Stat6

Summary

Gene Symbol: Stat6
Description: signal transducer and activator of transcription 6
Alias: signal transducer and transcription activator 6
Species: mouse
Products:     Stat6

Top Publications

  1. Jankovic D, Kullberg M, Noben Trauth N, Caspar P, Paul W, Sher A. Single cell analysis reveals that IL-4 receptor/Stat6 signaling is not required for the in vivo or in vitro development of CD4+ lymphocytes with a Th2 cytokine profile. J Immunol. 2000;164:3047-55 pubmed
    ..IL-2-) develop in significant numbers in helminth-infected mice deficient in either IL-4R alpha-chain or Stat6. While an expanded population of Th1 (IL-4-, IL-5-, IFN-gamma+, IL-2+) lymphocytes was observed in the same ..
  2. Mathew A, MacLean J, DeHaan E, Tager A, Green F, Luster A. Signal transducer and activator of transcription 6 controls chemokine production and T helper cell type 2 cell trafficking in allergic pulmonary inflammation. J Exp Med. 2001;193:1087-96 pubmed
    ..Here we show that Stat6 also controls Th2 cell recruitment and effector function in allergic inflammation in vivo...
  3. Foster P, Webb D, Yang M, Herbert C, Kumar R. Dissociation of T helper type 2 cytokine-dependent airway lesions from signal transducer and activator of transcription 6 signalling in experimental chronic asthma. Clin Exp Allergy. 2003;33:688-95 pubmed
    ..Airway lesions in wild-type mice were compared with those in STAT6-deficient mice and in IL-4/13 double-deficient mice by histomorphometry and immunohistochemistry...
  4. Knott M, Matthaei K, Foster P, Dent L. The roles of eotaxin and the STAT6 signalling pathway in eosinophil recruitment and host resistance to the nematodes Nippostrongylus brasiliensis and Heligmosomoides bakeri. Mol Immunol. 2009;46:2714-22 pubmed publisher
    ..brasiliensis. This study was designed to assess the importance of the eosinophil chemokine eotaxin and the STAT6/interleukin (IL)-4/IL-13 signalling pathway in early resistance to N. brasiliensis...
  5. Mahalingam S, Karupiah G, Takeda K, Akira S, Matthaei K, Foster P. Enhanced resistance in STAT6-deficient mice to infection with ectromelia virus. Proc Natl Acad Sci U S A. 2001;98:6812-7 pubmed
    We inoculated BALB/c mice deficient in STAT6 (STAT6(-/-)) and their wild-type (wt) littermates (STAT6(+/+)) with the natural mouse pathogen, ectromelia virus (EV)...
  6. Fang T, Yashiro Ohtani Y, Del Bianco C, Knoblock D, Blacklow S, Pear W. Notch directly regulates Gata3 expression during T helper 2 cell differentiation. Immunity. 2007;27:100-10 pubmed
    ..Together, these data implicate Gata3 as a direct transcriptional Notch target that acts in concert with Notch signaling to generate optimal Th2 cell responses. ..
  7. Suzuki K, Nakajima H, Kagami S, Suto A, Ikeda K, Hirose K, et al. Proteolytic processing of Stat6 signaling in mast cells as a negative regulatory mechanism. J Exp Med. 2002;196:27-38 pubmed
    Accumulating evidence has shown the importance of Stat6-mediated signaling in allergic diseases. In this study, we show a novel regulatory mechanism of Stat6-mediated signaling in mast cells...
  8. Voehringer D, Reese T, Huang X, Shinkai K, Locksley R. Type 2 immunity is controlled by IL-4/IL-13 expression in hematopoietic non-eosinophil cells of the innate immune system. J Exp Med. 2006;203:1435-46 pubmed
    ..Thus, components of type 2 immunity mediated by IL-4/IL-13 are partitioned between T cell-dependent IgE and an innate non-eosinophil tissue component, suggesting new strategies for interventions in allergic immunity. ..
