Stc1

Summary

Gene Symbol: Stc1
Description: stanniocalcin 1
Alias: Stc, stanniocalcin-1, STC-1
Species: mouse
Products:     Stc1

Top Publications

  1. Serlachius M, Andersson L. Upregulated expression of stanniocalcin-1 during adipogenesis. Exp Cell Res. 2004;296:256-64 pubmed
    Stanniocalcin-1 (STC-1) is a 56-kDa homodimeric protein originally discovered in bony fish, where it protects against toxic levels of environmental calcium by lowering the uptake of calcium via the gills and by increasing the ..
  2. Westberg J, Serlachius M, Lankila P, Penkowa M, Hidalgo J, Andersson L. Hypoxic preconditioning induces neuroprotective stanniocalcin-1 in brain via IL-6 signaling. Stroke. 2007;38:1025-30 pubmed
    ..Stanniocalcin-1 (STC-1) is a 56-kDa homodimeric glycoprotein originally discovered in bony fish, where it regulates calcium/phosphate ..
  3. Huang L, Garcia G, LOU Y, Zhou Q, Truong L, DiMattia G, et al. Anti-inflammatory and renal protective actions of stanniocalcin-1 in a model of anti-glomerular basement membrane glomerulonephritis. Am J Pathol. 2009;174:1368-78 pubmed publisher
    We have previously shown that stanniocalcin-1 (STC1) inhibits the transendothelial migration of macrophages and T cells, suppresses superoxide generation in macrophages, and attenuates macrophage responses to chemoattractants...
  4. Nguyen A, Chang A, Reddel R. Stanniocalcin-1 acts in a negative feedback loop in the prosurvival ERK1/2 signaling pathway during oxidative stress. Oncogene. 2009;28:1982-92 pubmed publisher
    Mammalian Stanniocalcin-1 (STC1) is a glycoprotein that has been implicated in various biological processes including angiogenesis...
  5. McCudden C, James K, Hasilo C, Wagner G. Characterization of mammalian stanniocalcin receptors. Mitochondrial targeting of ligand and receptor for regulation of cellular metabolism. J Biol Chem. 2002;277:45249-58 pubmed
    The polypeptide hormone stanniocalcin (STC) is widely expressed in mammalian tissues...
  6. Varghese R, Gagliardi A, Bialek P, Yee S, Wagner G, DiMattia G. Overexpression of human stanniocalcin affects growth and reproduction in transgenic mice. Endocrinology. 2002;143:868-76 pubmed
    In mammals stanniocalcin (STC) is widely expressed, and in the kidney and gut it regulates serum calcium levels by promoting phosphate reabsorption...
  7. Sheikh Hamad D. Mammalian stanniocalcin-1 activates mitochondrial antioxidant pathways: new paradigms for regulation of macrophages and endothelium. Am J Physiol Renal Physiol. 2010;298:F248-54 pubmed publisher
    The mammalian homolog of the fish calcium regulatory hormone stanniocalcin-1 (STC1) is ubiquitously expressed and likely functions in an autocrine/paracrine fashion...
  8. Wang Y, Huang L, Abdelrahim M, Cai Q, Truong A, Bick R, et al. Stanniocalcin-1 suppresses superoxide generation in macrophages through induction of mitochondrial UCP2. J Leukoc Biol. 2009;86:981-8 pubmed publisher
    Mammalian STC1 decreases the mobility of macrophages and diminishes their response to chemokines. In the current experiments, we sought to determine the impact of STC1 on energy metabolism and superoxide generation in mouse macrophages...
  9. Kanellis J, Bick R, Garcia G, Truong L, Tsao C, Etemadmoghadam D, et al. Stanniocalcin-1, an inhibitor of macrophage chemotaxis and chemokinesis. Am J Physiol Renal Physiol. 2004;286:F356-62 pubmed
    ..The mammalian counterpart of the fish calcium-regulating hormone stanniocalcin-1 (STC1) is expressed in multiple organs including the thymus and spleen, and hence, we hypothesized that it may have a ..

