Stat5a

Summary

Gene Symbol: Stat5a
Description: signal transducer and activator of transcription 5A
Alias: AA959963, STAT5, signal transducer and activator of transcription 5A, mammary gland factor STAT5A
Species: mouse
Products:     Stat5a

Top Publications

  1. Shillingford J, Miyoshi K, Robinson G, Bierie B, Cao Y, Karin M, et al. Proteotyping of mammary tissue from transgenic and gene knockout mice with immunohistochemical markers: a tool to define developmental lesions. J Histochem Cytochem. 2003;51:555-65 pubmed
    ..We propose that the technique of proteotyping will have wide applications in the analyses of defects in other mouse models. ..
  2. Cui Y, Riedlinger G, Miyoshi K, Tang W, Li C, Deng C, et al. Inactivation of Stat5 in mouse mammary epithelium during pregnancy reveals distinct functions in cell proliferation, survival, and differentiation. Mol Cell Biol. 2004;24:8037-47 pubmed
    ..study explored the functions of the signal transducers and activators of transcription 5a and 5b (referred to as Stat5 here) during different stages of mouse mammary gland development by using conditional gene inactivation...
  3. Walz C, Ahmed W, Lazarides K, Betancur M, Patel N, Hennighausen L, et al. Essential role for Stat5a/b in myeloproliferative neoplasms induced by BCR-ABL1 and JAK2(V617F) in mice. Blood. 2012;119:3550-60 pubmed publisher
    ..In the present study, we used mice with a conditional null mutation in the Stat5a/b gene locus to determine the requirement for STAT5 in MPNs induced by BCR-ABL1 and JAK2(V617F) in retroviral ..
  4. Duy C, Hurtz C, Shojaee S, Cerchietti L, Geng H, Swaminathan S, et al. BCL6 enables Ph+ acute lymphoblastic leukaemia cells to survive BCR-ABL1 kinase inhibition. Nature. 2011;473:384-8 pubmed publisher
    ..We identify BCL6 as a central component of this drug-resistance pathway and demonstrate that targeted inhibition of BCL6 leads to eradication of drug-resistant and leukaemia-initiating subclones. ..
  5. Kelly J, Spolski R, Imada K, Bollenbacher J, Lee S, Leonard W. A role for Stat5 in CD8+ T cell homeostasis. J Immunol. 2003;170:210-7 pubmed
    ..We have now investigated the role of Stat5 proteins in this process. Whereas Stat5a and Stat5b KO mice have decreased numbers of CD8+ T cells, Stat5-transgenic mice have an increased number of these ..
  6. Friedbichler K, Kerenyi M, Kovacic B, Li G, Hoelbl A, Yahiaoui S, et al. Stat5a serine 725 and 779 phosphorylation is a prerequisite for hematopoietic transformation. Blood. 2010;116:1548-58 pubmed publisher
    ..We have modeled persistent Stat5 activity by using an oncogenic Stat5a variant (cS5)...
  7. Liu X, Gallego M, Smith G, Robinson G, Hennighausen L. Functional rescue of Stat5a-null mammary tissue through the activation of compensating signals including Stat5b. Cell Growth Differ. 1998;9:795-803 pubmed
    ..and lactogenesis through the Janus kinase-signal transducers and activators of transcription pathway, with Stat5a being a principal and obligate cytoplasmic and nuclear signaling molecule...
  8. Hoelbl A, Schuster C, Kovacic B, Zhu B, Wickre M, Hoelzl M, et al. Stat5 is indispensable for the maintenance of bcr/abl-positive leukaemia. EMBO Mol Med. 2010;2:98-110 pubmed publisher
    ..So far, the transcription factors Stat3 and Stat5a/b have been implicated in bcr/abl-induced initial transformation...
  9. Johnston R, Choi Y, Diamond J, Yang J, Crotty S. STAT5 is a potent negative regulator of TFH cell differentiation. J Exp Med. 2012;209:243-50 pubmed publisher
    ..In this study, we show that STAT5 inhibits T(FH) cell differentiation and function...

More Information

Publications62

  1. Clark D, Williams C, Duplessis T, Moring K, Notwick A, Long W, et al. ERBB4/HER4 potentiates STAT5A transcriptional activity by regulating novel STAT5A serine phosphorylation events. J Biol Chem. 2005;280:24175-80 pubmed
    ..in the breast are mediated through the signal transducer and activator of transcription (STAT) family member STAT5A, and ERBB4 directly activates STAT5A, in part, through phosphorylation of STAT5A at the regulatory Tyr-694...