  9. Chapoval S, Dasgupta P, Smith E, DeTolla L, Lipsky M, Kelly Welch A, et al. STAT6 expression in multiple cell types mediates the cooperative development of allergic airway disease. J Immunol. 2011;186:2571-83 pubmed publisher
    ..They both share a common receptor subunit, IL-4R?, and signal through the STAT6 pathway. STAT6(-/-) mice have impaired Th2 differentiation and reduced airway response to allergen...
  10. Ong Y, Reese M, Boothroyd J. Toxoplasma rhoptry protein 16 (ROP16) subverts host function by direct tyrosine phosphorylation of STAT6. J Biol Chem. 2010;285:28731-40 pubmed publisher
    ..These properties were shown to be partially mediated by dysregulation of the host transcription factors STAT3 and STAT6, but the molecular mechanisms underlying this phenotype were unclear...

Detail Information

Publications62

  1. Jankovic D, Kullberg M, Noben Trauth N, Caspar P, Paul W, Sher A. Single cell analysis reveals that IL-4 receptor/Stat6 signaling is not required for the in vivo or in vitro development of CD4+ lymphocytes with a Th2 cytokine profile. J Immunol. 2000;164:3047-55 pubmed
    ..IL-2-) develop in significant numbers in helminth-infected mice deficient in either IL-4R alpha-chain or Stat6. While an expanded population of Th1 (IL-4-, IL-5-, IFN-gamma+, IL-2+) lymphocytes was observed in the same ..
  2. Mathew A, MacLean J, DeHaan E, Tager A, Green F, Luster A. Signal transducer and activator of transcription 6 controls chemokine production and T helper cell type 2 cell trafficking in allergic pulmonary inflammation. J Exp Med. 2001;193:1087-96 pubmed
    ..Here we show that Stat6 also controls Th2 cell recruitment and effector function in allergic inflammation in vivo...
  3. Foster P, Webb D, Yang M, Herbert C, Kumar R. Dissociation of T helper type 2 cytokine-dependent airway lesions from signal transducer and activator of transcription 6 signalling in experimental chronic asthma. Clin Exp Allergy. 2003;33:688-95 pubmed
    ..Airway lesions in wild-type mice were compared with those in STAT6-deficient mice and in IL-4/13 double-deficient mice by histomorphometry and immunohistochemistry...
  4. Knott M, Matthaei K, Foster P, Dent L. The roles of eotaxin and the STAT6 signalling pathway in eosinophil recruitment and host resistance to the nematodes Nippostrongylus brasiliensis and Heligmosomoides bakeri. Mol Immunol. 2009;46:2714-22 pubmed publisher
    ..brasiliensis. This study was designed to assess the importance of the eosinophil chemokine eotaxin and the STAT6/interleukin (IL)-4/IL-13 signalling pathway in early resistance to N. brasiliensis...
  5. Mahalingam S, Karupiah G, Takeda K, Akira S, Matthaei K, Foster P. Enhanced resistance in STAT6-deficient mice to infection with ectromelia virus. Proc Natl Acad Sci U S A. 2001;98:6812-7 pubmed
    We inoculated BALB/c mice deficient in STAT6 (STAT6(-/-)) and their wild-type (wt) littermates (STAT6(+/+)) with the natural mouse pathogen, ectromelia virus (EV)...
  6. Fang T, Yashiro Ohtani Y, Del Bianco C, Knoblock D, Blacklow S, Pear W. Notch directly regulates Gata3 expression during T helper 2 cell differentiation. Immunity. 2007;27:100-10 pubmed
    ..Together, these data implicate Gata3 as a direct transcriptional Notch target that acts in concert with Notch signaling to generate optimal Th2 cell responses. ..
  7. Suzuki K, Nakajima H, Kagami S, Suto A, Ikeda K, Hirose K, et al. Proteolytic processing of Stat6 signaling in mast cells as a negative regulatory mechanism. J Exp Med. 2002;196:27-38 pubmed
    Accumulating evidence has shown the importance of Stat6-mediated signaling in allergic diseases. In this study, we show a novel regulatory mechanism of Stat6-mediated signaling in mast cells...
