stanniocalcin 2


Gene Symbol: stanniocalcin 2
Description: stanniocalcin 2
Alias: AW125853, Stc-2, Stc2l, mustc2, stanniocalcin-2
Species: mouse
Products:     stanniocalcin 2

Top Publications

  1. Moore E, Kuestner R, Conklin D, Whitmore T, Downey W, Buddle M, et al. Stanniocalcin 2: characterization of the protein and its localization to human pancreatic alpha cells. Horm Metab Res. 1999;31:406-14 pubmed
    ..Double immunostaining for STC2 and either insulin or glucagon revealed that STC2 protein is found in the alpha cells, but not the beta cells. We speculate that STC2 may play a role in glucose homeostasis. ..
  2. Ito D, Walker J, Thompson C, Moroz I, Lin W, Veselits M, et al. Characterization of stanniocalcin 2, a novel target of the mammalian unfolded protein response with cytoprotective properties. Mol Cell Biol. 2004;24:9456-69 pubmed
    ..Here we describe the characterization of stanniocalcin 2 (STC2), a mammalian homologue of a calcium- and phosphate-regulating hormone first identified in fish, as a ..
  3. Chang A, Hook J, Lemckert F, McDonald M, Nguyen M, Hardeman E, et al. The murine stanniocalcin 2 gene is a negative regulator of postnatal growth. Endocrinology. 2008;149:2403-10 pubmed publisher
    ..This effect was not mediated through the GH/IGF-I axis. The results are consistent with STC2 being a negative regulator of postnatal growth. ..
  4. Chang A, Reddel R. Identification of a second stanniocalcin cDNA in mouse and human: stanniocalcin 2. Mol Cell Endocrinol. 1998;141:95-9 pubmed
    ..In contrast to STC-1, the predicted amino acid sequence of STC-2 contains a cluster of histidine residues in the C-terminal portion of the protein, which suggests that STC-2 may interact with metal ions. ..
  5. Miyata K, Yasukawa T, Fukuda M, Takeuchi T, Yamazaki K, Sakumi K, et al. Induction of apoptosis and cellular senescence in mice lacking transcription elongation factor, Elongin A. Cell Death Differ. 2007;14:716-26 pubmed
    ..Taken together, our results suggest that Elongin A is required for the transcription of genes essential for early embryonic development and downregulation of its activity is tightly associated with cellular senescence. ..
  6. Harper T, Joshi A, Elferink C. Identification of stanniocalcin 2 as a novel aryl hydrocarbon receptor target gene. J Pharmacol Exp Ther. 2013;344:579-88 pubmed publisher set with minimal overlap, compared with previous array studies, culminating in the identification of Stanniocalcin 2 (Stc2) as a novel receptor target gene previously reported to have a cytoprotective role in endoplasmic ..
  7. Steffensen L, Conover C, Bjørklund M, Ledet T, Bentzon J, Oxvig C. Stanniocalcin-2 overexpression reduces atherosclerosis in hypercholesterolemic mice. Atherosclerosis. 2016;248:36-43 pubmed publisher
    ..Furthermore, we demonstrate that lesion development can be inhibited in an experimental model by driving the balance towards inhibited PAPP-A. ..
  8. Ishibashi K, Miyamoto K, Taketani Y, Morita K, Takeda E, Sasaki S, et al. Molecular cloning of a second human stanniocalcin homologue (STC2). Biochem Biophys Res Commun. 1998;250:252-8 pubmed
    ..We have cloned a widely expressed new human stanniocalcin homologue which suppressed the expression of renal Na-phosphate cotransporter. ..
  9. Fazio E, DiMattia G, Chadi S, Kernohan K, Pin C. Stanniocalcin 2 alters PERK signalling and reduces cellular injury during cerulein induced pancreatitis in mice. BMC Cell Biol. 2011;12:17 pubmed publisher
    b>Stanniocalcin 2 (STC2) is a secreted protein activated by (PKR)-like Endoplasmic Reticulum Kinase (PERK) signalling under conditions of ER stress in vitro...

More Information


  1. Zeiger W, Ito D, Swetlik C, Oh Hora M, Villereal M, Thinakaran G. Stanniocalcin 2 is a negative modulator of store-operated calcium entry. Mol Cell Biol. 2011;31:3710-22 pubmed publisher
    ..Furthermore, our findings implicate the modulation of SOCE through STC2 expression as one of the prosurvival measures of the unfolded protein response. ..
  2. Fagman H, Amendola E, Parrillo L, Zoppoli P, Marotta P, Scarfò M, et al. Gene expression profiling at early organogenesis reveals both common and diverse mechanisms in foregut patterning. Dev Biol. 2011;359:163-75 pubmed publisher
    ..As an initial step in this direction we describe a regulatory pathway involving the anti-apoptotic gene Bcl2 that controls cell survival in early thyroid development. ..
  3. Joshi A, Hossain E, Elferink C. Epigenetic Regulation by Agonist-Specific Aryl Hydrocarbon Receptor Recruitment of Metastasis-Associated Protein 2 Selectively Induces Stanniocalcin 2 Expression. Mol Pharmacol. 2017;92:366-374 pubmed publisher
    ..Recent studies identified stanniocalcin 2 (Stc2) as a novel AhR target gene responsive to the endogenous AhR agonist cinnabarinic acid (CA)...
  4. Yadav N, Lee J, Kim J, Shen J, Hu M, Aldaz C, et al. Specific protein methylation defects and gene expression perturbations in coactivator-associated arginine methyltransferase 1-deficient mice. Proc Natl Acad Sci U S A. 2003;100:6464-8 pubmed
    ..These findings provide genetic evidence for the essential role of CARM1 in estrogen-mediated transcriptional activation. ..
  5. Takei Y, Yamamoto H, Sato T, Otani A, Kozai M, Masuda M, et al. Stanniocalcin 2 is associated with ectopic calcification in ?-klotho mutant mice and inhibits hyperphosphatemia-induced calcification in aortic vascular smooth muscle cells. Bone. 2012;50:998-1005 pubmed publisher
  6. Jepsen M, Kløverpris S, Mikkelsen J, Pedersen J, Füchtbauer E, Laursen L, et al. Stanniocalcin-2 inhibits mammalian growth by proteolytic inhibition of the insulin-like growth factor axis. J Biol Chem. 2015;290:3430-9 pubmed publisher
    ..Our work identifies STC2 as a novel proteinase inhibitor and a previously unrecognized extracellular component of the IGF system. ..