crossreactive αβ T Cell Receptors Are the Predominant Targets of Thymocyte Negative Selection. Immunity. 2015;43:859-69 pubmed publisher
    ..Thus, broadly crossreactive TCRs arise at low frequency in the pre-selection repertoire but constitute the primary drivers of thymic negative selection and iIEL lineage differentiation. ..
  9. Freund Brown J, Choa R, Singh B, Robertson T, Ferry G, Viver E, et al. Cutting Edge: Murine NK Cells Degranulate and Retain Cytotoxic Function without Store-Operated Calcium Entry. J Immunol. 2017;: pubmed publisher
    ..Our data suggest that mouse NK cells use different signaling mechanisms for cytotoxicity compared with other cytotoxic lymphocytes. ..
  10. Williams R, Manji S, Parker N, Hancock M, Van Stekelenburg L, Eid J, et al. Identification and characterization of the STIM (stromal interaction molecule) gene family: coding for a novel class of transmembrane proteins. Biochem J. 2001;357:673-85 pubmed
    ..and characterized cDNA sequences representing a single gene in humans and other vertebrates, which we have called STIM2. We identified a single STIM homologue in Drosophila melanogaster (D-Stim) and Caenorhabditis elegans, but no ..
  11. Gilio K, van Kruchten R, Braun A, Berna Erro A, Feijge M, Stegner D, et al. Roles of platelet STIM1 and Orai1 in glycoprotein VI- and thrombin-dependent procoagulant activity and thrombus formation. J Biol Chem. 2010;285:23629-38 pubmed publisher
    ..Both proteins contribute to collagen-dependent arterial thrombosis in mice in vivo. It is unclear whether STIM2 is involved...
  12. Bojarski L, Pomorski P, Szybinska A, Drab M, Skibinska Kijek A, Gruszczynska Biegala J, et al. Presenilin-dependent expression of STIM proteins and dysregulation of capacitative Ca2+ entry in familial Alzheimer's disease. Biochim Biophys Acta. 2009;1793:1050-7 pubmed publisher
    ..We demonstrate that cellular levels of STIM1 and STIM2 proteins, which are key players in CCE, depend on presenilins...
  13. Concepcion A, Vaeth M, Wagner L, Eckstein M, Hecht L, Yang J, et al. Store-operated Ca2+ entry regulates Ca2+-activated chloride channels and eccrine sweat gland function. J Clin Invest. 2016;126:4303-4318 pubmed publisher patients and mice with ectodermal tissue-specific deletion of Orai1 (Orai1K14Cre) or Stim1 and Stim2 (Stim1/2K14Cre) failed to sweat despite normal sweat gland development...
  14. Vaeth M, Maus M, Klein Hessling S, Freinkman E, Yang J, Eckstein M, et al. Store-Operated Ca2+ Entry Controls Clonal Expansion of T Cells through Metabolic Reprogramming. Immunity. 2017;47:664-679.e6 pubmed publisher
    ..release-activated Ca2+ (CRAC) channels that are activated by stromal interaction molecule (STIM) 1 and STIM2. SOCE regulates many Ca2+-dependent signaling molecules, including calcineurin, and inhibition of SOCE ..
  15. Waite J, Vardhana S, Shaw P, Jang J, McCarl C, Cameron T, et al. Interference with Ca(2+) release activated Ca(2+) (CRAC) channel function delays T-cell arrest in vivo. Eur J Immunol. 2013;43:3343-54 pubmed publisher
    ..CRAC channel function is not required for homing to SLOs, but enhances spatiotemporal coordination of TCR signaling and motility arrest. ..
  16. Oh Hora M, Komatsu N, Pishyareh M, Feske S, Hori S, Taniguchi M, et al. Agonist-selected T cell development requires strong T cell receptor signaling and store-operated calcium entry. Immunity. 2013;38:881-95 pubmed publisher
    ..Here we have used mice lacking the endoplasmic reticulum Ca2+ sensors stromal interaction molecule 1 (STIM1) and STIM2 to show that STIM-induced store-operated Ca2+ entry is not essential for thymic development of conventional TCR??+ ..