  8. Voehringer D, Reese T, Huang X, Shinkai K, Locksley R. Type 2 immunity is controlled by IL-4/IL-13 expression in hematopoietic non-eosinophil cells of the innate immune system. J Exp Med. 2006;203:1435-46 pubmed
    ..Thus, components of type 2 immunity mediated by IL-4/IL-13 are partitioned between T cell-dependent IgE and an innate non-eosinophil tissue component, suggesting new strategies for interventions in allergic immunity. ..
  9. Chapoval S, Dasgupta P, Smith E, DeTolla L, Lipsky M, Kelly Welch A, et al. STAT6 expression in multiple cell types mediates the cooperative development of allergic airway disease. J Immunol. 2011;186:2571-83 pubmed publisher
    ..They both share a common receptor subunit, IL-4R?, and signal through the STAT6 pathway. STAT6(-/-) mice have impaired Th2 differentiation and reduced airway response to allergen...
  10. Ong Y, Reese M, Boothroyd J. Toxoplasma rhoptry protein 16 (ROP16) subverts host function by direct tyrosine phosphorylation of STAT6. J Biol Chem. 2010;285:28731-40 pubmed publisher
    ..These properties were shown to be partially mediated by dysregulation of the host transcription factors STAT3 and STAT6, but the molecular mechanisms underlying this phenotype were unclear...
  11. Zaph C, Du Y, Saenz S, Nair M, Perrigoue J, Taylor B, et al. Commensal-dependent expression of IL-25 regulates the IL-23-IL-17 axis in the intestine. J Exp Med. 2008;205:2191-8 pubmed publisher
    ..We propose that acquisition of, or alterations in, commensal bacteria influences intestinal immune homeostasis via direct regulation of the IL-25-IL-23-IL-17 axis. ..
  12. Tang X, Marciano D, Leeman S, Amar S. LPS induces the interaction of a transcription factor, LPS-induced TNF-alpha factor, and STAT6(B) with effects on multiple cytokines. Proc Natl Acad Sci U S A. 2005;102:5132-7 pubmed
    ..that we call signal transducer and activator of transcription (STAT) 6(B) because of its considerable homology to STAT6 [here referred to as STAT6(A)]. The STAT6(B) gene expression was found to be activated by LPS...
  13. Chen H, Sun H, You F, Sun W, Zhou X, Chen L, et al. Activation of STAT6 by STING is critical for antiviral innate immunity. Cell. 2011;147:436-46 pubmed publisher
    b>STAT6 plays a prominent role in adaptive immunity by transducing signals from extracellular cytokines. We now show that STAT6 is required for innate immune signaling in response to virus infection...
  14. Tarleton R, Grusby M, Zhang L. Increased susceptibility of Stat4-deficient and enhanced resistance in Stat6-deficient mice to infection with Trypanosoma cruzi. J Immunol. 2000;165:1520-5 pubmed
    ..cruzi, mice with induced deficiencies in the Stat4 or Stat6 genes were infected with T. cruzi...
  15. Gray M, Poljakovic M, Kepka Lenhart D, Morris S. Induction of arginase I transcription by IL-4 requires a composite DNA response element for STAT6 and C/EBPbeta. Gene. 2005;353:98-106 pubmed
    ..7 macrophage cells. IL-4 induction required a composite response element containing STAT6 and C/EBP sites located 2.86 kb upstream of the transcription start site...
  16. Matsukawa A, Kaplan M, Hogaboam C, Lukacs N, Kunkel S. Pivotal role of signal transducer and activator of transcription (Stat)4 and Stat6 in the innate immune response during sepsis. J Exp Med. 2001;193:679-88 pubmed
    Signal transducer and activator of transcription (Stat)4 and Stat6 are transcription factors that provide type 1 and type 2 response, respectively...
