Stat4

Summary

Gene Symbol: Stat4
Description: signal transducer and activator of transcription 4
Species: mouse

Top Publications

  1. ncbi Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages
    Laurie E Harrington
    Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    Nat Immunol 6:1123-32. 2005
  2. ncbi IL-1 family members and STAT activators induce cytokine production by Th2, Th17, and Th1 cells
    Liying Guo
    Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 106:13463-8. 2009
  3. ncbi Microenvironment-dependent requirement of STAT4 for the induction of P-selectin ligands and effector cytokines on CD4+ T cells in healthy and parasite-infected mice
    Uta Syrbe
    Charite, Campus Mitte, Experimentelle Rheumatologie, c o Deutsches Rheumaforschungszentrum, Schumannstrasse 21 22, 10117 Berlin, Germany
    J Immunol 177:7673-9. 2006
  4. ncbi The emerging role of T cell Ig mucin 1 in alloimmune responses in an experimental mouse transplant model
    Takuya Ueno
    Transplantation Research Center, Renal Division, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    J Clin Invest 118:742-51. 2008
  5. ncbi Airway exposure levels of lipopolysaccharide determine type 1 versus type 2 experimental asthma
    Yoon Keun Kim
    Department of Life Science, Postech Biotech Center, Pohang University of Science and Technology, Namgu, Pohang, Gyeongbuk, Republic of Korea
    J Immunol 178:5375-82. 2007
  6. ncbi SDF-1/CXCR4 mediates acute protection of cardiac function through myocardial STAT3 signaling following global ischemia/reperfusion injury
    Chunyan Huang
    Department of Surgery, Indiana University School of Medicine, Indianapolis, Indiana, USA
    Am J Physiol Heart Circ Physiol 301:H1496-505. 2011
  7. ncbi Regulation of IFN-gamma production by B effector 1 cells: essential roles for T-bet and the IFN-gamma receptor
    David P Harris
    Trudeau Institute, Saranac Lake, NY 12983, USA
    J Immunol 174:6781-90. 2005
  8. ncbi STAT4 signal pathways regulate inflammation and airway physiology changes in allergic airway inflammation locally via alteration of chemokines
    Kavita Raman
    Department of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    J Immunol 170:3859-65. 2003
  9. ncbi Negative regulation of interleukin-12 signaling by suppressor of cytokine signaling-1
    Joanne L Eyles
    The Walter and Eliza Hall Institute for Medical Research and The Cooperative Research Center for Cellular Growth Factors, PO Royal Melbourne Hospital, VIC 3050, Australia
    J Biol Chem 277:43735-40. 2002
  10. ncbi High basal STAT4 balanced by STAT1 induction to control type 1 interferon effects in natural killer cells
    Takuya Miyagi
    Department of Molecular Microbiology and Immunology, Brown University, Providence, RI 02912, USA
    J Exp Med 204:2383-96. 2007

Research Grants

  1. Resources Core
    Mark Kaplan; Fiscal Year: 2006
  2. STAT4 IMMUNOLOGY
    Mark Kaplan; Fiscal Year: 2003
  3. Stat4 Immunobiology
    Mark Kaplan; Fiscal Year: 2007
  4. The role of PU.1 in T helper 2 function
    Mark Kaplan; Fiscal Year: 2009
  5. Stat4 Immunobiology
    Mark H Kaplan; Fiscal Year: 2010
  6. The role of PU.1 in T helper cell heterogeneity
    Mark H Kaplan; Fiscal Year: 2010
  7. Tumor-induced immune suppression
    Suzanne Ostrand Rosenberg; Fiscal Year: 2007
  8. Cell-based tumor vaccines targeting CD4+ T lymphocytes
    Suzanne Ostrand Rosenberg; Fiscal Year: 2010
  9. Control of Spermatogonial Stem Cell Fate Decisions by bHLH Transcription Regulato
    Jon M Oatley; Fiscal Year: 2010
  10. Role of micro-RNAs in T cells and other immune/haematopoietic cells
    Anjana Rao; Fiscal Year: 2007

Scientific Experts

Detail Information

Publications95

  1. ncbi Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages
    Laurie E Harrington
    Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    Nat Immunol 6:1123-32. 2005
    ..naive precursor cells to differentiate into T(H)-17 cells independently of the transcription factors STAT1, T-bet, STAT4 and STAT6...
  2. ncbi IL-1 family members and STAT activators induce cytokine production by Th2, Th17, and Th1 cells
    Liying Guo
    Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 106:13463-8. 2009
    ..IL-17A in response to IL-1beta and a STAT3 activator and Th1 cells produce IFNgamma in response to IL-18 and a STAT4 inducer...
  3. ncbi Microenvironment-dependent requirement of STAT4 for the induction of P-selectin ligands and effector cytokines on CD4+ T cells in healthy and parasite-infected mice
    Uta Syrbe
    Charite, Campus Mitte, Experimentelle Rheumatologie, c o Deutsches Rheumaforschungszentrum, Schumannstrasse 21 22, 10117 Berlin, Germany
    J Immunol 177:7673-9. 2006
    ..b>STAT4 is strongly involved in these processes...
  4. ncbi The emerging role of T cell Ig mucin 1 in alloimmune responses in an experimental mouse transplant model
    Takuya Ueno
    Transplantation Research Center, Renal Division, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    J Clin Invest 118:742-51. 2008
    ..TIM-1-specific antibody treatment was more effective in Th1-type cytokine-deficient Stat4(-/-) recipients as compared with Th2-type cytokine-deficient Stat6(-/-) recipients...
  5. ncbi Airway exposure levels of lipopolysaccharide determine type 1 versus type 2 experimental asthma
    Yoon Keun Kim
    Department of Life Science, Postech Biotech Center, Pohang University of Science and Technology, Namgu, Pohang, Gyeongbuk, Republic of Korea
    J Immunol 178:5375-82. 2007
    ..mice, whereas the asthma phenotypes induced by high-dose LPS were abolished in the homozygous null mutation of the STAT4 gene...
  6. ncbi SDF-1/CXCR4 mediates acute protection of cardiac function through myocardial STAT3 signaling following global ischemia/reperfusion injury
    Chunyan Huang
    Department of Surgery, Indiana University School of Medicine, Indianapolis, Indiana, USA
    Am J Physiol Heart Circ Physiol 301:H1496-505. 2011
    ..Our results represent the first evidence that the SDF-1/CXCR4 axis upregualtes myocardial STAT3 activation and, thereby, mediates acute cardioprotection in response to global I/R...
  7. ncbi Regulation of IFN-gamma production by B effector 1 cells: essential roles for T-bet and the IFN-gamma receptor
    David P Harris
    Trudeau Institute, Saranac Lake, NY 12983, USA
    J Immunol 174:6781-90. 2005
    ....
