Stat1

Summary

Gene Symbol: Stat1
Description: signal transducer and activator of transcription 1
Alias: 2010005J02Rik, AA408197, signal transducer and activator of transcription 1
Species: mouse
Products:     Stat1

Top Publications

  1. Chang Y, Tsai C, Huang W, Wang C, Chen C, Lin Y, et al. Autophagy facilitates IFN-gamma-induced Jak2-STAT1 activation and cellular inflammation. J Biol Chem. 2010;285:28715-22 pubmed publisher
    ..Here, we show that autophagy facilitates IFN-gamma-activated Jak2-STAT1. IFN-gamma induces autophagy in wild-type but not in autophagy protein 5 (Atg5(-/-))-deficient mouse embryonic ..
  2. Halford W, Weisend C, Grace J, Soboleski M, Carr D, Balliet J, et al. ICP0 antagonizes Stat 1-dependent repression of herpes simplex virus: implications for the regulation of viral latency. Virol J. 2006;3:44 pubmed
    ..In contrast, rag2-/- mice that lacked the IFN-alpha/beta receptor (rag2-/- ifnar-/-) or Stat 1 (rag2-/- stat1-/-) failed to repress ICP0- viral replication, resulting in uncontrolled viral spread and death...
  3. Wallner B, Leitner N, Vielnascher R, Kernbauer E, Kolbe T, Karaghiosoff M, et al. Generation of mice with a conditional Stat1 null allele. Transgenic Res. 2012;21:217-24 pubmed publisher
    ..Signaling upon stimulation by IFN type I, II and III is mediated by the Jak-Stat pathway. STAT1 is activated by all three IFN receptor complexes and absence of STAT1 from mice increases their susceptibility to ..
  4. Mumphrey S, Changotra H, Moore T, Heimann Nichols E, Wobus C, Reilly M, et al. Murine norovirus 1 infection is associated with histopathological changes in immunocompetent hosts, but clinical disease is prevented by STAT1-dependent interferon responses. J Virol. 2007;81:3251-63 pubmed
    ..replicates and rapidly disseminates to various tissues in immunocompetent mice and that infection is restricted by STAT1-dependent interferon responses at the levels of viral replication and virus dissemination...
  5. Wilson N, Foster S, Wang X, Knezevic K, Schütte J, Kaimakis P, et al. Combinatorial transcriptional control in blood stem/progenitor cells: genome-wide analysis of ten major transcriptional regulators. Cell Stem Cell. 2010;7:532-44 pubmed publisher
    ..Taken together, this study demonstrates the power of genome-wide analysis in generating novel functional insights into the transcriptional control of stem and progenitor cells. ..
  6. Collison L, Delgoffe G, Guy C, Vignali K, Chaturvedi V, Fairweather D, et al. The composition and signaling of the IL-35 receptor are unconventional. Nat Immunol. 2012;13:290-9 pubmed publisher
    ..Signaling through the IL-35 receptor required the transcription factors STAT1 and STAT4, which formed a unique heterodimer that bound to distinct sites in the promoters of the genes encoding ..
  7. Longman R, Braun D, Pellegrini S, Rice C, Darnell R, Albert M. Dendritic-cell maturation alters intracellular signaling networks, enabling differential effects of IFN-alpha/beta on antigen cross-presentation. Blood. 2007;109:1113-22 pubmed
    ..Despite equivalent IFNAR expression, immature conventional DCs (cDCs) activate STAT1 in response to IFN-alpha/beta, whereas exposure of mature DCs to IFN-alpha/beta results in signaling via STAT4...
  8. Kernbauer E, Maier V, Stoiber D, Strobl B, Schneckenleithner C, Sexl V, et al. Conditional Stat1 ablation reveals the importance of interferon signaling for immunity to Listeria monocytogenes infection. PLoS Pathog. 2012;8:e1002763 pubmed publisher
    b>Signal transducer and activator of transcription 1 (Stat1) is a key player in responses to interferons (IFN). Mutations of Stat1 cause severe immune deficiencies in humans and mice...