Scientific Experts

More Information

Publications42

  1. Hayase S, Sasaki Y, Matsubara T, Seo D, Miyakoshi M, Murata T, et al. Expression of stanniocalcin 1 in thyroid side population cells and thyroid cancer cells. Thyroid. 2015;25:425-36 pubmed publisher
    ..Among genes up-regulated, stanniocalcin 1 (STC1) was chosen for study because of its expression in various thyroid cells by Western blotting and ..
  2. Zaidi D, James K, Wagner G. Passive immunization of lactating mice with stanniocalcin-1 antiserum reduces mammary gland development, milk fat content, and postnatal pup growth. Am J Physiol Endocrinol Metab. 2006;291:E974-81 pubmed
    During pregnancy and lactation in rodents, stanniocalcin-1 (STC-1) production by the ovaries is upregulated markedly and released into the circulation. The mammary glands are one target of this systemically delivered hormone...
  3. Pan J, Huang L, Belousova T, Lu L, Yang Y, Reddel R, et al. Stanniocalcin-1 inhibits renal ischemia/reperfusion injury via an AMP-activated protein kinase-dependent pathway. J Am Soc Nephrol. 2015;26:364-78 pubmed publisher
    ..Reactive oxygen species are critical for the genesis of ischemic AKI. Stanniocalcin-1 (STC1) suppresses superoxide generation through induction of uncoupling proteins (UCPs), and transgenic overexpression of ..
  4. Huang L, Zhang L, Ju H, Li Q, Pan J, Al Lawati Z, et al. Stanniocalcin-1 inhibits thrombin-induced signaling and protects from bleomycin-induced lung injury. Sci Rep. 2015;5:18117 pubmed publisher
    ..Stanniocalcin-1 (STC1) activates anti-oxidant pathways, inhibits inflammation and provides cytoprotection; hence, we hypothesized that ..
  5. Jiang W, Chang A, Satoh M, Furuichi Y, Tam P, Reddel R. The distribution of stanniocalcin 1 protein in fetal mouse tissues suggests a role in bone and muscle development. J Endocrinol. 2000;165:457-66 pubmed
    We previously isolated a mammalian gene STC1 that encodes a glycoprotein related to stanniocalcin (STC), a fish hormone that plays a major role in calcium homeostasis...
  6. Zlot C, Ingle G, Hongo J, Yang S, Sheng Z, Schwall R, et al. Stanniocalcin 1 is an autocrine modulator of endothelial angiogenic responses to hepatocyte growth factor. J Biol Chem. 2003;278:47654-9 pubmed
    b>Stanniocalcin 1 (STC1) is a secreted glycoprotein originally described as a hormone involved in calcium and phosphate homeostasis in bony fishes...
  7. Stasko S, DiMattia G, Wagner G. Dynamic changes in stanniocalcin gene expression in the mouse uterus during early implantation. Mol Cell Endocrinol. 2001;174:145-9 pubmed
    ..Stanniocalcin (STC) is a new mammalian polypeptide hormone with roles in ion transport, reproduction and development...
  8. Westberg J, Serlachius M, Lankila P, Andersson L. Hypoxic preconditioning induces elevated expression of stanniocalcin-1 in the heart. Am J Physiol Heart Circ Physiol. 2007;293:H1766-71 pubmed
    ..Stanniocalcin-1 (STC-1) is an evolutionarily conserved glycoprotein originally discovered in fish, in which it regulates calcium/..
  9. Tang S, Wu C, Wu S, Peng C, Perng W, Kang B, et al. Stanniocalcin-1 ameliorates lipopolysaccharide-induced pulmonary oxidative stress, inflammation, and apoptosis in mice. Free Radic Biol Med. 2014;71:321-31 pubmed publisher
    Stanniocalcin-1 (STC1) is an endogenous glycoprotein whose anti-inflammatory effects occur through induction of uncoupling proteins to reduce oxidative stress...
  10. Turner J, Sazonova O, Wang H, Pozzi A, Wagner G. Induction of the renal stanniocalcin-1 gene in rodents by water deprivation. Mol Cell Endocrinol. 2010;328:8-15 pubmed publisher
    Stanniocalcin-1 (STC-1) is made by kidney collecting duct cells for targeting of nephron mitochondria to promote respiratory uncoupling and calcium uniport activity...
  11. Stasko S, Wagner G. Possible roles for stanniocalcin during early skeletal patterning and joint formation in the mouse. J Endocrinol. 2001;171:237-48 pubmed
    Stanniocalcin (STC) is a polypeptide hormone discovered first in fish and more recently in mammals...