  8. ncbi STAT4 signal pathways regulate inflammation and airway physiology changes in allergic airway inflammation locally via alteration of chemokines
    Kavita Raman
    Department of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    J Immunol 170:3859-65. 2003
    Mice homozygous for the STAT4-null mutation were sensitized to cockroach Ag, challenged intratracheally 21 days later, and compared with STAT4-competent allergic mice...
  9. ncbi Negative regulation of interleukin-12 signaling by suppressor of cytokine signaling-1
    Joanne L Eyles
    The Walter and Eliza Hall Institute for Medical Research and The Cooperative Research Center for Cellular Growth Factors, PO Royal Melbourne Hospital, VIC 3050, Australia
    J Biol Chem 277:43735-40. 2002
    ..SOCS-1(-/-) disease, we generated mice lacking both SOCS-1 and signal transducer and activator of transcription 4 (STAT4), an essential component of the IL-12 signaling pathway...
  10. ncbi High basal STAT4 balanced by STAT1 induction to control type 1 interferon effects in natural killer cells
    Takuya Miyagi
    Department of Molecular Microbiology and Immunology, Brown University, Providence, RI 02912, USA
    J Exp Med 204:2383-96. 2007
    ..Regulation of their access to particular signaling pathways is poorly understood. STAT4 is important for IFN-gamma induction, and NK cells are major producers of this cytokine...
  11. ncbi Distinct characteristics of murine STAT4 activation in response to IL-12 and IFN-alpha
    Lisa S Berenson
    Department of Pathology and Center for Immunology, Washington University of School of Medicine, St Louis, MO 63110, USA
    J Immunol 177:5195-203. 2006
    The role of type I IFN in Th1 development, STAT4 activation, and IFN-gamma production in murine T cells has remained unresolved despite extensive examination...
  12. ncbi Effector mechanisms of the autoimmune syndrome in the murine model of autoimmune polyglandular syndrome type 1
    Jason J DeVoss
    Diabetes Center, University of California, San Francisco, CA 94143, USA
    J Immunol 181:4072-9. 2008
    ..Depletion of CD4(+) T cells using a neutralizing Ab ameliorated the disease process. Thus, therapies targeted specifically at the CD4(+) T cell subset may help control autoimmune disease in patients with APS1...
  13. ncbi Dendritic-cell maturation alters intracellular signaling networks, enabling differential effects of IFN-alpha/beta on antigen cross-presentation
    Randy S Longman
    Rockefeller University, New York, NY, USA
    Blood 109:1113-22. 2007
    ..STAT1 in response to IFN-alpha/beta, whereas exposure of mature DCs to IFN-alpha/beta results in signaling via STAT4. Microarray analysis revealed numerous transcriptional changes resulting from the altered signaling...
  14. ncbi Coordinated and distinct roles for IFN-alpha beta, IL-12, and IL-15 regulation of NK cell responses to viral infection
    Khuong B Nguyen
    Deparment of Molecular Microbiology and Immunology, Brown University, Providence, RI 02912, USA
    J Immunol 169:4279-87. 2002
    ..IL-12/STAT4 was critical for NK cell IFN-gamma expression, whereas IFN-alphabeta/STAT1 were required for induction of ..
  15. ncbi Helper T cell IL-2 production is limited by negative feedback and STAT-dependent cytokine signals
    Alejandro V Villarino
    Department of Pathobiology, University of Pennsylvania School of Veterinary Medicine, Philadelphia, PA 19104, USA
    J Exp Med 204:65-71. 2007
    ..by several signal transducer and activator of transcription (STAT) family transcription factors, namely STAT5, STAT4, and STAT6...
  16. ncbi T-bet is a STAT1-induced regulator of IL-12R expression in naïve CD4+ T cells
    Maryam Afkarian
    Department of Pathology and Immunology, Howard Hughes Medical Institute, Washington University School of Medicine, Box 8118, 660 S Euclid Ave, St Louis, MO 63110, USA
    Nat Immunol 3:549-57. 2002
    ..through signal transducer and activator of transcription 1 (STAT1) and interleukin-12 (IL-12) signaling through STAT4 activation...
  17. ncbi Stat4 and Stat6 signaling in hepatic ischemia/reperfusion injury in mice: HO-1 dependence of Stat4 disruption-mediated cytoprotection
    Xiu Da Shen
    Dumont UCLA Transplant Center, Division of Liver and Pancreas Transplantation, Department of Surgery, Los Angeles, CA 90095, USA
    Hepatology 37:296-303. 2003
    ..This study analyzes the role of signal transducer and activator of transcription 4 (Stat4) and Stat6 signaling in liver I/R injury...
  18. ncbi Critical role for STAT4 activation by type 1 interferons in the interferon-gamma response to viral infection
    Khuong B Nguyen
    Department of Molecular Microbiology and Immunology, Division of Biology and Medicine, Brown University, Providence, RI 02912, USA
    Science 297:2063-6. 2002
    ..Here we show that IFN-alpha/beta activate STAT4 directly (STAT, signal transducers and activators of transcription) and that this is required for IFN-gamma ..
  19. ncbi Cutting edge: a murine, IL-12-independent pathway of IFN-gamma induction by gram-negative bacteria based on STAT4 activation by Type I IFN and IL-18 signaling
    Marina A Freudenberg
    Max Planck Institut fur Immunbiologie, Freiburg, Germany
    J Immunol 169:1665-8. 2002
    ..pathway is based on a synergism of IFN-alphabeta and IL-18, and is independent of IL-12 signaling yet dependent on STAT4. In contradiction to current dogma, we show further that IFN-alphabeta alone induces tyrosine phosphorylation of ..
  20. ncbi Stat3 and Stat4: members of the family of signal transducers and activators of transcription
    Z Zhong
    Laboratory of Molecular Cell Biology, Rockefeller University, New York, NY 10021
    Proc Natl Acad Sci U S A 91:4806-10. 1994
    ..While Stat1 and Stat3 are widely expressed, Stat4 expression is restricted to testis, thymus, and spleen...
  21. ncbi Identification of STAT4-dependent and independent mechanisms of resistance to Toxoplasma gondii
    G Cai
    Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    J Immunol 165:2619-27. 2000
    ..To identify the transcription factors involved in this mechanism of resistance, mice deficient in STAT4, a protein involved in IL-12 signaling, were infected with T. gondii and their immune responses were analyzed...
  22. ncbi Requirement for Stat4 in interleukin-12-mediated responses of natural killer and T cells
    W E Thierfelder
    Department of Biochemistry, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Nature 382:171-4. 1996
    ..b>Stat4 was initially cloned as a result of its homology with Stat1 (refs 4, 5) and is widely expressed, although it is ..