  17. Amsen D, Antov A, Jankovic D, Sher A, Radtke F, Souabni A, et al. Direct regulation of Gata3 expression determines the T helper differentiation potential of Notch. Immunity. 2007;27:89-99 pubmed
    ..Moreover, absence of GATA-3 turned Notch from a Th2 inducer into a powerful inducer of Th1 differentiation. Therefore, Gata3 is a critical element determining inductive Th2 differentiation and limiting Th1 differentiation by Notch. ..
  18. Reese T, Liang H, Tager A, Luster A, Van Rooijen N, Voehringer D, et al. Chitin induces accumulation in tissue of innate immune cells associated with allergy. Nature. 2007;447:92-6 pubmed
    ..Chitin is a recognition element for tissue infiltration by innate cells implicated in allergic and helminth immunity and this process can be negatively regulated by a vertebrate chitinase. ..
  19. Andrews R, Ericksen M, Cunningham C, Daines M, Hershey G. Analysis of the life cycle of stat6. Continuous cycling of STAT6 is required for IL-4 signaling. J Biol Chem. 2002;277:36563-9 pubmed
    ..It is known that Stat6 is rapidly activated in response to IL-4; however, the fate of activated Stat6 is less clear...
  20. Weng M, Huntley D, Huang I, Foye Jackson O, Wang L, Sarkissian A, et al. Alternatively activated macrophages in intestinal helminth infection: effects on concurrent bacterial colitis. J Immunol. 2007;179:4721-31 pubmed
    ..rodentium. We show that via a STAT6-dependent mechanism H...
  21. Chitnis T, Najafian N, Benou C, Salama A, Grusby M, Sayegh M, et al. Effect of targeted disruption of STAT4 and STAT6 on the induction of experimental autoimmune encephalomyelitis. J Clin Invest. 2001;108:739-47 pubmed
    ..Here we used animals with targeted deletion of the STAT4 or STAT6 genes to determine the role of these signaling molecules in EAE...
  22. Yamashita M, Ukai Tadenuma M, Miyamoto T, Sugaya K, Hosokawa H, Hasegawa A, et al. Essential role of GATA3 for the maintenance of type 2 helper T (Th2) cytokine production and chromatin remodeling at the Th2 cytokine gene loci. J Biol Chem. 2004;279:26983-90 pubmed
    ..Thus, GATA3 plays important roles in the maintenance of the Th2 phenotype and continuous chromatin remodeling of the specific Th2 cytokine gene locus through cell division. ..
  23. Lee P, Zhang X, Shan P, Ma B, Lee C, Homer R, et al. ERK1/2 mitogen-activated protein kinase selectively mediates IL-13-induced lung inflammation and remodeling in vivo. J Clin Invest. 2006;116:163-73 pubmed
    ..In these settings, STAT6 is believed to be the canonical signaling molecule mediating the tissue effects of IL-13...
  24. Ricardo Gonzalez R, Red Eagle A, Odegaard J, Jouihan H, Morel C, Heredia J, et al. IL-4/STAT6 immune axis regulates peripheral nutrient metabolism and insulin sensitivity. Proc Natl Acad Sci U S A. 2010;107:22617-22 pubmed publisher
    ..Here, we demonstrate that the IL-4/STAT6 immune axis, a key pathway in helminth immunity and allergies, controls peripheral nutrient metabolism and insulin ..
  25. Zhou P, Szot G, Guo Z, Kim O, He G, Wang J, et al. Role of STAT4 and STAT6 signaling in allograft rejection and CTLA4-Ig-mediated tolerance. J Immunol. 2000;165:5580-7 pubmed
    STAT4(-/-) mice have impaired type 1 T cell differentiation, whereas STAT6(-/-) mice fail to generate type 2 responses...
  26. Kitajima M, Lee H, Nakayama T, Ziegler S. TSLP enhances the function of helper type 2 cells. Eur J Immunol. 2011;41:1862-71 pubmed publisher
    ..Taken together, these results indicate that TSLP is involved in exacerbation of mouse Th2-mediated allergic inflammation in a Th2 environment through direct stimulation of Th2 effector cells. ..