  9. Thibault D, Chu A, Graham K, Balboni I, Lee L, Kohlmoos C, et al. IRF9 and STAT1 are required for IgG autoantibody production and B cell expression of TLR7 in mice. J Clin Invest. 2008;118:1417-26 pubmed publisher
    ..Here, we demonstrate that 2 IFN-I signaling molecules, IFN regulatory factor 9 (IRF9) and STAT1, were required for the production of IgG autoantibodies in the pristane-induced mouse model of SLE...
  10. Sanz E, Hofer M, Unzeta M, Campbell I. Minimal role for STAT1 in interleukin-6 signaling and actions in the murine brain. Glia. 2008;56:190-9 pubmed
    ..The binding of IL-6 to its receptor (IL6R) triggers gp130-mediated activation of STAT1 and STAT3 as well as SHP2 phosphatase and ERK1/2...

Detail Information

Publications62

  1. Chang Y, Tsai C, Huang W, Wang C, Chen C, Lin Y, et al. Autophagy facilitates IFN-gamma-induced Jak2-STAT1 activation and cellular inflammation. J Biol Chem. 2010;285:28715-22 pubmed publisher
    ..Here, we show that autophagy facilitates IFN-gamma-activated Jak2-STAT1. IFN-gamma induces autophagy in wild-type but not in autophagy protein 5 (Atg5(-/-))-deficient mouse embryonic ..
  2. Halford W, Weisend C, Grace J, Soboleski M, Carr D, Balliet J, et al. ICP0 antagonizes Stat 1-dependent repression of herpes simplex virus: implications for the regulation of viral latency. Virol J. 2006;3:44 pubmed
    ..In contrast, rag2-/- mice that lacked the IFN-alpha/beta receptor (rag2-/- ifnar-/-) or Stat 1 (rag2-/- stat1-/-) failed to repress ICP0- viral replication, resulting in uncontrolled viral spread and death...
  3. Wallner B, Leitner N, Vielnascher R, Kernbauer E, Kolbe T, Karaghiosoff M, et al. Generation of mice with a conditional Stat1 null allele. Transgenic Res. 2012;21:217-24 pubmed publisher
    ..Signaling upon stimulation by IFN type I, II and III is mediated by the Jak-Stat pathway. STAT1 is activated by all three IFN receptor complexes and absence of STAT1 from mice increases their susceptibility to ..
  4. Mumphrey S, Changotra H, Moore T, Heimann Nichols E, Wobus C, Reilly M, et al. Murine norovirus 1 infection is associated with histopathological changes in immunocompetent hosts, but clinical disease is prevented by STAT1-dependent interferon responses. J Virol. 2007;81:3251-63 pubmed
    ..replicates and rapidly disseminates to various tissues in immunocompetent mice and that infection is restricted by STAT1-dependent interferon responses at the levels of viral replication and virus dissemination...
  5. Wilson N, Foster S, Wang X, Knezevic K, Schütte J, Kaimakis P, et al. Combinatorial transcriptional control in blood stem/progenitor cells: genome-wide analysis of ten major transcriptional regulators. Cell Stem Cell. 2010;7:532-44 pubmed publisher
    ..Taken together, this study demonstrates the power of genome-wide analysis in generating novel functional insights into the transcriptional control of stem and progenitor cells. ..
  6. Collison L, Delgoffe G, Guy C, Vignali K, Chaturvedi V, Fairweather D, et al. The composition and signaling of the IL-35 receptor are unconventional. Nat Immunol. 2012;13:290-9 pubmed publisher
    ..Signaling through the IL-35 receptor required the transcription factors STAT1 and STAT4, which formed a unique heterodimer that bound to distinct sites in the promoters of the genes encoding ..