  17. Decuypere J, Monaco G, Kiviluoto S, Oh Hora M, Luyten T, De Smedt H, et al. STIM1, but not STIM2, is required for proper agonist-induced Ca2+ signaling. Cell Calcium. 2010;48:161-7 pubmed publisher
    The stromal interaction molecules STIM1 and STIM2 sense a decreasing Ca(2+) concentration in the lumen of the endoplasmic reticulum and activate Ca(2+) channels in the plasma membrane...
  18. Garcia Alvarez G, Shetty M, Lu B, Yap K, Oh Hora M, Sajikumar S, et al. Impaired spatial memory and enhanced long-term potentiation in mice with forebrain-specific ablation of the Stim genes. Front Behav Neurosci. 2015;9:180 pubmed publisher
    ..genes in learning and memory, we generated three mouse strains with conditional deletion (cKO) of Stim1 and/or Stim2 in the forebrain...
  19. Fernandez R, Wan J, Song S, Smith K, Gu Y, Tauseef M, et al. Upregulated expression of STIM2, TRPC6, and Orai2 contributes to the transition of pulmonary arterial smooth muscle cells from a contractile to proliferative phenotype. Am J Physiol Cell Physiol. 2015;308:C581-93 pubmed publisher
    ..Stromal interacting molecule proteins (e.g., STIM2) and Orai2 both contribute to SOCE and we have previously shown that STIM2 and Orai2, specifically, are ..
  20. Vaeth M, Yang J, Yamashita M, Zee I, Eckstein M, Knosp C, et al. ORAI2 modulates store-operated calcium entry and T cell-mediated immunity. Nat Commun. 2017;8:14714 pubmed publisher
    ..Our study demonstrates that ORAI1 and ORAI2 form heteromeric CRAC channels, in which ORAI2 fine-tunes the magnitude of SOCE to modulate immune responses. ..
  21. Popugaeva E, Pchitskaya E, Speshilova A, Alexandrov S, Zhang H, Vlasova O, et al. STIM2 protects hippocampal mushroom spines from amyloid synaptotoxicity. Mol Neurodegener. 2015;10:37 pubmed publisher
    ..We further discovered that expression of STIM2 protein rescued CaMKII activity and protected mushroom spines from amyloid toxicity in vitro and in vivo...
  22. Mancarella S, Potireddy S, Wang Y, Gao H, Gandhirajan R, Autieri M, et al. Targeted STIM deletion impairs calcium homeostasis, NFAT activation, and growth of smooth muscle. FASEB J. 2013;27:893-906 pubmed publisher
    ..Cre-lox technology was used to generate smooth muscle (sm)-targeted STIM1-, STIM2-, and double STIM1/STIM2-knockout (KO) mouse models, which reveal the essential role of STIM proteins in Ca(2+) ..
  23. Maus M, Cuk M, Patel B, Lian J, Ouimet M, Kaufmann U, et al. Store-Operated Ca2+ Entry Controls Induction of Lipolysis and the Transcriptional Reprogramming to Lipid Metabolism. Cell Metab. 2017;25:698-712 pubmed publisher
    ..entry (SOCE) is a ubiquitous Ca2+ influx pathway regulated by stromal interaction molecule 1 (STIM1), STIM2, and the Ca2+ channel ORAI1...
  24. Clemens R, Chong J, Grimes D, Hu Y, Lowell C. STIM1 and STIM2 cooperatively regulate mouse neutrophil store-operated calcium entry and cytokine production. Blood. 2017;130:1565-1577 pubmed publisher
    ..STIM1 and STIM2 are calcium-sensing molecules that link calcium depletion of the endoplasmic reticulum with opening of plasma ..
  25. Matsumoto M, Fujii Y, Baba A, Hikida M, Kurosaki T, Baba Y. The calcium sensors STIM1 and STIM2 control B cell regulatory function through interleukin-10 production. Immunity. 2011;34:703-14 pubmed publisher
    ..However, its physiological role in B cells remains elusive. Here, we show that ER calcium sensors STIM1- and STIM2-induced SOC influx is critical for B cell regulatory function...