Gene Symbol: Stim1
Description: stromal interaction molecule 1
Alias: SIM, stromal interaction molecule 1
Species: mouse
Products:     Stim1

Top Publications

  1. Zhang H, Clemens R, Liu F, Hu Y, Baba Y, Theodore P, et al. STIM1 calcium sensor is required for activation of the phagocyte oxidase during inflammation and host defense. Blood. 2014;123:2238-49 pubmed publisher
    The stromal-interacting molecule 1 (STIM1) is a potent sensor of intracellular calcium, which in turn regulates entry of external calcium through plasma membrane channels to affect immune cell activation...
  2. Schuhmann M, Stegner D, Berna Erro A, Bittner S, Braun A, Kleinschnitz C, et al. Stromal interaction molecules 1 and 2 are key regulators of autoreactive T cell activation in murine autoimmune central nervous system inflammation. J Immunol. 2010;184:1536-42 pubmed publisher
    ..In this study, we studied T cell function in mice lacking STIM1 or STIM2 in a model of myelin-oligodendrocyte glycoprotein (MOG(35-55))-induced experimental autoimmune ..
  3. Grosse J, Braun A, Varga Szabo D, Beyersdorf N, Schneider B, Zeitlmann L, et al. An EF hand mutation in Stim1 causes premature platelet activation and bleeding in mice. J Clin Invest. 2007;117:3540-50 pubmed
    ..We have established a mouse line expressing an activating EF hand motif mutant of stromal interaction molecule 1 (Stim1), an ER receptor recently identified as the Ca2+ sensor responsible for activation of Ca2+ ..
  4. Zhou Y, Meraner P, Kwon H, Machnes D, Oh Hora M, Zimmer J, et al. STIM1 gates the store-operated calcium channel ORAI1 in vitro. Nat Struct Mol Biol. 2010;17:112-6 pubmed publisher
    ..Ca(2+) (CRAC) channel in mammalian T cells and mast cells depends on the sensor protein stromal interaction molecule 1 (STIM1) and the channel subunit ORAI1...
  5. Nunes P, Cornut D, Bochet V, Hasler U, Oh Hora M, Waldburger J, et al. STIM1 juxtaposes ER to phagosomes, generating Ca²? hotspots that boost phagocytosis. Curr Biol. 2012;22:1990-7 pubmed publisher
    ..Here, we show that the ER Ca(2+) sensor stromal interaction molecule 1 (STIM1) sustains high-efficiency phagocytosis by recruiting thin ER cisternae that interact ..
  6. Feske S. ORAI1 and STIM1 deficiency in human and mice: roles of store-operated Ca2+ entry in the immune system and beyond. Immunol Rev. 2009;231:189-209 pubmed publisher
    ..ORAI1 as the pore-forming subunit of the CRAC channel in the plasma membrane and stromal interaction molecule-1 (STIM1) sensing the ER Ca2+ concentration and activating ORAI1-CRAC channels...
  7. Yang S, Zhang J, Huang X. Orai1 and STIM1 are critical for breast tumor cell migration and metastasis. Cancer Cell. 2009;15:124-34 pubmed publisher
    ..We report here that Orai1 and STIM1, both of which are involved in store-operated calcium entry, are essential for breast tumor cell migration in ..
  8. Williams R, Manji S, Parker N, Hancock M, Van Stekelenburg L, Eid J, et al. Identification and characterization of the STIM (stromal interaction molecule) gene family: coding for a novel class of transmembrane proteins. Biochem J. 2001;357:673-85 pubmed
    b>STIM1 (where STIM is stromal interaction molecule) is a candidate tumour suppressor gene that maps to human chromosome 11p15.5, a region implicated in a variety of cancers, particularly embryonal rhabdomyosarcoma...
  9. Baba Y, Hayashi K, Fujii Y, Mizushima A, Watarai H, Wakamori M, et al. Coupling of STIM1 to store-operated Ca2+ entry through its constitutive and inducible movement in the endoplasmic reticulum. Proc Natl Acad Sci U S A. 2006;103:16704-9 pubmed
    ..b>STIM1, a putative Ca(2+) sensor in the endoplasmic reticulum (ER), has been recently shown to be necessary for SOC ..