  7. Longman R, Braun D, Pellegrini S, Rice C, Darnell R, Albert M. Dendritic-cell maturation alters intracellular signaling networks, enabling differential effects of IFN-alpha/beta on antigen cross-presentation. Blood. 2007;109:1113-22 pubmed
    ..Despite equivalent IFNAR expression, immature conventional DCs (cDCs) activate STAT1 in response to IFN-alpha/beta, whereas exposure of mature DCs to IFN-alpha/beta results in signaling via STAT4...
  8. Kernbauer E, Maier V, Stoiber D, Strobl B, Schneckenleithner C, Sexl V, et al. Conditional Stat1 ablation reveals the importance of interferon signaling for immunity to Listeria monocytogenes infection. PLoS Pathog. 2012;8:e1002763 pubmed publisher
    b>Signal transducer and activator of transcription 1 (Stat1) is a key player in responses to interferons (IFN). Mutations of Stat1 cause severe immune deficiencies in humans and mice...
  9. Thibault D, Chu A, Graham K, Balboni I, Lee L, Kohlmoos C, et al. IRF9 and STAT1 are required for IgG autoantibody production and B cell expression of TLR7 in mice. J Clin Invest. 2008;118:1417-26 pubmed publisher
    ..Here, we demonstrate that 2 IFN-I signaling molecules, IFN regulatory factor 9 (IRF9) and STAT1, were required for the production of IgG autoantibodies in the pristane-induced mouse model of SLE...
  10. Sanz E, Hofer M, Unzeta M, Campbell I. Minimal role for STAT1 in interleukin-6 signaling and actions in the murine brain. Glia. 2008;56:190-9 pubmed
    ..The binding of IL-6 to its receptor (IL6R) triggers gp130-mediated activation of STAT1 and STAT3 as well as SHP2 phosphatase and ERK1/2...
  11. Schroder K, Spille M, Pilz A, Lattin J, Bode K, Irvine K, et al. Differential effects of CpG DNA on IFN-beta induction and STAT1 activation in murine macrophages versus dendritic cells: alternatively activated STAT1 negatively regulates TLR signaling in macrophages. J Immunol. 2007;179:3495-503 pubmed
    Classical STAT1 activation in response to TLR agonists occurs by phosphorylation of the Y701 and S727 residues through autocrine type I IFN signaling and p38 MAPK signaling, respectively...
  12. Putz E, Gotthardt D, Hoermann G, Csiszar A, Wirth S, Berger A, et al. CDK8-mediated STAT1-S727 phosphorylation restrains NK cell cytotoxicity and tumor surveillance. Cell Rep. 2013;4:437-44 pubmed publisher
    The transcription factor STAT1 is important in natural killer (NK) cells, which provide immediate defense against tumor and virally infected cells...
  13. Park K, Scott A. Cholesterol 25-hydroxylase production by dendritic cells and macrophages is regulated by type I interferons. J Leukoc Biol. 2010;88:1081-7 pubmed publisher
    ..of Ch25h relies on the TRIF-mediated production of type I IFNs and requires signaling through the IFNαR and JAK/STAT1 pathway. Treatment of BMDCs and macrophages with IFN-α or IFN-β induces Ch25h in a STAT1-dependent manner...
  14. Fitzgerald D, Zhang G, El Behi M, Fonseca Kelly Z, Li H, Yu S, et al. Suppression of autoimmune inflammation of the central nervous system by interleukin 10 secreted by interleukin 27-stimulated T cells. Nat Immunol. 2007;8:1372-9 pubmed
    ..Our data show that IL-27-induced production of IL-10 by effector T cells contributes to the immunomodulatory function of IL-27. ..
  15. Lenschow D, Lai C, Frias Staheli N, Giannakopoulos N, Lutz A, Wolff T, et al. IFN-stimulated gene 15 functions as a critical antiviral molecule against influenza, herpes, and Sindbis viruses. Proc Natl Acad Sci U S A. 2007;104:1371-6 pubmed
    ..The demonstration of ISG15 as a novel antiviral molecule with activity against both RNA and DNA viruses provides a target for the development of therapies against important human pathogens...