  2. Couldrey C, Bradley H, Bunting K. A STAT5 modifier locus on murine chromosome 7 modulates engraftment of hematopoietic stem cells during steady-state hematopoiesis. Blood. 2005;105:1476-83 pubmed
    Homologous disruption of expression of signal transducer and activator of transcription 5a (STAT5a) and STAT5b (STAT5ab(-/-)) in mice results in hematopoietic stem cells (HSCs) that can engraft irradiated hosts alone but are ..
  3. Kovanen P, Young L, Al Shami A, Rovella V, Pise Masison C, Radonovich M, et al. Global analysis of IL-2 target genes: identification of chromosomal clusters of expressed genes. Int Immunol. 2005;17:1009-21 pubmed
    ..3, a region that contains genes encoding the tumor necrosis factor (TNF) superfamily members TNF, LT-alpha and LT-beta. ..
  4. Moriggl R, Gouilleux Gruart V, Jähne R, Berchtold S, Gartmann C, Liu X, et al. Deletion of the carboxyl-terminal transactivation domain of MGF-Stat5 results in sustained DNA binding and a dominant negative phenotype. Mol Cell Biol. 1996;16:5691-700 pubmed
    ..Seven members of the Stat gene family are known. MGF-Stat5a has been discovered as a mediator of the prolactin response in mammary epithelial cells...
  5. Yamaji D, Na R, Feuermann Y, Pechhold S, Chen W, Robinson G, et al. Development of mammary luminal progenitor cells is controlled by the transcription factor STAT5A. Genes Dev. 2009;23:2382-7 pubmed publisher
    Mammary alveologenesis is abrogated in the absence of the transcription factors STAT5A/5B, which mediate cytokine signaling. To reveal the underlying causes for this developmental block, we studied mammary stem and progenitor cells...
  6. Miyoshi K, Meyer B, Gruss P, Cui Y, Renou J, Morgan F, et al. Mammary epithelial cells are not able to undergo pregnancy-dependent differentiation in the absence of the helix-loop-helix inhibitor Id2. Mol Endocrinol. 2002;16:2892-901 pubmed
    ..The epithelial cells retained the ductal marker Na-K-Cl cotransporter (NKCC)1. Nuclear localization of Stat5a and down-regulation of NKCC1 was observed in some areas, indicating a limited response to pregnancy signals...
  7. Villarino A, Tato C, Stumhofer J, Yao Z, Cui Y, Hennighausen L, et al. Helper T cell IL-2 production is limited by negative feedback and STAT-dependent cytokine signals. J Exp Med. 2007;204:65-71 pubmed
    ..mediated by several signal transducer and activator of transcription (STAT) family transcription factors, namely STAT5, STAT4, and STAT6...
  8. Fievez L, Desmet C, Henry E, Pajak B, Hegenbarth S, Garze V, et al. STAT5 is an ambivalent regulator of neutrophil homeostasis. PLoS ONE. 2007;2:e727 pubmed
    Although STAT5 promotes survival of hematopoietic progenitors, STAT5-/- mice develop mild neutrophilia...
  9. Shelburne C, McCoy M, Piekorz R, Sexl V, Roh K, Jacobs Helber S, et al. Stat5 expression is critical for mast cell development and survival. Blood. 2003;102:1290-7 pubmed
    ..Bone marrow-derived mast cell (BMMC) populations cultured from Stat5A/B-deficient mice survived in IL-3 + SCF, but not in either cytokine alone...
  10. Bradley H, Couldrey C, Bunting K. Hematopoietic-repopulating defects from STAT5-deficient bone marrow are not fully accounted for by loss of thrombopoietin responsiveness. Blood. 2004;103:2965-72 pubmed
    ..We have directly compared bone marrow (BM) from mice mutant for STAT5a and STAT5b (STAT5ab(-/-)) with that from mice lacking c-Mpl (c-Mpl(-/-)), the thrombopoietin receptor...
  11. Liu F, Kunter G, Krem M, Eades W, Cain J, Tomasson M, et al. Csf3r mutations in mice confer a strong clonal HSC advantage via activation of Stat5. J Clin Invest. 2008;118:946-55 pubmed publisher
    ..the proliferative advantage conferred by the mutant Csf3r was abrogated in myeloid progenitors lacking both Stat5A and Stat5B, and HSC function was reduced in mice expressing a truncated mutant Csf3r engineered to have impaired ..