More Information


  1. Skibinska Kijek A, Wisniewska M, Gruszczynska Biegala J, Methner A, Kuznicki J. Immunolocalization of STIM1 in the mouse brain. Acta Neurobiol Exp (Wars). 2009;69:413-28 pubmed
    ..Entry (CCE) in neurons seems to depend, as in non-excitatory cells, on endoplasmic reticulum calcium sensors STIM1 or STIM2. We show localization of STIM1 in the mouse brain by immunohistochemistry with a specific antibody...
  2. Oh Hora M, Yamashita M, Hogan P, Sharma S, Lamperti E, Chung W, et al. Dual functions for the endoplasmic reticulum calcium sensors STIM1 and STIM2 in T cell activation and tolerance. Nat Immunol. 2008;9:432-43 pubmed publisher
    ..Here we show that mouse T cells and fibroblasts lacking the calcium sensor STIM1 had severely impaired store-operated Ca2+ influx, whereas deficiency in the calcium sensor STIM2 had a smaller ..
  3. Baba Y, Nishida K, Fujii Y, Hirano T, Hikida M, Kurosaki T. Essential function for the calcium sensor STIM1 in mast cell activation and anaphylactic responses. Nat Immunol. 2008;9:81-8 pubmed
    ..Here we show that the Ca2+-binding endoplasmic reticulum protein STIM1 is critical to mast cell function...
  4. Berna Erro A, Braun A, Kraft R, Kleinschnitz C, Schuhmann M, Stegner D, et al. STIM2 regulates capacitive Ca2+ entry in neurons and plays a key role in hypoxic neuronal cell death. Sci Signal. 2009;2:ra67 pubmed publisher
    ..In nonexcitable cells, CCE is controlled by the endoplasmic reticulum (ER)-resident Ca(2+) sensor STIM1, whereas the closely related protein STIM2 has been proposed to regulate basal cytosolic and ER Ca(2+) ..
  5. Ma J, McCarl C, Khalil S, Lüthy K, Feske S. T-cell-specific deletion of STIM1 and STIM2 protects mice from EAE by impairing the effector functions of Th1 and Th17 cells. Eur J Immunol. 2010;40:3028-42 pubmed publisher
    ..We show that mice with T-cell-specific deletion of STIM1 or STIM2 are protected from EAE, a mouse model of multiple sclerosis (MS)...
  6. Stiber J, Hawkins A, Zhang Z, Wang S, Burch J, Graham V, et al. STIM1 signalling controls store-operated calcium entry required for development and contractile function in skeletal muscle. Nat Cell Biol. 2008;10:688-97 pubmed publisher
    It is now well established that stromal interaction molecule 1 (STIM1) is the calcium sensor of endoplasmic reticulum stores required to activate store-operated calcium entry (SOC) channels at the surface of non-excitable cells...
  7. Braun A, Gessner J, Varga Szabo D, Syed S, Konrad S, Stegner D, et al. STIM1 is essential for Fcgamma receptor activation and autoimmune inflammation. Blood. 2009;113:1097-104 pubmed publisher
    ..Here we show that macrophages lacking the endoplasmic reticulum-resident calcium sensor, STIM1, cannot activate FcgammaR-induced Ca(2+) entry and phagocytosis...
  8. Srikanth S, Jung H, Kim K, Souda P, Whitelegge J, Gwack Y. A novel EF-hand protein, CRACR2A, is a cytosolic Ca2+ sensor that stabilizes CRAC channels in T cells. Nat Cell Biol. 2010;12:436-46 pubmed publisher
    Orai1 and STIM1 are critical components of Ca(2+) release-activated Ca(2+) (CRAC) channels that mediate store-operated Ca(2+) entry (SOCE) in immune cells...
  9. Edwards J, Friedrich O, Cully T, von Wegner F, Murphy R, Launikonis B. Upregulation of store-operated Ca2+ entry in dystrophic mdx mouse muscle. Am J Physiol Cell Physiol. 2010;299:C42-50 pubmed publisher
    ..The shift in SOCE activation and deactivation thresholds was accompanied by an approximately threefold increase in STIM1 and Orai1 proteins in dystrophic muscle...