  16. Farlik M, Reutterer B, Schindler C, Greten F, Vogl C, Muller M, et al. Nonconventional initiation complex assembly by STAT and NF-kappaB transcription factors regulates nitric oxide synthase expression. Immunity. 2010;33:25-34 pubmed publisher
    ..Here we showed sequential and cooperative contributions of the transcription factors ISGF3 (a complex containing STAT1, STAT2, and IRF9 subunits) and NF-kappaB to the transcriptional induction of the Nos2 gene in macrophages infected ..
  17. Johnson L, Scott P. STAT1 expression in dendritic cells, but not T cells, is required for immunity to Leishmania major. J Immunol. 2007;178:7259-66 pubmed
    ..Although IFN-gammaR/STAT1 signaling promotes a Th1 response via the up-regulation of T-bet, the requirement for STAT1 in Th1 cell ..
  18. Miyagi T, Gil M, Wang X, Louten J, Chu W, Biron C. High basal STAT4 balanced by STAT1 induction to control type 1 interferon effects in natural killer cells. J Exp Med. 2007;204:2383-96 pubmed
    The best-characterized type 1 interferon (IFN) signaling pathway depends on signal transducer and activator of transcription 1 (STAT1) and STAT2. The cytokines can, however, conditionally activate all STATs...
  19. Rayamajhi M, Humann J, Penheiter K, Andreasen K, Lenz L. Induction of IFN-alphabeta enables Listeria monocytogenes to suppress macrophage activation by IFN-gamma. J Exp Med. 2010;207:327-37 pubmed publisher
    ..Such cross talk permits prioritization of IFN-alphabeta-type immune responses and may contribute to the beneficial effects of IFN-beta in treatment of inflammatory diseases such as multiple sclerosis. ..
  20. Hannesdóttir L, Daschil N, Philipp S, Tymoszuk P, Muller Holzner E, Klima G, et al. MMTV-neu mice deficient in STAT1 are susceptible to develop ovarian teratomas. Int J Dev Biol. 2012;56:279-83 pubmed publisher
    b>Signal transducer and activator of transcription 1 (STAT1) serves in the protection of the organism against pathogens and other harmful insults...
  21. Liddle F, Alvarez J, Poli V, Frank D. Tyrosine phosphorylation is required for functional activation of disulfide-containing constitutively active STAT mutants. Biochemistry. 2006;45:5599-605 pubmed
    ..Constitutively active forms of STAT1 and STAT3 (STAT1C and STAT3C) have been developed to determine the effects of STAT activation in isolation from ..
  22. Hu Y, Hu X, Boumsell L, Ivashkiv L. IFN-gamma and STAT1 arrest monocyte migration and modulate RAC/CDC42 pathways. J Immunol. 2008;180:8057-65 pubmed
    ..Inhibition was dependent on STAT1 and downstream genes, whereas STAT3 promoted migration...
  23. Trusca V, Fuior E, Florea I, Kardassis D, Simionescu M, Gafencu A. Macrophage-specific up-regulation of apolipoprotein E gene expression by STAT1 is achieved via long range genomic interactions. J Biol Chem. 2011;286:13891-904 pubmed publisher
    ..12-myristate 13-acetate-induced differentiation of macrophages is accompanied by a robust induction of apoE and STAT1 expression. In macrophages (but not in hepatocytes), STAT1 up-regulated apoE gene expression via ME.2...
  24. Batten M, Li J, Yi S, Kljavin N, Danilenko D, Lucas S, et al. Interleukin 27 limits autoimmune encephalomyelitis by suppressing the development of interleukin 17-producing T cells. Nat Immunol. 2006;7:929-36 pubmed
    ..This suppressive activity was dependent on the transcription factor STAT1 and was independent of interferon-gamma. Finally, IL-27 suppressed IL-6-mediated T cell proliferation...
  25. Pilz A, Kratky W, Stockinger S, Simma O, Kalinke U, Lingnau K, et al. Dendritic cells require STAT-1 phosphorylated at its transactivating domain for the induction of peptide-specific CTL. J Immunol. 2009;183:2286-93 pubmed publisher
    ....