  23. ncbi Impaired IL-12 responses and enhanced development of Th2 cells in Stat4-deficient mice
    M H Kaplan
    Department of Cancer Biology, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Nature 382:174-7. 1996
    ..b>STAT4 is one member of this family, and is activated only in response to the cytokine interleukin (IL)-12 (refs 5, 6)...
  24. ncbi Transforming growth factor-beta1 enhances the interferon-gamma-dependent, interleukin-12-independent pathway of T helper 1 cell differentiation
    Ronald B Smeltz
    Laboratory of Immunology, National Institutes of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Immunology 114:484-92. 2005
    ..These data have important implications for strategies being considered for the use of TGF-beta-producing T cells for the treatment of autoimmune disorders...
  25. ncbi Th2 cells are required for the Schistosoma mansoni egg-induced granulomatous response
    M H Kaplan
    Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, MA 02115, USA
    J Immunol 160:1850-6. 1998
    ..mansoni ova in Stat4- and Stat6-deficient mice, which lack Th1 and Th2 cells, respectively...
  26. ncbi Type I IFNs provide a third signal to CD8 T cells to stimulate clonal expansion and differentiation
    Julie M Curtsinger
    Department of Laboratory Medicine and Pathology, Center for Immunology, University of Minnesota, Minneapolis, MN 55455, USA
    J Immunol 174:4465-9. 2005
    ..We show that IFN-alpha beta can provide the third signal directly to CD8 T cells via a STAT4-dependent pathway to stimulate survival, development of cytolytic function, and production of IFN-gamma...
  27. ncbi IL-27 limits IL-2 production during Th1 differentiation
    Alejandro V Villarino
    Department of Pathobiology, University of Pennsylvania School of Veterinary Medicine, Philadelphia, PA 19104, USA
    J Immunol 176:237-47. 2006
    ....
  28. ncbi Inhibition of Th1 development mediated by GATA-3 through an IL-4-independent mechanism
    W Ouyang
    Department of Pathology and Center for Immunology, Howard Hughes Medical Institute, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Immunity 9:745-55. 1998
    ..Here, we show that loss of GATA-3 expression by developing Th1 cells requires IL-12 signaling through Stat4 and does not simply result from an absence of IL-4...
  29. ncbi A crucial role for T-bet in selectin ligand expression in T helper 1 (Th1) cells
    Greg H Underhill
    Department of Microbiology Immunology, Feinberg School of Medicine, Northwestern University, 303 E Chicago Ave, Chicago, IL 60611, USA
    Blood 106:3867-73. 2005
    ..Further, we show that T-bet is responsible for the signal transducer and activator of transcription 4 (Stat4)-independent increase in Th1 cells of fucosyltransferase VII (FucT-VII)...
  30. ncbi Disruption of the STAT4 signaling pathway protects from autoimmune diabetes while retaining antiviral immune competence
    A Holz
    Department of Neuropharmacology, Division of Virology, The Scripps Research Institute, La Jolla, CA 92037, USA
    J Immunol 163:5374-82. 1999
    The role of the STAT4 signaling pathway in autoimmune diabetes was investigated using the rat insulin promoter lymphocytic choriomeningitis virus model of virally induced autoimmune diabetes...
  31. ncbi The biology of Stat4 and Stat6
    A L Wurster
    Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, Massachusetts, MA 02115, USA
    Oncogene 19:2577-84. 2000
    ..Stat6 and Stat4 are two STAT family members that specifically mediate signals that emanate from the IL-4 and IL-12 receptors, ..
  32. ncbi Tyk2 negatively regulates adaptive Th1 immunity by mediating IL-10 signaling and promoting IFN-gamma-dependent IL-10 reactivation
    Michael H Shaw
    Department of Molecular Microbiology and Immunology, Brown University, Providence, RI 02906, USA
    J Immunol 176:7263-71. 2006
    ..Thus, Tyk2 can be viewed as a dual-function Jak, mediating both pro and anti-inflammatory cytokine responses...
  33. ncbi Increased susceptibility of Stat4-deficient and enhanced resistance in Stat6-deficient mice to infection with Trypanosoma cruzi
    R L Tarleton
    Department of Cellular Biology, University of Georgia, Athens, GA 30602, USA
    J Immunol 165:1520-5. 2000
    ..cruzi, mice with induced deficiencies in the Stat4 or Stat6 genes were infected with T. cruzi...
  34. ncbi Role of Stat4-mediated signal transduction events in the generation of aggressor CD4+ T cells in herpetic stromal keratitis pathogenesis
    Kaustuv Banerjee
    Comparative and Experimental Medicine, College of Veterinary Medicine, The University of Tennessee, Knoxville, TN 37916, USA
    J Interferon Cytokine Res 27:65-75. 2007
    ..involved in the development of aggressor CD4(+) T cells, ocular HSV infection was followed in mice deficient in Stat4 (Stat4(-/-) mice), the signal transducer for the cytokine interleukin-12 (IL-12)...
  35. ncbi STAT-4 mediated IL-12 signaling pathway is critical for the development of protective immunity in cutaneous leishmaniasis
    L M Stamm
    Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, USA
    Eur J Immunol 29:2524-9. 1999
    Recent studies have demonstrated that two IL-12 signaling pathways, a STAT 4 - dependent and STAT4 - independent, are involved in the development of a Th1-like response...
  36. ncbi GATA-3 suppresses Th1 development by downregulation of Stat4 and not through effects on IL-12Rbeta2 chain or T-bet
    Takashi Usui
    Mucosal Immunity Section, Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Disease, National Institutes of Health, Bethesda, MD 20892, USA
    Immunity 18:415-28. 2003
    To further understand the interaction among GATA-3, Stat4, and T-bet in helper T cell development, we first showed that retroviral expression of GATA-3 in developing Th1 cells suppresses Th1 development through downregulation of Stat4 ..
  37. ncbi T helper type 1-specific Brg1 recruitment and remodeling of nucleosomes positioned at the IFN-gamma promoter are Stat4 dependent
    Fuping Zhang
    Department of Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    J Exp Med 203:1493-505. 2006
    ..and positioned nucleosomes are remodeled, in a Th1-specific manner that is dependent on the transcription factor Stat4 and calcineurin phosphatase activity...
  38. ncbi Generation of T follicular helper cells is mediated by interleukin-21 but independent of T helper 1, 2, or 17 cell lineages
    Roza I Nurieva
    Department of Immunology, University of Texas MD Anderson Cancer Center and Graduate School of Biomedical Sciences, Houston, TX 77030, USA
    Immunity 29:138-49. 2008
    ..This study thus demonstrates that Tfh is a distinct Th cell lineage...