  12. Stasko S, Wagner G. Stanniocalcin gene expression during mouse urogenital development: a possible role in mesenchymal-epithelial signalling. Dev Dyn. 2001;220:49-59 pubmed
    Stanniocalcin (STC) is a polypeptide hormone first discovered in fish and more recently in mammals...
  13. Bhatnagar S, Zhu X, Ou J, Lin L, Chamberlain L, Zhu L, et al. Genetic and pharmacological reactivation of the mammalian inactive X chromosome. Proc Natl Acad Sci U S A. 2014;111:12591-8 pubmed publisher
    ..A homozygous mouse knockout of one of the XCIFs, stanniocalcin 1 (STC1), has an expected XCI defect but surprisingly is phenotypically normal...
  14. Varghese R, Wong C, Deol H, Wagner G, DiMattia G. Comparative analysis of mammalian stanniocalcin genes. Endocrinology. 1998;139:4714-25 pubmed
    The recent discovery of mammalian stanniocalcin (STC) prompted an investigation of its gene structure and expression pattern to study its function and regulation...
  15. Law A, Hébert R, Nasrallah R, Langenbach R, Wong C, Wagner G. Cyclooxygenase-2 mediates induction of the renal stanniocalcin-1 gene by arginine vasopressin. Mol Cell Endocrinol. 2013;381:210-9 pubmed publisher
    In rats and mice, the renal stanniocalcin-1 (STC-1) gene is expressed in most nephron segments, but is differentially induced in response to dehydration...
  16. Chang A, Cha J, Koentgen F, Reddel R. The murine stanniocalcin 1 gene is not essential for growth and development. Mol Cell Biol. 2005;25:10604-10 pubmed
    The stanniocalcin 1 (STC1) gene is expressed in a wide variety of tissues, including the kidney, prostate, thyroid, bone, and ovary...
  17. Chen H, Chen J, Yu S, Li H, Yang P, Su C, et al. Transcriptome analysis in blastocyst hatching by cDNA microarray. Hum Reprod. 2005;20:2492-501 pubmed
    ..This work provides important information for studying the mechanisms of blastocyst hatching and implantation. These hatching-specific genes may have potential as new drug targets for controlling fertility. ..
  18. Yeung H, Chan D, Mak N, Wagner G, Wong C. Identification of signal transduction pathways that modulate dibutyryl cyclic adenosine monophosphate activation of stanniocalcin gene expression in neuroblastoma cells. Endocrinology. 2003;144:4446-52 pubmed
    Stanniocalcin (STC) is a new mammalian polypeptide hormone and appears to be a regulator of neuronal function...
  19. Yoshiko Y, Aubin J, Maeda N. Stanniocalcin 1 (STC1) protein and mRNA are developmentally regulated during embryonic mouse osteogenesis: the potential of stc1 as an autocrine/paracrine factor for osteoblast development and bone formation. J Histochem Cytochem. 2002;50:483-92 pubmed
    b>STC1, a mammalian homologue of stanniocalcin (STC) which plays a major role in calcium/phosphate homeostasis in fish, has been recently isolated...
  20. Huang L, Belousova T, Pan J, Du J, Ju H, Lu L, et al. AKI after conditional and kidney-specific knockdown of stanniocalcin-1. J Am Soc Nephrol. 2014;25:2303-15 pubmed publisher
    ..Our observations suggest that stanniocalcin-1 is critical for tubular epithelial survival under physiologic conditions. ..
  21. Liu D, Shang H, Liu Y. Stanniocalcin-1 Protects a Mouse Model from Renal Ischemia-Reperfusion Injury by Affecting ROS-Mediated Multiple Signaling Pathways. Int J Mol Sci. 2016;17: pubmed publisher
    Stanniocalcin-1 (STC-1) protects against renal ischemia-reperfusion injury (RIRI). However, the molecular mechanisms remain widely unknown...
  22. Chang A, Hook J, Lemckert F, McDonald M, Nguyen M, Hardeman E, et al. The murine stanniocalcin 2 gene is a negative regulator of postnatal growth. Endocrinology. 2008;149:2403-10 pubmed publisher
    ..There are two closely related proteins in mammals, STC1 and STC2, with functions that are currently unclear...
  23. Chang A, Dunham M, Jeffrey K, Reddel R. Molecular cloning and characterization of mouse stanniocalcin cDNA. Mol Cell Endocrinol. 1996;124:185-7 pubmed
    ..As in human, the mRNA is expressed in many mouse tissues, suggesting that mammalian stanniocalcin has a paracrine rather than endocrine role. ..