  27. Perona Wright G, Mohrs K, Mayer K, Mohrs M. Differential regulation of IL-4Ralpha expression by antigen versus cytokine stimulation characterizes Th2 progression in vivo. J Immunol. 2010;184:615-23 pubmed publisher
    ..The IL-4Ralpha chain is an essential component of the IL-4 receptor and signals via STAT6. In this study, we show that infection with a helminth pathogen elicited broad upregulation of IL-4Ralpha on ..
  28. Miyamoto H, Katsuyama E, Miyauchi Y, Hoshi H, Miyamoto K, Sato Y, et al. An essential role for STAT6-STAT1 protein signaling in promoting macrophage cell-cell fusion. J Biol Chem. 2012;287:32479-84 pubmed
    ..By contrast, lack of STAT6 increased STAT1 activation, significantly inhibiting cell-cell fusion and decreasing OC-STAMP and DC-STAMP ..
  29. Shirey K, Cole L, Keegan A, Vogel S. Francisella tularensis live vaccine strain induces macrophage alternative activation as a survival mechanism. J Immunol. 2008;181:4159-67 pubmed
    ..Ft LVS failed to induce alternative activation in IL-4Ralpha(-/-) or STAT6(-/-) macrophages and prolonged the classical inflammatory response in these cells, resulting in intracellular ..
  30. Hoshino A, Tsuji T, Matsuzaki J, Jinushi T, Ashino S, Teramura T, et al. STAT6-mediated signaling in Th2-dependent allergic asthma: critical role for the development of eosinophilia, airway hyper-responsiveness and mucus hypersecretion, distinct from its role in Th2 differentiation. Int Immunol. 2004;16:1497-505 pubmed
    ..However, neither eosinophilia, AHR nor mucus hypersecretion was induced in Th2 cell-transferred STAT6-/- mice...
  31. Finkelman F, Morris S, Orekhova T, Mori M, Donaldson D, Reiner S, et al. Stat6 regulation of in vivo IL-4 responses. J Immunol. 2000;164:2303-10 pubmed
    Although in vitro development of a Th2 response from naive CD4+ T cells is Stat6 dependent, mice immunized with a goat Ab to mouse IgD have been reported to produce a normal primary IL-4 response in Stat6-deficient mice...
  32. Vats D, Mukundan L, Odegaard J, Zhang L, Smith K, Morel C, et al. Oxidative metabolism and PGC-1beta attenuate macrophage-mediated inflammation. Cell Metab. 2006;4:13-24 pubmed
    ..We show here that in response to interleukin-4 (IL-4), signal transducer and activator of transcription 6 (STAT6) and PPARgamma-coactivator-1beta (PGC-1beta) induce macrophage programs for fatty acid oxidation and mitochondrial ..
  33. Omori M, Ziegler S. Induction of IL-4 expression in CD4(+) T cells by thymic stromal lymphopoietin. J Immunol. 2007;178:1396-404 pubmed
    ..Further analysis has shown that TSLP-induced Th2 differentiation is dependent on Stat6 and independent of IL-2 and that TSLP treatment leads to immediate, direct Il-4 gene transcription...
  34. Jin D, Takamoto M, Hu T, Taki S, Sugane K. STAT6 signalling is important in CD8 T-cell activation and defence against Toxoplasma gondii infection in the brain. Immunology. 2009;127:187-95 pubmed publisher
    ..We investigated the role of STAT6 signalling in Toxoplasma gondii-infected mice using STAT6-deficient (STAT6(-/-)) and wild-type (WT) mice...
  35. Katsumoto T, Kimura M, Yamashita M, Hosokawa H, Hashimoto K, Hasegawa A, et al. STAT6-dependent differentiation and production of IL-5 and IL-13 in murine NK2 cells. J Immunol. 2004;173:4967-75 pubmed
    ..The production of IL-5 and IL-13 in NK2 cells was found to be STAT6 dependent...