  39. ncbi Synergy of IL-12 and IL-18 for IFN-gamma gene expression: IL-12-induced STAT4 contributes to IFN-gamma promoter activation by up-regulating the binding activity of IL-18-induced activator protein 1
    Masakiyo Nakahira
    Department of Oncology, Osaka University Graduate School of Medicine, 2 2, Yamada oka, Suita, Osaka 565 0871, Japan
    J Immunol 168:1146-53. 2002
    IL-12 and IL-18 synergistically enhance IFN-gamma mRNA transcription by activating STAT4 and AP-1, respectively. However, it is still unknown how STAT4/AP-1 elicit IFN-gamma promoter activation...
  40. ncbi JAK/STAT signaling by cytokine receptors
    K D Liu
    Gladstone Institute of Virology and Immunology, San Francisco, California 94141, USA
    Curr Opin Immunol 10:271-8. 1998
    ..This signaling pathway influences normal cell survival and growth mechanisms and may contribute to oncogenic transformation...
  41. ncbi A signal transducer and activator of transcription (Stat)4-independent pathway for the development of T helper type 1 cells
    M H Kaplan
    Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    J Exp Med 188:1191-6. 1998
    ..We have generated mice lacking both Stat4 and Stat6 to examine the ability of Th cells to develop in the absence of these two transcription factors...
  42. ncbi A point mutation in the IL-12R beta 2 gene underlies the IL-12 unresponsiveness of Lps-defective C57BL/10ScCr mice
    A Poltorak
    The Scripps Research Institute, La Jolla, CA 92037 Max Planck Institut für Immunbiologie, Freiburg, Germany
    J Immunol 167:2106-11. 2001
    ..phosphorylation of Janus kinase 2, but, unlike the wild-type IL-12R, can no longer mediate phosphorylation of STAT4. Because the phosphorylation of STAT4 is a prerequisite for the IL-12-mediated induction of IFN-gamma, its absence ..
  43. ncbi Modulation of chromatin structure regulates cytokine gene expression during T cell differentiation
    S Agarwal
    Department of Pathology, Harvard Medical School, Center for Blood Research, Boston, Massachusetts 02115, USA
    Immunity 9:765-75. 1998
    ..We propose that chromatin remodeling of cytokine gene loci is functionally associated with productive T cell differentiation and may explain the coordinate regulation of Th2 cytokine genes...
  44. ncbi Vaccine-induced protection against 3 systemic mycoses endemic to North America requires Th17 cells in mice
    Marcel Wuthrich
    Department of Pediatrics, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin 53706, USA
    J Clin Invest 121:554-68. 2011
    ..These data suggest that human vaccines against systemic fungal infections should be designed to induce Th17 cells if they are to be effective...
  45. ncbi Inhibition of hormone and cytokine-stimulated osteoclastogenesis and bone resorption by interleukin-4 and interleukin-13 is associated with increased osteoprotegerin and decreased RANKL and RANK in a STAT6-dependent pathway
    Py Palmqvist
    Departments of Oral Cell Biology and Periodontics, Umea University, Umeå S 901 87, Sweden
    J Biol Chem 281:2414-29. 2006
    ..The data indicate that IL-4 and IL-13, via a STAT6-dependent pathway, inhibit osteoclast differentiation and bone resorption by activating receptors on osteoblasts and osteoclasts that affect the RANKL/RANK/OPG system...
  46. ncbi Stat4 is critical for the balance between Th17 cells and regulatory T cells in colitis
    Jiangnan Xu
    Center for Vascular and Inflammatory Diseases, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    J Immunol 186:6597-606. 2011
    ..In this study, by adding Stat4 deficiency to Stat6/T-bet double knockout, we further dissected the role of Stat4 in Th1 development and colitis ..
  47. ncbi Epigenetic instability of cytokine and transcription factor gene loci underlies plasticity of the T helper 17 cell lineage
    Ryuta Mukasa
    Department of Pathology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Immunity 32:616-27. 2010
    ..but were rapidly reversed downstream of IL-12-induced silencing of the Rorc gene by the transcription factors STAT4 and T-bet...
  48. ncbi Type I IFN controls chikungunya virus via its action on nonhematopoietic cells
    Clementine Schilte
    Department of Immunology, Unité Immunobiologie des Cellules Dendritiques, Institut Pasteur, 75724 Paris, Cedex 15, France
    J Exp Med 207:429-42. 2010
    ..This study defines an essential role for type I IFN, produced via cooperation between multiple host sensors and acting directly on nonhematopoietic cells, in the control of CHIKV...
  49. ncbi CD4+ T-cell-mediated anti-tumor immunity can be uncoupled from autoimmunity via the STAT4/STAT6 signaling axis
    Sheng Zhang
    Department of Pathology and Molecular Medicine, McMaster University, Ontario, Canada
    Eur J Immunol 39:1252-9. 2009
    ..demonstrated that CD4(+) T-cell-mediated anti-tumor immunity and autoimmunity could be separated by modulating the STAT4/STAT6 signaling axis...
  50. ncbi Toll-like receptor and IL-12 signaling control susceptibility to contact hypersensitivity
    Stefan F Martin
    Allergy Research Group, Department of Dermatology, University Medical Center Freiburg, D 79104 Freiburg, Germany
    J Exp Med 205:2151-62. 2008
    ..Finally, CHS was inducible in germ-free wild-type and IL-12Rbeta2-deficient mice, but not in germ-free TLR4/IL-12Rbeta2 double deficient mice, suggesting that the necessary TLR activation may proceed via endogenous ligands...
  51. ncbi IL-12 is required for anti-OX40-mediated CD4 T cell survival
    Carl E Ruby
    Earle A Chiles Research Institute, Providence Portland Medical Center, Portland, OR 97213, USA
    J Immunol 180:2140-8. 2008
    ..this window of IL-12Rbeta2 expression, was required for enhanced T cell survival and survival was associated with STAT4-specific signaling...
  52. ncbi IL-23 drives pathogenic IL-17-producing CD8+ T cells
    Bogoljub Ciric
    Department of Neurology, Thomas Jefferson University, Philadelphia, PA 19107, USA
    J Immunol 182:5296-305. 2009
    ..Both STAT1 and STAT4 are required for optimal development of Tc17 cells and maximal secretion of cytokines...
  53. ncbi Orally induced peripheral nonresponsiveness is maintained in the absence of functional Th1 or Th2 cells
    H N Shi
    Mucosal Immunology Laboratory, Massachusetts General Hospital, Charlestown 02129, USA
    J Immunol 162:5143-8. 1999
    ..In the mucosa, however, the absence of Th1 and Th2 cytokines can markedly affect this response, perhaps by regulation of TGF-beta-secreting cells...