  12. Lin J, Li P, Liu D, Jin H, He J, Ata Ur Rasheed M, et al. Critical Role of STAT5 transcription factor tetramerization for cytokine responses and normal immune function. Immunity. 2012;36:586-99 pubmed publisher
    ..We generated Stat5a-Stat5b double knockin (DKI) N-domain mutant mice in which STAT5 proteins form dimers but not tetramers, identified ..
  13. Feldman G, Rosenthal L, Liu X, Hayes M, Wynshaw Boris A, Leonard W, et al. STAT5A-deficient mice demonstrate a defect in granulocyte-macrophage colony-stimulating factor-induced proliferation and gene expression. Blood. 1997;90:1768-76 pubmed
    ..In this report we have used mice that are deficient in STAT5A (one of two homologues of STAT5) to study the role of STAT5A in GM-CSF stimulation of cells...
  14. Grebien F, Kerenyi M, Kovacic B, Kolbe T, Becker V, Dolznig H, et al. Stat5 activation enables erythropoiesis in the absence of EpoR and Jak2. Blood. 2008;111:4511-22 pubmed publisher
    ..Here we demonstrate that expression of a constitutively activated Stat5a mutant (cS5) was sufficient to relieve the proliferation defect of Jak2(-/-) and EpoR(-/-) cells in an Epo-..
  15. Miyoshi K, Shillingford J, Smith G, Grimm S, Wagner K, Oka T, et al. Signal transducer and activator of transcription (Stat) 5 controls the proliferation and differentiation of mammary alveolar epithelium. J Cell Biol. 2001;155:531-42 pubmed
    ..the prolactin receptor (PrlR) and the signal transducers and activators of transcription 5a and 5b (referred to as Stat5) in the formation and differentiation of mammary alveolar epithelium...
  16. Dai X, Chen Y, Di L, Podd A, Li G, Bunting K, et al. Stat5 is essential for early B cell development but not for B cell maturation and function. J Immunol. 2007;179:1068-79 pubmed
    The two closely related Stat5 (Stat5A and Stat5B) proteins are activated by a broad spectrum of cytokines...
  17. Gallego M, Binart N, Robinson G, Okagaki R, Coschigano K, Perry J, et al. Prolactin, growth hormone, and epidermal growth factor activate Stat5 in different compartments of mammary tissue and exert different and overlapping developmental effects. Dev Biol. 2001;229:163-75 pubmed
    ..and alveolar differentiation during pregnancy, which corresponded with reduced phosphorylation levels of Stat5a and 5b, and impaired expression of milk protein genes...
  18. Zhang Y, Laz E, Waxman D. Dynamic, sex-differential STAT5 and BCL6 binding to sex-biased, growth hormone-regulated genes in adult mouse liver. Mol Cell Biol. 2012;32:880-96 pubmed publisher
    ..b>STAT5 is an essential transcriptional mediator of the sex-dependent effects of GH in the liver, but the mechanisms that ..
  19. Lin J, Leonard W. The role of Stat5a and Stat5b in signaling by IL-2 family cytokines. Oncogene. 2000;19:2566-76 pubmed
    The activation of Stat5 proteins (Stat5a and Stat5b) is one of the earliest signaling events mediated by IL-2 family cytokines, allowing the rapid delivery of signals from the membrane to the nucleus...
  20. Ren S, Cai H, Li M, Furth P. Loss of Stat5a delays mammary cancer progression in a mouse model. Oncogene. 2002;21:4335-9 pubmed
    A genetic study was conducted to determine if activated Stat5a contributes to mammary carcinogenesis and to evaluate the mechanism...
  21. Liu X, Robinson G, Wagner K, Garrett L, Wynshaw Boris A, Hennighausen L. Stat5a is mandatory for adult mammary gland development and lactogenesis. Genes Dev. 1997;11:179-86 pubmed
    ..The activity pattern of two STAT proteins, Stat5a and Stat5b, in mammary tissue during pregnancy suggests an active role for these transcription factors in ..
  22. Malin S, McManus S, Cobaleda C, Novatchkova M, Delogu A, Bouillet P, et al. Role of STAT5 in controlling cell survival and immunoglobulin gene recombination during pro-B cell development. Nat Immunol. 2010;11:171-9 pubmed publisher
    b>STAT5 and interleukin 7 (IL-7) signaling are thought to control B lymphopoiesis by regulating the expression of key transcription factors and by activating variable (V(H)) gene segments at the immunoglobulin heavy-chain (Igh) locus...