  24. Filvaroff E, Guillet S, Zlot C, Bao M, Ingle G, Steinmetz H, et al. Stanniocalcin 1 alters muscle and bone structure and function in transgenic mice. Endocrinology. 2002;143:3681-90 pubmed
    Fish stanniocalcin (STC) inhibits uptake of calcium and stimulates phosphate reabsorption...
  25. Ishibashi K, Imai M. Prospect of a stanniocalcin endocrine/paracrine system in mammals. Am J Physiol Renal Physiol. 2002;282:F367-75 pubmed
    ..and antihypercalcemic hormones are basically not necessary, in mammals, the discovery of a mammalian homolog, STC1, was surprising and intriguing...
  26. Durukan Tolvanen A, Westberg J, Serlachius M, Chang A, Reddel R, Andersson L, et al. Stanniocalcin 1 is important for poststroke functionality, but dispensable for ischemic tolerance. Neuroscience. 2013;229:49-54 pubmed publisher
    b>Stanniocalcin 1 (STC1), originally described as an antihypercalcemic hormone in fish, is highly expressed in differentiated mammalian neurons. Mild hypoxic treatment and focal cerebral ischemia induce upregulation of STC1 in the brain...
  27. Law A, Wong C, Turner J, Gonzalez A, Prieto M, Wagner G. Vasopressin controls stanniocalcin-1 gene expression in rat and mouse kidney. Mol Cell Endocrinol. 2012;348:183-8 pubmed publisher
    Renal stanniocalcin-1 (STC-1) is made by collecting duct principal cells for autocrine and paracrine targeting of the distal nephron...
  28. Jauhiainen S, Häkkinen S, Toivanen P, Heinonen S, Jyrkkänen H, Kansanen E, et al. Vascular endothelial growth factor (VEGF)-D stimulates VEGF-A, stanniocalcin-1, and neuropilin-2 and has potent angiogenic effects. Arterioscler Thromb Vasc Biol. 2011;31:1617-24 pubmed publisher
    ..reverse transcription-polymerase chain reaction, and Western blot revealed increases in VEGF-A, stanniocalcin-1 (STC1), and neuropilin (NRP) 2 expression by hVEGF-D(?N?C) stimulation, whereas induction with hVEGF-A(165) altered the ..
  29. Hasilo C, McCudden C, Gillespie J, James K, Hirvi E, Zaidi D, et al. Nuclear targeting of stanniocalcin to mammary gland alveolar cells during pregnancy and lactation. Am J Physiol Endocrinol Metab. 2005;289:E634-42 pubmed
    In most mammalian tissues, the stanniocalcin-1 gene (STC-1) produces a 50-kDa polypeptide hormone known as STC50. Within the ovaries, however, the STC-1 gene generates three higher-molecular-mass variants known as big STC...
  30. Ono M, Ohkouchi S, Kanehira M, Tode N, Kobayashi M, Ebina M, et al. Mesenchymal stem cells correct inappropriate epithelial-mesenchyme relation in pulmonary fibrosis using stanniocalcin-1. Mol Ther. 2015;23:549-60 pubmed publisher
    ..study, we show that MSCs can correct the inadequate-communication between epithelial and mesenchymal cells through STC1 (Stanniocalcin-1) secretion in a bleomycin-induced IPF model...
  31. Huang L, Belousova T, Chen M, DiMattia G, Liu D, Sheikh Hamad D. Overexpression of stanniocalcin-1 inhibits reactive oxygen species and renal ischemia/reperfusion injury in mice. Kidney Int. 2012;82:867-77 pubmed publisher
    ..Stanniocalcin-1 (STC1) suppresses superoxide generation in many systems through the induction of mitochondrial uncoupling proteins and ..
  32. Mu W, Wang W, Schimenti J. An allelic series uncovers novel roles of the BRCT domain-containing protein PTIP in mouse embryonic vascular development. Mol Cell Biol. 2008;28:6439-51 pubmed publisher
    ..These and other data suggest that PTIP has multiple functions, one of which is to promote the formation of transcriptional complexes that provide specificity of developmental gene expression. ..
  33. Roddy G, Viker K, Winkler N, Bahler C, Holman B, Sheikh Hamad D, et al. Stanniocalcin-1 Is an Ocular Hypotensive Agent and a Downstream Effector Molecule That Is Necessary for the Intraocular Pressure-Lowering Effects of Latanoprost. Invest Ophthalmol Vis Sci. 2017;58:2715-2724 pubmed publisher
    ..IOP was evaluated in stanniocalcin-1 (STC-1-/-) and wild-type mice following treatment with latanoprost or Rho kinase inhibitor Y27632...