  54. ncbi Cysteine protease B of Leishmania mexicana inhibits host Th1 responses and protective immunity
    Laurence U Buxbaum
    Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    J Immunol 171:3711-7. 2003
    ..Lesion resolution was Th1 dependent, as Deltacpb-infected IL-12p40(-/-) and STAT4(-/-) mice developed high parasite burdens and progressive disease. Moreover, when L...
  55. ncbi Regulatory functions of CD8+CD28- T cells in an autoimmune disease model
    Nader Najafian
    Brigham and Women s Hospital, Boston, Massachusetts, USA
    J Clin Invest 112:1037-48. 2003
    ..These are the first data establishing that regulatory CD8+CD28- T cells occur in normal mice and play a critical role in disease resistance in CD28-/- animals...
  56. ncbi T helper-cell phenotype regulates atherosclerosis in mice under conditions of mild hypercholesterolemia
    S A Huber
    Department of Pathology, University of Vermont, Burlington, USA
    Circulation 103:2610-6. 2001
    ..T cells are implicated in atherosclerosis, but little is known about the genetic control or molecular pathways, especially under conditions of mild hypercholesterolemia...
  57. ncbi A role for IL-27 in early regulation of Th1 differentiation
    Toshiyuki Owaki
    Intractable Immune System Disease Research Center, Tokyo Medical University, Japan
    J Immunol 175:2191-200. 2005
    ..of IL-27 to induce Th1 differentiation was most prominent under Th1-polarizing conditions, but without IL-12 in a STAT4- and IFN-gamma-independent manner, and was overruled by IL-12 dose dependently...
  58. ncbi An absolute requirement for STAT4 and a role for IFN-gamma as an amplifying factor in IL-12 induction of the functional IL-18 receptor complex
    M Nakahira
    Department of Oncology, Biomedical Research Center, Osaka University Graduate School of Medicine, 2 2 Yamada oka, Suita, Osaka 565 0871, Japan
    J Immunol 167:1306-12. 2001
    ..IL-12 induction of an IL-18R complex and IL-18Rbeta mRNA expression was not observed in STAT4-deficient (STAT4(-/-)) T cells and was substantially decreased in IFN-gamma(-/-) T cells...
  59. ncbi Selective loss of type I interferon-induced STAT4 activation caused by a minisatellite insertion in mouse Stat2
    J D Farrar
    Department of Pathology and Center for Immunology, Howard Hughes Medical Institute, Washington University School of Medicine, 660 S Euclid, St Louis, MO 63110, USA
    Nat Immunol 1:65-9. 2000
    ..immunity to direct the development of T helper subsets, for example toward subset 1 (TH1) development through STAT4 activation...
  60. ncbi Th1 and Th2 mediate acute graft-versus-host disease, each with distinct end-organ targets
    B Nikolic
    Bone Marrow Transplantation Section, Transplantation Biology Research Center, Surgical Service, Massachusetts General Hospital Harvard Medical School, Boston, Massachusetts 02129, USA
    J Clin Invest 105:1289-98. 2000
    b>STAT4 and STAT6 are transcription factors that play crucial roles in responding to IL-12 and IL-4, respectively. STAT4 gene knockout (STAT4(-/-)) mice have markedly reduced Th1 responses and enhanced Th2 responses...
  61. ncbi Effect of targeted disruption of signal transducer and activator of transcription (Stat)4 and Stat6 genes on the autoimmune diabetes development induced by multiple low doses of streptozotocin
    Marina Cetkovic-Cvrlje
    Department of Immunology, Parker Hughes Institute, 2720 Patton Road, St Paul, MN 55113, USA
    Clin Immunol 114:299-306. 2005
    The MLDS (multiple low doses of streptozotocin) model of diabetes was induced in Stat4(-/-), Stat6(-/-), and double-deficient Stat4(-/-)/6(-/-) mice to examine the role of STAT4/STAT6 deficiency in development of autoimmune diabetes...
  62. ncbi Different competitive capacities of Stat4- and Stat6-deficient CD4+ T cells during lymphophenia-driven proliferation
    Vanesa Sanchez-Guajardo
    Lymphocyte Population Biology Unit, Institute Pasteur, France
    J Immunol 174:1178-87. 2005
    ..Because Stat4 and Stat6 proteins are implicated in the Th1 vs Th2 generation and maintenance, respectively, we compare in this ..
  63. ncbi Effect of targeted disruption of STAT4 and STAT6 on the induction of experimental autoimmune encephalomyelitis
    T Chitnis
    Center for Neurologic Diseases, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Clin Invest 108:739-47. 2001
    ..Here we used animals with targeted deletion of the STAT4 or STAT6 genes to determine the role of these signaling molecules in EAE...
  64. ncbi Physiological mechanisms of regulating alloimmunity: cytokines, CTLA-4, CD25+ cells, and the alloreactive T cell clone size
    Masayuki Sho
    Department of Medicine, Children s Hospital, Laboratory of Immunogenetics and Transplantation, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Immunol 169:3744-51. 2002
    ..D2 (minor mismatch) and C57BL/6 (major mismatch), into BALB/c recipients. Recipients were wild type, STAT4(-/-) (Th1 deficient), or STAT6(-/-) (Th2 deficient) mice...
  65. ncbi Deletion of MyD88 markedly attenuates sepsis-induced T and B lymphocyte apoptosis but worsens survival
    Octavia M Peck-Palmer
    Department of Anesthesiology, Division of Laboratory and Genomic Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
    J Leukoc Biol 83:1009-18. 2008
    ..TLR4, and IL-1R), intracellular signaling proteins (MyD88 and TRIF), cytoplasmic transcription factors (STAT1 and STAT4), and the MAPK pathway (JNK1) in sepsis-induced lymphocyte apoptosis...
  66. ncbi STAT4 is required for antibacterial defense but enhances mortality during polymicrobial sepsis
    C J Godshall
    Veterans Affairs Medical Center and Department of Surgery, University of Louisville School of Medicine, Louisville, Kentucky 40292, USA
    Clin Diagn Lab Immunol 8:1044-8. 2001
    The signal transducer and activator of transcription factor 4 (STAT4) pathway mediates the intracellular effects of interleukin-12 (IL-12), leading to the production of gamma interferon, induction of a T helper type 1 response, and ..
  67. ncbi IL-12 signaling drives CD8+ T cell IFN-gamma production and differentiation of KLRG1+ effector subpopulations during Toxoplasma gondii Infection
    Douglas C Wilson
    Department of Molecular Microbiology and Immunology, Brown University, Providence, RI 02912, USA
    J Immunol 180:5935-45. 2008
    ..gondii...