  10. Furukawa Y, Haruyama N, Nikaido M, Nakanishi M, Ryu N, Oh Hora M, et al. Stim1 Regulates Enamel Mineralization and Ameloblast Modulation. J Dent Res. 2017;96:1422-1429 pubmed publisher
    Loss-of-function mutations in the Ca2+ release-activated Ca2+ channel genes ORAI1 and STIM1 abolish store-operated Ca2+ entry (SOCE) and result in ectodermal dysplasia with amelogenesis imperfecta...
  11. Zhao G, Li T, Brochet D, Rosenberg P, Lederer W. STIM1 enhances SR Ca2+ content through binding phospholamban in rat ventricular myocytes. Proc Natl Acad Sci U S A. 2015;112:E4792-801 pubmed publisher
    In ventricular myocytes, the physiological function of stromal interaction molecule 1 (STIM1), an endo/sarcoplasmic reticulum (ER/SR) Ca(2+) sensor, is unclear with respect to its cellular localization, its Ca(2+)-dependent mobilization, ..
  12. Klejman M, Gruszczynska Biegala J, Skibinska Kijek A, Wisniewska M, Misztal K, Blazejczyk M, et al. Expression of STIM1 in brain and puncta-like co-localization of STIM1 and ORAI1 upon depletion of Ca(2+) store in neurons. Neurochem Int. 2009;54:49-55 pubmed publisher
    ..that Store Operated Ca(2+) Entry (SOCE) in non-excitable cells is based on the interaction of ER calcium sensor STIM1 with the plasma membrane Ca(2+) channel protein ORAI1...
  13. Tamarina N, Kuznetsov A, Philipson L. Reversible translocation of EYFP-tagged STIM1 is coupled to calcium influx in insulin secreting beta-cells. Cell Calcium. 2008;44:533-44 pubmed publisher
    Calcium (Ca(2+)) signaling regulates insulin secretion in pancreatic beta-cells. STIM1 has been proposed to function as an endoplasmic reticulum (ER) Ca(2+) sensor regulating store-operated Ca(2+) entry (SOCE)...
  14. Majewski Ł, Maciąg F, Boguszewski P, Wasilewska I, Wiera G, Wójtowicz T, et al. Overexpression of STIM1 in neurons in mouse brain improves contextual learning and impairs long-term depression. Biochim Biophys Acta Mol Cell Res. 2017;1864:1071-1087 pubmed publisher
    b>STIM1 is an endoplasmic reticulum calcium sensor that is involved in several processes in neurons, including store-operated calcium entry. STIM1 also inhibits voltage-gated calcium channels, such as Cav1.2 and Cav3...
  15. Henke N, Albrecht P, Pfeiffer A, Toutzaris D, Zanger K, Methner A. Stromal interaction molecule 1 (STIM1) is involved in the regulation of mitochondrial shape and bioenergetics and plays a role in oxidative stress. J Biol Chem. 2012;287:42042-52 pubmed publisher
    ..over the plasma membrane is activated by depletion of intracellular Ca(2+) stores and is mediated by the sensor STIM1 and the channel ORAI1...
  16. McDonald B, Bunker J, Erickson S, Oh Hora M, Bendelac A. Crossreactive αβ T Cell Receptors Are the Predominant Targets of Thymocyte Negative Selection. Immunity. 2015;43:859-69 pubmed publisher
    ..Thus, broadly crossreactive TCRs arise at low frequency in the pre-selection repertoire but constitute the primary drivers of thymic negative selection and iIEL lineage differentiation. ..
  17. Prins D, Michalak M. STIM1 is cleaved by calpain. FEBS Lett. 2015;589:3294-301 pubmed publisher
    ..entry (SOCE) is a pathway that moves Ca(2+) across the plasma membrane and is mediated by two major proteins, STIM1 and Orai1...
