Gene Symbol: Stil
Description: Scl/Tal1 interrupting locus
Alias: Sil, SCL-interrupting locus protein homolog, Tal1 interrupting locus
Species: mouse
Products:     Stil

Top Publications

  1. Izraeli S, Lowe L, Bertness V, Campaner S, Hahn H, Kirsch I, et al. Genetic evidence that Sil is required for the Sonic Hedgehog response pathway. Genesis. 2001;31:72-7 pubmed
    The Sil gene encodes a cytosolic protein required for mouse embryonic midline and left/right axial development...
  2. Collazo Garcia N, Scherer P, Aplan P. Cloning and characterization of a murine SIL gene. Genomics. 1995;30:506-13 pubmed
    The human SIL gene is disrupted by a site-specific interstitial deletion in 25% of children with T-cell acute lymphoblastic leukemia...
  3. Gottgens B, Gilbert J, Barton L, Grafham D, Rogers J, Bentley D, et al. Long-range comparison of human and mouse SCL loci: localized regions of sensitivity to restriction endonucleases correspond precisely with peaks of conserved noncoding sequences. Genome Res. 2001;11:87-97 pubmed
    ..The SCL gene is flanked upstream by the SIL gene and downstream by the MAP17 gene in both species, but the gene order is not collinear downstream from MAP17...
  4. Castiel A, Danieli M, David A, Moshkovitz S, Aplan P, Kirsch I, et al. The Stil protein regulates centrosome integrity and mitosis through suppression of Chfr. J Cell Sci. 2011;124:532-9 pubmed publisher
    Stil (Sil, SCL/TAL1 interrupting locus) is a cytosolic and centrosomal protein expressed in proliferating cells that is required for mouse and zebrafish neural development and is mutated in familial microcephaly...
  5. Vulprecht J, David A, Tibelius A, Castiel A, Konotop G, Liu F, et al. STIL is required for centriole duplication in human cells. J Cell Sci. 2012;125:1353-62 pubmed publisher
    ..STIL (SCL/TAL1 interrupting locus, also known as SIL) is a centrosomal protein that is essential for mouse and zebrafish embryonic ..
  6. Izraeli S, Colaizzo Anas T, Bertness V, Mani K, Aplan P, Kirsch I. Expression of the SIL gene is correlated with growth induction and cellular proliferation. Cell Growth Differ. 1997;8:1171-9 pubmed
    The SIL gene was discovered at the site of a cancer-associated interstitial deletion in which its promoter assumed the regulation of a second gene, SCL...
  7. Izraeli S, Lowe L, Bertness V, Good D, Dorward D, Kirsch I, et al. The SIL gene is required for mouse embryonic axial development and left-right specification. Nature. 1999;399:691-4 pubmed
    ..Here we show that mouse embryos lacking the early-response gene SIL have axial midline defects, a block in midline Sonic hedgehog (Shh) signalling and randomized cardiac looping...
  8. Campaner S, Kaldis P, Izraeli S, Kirsch I. Sil phosphorylation in a Pin1 binding domain affects the duration of the spindle checkpoint. Mol Cell Biol. 2005;25:6660-72 pubmed
    b>SIL is an immediate-early gene that is essential for embryonic development and is implicated in T-cell leukemia-associated translocations...
  9. David A, Liu F, Tibelius A, Vulprecht J, Wald D, Rothermel U, et al. Lack of centrioles and primary cilia in STIL(-/-) mouse embryos. Cell Cycle. 2014;13:2859-68 pubmed publisher
    ..Genetic ablation of STIL, an essential component of the centriole replication machinery in mammalian cells, causes embryonic lethality in ..

Scientific Experts

More Information


  1. Aplan P, Lombardi D, Kirsch I. Structural characterization of SIL, a gene frequently disrupted in T-cell acute lymphoblastic leukemia. Mol Cell Biol. 1991;11:5462-9 pubmed
    The SIL (SCL interrupting locus) gene was initially discovered at the site of a genomic rearrangement in a T-cell acute lymphoblastic leukemia cell line...
  2. Loebel D, O Rourke M, Steiner K, Banyer J, Tam P. Isolation of differentially expressed genes from wild-type and Twist mutant mouse limb buds. Genesis. 2002;33:103-13 pubmed
  3. Colaizzo Anas T, Aplan P. Cloning and characterization of the SIL promoter. Biochim Biophys Acta. 2003;1625:207-13 pubmed
    The SIL gene undergoes a site-specific rearrangement with the SCL gene in 25% of patients with T cell acute lymphoblastic leukemia (ALL)...