  68. ncbi Signal transducer and activator of transcription 4 (STAT4), but not IL-12 contributes to Pseudomonas aeruginosa-induced lung inflammation in mice
    Rory O'Sullivan
    Department of Microbiology and Immunology, Dalhousie University, Halifax, NS, Canada B3K 6R8
    Immunobiology 213:469-79. 2008
    ..through its associated intracellular signaling molecule, the signal transducer and activator of transcription 4 (STAT4). To examine a specific role of IL-12 and STAT4 in P...
  69. ncbi Stat4 suppresses the proliferation of connective tissue-type mast cells
    Tatsuki R Kataoka
    Department of Pathology, Medical School Graduate School of Frontier Bioscience, Osaka University, Osaka, Japan
    Lab Invest 88:856-64. 2008
    ..b>Stat4 is also expressed in T cells and plays important roles in their homeostasis...
  70. ncbi Early target genes of IL-12 and STAT4 signaling in th cells
    Riikka J Lund
    Turku Centre for Biotechnology, Turku University and Abo Akademi, Turku Graduate School of Biomedical Sciences, Turku University, Turku, Finland
    J Immunol 172:6775-82. 2004
    IL-12 signaling through STAT4 is essential for induction of optimal levels of IFN-gamma production and commitment of Th1 cells...
  71. ncbi STATs as activators of apoptosis
    C Schindler
    Dept of Microbiology, Columbia University, NY 10032, USA
    Trends Cell Biol 8:97-8. 1998
    ..However, STATs appear to have a dark side as well and contribute to programmed cell death. Intriguingly, a recent study suggests that this might occur in a manner that is distinct from the standard STAT signalling paradigm...
  72. ncbi Cytokines, Jaks, Stats, health and disease
    M P Brown
    Cell and Gene Therapy Program, St Jude Children's Research Hospital, Memphis, Tennessee, USA
    Aust N Z J Med 29:73-8. 1999
  73. ncbi Beta-glycoglycosphingolipid-induced alterations of the STAT signaling pathways are dependent on CD1d and the lipid raft protein flotillin-2
    Gadi Lalazar
    Liver Unit, Department of Medicine, Hebrew University Hadassah Medical Center, P O B 12000, Jerusalem, Israel, IL 91120
    Am J Pathol 174:1390-9. 2009
    ..Our results show that beta-glycosphingolipids have beneficial effects in natural killer T cell-dependent immune-mediated metabolic and malignant animal models in vivo...
  74. ncbi Cutting edge: differential requirements for Stat4 in expression of glycosyltransferases responsible for selectin ligand formation in Th1 cells
    S J White
    Department of Microbiology Immunology, Northwestern University Medical School, Chicago, IL 60611, USA
    J Immunol 167:628-31. 2001
    A role for Stat4 in IL-12-induced up-regulation of selectin ligands on Th1 cells was explored...
  75. ncbi Role of interleukin-12 and stat-4 in the regulation of airway inflammation and hyperreactivity in respiratory syncytial virus infection
    K K Tekkanat
    Department of Pediatrics, University of Michigan Medical School, 1301 Catherine, Ann Arbor, MI 48109 0602, USA
    Am J Pathol 159:631-8. 2001
    ..These studies support the importance of IL-12 in the immune response to RSV infection resulting in resolution of disease and protection from inappropriate inflammatory responses...
  76. ncbi Adenovirus-mediated interferon gamma gene therapy for allergic asthma: involvement of interleukin 12 and STAT4 signaling
    Aruna K Behera
    Division of Allergy and Immunology, Joy McCann Culverhouse Airway Disease Center, University of South Florida College of Medicine, Tampa, FL 33620, USA
    Hum Gene Ther 13:1697-709. 2002
    ..The IFN-gamma effects were dependent on IL-12 and STAT4 (signal transducer and activator of transcription 4), as mice treated with antibodies to IL-12 and STAT4 deficient ..
  77. ncbi Differential contribution of IL-4 and STAT6 vs STAT4 to the development of lupus nephritis
    Ram Raj Singh
    University of Cincinnati College of Medicine, Department of Internal Medicine, Veterans Affairs Medical Center and Children s Medical Center, Cincinnati, OH 45220, USA
    J Immunol 170:4818-25. 2003
    ..b>STAT4 deficiency, however, decreases type 1 and increases type 2 cytokine responses, and accelerates nephritis, in the ..
  78. ncbi SLIM is a nuclear ubiquitin E3 ligase that negatively regulates STAT signaling
    Takashi Tanaka
    Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Immunity 22:729-36. 2005
    ..Here, we report on a nuclear protein that contains both PDZ and LIM domains and that interacts with activated STAT4 molecules...
  79. ncbi Mycobacterial trehalose 6,6'-dimycolate preferentially induces type 1 helper T cell responses through signal transducer and activator of transcription 4 protein
    Ryuta Oiso
    Department of Host Defense, Osaka City University Graduate School of Medicine, Abeno Ku, Osaka 545 8585, Japan
    Microb Pathog 39:35-43. 2005
    ..we have analyzed footpad reaction, histopathology and cytokine profile of experimental granulomatous lesions using STAT4-deficient mice...
  80. ncbi Stat4-null non-obese diabetic mice: protection from diabetes and experimental allergic encephalomyelitis, but with concomitant epitope spread
    Rosemary J Boyton
    Department of Infectious Diseases and Transplantation Biology Group, Medical Research Council, Clinical Sciences Centre, Faculty of Medicine, Imperial College London, Hammersmith Hospital, Du Cane Road, London W12 ONN, UK
    Int Immunol 17:1157-65. 2005
    ..for molecules involved in cytokine receptor signal transduction, signal transducer and activator of transcription (Stat4) and Stat6...
  81. ncbi CD4+ T cells mediate abscess formation in intra-abdominal sepsis by an IL-17-dependent mechanism
    Doo Ryeon Chung
    Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    J Immunol 170:1958-63. 2003
    ..induction of abscesses required T cell costimulation via the CD28-B7 pathway, and T cell transfer experiments with STAT4(-/-) and STAT6(-/-) mice demonstrated that this host response is dependent on STAT4 signaling...
  82. ncbi Frontline: absence of functional STAT4 activation despite detectable tyrosine phosphorylation induced by murine IFN-alpha
    Lisa S Berenson
    Department of Pathology and Center for Immunology, Washington University School of Medicine, St Louis, MO 63110, USA
    Eur J Immunol 34:2365-74. 2004
    We previously reported that IL-12, but not IFN-alphaA/D, induces T helper type (Th) 1 development and STAT4 phosphorylation in murine CD4+ T cells...