  18. Li T, FINCH E, Graham V, Zhang Z, Ding J, Burch J, et al. STIM1-Ca(2+) signaling is required for the hypertrophic growth of skeletal muscle in mice. Mol Cell Biol. 2012;32:3009-17 pubmed publisher
    ..Here, we show that Ca(2+) signaling governed by stromal interaction molecule 1 (STIM1) plays a central role in the integration of signaling and, therefore, muscle growth and ..
  19. Demaurex N, Nunes P. The role of STIM and ORAI proteins in phagocytic immune cells. Am J Physiol Cell Physiol. 2016;310:C496-508 pubmed publisher
    ..Here, we review evidence from cell lines and mouse models linking STIM and ORAI proteins to the control of specific innate immune functions of neutrophils, macrophages, and dendritic cells. ..
  20. Michaelis M, Nieswandt B, Stegner D, Eilers J, Kraft R. STIM1, STIM2, and Orai1 regulate store-operated calcium entry and purinergic activation of microglia. Glia. 2015;63:652-63 pubmed publisher
    ..sensors and Orai Ca(2+) channel subunits, that comprise the molecular machinery of SOCE, showed relevant levels of STIM1, STIM2, and Orai1 in cultured mouse microglia...
  21. Concepcion A, Vaeth M, Wagner L, Eckstein M, Hecht L, Yang J, et al. Store-operated Ca2+ entry regulates Ca2+-activated chloride channels and eccrine sweat gland function. J Clin Invest. 2016;126:4303-4318 pubmed publisher
    ..Loss-of-function mutations in the Ca2+ release-activated Ca2+ (CRAC) channel genes ORAI1 and STIM1 abolish store-operated Ca2+ entry (SOCE), and patients with these CRAC channel mutations suffer from anhidrosis ..
  22. Li Y, Lou C, Wang W. STIM1 deficiency protects the liver from ischemia/reperfusion injury in mice. Biochem Biophys Res Commun. 2018;496:422-428 pubmed publisher
    ..b>Stromal interaction molecule 1 (STIM1) plays essential role in regulating the induction of cellular responses to a number of stress ..
  23. Yarkoni Y, Cambier J. Differential STIM1 expression in T and B cell subsets suggests a role in determining antigen receptor signal amplitude. Mol Immunol. 2011;48:1851-8 pubmed publisher
    ..The primary mechanism of extracellular Ca(2+) entry in lymphocytes is the CRAC influx. STIM1 is a crucial component of the CRAC influx mechanism in lymphocytes, acting as a sensor of low Ca(2+) concentration ..
  24. Prins D, Groenendyk J, Touret N, Michalak M. Modulation of STIM1 and capacitative Ca2+ entry by the endoplasmic reticulum luminal oxidoreductase ERp57. EMBO Rep. 2011;12:1182-8 pubmed publisher
    b>STIM1 is an endoplasmic reticulum (ER) membrane Ca(2+) sensor responsible for activation of store-operated Ca(2+) influx...
  25. Cully T, Edwards J, Friedrich O, Stephenson D, Murphy R, Launikonis B. Changes in plasma membrane Ca-ATPase and stromal interacting molecule 1 expression levels for Ca(2+) signaling in dystrophic mdx mouse muscle. Am J Physiol Cell Physiol. 2012;303:C567-76 pubmed publisher
    ..responsible for rapidly activated SOCE appears to be the stromal interacting molecule 1L (STIM1L) isoform of STIM1 protein, which directly interacts with the Orai1 Ca(2+) channel in the t-system...
  26. Tian G, Tepikin A, Tengholm A, Gylfe E. cAMP induces stromal interaction molecule 1 (STIM1) puncta but neither Orai1 protein clustering nor store-operated Ca2+ entry (SOCE) in islet cells. J Biol Chem. 2012;287:9862-72 pubmed publisher
    ..the endoplasmic reticulum (ER) resulting in translocation of the transmembrane Ca(2+) sensor protein, stromal interaction molecule 1 (STIM1), to the junctions between ER and the plasma membrane where it binds to the Ca(2+) channel ..
  27. Sogkas G, Vögtle T, Rau E, Gewecke B, Stegner D, Schmidt R, et al. Orai1 controls C5a-induced neutrophil recruitment in inflammation. Eur J Immunol. 2015;45:2143-53 pubmed publisher
    b>Stromal interaction molecule 1 (STIM1)-dependent store operated calcium-entry (SOCE) through Orai1-mediated calcium (Ca(2+) ) influx is considered a major pathway of Ca(2+) signaling, serving T-cell, mast cell, and platelet responses...