  26. Kimura A, Naka T, Nohara K, Fujii Kuriyama Y, Kishimoto T. Aryl hydrocarbon receptor regulates Stat1 activation and participates in the development of Th17 cells. Proc Natl Acad Sci U S A. 2008;105:9721-6 pubmed publisher
    ..We were able to demonstrate that Ahr interacts with Stat1 and Stat5, which negatively regulate Th17 development...
  27. Mullarky I, Szaba F, Kummer L, Wilhelm L, Parent M, Johnson L, et al. Gamma interferon suppresses erythropoiesis via interleukin-15. Infect Immun. 2007;75:2630-3 pubmed
    ..These findings identified new therapeutic targets for anemia. ..
  28. Hofer M, Li W, Lim S, Campbell I. The type I interferon-alpha mediates a more severe neurological disease in the absence of the canonical signaling molecule interferon regulatory factor 9. J Neurosci. 2010;30:1149-57 pubmed publisher
    ..Interferon regulatory factor (IRF9) is involved in type I IFN-regulated gene expression where it associates with STAT1:STAT2 heterodimers to form the transcriptional complex ISGF3...
  29. Bancerek J, Poss Z, Steinparzer I, Sedlyarov V, Pfaffenwimmer T, Mikulic I, et al. CDK8 kinase phosphorylates transcription factor STAT1 to selectively regulate the interferon response. Immunity. 2013;38:250-62 pubmed publisher
    ..b>STAT1 and STAT3 TAD phosphorylation occurs upon promoter binding by an unknown kinase...
  30. Ramsauer K, Farlik M, Zupkovitz G, Seiser C, Kröger A, Hauser H, et al. Distinct modes of action applied by transcription factors STAT1 and IRF1 to initiate transcription of the IFN-gamma-inducible gbp2 gene. Proc Natl Acad Sci U S A. 2007;104:2849-54 pubmed
    A subgroup of genes induced by IFN-gamma requires both STAT1 and IRF1 for transcriptional activation. Using WT, stat1(-/-), or irf1(-/-) cells, we analyzed the changes induced by IFN-gamma in gbp2 promoter chromatin...
  31. Klover P, Muller W, Robinson G, Pfeiffer R, Yamaji D, Hennighausen L. Loss of STAT1 from mouse mammary epithelium results in an increased Neu-induced tumor burden. Neoplasia. 2010;12:899-905 pubmed
    Type I and type II classes of interferons (IFNs) signal through the JAK/STAT1 pathway and are known to be important in adaptive and innate immune responses and in protection against tumors...
  32. Perry S, Buck M, Lada S, Schindler C, Shresta S. STAT2 mediates innate immunity to Dengue virus in the absence of STAT1 via the type I interferon receptor. PLoS Pathog. 2011;7:e1001297 pubmed publisher
    ..of transcription (STAT) 1-deficient mice are resistant to DENV-induced disease, but little is known about this STAT1-independent mechanism of protection...
  33. Kovacic B, Stoiber D, Moriggl R, Weisz E, Ott R, Kreibich R, et al. STAT1 acts as a tumor promoter for leukemia development. Cancer Cell. 2006;10:77-87 pubmed
    The tumor suppressor STAT1 is considered a key regulator of the surveillance of developing tumors. Here, we describe an unexpected tumor-promoting role for STAT1 in leukemia...
  34. Barthson J, Germano C, Moore F, Maida A, Drucker D, Marchetti P, et al. Cytokines tumor necrosis factor-α and interferon-γ induce pancreatic β-cell apoptosis through STAT1-mediated Bim protein activation. J Biol Chem. 2011;286:39632-43 pubmed publisher
    ..Bim expression was transcriptionally regulated by STAT1, and its activation triggered cleavage of caspases...