  36. Park J, Adoro S, Guinter T, Erman B, Alag A, Catalfamo M, et al. Signaling by intrathymic cytokines, not T cell antigen receptors, specifies CD8 lineage choice and promotes the differentiation of cytotoxic-lineage T cells. Nat Immunol. 2010;11:257-64 pubmed publisher
  37. Welch J, Escoubet Lozach L, Sykes D, Liddiard K, Greaves D, Glass C. TH2 cytokines and allergic challenge induce Ym1 expression in macrophages by a STAT6-dependent mechanism. J Biol Chem. 2002;277:42821-9 pubmed
    ..and macrophage cell lines revealed the presence of multiple signal transducers and activators of transcription 6 (STAT6) response elements that function in a combinatorial manner to mediate transcriptional responses to IL-4...
  38. Oliver J, Stolberg V, Chensue S, King P. IL-4 acts as a potent stimulator of IFN-? expression in CD8+ T cells through STAT6-dependent and independent induction of Eomesodermin and T-bet. Cytokine. 2012;57:191-9 pubmed publisher
    ..dependent upon activation of MAPK and PI3K but independent of the canonical IL-4-activated transcription factor, STAT6. In contrast, expression of IFN-? induced by IL-4/CD3/CD28 stimulation showed additional dependency upon STAT6 ..
  39. Patel D, Li W, Park J, Sofi M, Gourley T, Hangoc G, et al. Constitutive expression of CIITA directs CD4 T cells to produce Th2 cytokines in the thymus. Cell Immunol. 2005;233:30-40 pubmed
    ..CIITA Tg Th1 cells also expressed IL-4, IL-5, and IL-13 in the absence of Stat6. There was an approximate 10-fold increase in the number of peripheral naïve CD4 T cells and NK1...
  40. Cooney L, Towery K, Endres J, Fox D. Sensitivity and resistance to regulation by IL-4 during Th17 maturation. J Immunol. 2011;187:4440-50 pubmed publisher
    ..Downregulation of IL-17 by IL-4 is dependent on STAT6 and mediated by inhibition of STAT3 binding at the Il17a promoter...
  41. Munitz A, Brandt E, Mingler M, Finkelman F, Rothenberg M. Distinct roles for IL-13 and IL-4 via IL-13 receptor alpha1 and the type II IL-4 receptor in asthma pathogenesis. Proc Natl Acad Sci U S A. 2008;105:7240-5 pubmed publisher
    ..Taken together, our data provide a comprehensive mechanistic analysis of the critical role by which IL-13Ralpha1 mediates allergic lung pathology and highlight unforeseen roles for the type II IL-4R. ..
  42. Strait R, Morris S, Smiley K, Urban J, Finkelman F. IL-4 exacerbates anaphylaxis. J Immunol. 2003;170:3835-42 pubmed
    ..produced IFN-gamma, was T cell-, B cell-, and common gamma-chain-independent, and required IL-4Ralpha and Stat6. IL-4Ralpha signaling also enhanced anaphylaxis in mice infected with a nematode parasite that stimulates IL-4/IL-..
  43. Mishra B, Gundra U, Teale J. STAT6?/? mice exhibit decreased cells with alternatively activated macrophage phenotypes and enhanced disease severity in murine neurocysticercosis. J Neuroimmunol. 2011;232:26-34 pubmed publisher
    ..The infection in STAT6(-/-) mice resulted in significantly reduced accumulation of AAMs as well as enhanced susceptibility to infection ..
  44. Chen H, Reich N. Live cell imaging reveals continuous STAT6 nuclear trafficking. J Immunol. 2010;185:64-70 pubmed publisher
    The STAT6 transcription factor is essential for the development of protective immunity; however, the consequences of its activity can also contribute to the pathogenesis of autoimmune disease...