  28. Ng L, O Neill K, French D, Airey J, Singer C, Tian H, et al. TRPC1 and Orai1 interact with STIM1 and mediate capacitative Ca(2+) entry caused by acute hypoxia in mouse pulmonary arterial smooth muscle cells. Am J Physiol Cell Physiol. 2012;303:C1156-72 pubmed publisher
    ..if transient receptor potential canonical 1 (TRPC1) and Orai1 interact with stromal interacting molecule 1 (STIM1) and mediate CCE caused by acute hypoxia in mouse PASMCs...
  29. Leech C, Kopp R, Nelson H, Nandi J, Roe M. Stromal Interaction Molecule 1 (STIM1) Regulates ATP-sensitive Potassium (KATP) and Store-operated Ca2+ Channels in MIN6 β-Cells. J Biol Chem. 2017;292:2266-2277 pubmed publisher
    b>Stromal interaction molecule 1 (STIM1) regulates store-operated Ca2+ entry (SOCE) and other ion channels either as an endoplasmic reticulum Ca2+-sensing protein or when present in the plasma membrane...
  30. Mao X, Zhang J, Han Y, Luan C, Hu Y, Hao Z, et al. Deficient for endoplasmic reticulum calcium sensors Stim1 and Stim2 affects aberrant antibody affinity maturation in B cells. Oncotarget. 2016;7:60885-60895 pubmed publisher
    ..In our studies, mice deficient for both endoplasmic reticulum calciumsensor Stim1 and Stim2 was immunized with T-cell dependent and independent antigens. Antibody affinity was measured by ELISA...
  31. Furukawa Y, Teraguchi S, Ikegami T, Dagliyan O, Jin L, Hall D, et al. Intrinsic disorder mediates cooperative signal transduction in STIM1. J Mol Biol. 2014;426:2082-97 pubmed publisher
    ..The oligomerization of STIM1, which triggers extracellular Ca(2+) influx, exhibits cooperativity with respect to the local endoplasmic ..
  32. Steinckwich N, Myers P, Janardhan K, Flagler N, King D, Petranka J, et al. Role of the store-operated calcium entry protein, STIM1, in neutrophil chemotaxis and infiltration into a murine model of psoriasis-inflamed skin. FASEB J. 2015;29:3003-13 pubmed publisher
    b>Stromal interaction molecule 1 (STIM1) is a Ca(2+) sensor protein that initiates store-operated calcium entry (SOCE)...
  33. Cheng K, Alevizos I, Liu X, Swaim W, Yin H, Feske S, et al. STIM1 and STIM2 protein deficiency in T lymphocytes underlies development of the exocrine gland autoimmune disease, Sjogren's syndrome. Proc Natl Acad Sci U S A. 2012;109:14544-9 pubmed publisher lymphocytic infiltrates in submandibular glands from patients with pSS demonstrated significant reductions in STIM1 and STIM2 proteins...
  34. Nunes Hasler P, Maschalidi S, Lippens C, Castelbou C, Bouvet S, Guido D, et al. STIM1 promotes migration, phagosomal maturation and antigen cross-presentation in dendritic cells. Nat Commun. 2017;8:1852 pubmed publisher
    ..Here, we show that ablation of the store-operated-Ca2+-entry regulator STIM1 in mouse myeloid cells impairs cross-presentation and DC migration in vivo and in vitro...
  35. Ahmad F, Boulaftali Y, Greene T, Ouellette T, Poncz M, Feske S, et al. Relative contributions of stromal interaction molecule 1 and CalDAG-GEFI to calcium-dependent platelet activation and thrombosis. J Thromb Haemost. 2011;9:2077-86 pubmed publisher
    b>Stromal interaction molecule 1 (STIM1) was recently identified as a critical component of store-operated calcium entry (SOCE) in platelets...