  83. ncbi Differential requirement of signal transducer and activator of transcription-4 (Stat4) and Stat6 in a thyrotropin receptor-289-adenovirus-induced model of Graves' hyperthyroidism
    Kimberly J Land
    Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Evansville, Indiana 47712, USA
    Endocrinology 147:111-9. 2006
    ..previous studies using HEK-293 cells expressing the extracellular domain of the TSH receptor (TSHR) showed that Stat4-/- mice, which lack Th1 cells, are susceptible, whereas Stat6-/- mice, which lack Th2 cells, are resistant to the ..
  84. ncbi A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17
    Heon Park
    Department of Immunology, University of Washington, Seattle, Washington 98195, USA
    Nat Immunol 6:1133-41. 2005
    ..Thus, IL-17 expression characterizes a unique T helper lineage that regulates tissue inflammation...
  85. ncbi Synergistic effect of IL-2, IL-12, and IL-18 on thymocyte apoptosis and Th1/Th2 cytokine expression
    Maria Cecilia Rodriguez-Galan
    Laboratory of Experimental Immunology, Center for Cancer Research, National Cancer Institute, Frederick, MD 21702, USA
    J Immunol 174:2796-804. 2005
    ..The IL-2-plus-IL-18 or IL-12-plus-IL-18 effect on IFN-gamma and IL-13 expression is dependent on Stat4 and NF-kappaB but independent of Stat6, T-bet, or NFAT...
  86. ncbi GADD45beta/GADD45gamma and MEKK4 comprise a genetic pathway mediating STAT4-independent IFNgamma production in T cells
    Hongbo Chi
    Section of Immunobiology, Yale University School of Medicine, New Haven, CT, USA
    EMBO J 23:1576-86. 2004
    ..During Th1 differentiation, the GADD45beta/GADD45gamma/MEKK4 pathway appears to integrate upstream signals transduced by both T cell receptor and IL12/STAT4, leading to augmented IFNgamma production in a process independent of STAT4.
  87. ncbi Allograft rejection requires STAT5a/b-regulated antiapoptotic activity in T cells but not B cells
    Ye Zhang
    Division of Immunology and Organ Transplantation, Department of Surgery, University of Texas Medical School, Houston, TX 77030, USA
    J Immunol 176:128-37. 2006
    ..Thus, activated STAT5a/b-/- T cells produce cytokines prior to entering apoptosis, thereby promoting differentiation of B cells yielding donor-specific IgM and IgG Ab that mediate allograft rejection...
  88. ncbi Autoimmune diabetes is blocked in Stat4-deficient mice
    Zandong Yang
    Department of Internal Medicine, Division of Endocrinology and Metabolism, University of Virginia, P O Box 801413, Charlottesville, VA 22908, USA
    J Autoimmun 22:191-200. 2004
    ..b>STAT4 mediates IL-12 signaling and regulates T helper 1 (Th1) cell differentiation...
  89. ncbi Genome-wide isolation of growth and obesity QTL using mouse speed congenic strains
    Charles R Farber
    Department of Animal Science, University of California Davis, One Shields Ave, Davis, CA 95016 8521, USA
    BMC Genomics 7:102. 2006
    ..To confirm and further characterize each QTL, two panels of speed congenic strains were developed by introgressing CAST/EiJ (CAST) QTL alleles onto either mutant C57Bl/6J-hg/hg (HG) or wild type C57Bl/6J (B6) genetic backgrounds...
  90. ncbi STAT4 is required for interleukin-12-induced chromatin remodeling of the CD25 locus
    Audrey O'Sullivan
    Department of Microbiology and Immunology and the Walther Oncology Center, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    J Biol Chem 279:7339-45. 2004
    Signal transducer and activator of transcription 4 (STAT4) is a critical mediator of interleukin-12 (IL-12)-stimulated inflammatory immune responses...
  91. ncbi Contrasting roles for STAT4 and STAT6 signal transduction pathways in murine renal ischemia-reperfusion injury
    Naoko Yokota
    Division of Nephrology, Johns Hopkins Univ School of Medicine, Rm 970, 720 Rutland Ave, Baltimore, MD 21205, USA
    Am J Physiol Renal Physiol 285:F319-25. 2003
    ..We therefore hypothesized that mice that were STAT4 deficient would be protected from renal IRI and that STAT6-deficient mice would have a more severe course...
  92. ncbi IL-4 induces in vivo production of IFN-gamma by NK and NKT cells
    Suzanne C Morris
    Division of Immunology, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA
    J Immunol 176:5299-305. 2006
    ..B and T cell-independent; suppressed by an anti-IL-2Rbeta mAb that eliminates most NK and NKT cells; reduced in Stat4-deficient mice, which have decreased numbers of NK cells; and absent in Rag2/gamma(c)-double-deficient mice, which ..
  93. ncbi STAT4 requires the N-terminal domain for efficient phosphorylation
    Hua Chen Chang
    Department of Microbiology and Immunology and the Walther Oncology Center, Indiana University School of Medicine, and the Walther Cancer Institute, Indianapolis, Indiana, USA
    J Biol Chem 278:32471-7. 2003
    b>STAT4 (signal transducer and activator of transcription-4) mediates biological effects in response to interleukin-12 (IL-12). STAT4 has multiple domains that have distinct functions in signaling and gene activation...
  94. ncbi The homeostasis but not the differentiation of T cells is regulated by p27(Kip1)
    Randy Shen
    Department of Microbiology and Immunology, Walther Oncology Center, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    J Immunol 169:714-21. 2002
    ..While STAT4- and STAT6-deficient T cells have diminished proliferative responses to IL-12 and IL-4, respectively, ..
  95. ncbi Structure of the amino-terminal protein interaction domain of STAT-4
    U Vinkemeier
    Laboratory of Molecular Cell Biology and Laboratories of Molecular Biophysics, The Rockefeller University, New York, NY 10021, USA
    Science 279:1048-52. 1998
    ..Mutagenesis of an invariant tryptophan residue at the heart of this interface abolished cooperative DNA binding by the full-length protein in vitro and reduced the transcriptional response after cytokine stimulation in vivo...

Research Grants65

  1. Resources Core
    Mark Kaplan; Fiscal Year: 2006
    ..Thus, the Resource Core is the foundation of a highly interactive Program and will help the investigators in achieving the goal of a greater understanding of the pathogenesis of Atopic Dermatitis. ..
  2. STAT4 IMMUNOLOGY
    Mark Kaplan; Fiscal Year: 2003
    ..b>Stat4 is specifically activated by interleukin (IL)-12 and has been implicated in biological responses including ..
  3. Stat4 Immunobiology
    Mark Kaplan; Fiscal Year: 2007
    ..b>Stat4 is specifically activated by a small set of cytokines, including interleukin (IL)-12 and IL-23, and has been ..