  23. Kieslinger M, Woldman I, Moriggl R, Hofmann J, Marine J, Ihle J, et al. Antiapoptotic activity of Stat5 required during terminal stages of myeloid differentiation. Genes Dev. 2000;14:232-44 pubmed
    ..Our findings with dnStat5-expressing chicken myeloblasts were confirmed with primary hematopoietic cells from Stat5a/Stat5b-deficient mice...
  24. Kerenyi M, Grebien F, Gehart H, Schifrer M, Artaker M, Kovacic B, et al. Stat5 regulates cellular iron uptake of erythroid cells via IRP-2 and TfR-1. Blood. 2008;112:3878-88 pubmed publisher
    ..the erythropoietin receptor (EpoR)-Janus kinase 2 (Jak2)-signal transducer and activator of transcription 5 (Stat5) axis, regulating proliferation, differentiation, and survival...
  25. Srivastava S, Matsuda M, Hou Z, Bailey J, Kitazawa R, Herbst M, et al. Receptor activator of NF-kappaB ligand induction via Jak2 and Stat5a in mammary epithelial cells. J Biol Chem. 2003;278:46171-8 pubmed
    ..dominant negative mutants of recombinant Jak2 and Stat5 in CHOD6 cells, and by reconstituting the Jak2/Stat5 pathway in COS7 cells, we determined that Jak2 and Stat5a are essential for the PRL-induced RANKL expression in mammary gland.
  26. Yan D, Hutchison R, Mohi G. Critical requirement for Stat5 in a mouse model of polycythemia vera. Blood. 2012;119:3539-49 pubmed publisher
    ..Using a mouse genetic strategy, we show here that Stat5 is absolutely required for the pathogenesis of PV induced by Jak2V617F...
  27. Snow J, Abraham N, Ma M, Herndier B, Pastuszak A, Goldsmith M. Loss of tolerance and autoimmunity affecting multiple organs in STAT5A/5B-deficient mice. J Immunol. 2003;171:5042-50 pubmed
    ..However, in examining hemopoiesis in mice lacking both isoforms of STAT5, STAT5A, and STAT5B, we noted that a subset of these mice demonstrated dramatic alterations in several bone marrow ..
  28. Wang Z, Li G, Tse W, Bunting K. Conditional deletion of STAT5 in adult mouse hematopoietic stem cells causes loss of quiescence and permits efficient nonablative stem cell replacement. Blood. 2009;113:4856-65 pubmed publisher
    ..Here we show that loss of one allele of signal transducer and activator of transcription 5 (STAT5) in nonablated adult mutant mice permitted engraftment with wild-type HSC...
  29. Schuringa J, Chung K, Morrone G, Moore M. Constitutive activation of STAT5A promotes human hematopoietic stem cell self-renewal and erythroid differentiation. J Exp Med. 2004;200:623-35 pubmed
    ..We overexpressed the constitutively active mutant STAT5A(1*6) in human cord blood CD34+ cells and evaluated the effects on the hematopoietic potential of stem cells in a ..
  30. Zhu B, Kang K, Yu J, Chen W, Smith H, Lee D, et al. Genome-wide analyses reveal the extent of opportunistic STAT5 binding that does not yield transcriptional activation of neighboring genes. Nucleic Acids Res. 2012;40:4461-72 pubmed publisher
    ..upon growth hormone (GH) stimulation of wild-type (WT) mouse embryonic fibroblasts (MEFs) and MEFs overexpressing STAT5A more than 20-fold...
  31. Tsuruyama T, Nakamura T, Jin G, Ozeki M, Yamada Y, Hiai H. Constitutive activation of Stat5a by retrovirus integration in early pre-B lymphomas of SL/Kh strain mice. Proc Natl Acad Sci U S A. 2002;99:8253-8 pubmed
    We found that the second intron of Stat5a was one of the common integration sites of the endogenous ecotropic murine leukemia virus, i.e., SL/Kh virus integration-1 (Svi1), in early pre-B lymphomas in SL/Kh mice...
  32. Teglund S, McKay C, Schuetz E, van Deursen J, Stravopodis D, Wang D, et al. Stat5a and Stat5b proteins have essential and nonessential, or redundant, roles in cytokine responses. Cell. 1998;93:841-50 pubmed
    ..Among the Stats, the two highly related proteins, Stat5a and Stat5b, are activated by a variety of cytokines...