  36. Collins H, He L, Zou L, Qu J, Zhou L, Litovsky S, et al. Stromal interaction molecule 1 is essential for normal cardiac homeostasis through modulation of ER and mitochondrial function. Am J Physiol Heart Circ Physiol. 2014;306:H1231-9 pubmed publisher
    The endoplasmic reticulum (ER) Ca(2+) sensor stromal interaction molecule 1 (STIM1) has been implicated as a key mediator of store-dependent and store-independent Ca(2+) entry pathways and maintenance of ER structure...
  37. Estrada I, Donthamsetty R, Debski P, Zhou M, Zhang S, Yuan J, et al. STIM1 restores coronary endothelial function in type 1 diabetic mice. Circ Res. 2012;111:1166-75 pubmed publisher
    ..Many proteins, including stromal interaction molecule 1/2 (STIM1/2), Orai1/2/3, and sarcoplasmic/endoplasmic reticulum Ca(2+)-ATPase 3 (SERCA3), are involved ..
  38. Weidinger C, Shaw P, Feske S. STIM1 and STIM2-mediated Ca(2+) influx regulates antitumour immunity by CD8(+) T cells. EMBO Mol Med. 2013;5:1311-21 pubmed publisher
    ..Patients with loss-of-function mutations in the CRAC channel genes ORAI1 or STIM1 are immunodeficient and are prone to develop virus-associated tumours...
  39. Li S, Hao B, Lu Y, Yu P, Lee H, Yue J. Intracellular alkalinization induces cytosolic Ca2+ increases by inhibiting sarco/endoplasmic reticulum Ca2+-ATPase (SERCA). PLoS ONE. 2012;7:e31905 pubmed publisher
    ..of depletion of the ER Ca(2+) store by pHi rise is the activation of store-operated channels (SOCs) of Orai1 and Stim1, leading to increased Ca(2+) influx...
  40. Correll R, Goonasekera S, van Berlo J, Burr A, Accornero F, Zhang H, et al. STIM1 elevation in the heart results in aberrant Ca²⁺ handling and cardiomyopathy. J Mol Cell Cardiol. 2015;87:38-47 pubmed publisher
    b>Stromal interaction molecule 1 (STIM1) is a Ca(2+) sensor that partners with Orai1 to elicit Ca(2+) entry in response to endoplasmic reticulum (ER) Ca(2+) store depletion...
  41. Freund Brown J, Choa R, Singh B, Robertson T, Ferry G, Viver E, et al. Cutting Edge: Murine NK Cells Degranulate and Retain Cytotoxic Function without Store-Operated Calcium Entry. J Immunol. 2017;: pubmed publisher
    ..Our data suggest that mouse NK cells use different signaling mechanisms for cytotoxicity compared with other cytotoxic lymphocytes. ..
  42. Gandhirajan R, Meng S, Chandramoorthy H, Mallilankaraman K, Mancarella S, Gao H, et al. Blockade of NOX2 and STIM1 signaling limits lipopolysaccharide-induced vascular inflammation. J Clin Invest. 2013;123:887-902 pubmed publisher
    ..To determine whether stromal interaction molecule 1-dependent (STIM1-dependent) signaling drives endothelial dysfunction in response to LPS, we ..
  43. Hou P, Liu Z, Li N, Cheng W, Guo S. Knockdown of STIM1 improves neuronal survival after traumatic neuronal injury through regulating mGluR1-dependent Ca(2+) signaling in mouse cortical neurons. Cell Mol Neurobiol. 2015;35:283-92 pubmed publisher
    ..Here, we investigated the role of STIM1 in regulating metabotropic glutamate receptor 1 (mGluR1)-related Ca(2+) signaling and neuronal survival by using ..
  44. Overall M, Parker N, Scarcella D, Smith P, Dziadek M. Murine Stim1 maps to distal chromosome 7 and is not imprinted. Mamm Genome. 1998;9:657-9 pubmed
    b>STIM1 (GOK) maps to a region of human Chromosome (Chr) 11p15.5 that is implicated in several embryonal tumors, and some evidence indicates that STIM1 may have a growth suppressor role in rhabdomyosarcoma...