  35. Berenson L, Gavrieli M, Farrar J, Murphy T, Murphy K. Distinct characteristics of murine STAT4 activation in response to IL-12 and IFN-alpha. J Immunol. 2006;177:5195-203 pubmed
    ..Furthermore, loss of STAT1 increases IFN-alpha-induced STAT4 phosphorylation, but does not generate levels of STAT4 activation or IFN-gamma ..
  36. Gough D, Messina N, Hii L, Gould J, Sabapathy K, Robertson A, et al. Functional crosstalk between type I and II interferon through the regulated expression of STAT1. PLoS Biol. 2010;8:e1000361 pubmed publisher
    ..but our new data are more consistent with a previously proposed model indicating that regulated expression of STAT1 may also play a critical role in the priming process...
  37. Chen L, Wei P, Liu T, Kao C, Pai L, Lee C. STAT2 hypomorphic mutant mice display impaired dendritic cell development and antiviral response. J Biomed Sci. 2009;16:22 pubmed publisher
    ..In sum, the new allele of STAT2 mutant reported here reveals a role of STAT2 for DC development and a threshold requirement for full functions of type I IFNs. ..
  38. Bente D, Alimonti J, Shieh W, Camus G, Stroher U, Zaki S, et al. Pathogenesis and immune response of Crimean-Congo hemorrhagic fever virus in a STAT-1 knockout mouse model. J Virol. 2010;84:11089-100 pubmed publisher
    ..This new mouse model exhibits key features of fatal human CCHF, proves useful for the testing of therapeutic strategies, and can be used to study virus attenuation. ..
  39. Sun L, Ma K, Wang H, Xiao F, Gao Y, Zhang W, et al. JAK1-STAT1-STAT3, a key pathway promoting proliferation and preventing premature differentiation of myoblasts. J Cell Biol. 2007;179:129-38 pubmed
    ..JAK1, of all the signal transducer and activator of transcriptions (STATs) present in myoblasts, we find that only STAT1 knockdown promotes myogenic differentiation in both primary and immortalized myoblasts...
  40. Chan S, Vermi W, Luo J, Lucini L, Rickert C, Fowler A, et al. STAT1-deficient mice spontaneously develop estrogen receptor α-positive luminal mammary carcinomas. Breast Cancer Res. 2012;14:R16 pubmed
    ..STAT transcription factors play critical roles in mammary gland tumorigenesis, but the precise role of STAT1 remains unclear...
  41. Pasieka T, Cilloniz C, Lu B, Teal T, Proll S, Katze M, et al. Host responses to wild-type and attenuated herpes simplex virus infection in the absence of Stat1. J Virol. 2009;83:2075-87 pubmed publisher
    Humans and mice lacking the interferon signaling molecule Stat1 are sensitive to a variety of pathogens due to their presumed inability to mount a strong innate immune response...
  42. Zwaferink H, Stockinger S, Hazemi P, Lemmens Gruber R, Decker T. IFN-beta increases listeriolysin O-induced membrane permeabilization and death of macrophages. J Immunol. 2008;180:4116-23 pubmed
    ..This activity of IFN-beta required Stat1. Perturbation of the plasma membrane by LLO resulted in activation of the p38MAPK pathway...
  43. Kimura A, Naka T, Nakahama T, Chinen I, Masuda K, Nohara K, et al. Aryl hydrocarbon receptor in combination with Stat1 regulates LPS-induced inflammatory responses. J Exp Med. 2009;206:2027-35 pubmed publisher
    ..Ahr-deficient mice were more highly sensitive to LPS-induced lethal shock than WT mice. Signal transducer and activator of transcription 1 (Stat1) deficiency, as well as Ahr deficiency, augmented LPS-induced IL-6 production...
  44. Pasieka T, Lu B, Leib D. Enhanced pathogenesis of an attenuated herpes simplex virus for mice lacking Stat1. J Virol. 2008;82:6052-5 pubmed publisher
    Mice lacking the Stat1 interferon signaling gene were infected with herpes simplex virus type 1 (HSV-1) or an attenuated recombinant lacking virion host shutoff (Delta vhs)...