  45. Bunting K, Yu W, Bradley H, Haviernikova E, Kelly Welch A, Keegan A, et al. Increased numbers of committed myeloid progenitors but not primitive hematopoietic stem/progenitors in mice lacking STAT6 expression. J Leukoc Biol. 2004;76:484-90 pubmed
    Signal transducer and activator of transcription-6 (STAT6) plays important roles in cytokine signaling via interleukin-4 and -13 receptors (IL-4R and IL-13R)...
  46. Zhao A, Urban J, Sun R, Stiltz J, Morimoto M, Notari L, et al. Critical role of IL-25 in nematode infection-induced alterations in intestinal function. J Immunol. 2010;185:6921-9 pubmed publisher
    ..N. brasiliensis infection-induced upregulation of IL-25 depends upon IL-13 activation of STAT6. IL-25(-/-) mice had diminished intestinal smooth muscle and epithelial responses to N...
  47. Madden K, Whitman L, Sullivan C, Gause W, Urban J, Katona I, et al. Role of STAT6 and mast cells in IL-4- and IL-13-induced alterations in murine intestinal epithelial cell function. J Immunol. 2002;169:4417-22 pubmed
    ..2 IL-4R, initiates Jak-dependent tyrosine phosphorylation of the IL-4Ralpha-chain and the transcription factor, STAT6. In the present study, we investigated: 1) whether IL-13 has effects on intestinal epithelial cells similar to ..
  48. Lu X, Malumbres R, Shields B, Jiang X, Sarosiek K, Natkunam Y, et al. PTP1B is a negative regulator of interleukin 4-induced STAT6 signaling. Blood. 2008;112:4098-108 pubmed publisher
    ..Herein, we report that phosphorylated STAT6 may serve as a cytoplasmic substrate for PTP1B...
  49. Takeshita K, Yamasaki T, Akira S, Gantner F, Bacon K. Essential role of MHC II-independent CD4+ T cells, IL-4 and STAT6 in contact hypersensitivity induced by fluorescein isothiocyanate in the mouse. Int Immunol. 2004;16:685-95 pubmed
    ..recombinant INF-gamma, or the mast-cell depleting agent 48/80 significantly diminished edema formation, and Stat6(-/-) mice were fully protected from FITC-induced CHS, while DNFB-induced CHS was enhanced (Stat6(-/-), mast cell ..
  50. Yang M, Hogan S, Henry P, Matthaei K, McKenzie A, Young I, et al. Interleukin-13 mediates airways hyperreactivity through the IL-4 receptor-alpha chain and STAT-6 independently of IL-5 and eotaxin. Am J Respir Cell Mol Biol. 2001;25:522-30 pubmed
    ..Furthermore, IL-13-induced AHR, eosinophilia, and mucus production are critically dependent on the IL-4Ralpha chain and STAT-6. ..
  51. Morimoto M, Zhao A, Sun R, Stiltz J, Madden K, Mentink Kane M, et al. IL-13 receptor alpha2 regulates the immune and functional response to Nippostrongylus brasiliensis infection. J Immunol. 2009;183:1934-9 pubmed publisher
    ..infection-induced up-regulation of IL-13Ralpha2 gene expression was confined to smooth muscle and was dependent on STAT6 and IL-13, but not on IL-4...
  52. Iff J, Wang W, Sajic T, Oudry N, Gueneau E, Hopfgartner G, et al. Differential proteomic analysis of STAT6 knockout mice reveals new regulatory function in liver lipid homeostasis. J Proteome Res. 2009;8:4511-24 pubmed publisher
    ..IL-13 are anti-inflammatory cytokines signaling through the Signal Transducer and Activator of Transcription 6 (STAT6). Our study was aimed at evaluating the lack of STAT6 signaling on liver homeostasis...
  53. Villarino A, Tato C, Stumhofer J, Yao Z, Cui Y, Hennighausen L, et al. Helper T cell IL-2 production is limited by negative feedback and STAT-dependent cytokine signals. J Exp Med. 2007;204:65-71 pubmed
    ..signal transducer and activator of transcription (STAT) family transcription factors, namely STAT5, STAT4, and STAT6. Collectively, these findings establish that IL-2 production is limited by a network of autocrine and paracrine ..