  4. The role of PU.1 in T helper 2 function
    Mark Kaplan; Fiscal Year: 2009
    ..1 as a Th2-restricted negative regulatory factor of Th2 cytokine secretion. Regulation of PU.1 expression and function could be manipulated as a treatment for Th2 mediated diseases including asthma and allergies. ..
  5. Stat4 Immunobiology
    Mark H Kaplan; Fiscal Year: 2010
    ..b>Stat4, which is activated by IL-12 and IL-23, is critical in the generation of inflammatory responses in vivo...
  6. The role of PU.1 in T helper cell heterogeneity
    Mark H Kaplan; Fiscal Year: 2010
    ..Results from these studies will provide new information about how allergic disease develops, and how T cells could be targeted for the treatment of allergic disease. ..
  7. Tumor-induced immune suppression
    Suzanne Ostrand Rosenberg; Fiscal Year: 2007
    ..A better understanding of the regulation of tumor- induced immune suppression may reveal methods for controlling these cells in cancer patients, and thereby contribute to the development of effective cancer immunotherapies. ..
  8. Cell-based tumor vaccines targeting CD4+ T lymphocytes
    Suzanne Ostrand Rosenberg; Fiscal Year: 2010
    ..Aim 4: Determine if the MHC ll+livaccines produce a novel repertoire of peptides and if ocular melanoma patients'responses are skewed towards the novel peptides. ..
  9. Control of Spermatogonial Stem Cell Fate Decisions by bHLH Transcription Regulato
    Jon M Oatley; Fiscal Year: 2010
    ..Also, this research will expand general knowledge of stem cell biology that may be applicable to other tissue-specific stem cell populations important for sustaining life. ..
  10. Role of micro-RNAs in T cells and other immune/haematopoietic cells
    Anjana Rao; Fiscal Year: 2007
    ..Together these studies should greatly increase our understanding of the role of miRNAs in T cells and other cells of the immune and hematopoietic systems. ..
  11. Cell-based tumor vaccines targeting CD4+ T lymphocytes
    Suzanne Ostrand Rosenberg; Fiscal Year: 2009
    ..Aim 4: Determine if the MHC ll+li- vaccines produce a novel repertoire of peptides and if ocular melanoma patients' responses are skewed towards the novel peptides. ..
  12. Tumor-induced immune suppression.
    Suzanne Ostrand Rosenberg; Fiscal Year: 2009
    ..abstract_text> ..
  13. Control of Spermatogonial Stem Cell Fate Decisions by bHLH Transcription Regulato
    JON OATLEY; Fiscal Year: 2009
    ..Also, this research will expand general knowledge of stem cell biology that may be applicable to other tissue-specific stem cell populations important for sustaining life. ..
  14. Cell-based tumor vaccines targeting CD4+ T lymphocytes
    Suzanne Ostrand Rosenberg; Fiscal Year: 2009
    ..Aim 4: Determine if the MHC ll+li- vaccines produce a novel repertoire of peptides and if ocular melanoma patients' responses are skewed towards the novel peptides. ..
  15. T cell Function in Murine Model of Multiple Sclerosis
    Moses Rodriguez; Fiscal Year: 2010
    ..The findings are expected to provide new insights into the pathogenesis of axonal and neuronal injury in demyelinating disorders such as multiple sclerosis. ..
  16. Tumor-induced immune suppression.
    Suzanne Ostrand Rosenberg; Fiscal Year: 2010
    ..abstract_text> ..
  17. B CELL FUNCTION IN AUTOIMMUNE ARTHRITIS
    Alison Finnegan; Fiscal Year: 2010
    ....
  18. IFN-Is at the interface of Innate and Adapative Immunity
    Christian Schindler; Fiscal Year: 2009
    ..2. Determine the unique role Stat2 exhibits in regulating MHC-II expression in macrophages 3. Explore the role SUMOylation may play in regulating the kinetics of IFN stimulated STATs. ..
  19. T cell Function in Murine Model of Multiple Sclerosis
    Moses Rodriguez; Fiscal Year: 2007
    ..The findings are expected to provide new insights into the pathogenesis of axonal and neuronal injury in demyelinating disorders such as multiple sclerosis. ..
  20. IMMUNOLOGICAL DISEASE MECHANISMS
    Sankar Ghosh; Fiscal Year: 2006
    ..These accomplishments more than fulfill the promises made in our initial application to establish an NlAlD training program in immunology. In the next five years we expect to consolidate and expand on these gains. ..
  21. IL 3, IL 5, AND GM-CSF SIGNALING AND ASTHMA
    Christian Schindler; Fiscal Year: 1999
    ..2. Identify additional ligand specific components in the two signaling cascades activated by the IL-3 family of ligands. 3. Target the specific interactions between Stat 5 isoforms and the IL3beta receptor chain for interruption. ..
  22. IMMUNE PROMOTION OF REMYELINATION
    Moses Rodriguez; Fiscal Year: 1993
  23. PHI-381: A Novel Anti-Leukemic Agent
    Marina Cetkovic Cvrlje; Fiscal Year: 2003
    ..The knowledge gained from these studies described under Specific Aims 1-2 is expected to facilitate the design of innovative treatment regimens employing COBRA-1 for the treatment of metastatic solid tumors. ..
  24. IMMUNE PROMOTION OF REMYELINATION
    Moses Rodriguez; Fiscal Year: 2003
    ..These experiments have direct relevance for the development of novel human therapeutics for demyelinating disease. ..
  25. T CELL FUNCTION IN A MURINE MODEL OF MULTIPLE SCLEROSIS
    Moses Rodriguez; Fiscal Year: 2003
    ..These experiments are expected to provide new insights into the effector molecules released by the inflammatory response responsible for neurologic deficits in demyelinating disease. ..
  26. CELL BASED TUMOR VACCINES TARGETING CD4+ T LUMPHOCYTES
    Suzanne Ostrand Rosenberg; Fiscal Year: 2003
    ..Completion of these studies will provide the framework for conducting a clinical trial, and will provide mechanistic information for further improvement of the vaccines. ..
  27. CYTOKINE REGULATION IN EXPERIMENTAL ARTHRITIS
    Alison Finnegan; Fiscal Year: 2010
    ..These studies aim to develop novel insights into the autoimmune disease process that will facilitate the diagnosis and treatment of RA. ..
  28. CHARACTERIZATION OF A MAJOR OBESITY LOCUS
    Charles Farber; Fiscal Year: 2007
    ..Lastly, aim 3 uses a genetical genomics approach to map eQTL for genes within the congenic interval. Data from these aims will enhance our understanding of the genetics and physiology of obesity. ..