  33. Xu M, Nie L, Kim S, Sun X. STAT5-induced Id-1 transcription involves recruitment of HDAC1 and deacetylation of C/EBPbeta. EMBO J. 2003;22:893-904 pubmed
    ..Here, we provide evidence to suggest that STAT5 activates gene expression by recruiting HDAC...
  34. Goetz C, Harmon I, O Neil J, Burchill M, Farrar M. STAT5 activation underlies IL7 receptor-dependent B cell development. J Immunol. 2004;172:4770-8 pubmed
    ..To identify the function of the Raf and STAT5 pathways in IL7R-dependent B cell development, we used transgenic mice that express constitutively active forms of ..
  35. Nakajima H, Liu X, Wynshaw Boris A, Rosenthal L, Imada K, Finbloom D, et al. An indirect effect of Stat5a in IL-2-induced proliferation: a critical role for Stat5a in IL-2-mediated IL-2 receptor alpha chain induction. Immunity. 1997;7:691-701 pubmed
    b>Stat5a was identified as a prolactin-induced transcription factor but also is activated by other cytokines, including interleukin-2 (IL-2) and IL-7. We have now analyzed the immune system of Stat5a-deficient mice...
  36. Moriggl R, Sexl V, Kenner L, Duntsch C, Stangl K, Gingras S, et al. Stat5 tetramer formation is associated with leukemogenesis. Cancer Cell. 2005;7:87-99 pubmed
    ..To study the mechanism and role of Stat5 activation, we introduced a constitutively activated Stat5a mutant, cS5F, into murine bone marrow (BM) cells...
  37. Snow J, Abraham N, Ma M, Abbey N, Herndier B, Goldsmith M. STAT5 promotes multilineage hematolymphoid development in vivo through effects on early hematopoietic progenitor cells. Blood. 2002;99:95-101 pubmed
    ..Multilineage peripheral blood cytopenias were observed in adult mice lacking both isoforms of STAT5 (STAT5A and STAT5B) as well as accelerated rates of apoptosis in the bone marrow...
  38. Lockyer H, Tran E, Nelson B. STAT5 is essential for Akt/p70S6 kinase activity during IL-2-induced lymphocyte proliferation. J Immunol. 2007;179:5301-8 pubmed
    IL-2R activates two distinct signaling pathways mediated by the adaptor protein Shc and the transcription factor STAT5. Prior mutagenesis studies of the IL-2R have indicated that the Shc and STAT5 pathways are redundant in the ability to ..
  39. Socolovsky M, Fallon A, Wang S, Brugnara C, Lodish H. Fetal anemia and apoptosis of red cell progenitors in Stat5a-/-5b-/- mice: a direct role for Stat5 in Bcl-X(L) induction. Cell. 1999;98:181-91 pubmed
    ..is rapidly activated following EpoR stimulation, but its function in erythropoiesis has been unclear since adult Stat5a-/-5b-/- mice have normal steady-state hematocrit...
  40. Litterst C, Kliem S, Marilley D, Pfitzner E. NCoA-1/SRC-1 is an essential coactivator of STAT5 that binds to the FDL motif in the alpha-helical region of the STAT5 transactivation domain. J Biol Chem. 2003;278:45340-51 pubmed
    ..We found that only one of them, NCoA-1, acts as a coactivator for both STAT5a and STAT5b. The two coactivators p300/CBP and NCoA-1 cooperatively enhance STAT5a-mediated transactivation...
  41. Grimley P, Dong F, Rui H. Stat5a and Stat5b: fraternal twins of signal transduction and transcriptional activation. Cytokine Growth Factor Rev. 1999;10:131-57 pubmed
    b>Stat5a and Stat5b are discretely encoded transcription factors that mediate signals for a broad spectrum of cytokines...
  42. Lin J, Mietz J, Modi W, John S, Leonard W. Cloning of human Stat5B. Reconstitution of interleukin-2-induced Stat5A and Stat5B DNA binding activity in COS-7 cells. J Biol Chem. 1996;271:10738-44 pubmed
    We have isolated a second human Stat5 cDNA, Stat5B, and demonstrated that the genes encoding both Stat5A and Stat5B are located at chromosome 17q11.2. Both genes were constitutively transcribed in peripheral blood lymphocytes...