  45. Phuong T, Yun Y, Kim S, Kang T. Positive feedback control between STIM1 and NFATc3 is required for C2C12 myoblast differentiation. Biochem Biophys Res Commun. 2013;430:722-8 pubmed publisher
    Up-regulation of STIM1-mediated store-operated Ca(2+) entry (SOCE) and Ca(2+)-dependent NFAT signaling is important for myogenic differentiation...
  46. Matsumoto M, Fujii Y, Baba A, Hikida M, Kurosaki T, Baba Y. The calcium sensors STIM1 and STIM2 control B cell regulatory function through interleukin-10 production. Immunity. 2011;34:703-14 pubmed publisher
    ..However, its physiological role in B cells remains elusive. Here, we show that ER calcium sensors STIM1- and STIM2-induced SOC influx is critical for B cell regulatory function...
  47. Oh Hora M, Komatsu N, Pishyareh M, Feske S, Hori S, Taniguchi M, et al. Agonist-selected T cell development requires strong T cell receptor signaling and store-operated calcium entry. Immunity. 2013;38:881-95 pubmed publisher
    ..Here we have used mice lacking the endoplasmic reticulum Ca2+ sensors stromal interaction molecule 1 (STIM1) and STIM2 to show that STIM-induced store-operated Ca2+ entry is not essential for thymic ..
  48. Jozsef L, Tashiro K, Kuo A, Park E, Skoura A, Albinsson S, et al. Reticulon 4 is necessary for endoplasmic reticulum tubulation, STIM1-Orai1 coupling, and store-operated calcium entry. J Biol Chem. 2014;289:9380-95 pubmed publisher
    ..Mechanistically, we show this to be the result of defective STIM1-Orai1 coupling because of loss of ER tubulation and redistribution of STIM1 to ER sheets...
  49. Tong B, Lee C, Cheng W, Lai K, Foskett J, Cheung K. Familial Alzheimer's disease-associated presenilin 1 mutants promote γ-secretase cleavage of STIM1 to impair store-operated Ca2+ entry. Sci Signal. 2016;9:ra89 pubmed publisher
    ..CCE occurs when STIM1 detects decreases in Ca(2+) in the endoplasmic reticulum (ER) and activates ORAI channels to replenish Ca(2+) ..
  50. Takahashi Y, Murakami M, Watanabe H, Hasegawa H, Ohba T, Munehisa Y, et al. Essential role of the N-terminus of murine Orai1 in store-operated Ca2+ entry. Biochem Biophys Res Commun. 2007;356:45-52 pubmed
    ..Recently, human Orai1 (the channel-forming subunit) and STIM1 (the calcium sensor) were identified as essential molecules for SOCE...
  51. Waite J, Vardhana S, Shaw P, Jang J, McCarl C, Cameron T, et al. Interference with Ca(2+) release activated Ca(2+) (CRAC) channel function delays T-cell arrest in vivo. Eur J Immunol. 2013;43:3343-54 pubmed publisher
    ..CRAC channel function is not required for homing to SLOs, but enhances spatiotemporal coordination of TCR signaling and motility arrest. ..
  52. Ryu C, Jang D, Jung D, Kim Y, Shim H, Ryu H, et al. STIM1 Regulates Somatic Ca2+ Signals and Intrinsic Firing Properties of Cerebellar Purkinje Neurons. J Neurosci. 2017;37:8876-8894 pubmed publisher
    ..It has been well established in both neuronal and non-neuronal cells that stromal interaction molecule 1 (STIM1) initiates and regulates refilling Ca2+ into the ER...
  53. Sundivakkam P, Freichel M, Singh V, Yuan J, Vogel S, Flockerzi V, et al. The Ca(2+) sensor stromal interaction molecule 1 (STIM1) is necessary and sufficient for the store-operated Ca(2+) entry function of transient receptor potential canonical (TRPC) 1 and 4 channels in endothelial cells. Mol Pharmacol. 2012;81:510-26 pubmed publisher
    We addressed the requirement for stromal interaction molecule 1 (STIM1), the endoplasmic reticulum (ER) Ca(2+)-sensor, and Orai1, a Ca(2+) selective channel, in regulating Ca(2+) entry through the store-operated channels mouse transient ..