  54. Harrington L, Hatton R, Mangan P, Turner H, Murphy T, Murphy K, et al. Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages. Nat Immunol. 2005;6:1123-32 pubmed
    ..cells to differentiate into T(H)-17 cells independently of the transcription factors STAT1, T-bet, STAT4 and STAT6. These findings provide a basis for understanding how inhibition of IFN-gamma signaling enhances development of ..
  55. Park H, Li Z, Yang X, Chang S, Nurieva R, Wang Y, et al. A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17. Nat Immunol. 2005;6:1133-41 pubmed
    ..Thus, IL-17 expression characterizes a unique T helper lineage that regulates tissue inflammation. ..
  56. Konishi H, Tsutsui H, Murakami T, Yumikura Futatsugi S, Yamanaka K, Tanaka M, et al. IL-18 contributes to the spontaneous development of atopic dermatitis-like inflammatory skin lesion independently of IgE/stat6 under specific pathogen-free conditions. Proc Natl Acad Sci U S A. 2002;99:11340-5 pubmed
    ..b>Stat6-deficient KCASP1Tg displayed undetectable levels of IgE but manifested the same degree of cutaneous changes, ..
  57. Zhao A, Morimoto M, Dawson H, Elfrey J, Madden K, Gause W, et al. Immune regulation of protease-activated receptor-1 expression in murine small intestine during Nippostrongylus brasiliensis infection. J Immunol. 2005;175:2563-9 pubmed
    ..brasiliensis infection-induced alterations in PAR-1 responses, and 4) the STAT6 dependence of these responses...
  58. Zimmermann N, Mishra A, King N, Fulkerson P, Doepker M, Nikolaidis N, et al. Transcript signatures in experimental asthma: identification of STAT6-dependent and -independent pathways. J Immunol. 2004;172:1815-24 pubmed
    ..However, the majority of genes were common to both models representing an asthma signature genome. Analysis of STAT6-deficient mice revealed that an unexpectedly large segment of the asthma genes were STAT6 independent; this ..
  59. Stütz A, Pickart L, Trifilieff A, Baumruker T, Prieschl Strassmayr E, Woisetschläger M. The Th2 cell cytokines IL-4 and IL-13 regulate found in inflammatory zone 1/resistin-like molecule alpha gene expression by a STAT6 and CCAAT/enhancer-binding protein-dependent mechanism. J Immunol. 2003;170:1789-96 pubmed
    ..Induction of both genes was abolished in allergen-challenged STAT6-deficient mice...
  60. Kurowska Stolarska M, Kewin P, Murphy G, Russo R, Stolarski B, Garcia C, et al. IL-33 induces antigen-specific IL-5+ T cells and promotes allergic-induced airway inflammation independent of IL-4. J Immunol. 2008;181:4780-90 pubmed
    ..This polarization requires IL-1R-related molecule and MyD88 but not IL-4 or STAT6. The IL-33-induced T cell differentiation is also dependent on the phosphorylation of MAPKs and NF-kappaB but not ..
  61. Kuperman D, Huang X, Koth L, Chang G, Dolganov G, Zhu Z, et al. Direct effects of interleukin-13 on epithelial cells cause airway hyperreactivity and mucus overproduction in asthma. Nat Med. 2002;8:885-9 pubmed
    ..Here we show that mice lacking signal transducer and activator of transcription 6 (STAT6) were protected from all pulmonary effects of IL-13...
  62. Nguyen K, Qiu Y, Cui X, Goh Y, Mwangi J, David T, et al. Alternatively activated macrophages produce catecholamines to sustain adaptive thermogenesis. Nature. 2011;480:104-8 pubmed publisher
    ..Thus, we have discovered a role for alternatively activated macrophages in the orchestration of an important mammalian stress response, the response to cold. ..