  45. Schneckenleithner C, Bago Horvath Z, Dolznig H, Neugebauer N, Kollmann K, Kolbe T, et al. Putting the brakes on mammary tumorigenesis: loss of STAT1 predisposes to intraepithelial neoplasias. Oncotarget. 2011;2:1043-54 pubmed
    Multiparous Stat1-/- mice spontaneously develop mammary tumors with increased incidence: at an average age of 12 months, 55% of the animals suffer from mammary cancer, although the histopathology is heterogeneous...
  46. Pasieka T, Collins L, O Connor M, Chen Y, Parker Z, Berwin B, et al. Bioluminescent imaging reveals divergent viral pathogenesis in two strains of Stat1-deficient mice, and in αßγ interferon receptor-deficient mice. PLoS ONE. 2011;6:e24018 pubmed publisher
    ..IFN response to virus infection include the IFN receptors (IFNR), and the downstream factor signal transducer and activator of transcription 1 (Stat1)...
  47. Guarda G, Braun M, Staehli F, Tardivel A, Mattmann C, Forster I, et al. Type I interferon inhibits interleukin-1 production and inflammasome activation. Immunity. 2011;34:213-23 pubmed publisher
    ..Type I IFN signaling, via the STAT1 transcription factor, repressed the activity of the NLRP1 and NLRP3 inflammasomes, thereby suppressing caspase-1-..
  48. Ma H, Lu C, ZIEGLER J, Liu A, Sepulveda A, Okada H, et al. Absence of Stat1 in donor CD4⁺ T cells promotes the expansion of Tregs and reduces graft-versus-host disease in mice. J Clin Invest. 2011;121:2554-69 pubmed publisher
    b>STAT1 is the main signal transducer for type I and II IFNs and plays a central role in the regulation of innate and adaptive immune responses...
  49. Li H, Gelbard A, Martinez G, Esashi E, Zhang H, Nguyen Jackson H, et al. Cell-intrinsic role for IFN-α-STAT1 signals in regulating murine Peyer patch plasmacytoid dendritic cells and conditioning an inflammatory response. Blood. 2011;118:3879-89 pubmed publisher
    ..Type I IFN signaling via STAT1 has a cell-autonomous role in accrual of PP pDCs in vivo...
  50. Begitt A, Droescher M, Knobeloch K, Vinkemeier U. SUMO conjugation of STAT1 protects cells from hyperresponsiveness to IFNγ. Blood. 2011;118:1002-7 pubmed publisher
    The biologic effects of IFNγ are mediated by the transcription factor STAT1. The activity of STAT1 is inhibited by small ubiquitin-like modifier (SUMO) conjugation...
  51. Axtell R, de Jong B, Boniface K, van der Voort L, Bhat R, De Sarno P, et al. T helper type 1 and 17 cells determine efficacy of interferon-beta in multiple sclerosis and experimental encephalomyelitis. Nat Med. 2010;16:406-12 pubmed publisher
    ..Hence, IFN-beta is proinflammatory in T(H)17-induced EAE. Moreover, a high IL-17F concentration in the serum of people with RRMS is associated with nonresponsiveness to therapy with IFN-beta. ..
  52. Zwaferink H, Stockinger S, Reipert S, Decker T. Stimulation of inducible nitric oxide synthase expression by beta interferon increases necrotic death of macrophages upon Listeria monocytogenes infection. Infect Immun. 2008;76:1649-56 pubmed publisher
    ..Based on morphology, the maintenance of mitochondrial membrane potential, and a lack of dependence on caspase 1, we characterize the type of cell death occurring and show that infected macrophages die by interferon-upregulated necrosis. ..
  53. Mott K, Underhill D, Wechsler S, Town T, Ghiasi H. A role for the JAK-STAT1 pathway in blocking replication of HSV-1 in dendritic cells and macrophages. Virol J. 2009;6:56 pubmed publisher
    ..wild type mice, DCs and macrophages isolated from signal transducers and activators of transcription-1 deficient (STAT1-/-) mice were susceptible to HSV-1 replication and the production of viral mRNAs and DNA...