  43. Humphreys R, Hennighausen L. Signal transducer and activator of transcription 5a influences mammary epithelial cell survival and tumorigenesis. Cell Growth Differ. 1999;10:685-94 pubmed
    ..We present evidence that the prolactin-activated transcription factor signal transducer and activator of transcription 5a (Stat5a) has a crucial role in the regulation of cell death during mammary gland involution...
  44. Boucheron C, Dumon S, Santos S, Moriggl R, Hennighausen L, Gisselbrecht S, et al. A single amino acid in the DNA binding regions of STAT5A and STAT5B confers distinct DNA binding specificities. J Biol Chem. 1998;273:33936-41 pubmed
    b>STAT5A and STAT5B are two highly related transcription factors encoded by two distinct genes. STAT5A and STAT5B are activated by a broad range of cytokines and growth factors...
  45. Imada K, Bloom E, Nakajima H, Horvath Arcidiacono J, Udy G, Davey H, et al. Stat5b is essential for natural killer cell-mediated proliferation and cytolytic activity. J Exp Med. 1998;188:2067-74 pubmed
    We have analyzed the immune system in Stat5-deficient mice. Although Stat5a-/- splenocytes have a partial defect in anti-CD3-induced proliferation that can be overcome by high dose interleukin (IL)-2, we now demonstrate that defective ..
  46. Gobert S, Chretien S, Gouilleux F, Muller O, Pallard C, Dusanter Fourt I, et al. Identification of tyrosine residues within the intracellular domain of the erythropoietin receptor crucial for STAT5 activation. EMBO J. 1996;15:2434-41 pubmed
    ..Erythropoietin induces the activation of the short forms (80 kDa) of STAT5 in the cells...
  47. Mui A, Wakao H, O Farrell A, Harada N, Miyajima A. Interleukin-3, granulocyte-macrophage colony stimulating factor and interleukin-5 transduce signals through two STAT5 homologs. EMBO J. 1995;14:1166-75 pubmed
    ..complexes with available antibodies to the known STATs suggests that IL-3 activates the DNA-binding ability of STAT5, a protein which was originally characterized as a prolactin-responsive transcription factor in sheep...
  48. Meyer R, Laz E, Su T, Waxman D. Male-specific hepatic Bcl6: growth hormone-induced block of transcription elongation in females and binding to target genes inversely coordinated with STAT5. Mol Endocrinol. 2009;23:1914-26 pubmed publisher
    ..Indeed, STAT5 was bound to Bcl6 STAT5-binding region-B, previously associated with Bcl6 repression, in both male and female ..
  49. Engblom D, Kornfeld J, Schwake L, Tronche F, Reimann A, Beug H, et al. Direct glucocorticoid receptor-Stat5 interaction in hepatocytes controls body size and maturation-related gene expression. Genes Dev. 2007;21:1157-62 pubmed
    ..Using hepatocyte-specific and domain-selective mutations in the mouse we show that Stat5 in hepatocytes is essential for normal postnatal growth and that it mediates the growth-promoting effect of the ..
  50. Joliot V, Cormier F, Medyouf H, Alcalde H, Ghysdael J. Constitutive STAT5 activation specifically cooperates with the loss of p53 function in B-cell lymphomagenesis. Oncogene. 2006;25:4573-84 pubmed
    ..of persistent STAT5 activation, we generated transgenic mice in which a constitutively activated point mutant of STAT5A, STAT5A(S711F), was expressed at physiological level in their lymphoid compartment...
  51. Burchill M, Goetz C, Prlic M, O Neil J, Harmon I, Bensinger S, et al. Distinct effects of STAT5 activation on CD4+ and CD8+ T cell homeostasis: development of CD4+CD25+ regulatory T cells versus CD8+ memory T cells. J Immunol. 2003;171:5853-64 pubmed
    Using transgenic mice that express a constitutively active version of STAT5b, we demonstrate that STAT5 plays a key role in governing B cell development and T cell homeostasis...
  52. Shillingford J, Miyoshi K, Flagella M, Shull G, Hennighausen L. Mouse mammary epithelial cells express the Na-K-Cl cotransporter, NKCC1: characterization, localization, and involvement in ductal development and morphogenesis. Mol Endocrinol. 2002;16:1309-21 pubmed
  53. Kagami S, Nakajima H, Suto A, Hirose K, Suzuki K, Morita S, et al. Stat5a regulates T helper cell differentiation by several distinct mechanisms. Blood. 2001;97:2358-65 pubmed
    ..allergic inflammation is diminished in signal transducer and activator of transcription (Stat)5a-deficient (Stat5a(-/-)) mice...