  54. Stout B, Melendez K, Seagrave J, Holtzman M, Wilson B, Xiang J, et al. STAT1 activation causes translocation of Bax to the endoplasmic reticulum during the resolution of airway mucous cell hyperplasia by IFN-gamma. J Immunol. 2007;178:8107-16 pubmed
    ..A brief phosphorylation of STAT1 by IFN-gamma was required for cell death in airway epithelial cells (AEC), and during prolonged exposure to ..
  55. Crozat K, Georgel P, Rutschmann S, Mann N, Du X, Hoebe K, et al. Analysis of the MCMV resistome by ENU mutagenesis. Mamm Genome. 2006;17:398-406 pubmed
    ..Domino corresponds to a point mutation that alters the DNA binding domain of STAT1, leading to a defect of STAT1 activation...
  56. Chen S, Lin Y, Huang M, Wu M, Cheng S, Lei H, et al. CLEC5A is critical for dengue-virus-induced lethal disease. Nature. 2008;453:672-6 pubmed publisher
    ..as well as subcutaneous and vital-organ haemorrhaging, and reduce the mortality of DV infection by about 50% in STAT1-deficient mice...
  57. Sadzak I, Schiff M, Gattermeier I, Glinitzer R, Sauer I, Saalmuller A, et al. Recruitment of Stat1 to chromatin is required for interferon-induced serine phosphorylation of Stat1 transactivation domain. Proc Natl Acad Sci U S A. 2008;105:8944-9 pubmed publisher
    The transcription factor Stat1 plays an essential role in responses to interferons (IFNs). Activation of Stat1 is achieved by phosphorylation on Y701 that is followed by nuclear accumulation...
  58. Song J, So E, Lee C. Increased serine phosphorylation and activation of STAT1 by oncogenic Ras transfection. Mol Cells. 2002;13:322-6 pubmed
    Interferon (IFN)-gamma induces the activation of a signal transducer and activator of transcription 1 (STAT1), and regulates the growth response of diverse cell types...
  59. Gil M, Salomon R, Louten J, Biron C. Modulation of STAT1 protein levels: a mechanism shaping CD8 T-cell responses in vivo. Blood. 2006;107:987-93 pubmed
    ..The cytokines mediate profound antiproliferative effects. Signal transducer and activator of transcription 1 (STAT1)-dependent signaling pathways are required for inhibition of proliferation, and viral ..
  60. He F, Ge W, Martinowich K, Becker Catania S, Coskun V, Zhu W, et al. A positive autoregulatory loop of Jak-STAT signaling controls the onset of astrogliogenesis. Nat Neurosci. 2005;8:616-25 pubmed
    ..As such, activated STAT1/3 and STAT-mediated transcription are negligible at early, neurogenic stages, when neurogenic factors are highly ..
  61. de Hooge A, van de Loo F, Koenders M, Bennink M, Arntz O, Kolbe T, et al. Local activation of STAT-1 and STAT-3 in the inflamed synovium during zymosan-induced arthritis: exacerbation of joint inflammation in STAT-1 gene-knockout mice. Arthritis Rheum. 2004;50:2014-23 pubmed
    ..Exacerbation of arthritis in STAT-1(-/-) mice suggests an opposing effect of STAT-1, i.e., suppression of joint inflammation. The expression of SOCS-1 could be the underlying mechanism by which STAT-1 controls joint inflammation. ..
  62. Pilz A, Ramsauer K, Heidari H, Leitges M, Kovarik P, Decker T. Phosphorylation of the Stat1 transactivating domain is required for the response to type I interferons. EMBO Rep. 2003;4:368-73 pubmed
    Stat1 (signal transducer and activator of transcription 1) regulates transcription in response to the type I interferons IFN-alpha and IFN-beta, either in its dimerized form or as a subunit of the interferon-stimulated gene factor 3 (..