staggerer

Summary

Gene Symbol: staggerer
Description: RAR-related orphan receptor alpha
Alias: 9530021D13Rik, Nr1f1, ROR1, ROR2, ROR3, nmf267, staggerer, tmgc26, nuclear receptor ROR-alpha, RAR-related orphan receptor A, nuclear receptor RZR-alpha, nuclear receptor subfamily 1 group F member 1, retinoid-related orphan receptor-alpha
Species: mouse
Products:     staggerer

Top Publications

  1. Hamilton B, Frankel W, Kerrebrock A, Hawkins T, FitzHugh W, Kusumi K, et al. Disruption of the nuclear hormone receptor RORalpha in staggerer mice. Nature. 1996;379:736-9 pubmed
    Homozygous staggerer (sg) mice show a characteristic severe cerebellar ataxia due to a cell-autonomous defect in the development of Purkinje cells...
  2. Doulazmi M, Frederic F, Capone F, Becker Andre M, Delhaye Bouchaud N, Mariani J. A comparative study of Purkinje cells in two RORalpha gene mutant mice: staggerer and RORalpha(-/-). Brain Res Dev Brain Res. 2001;127:165-74 pubmed
    The staggerer (Rora(sg/sg)) mutation is a deletion in the RORalpha gene, one member of a family of nuclear receptor genes related to the retinoic acid receptor. Recently Steinmayr et al. (Proc. Natl. Acad. Sci...
  3. Qiu C, Shimokawa N, Iwasaki T, Parhar I, Koibuchi N. Alteration of cerebellar neurotropin messenger ribonucleic acids and the lack of thyroid hormone receptor augmentation by staggerer-type retinoic acid receptor-related orphan receptor-alpha mutation. Endocrinology. 2007;148:1745-53 pubmed
    The mutant mouse staggerer (sg) harbors a deletion within the gene encoding the retinoic acid receptor-related orphan receptor-alpha (RORalpha). Homozygotes show aberrant cerebellar development...
  4. Yamazaki T, Yang X, Chung Y, Fukunaga A, Nurieva R, Pappu B, et al. CCR6 regulates the migration of inflammatory and regulatory T cells. J Immunol. 2008;181:8391-401 pubmed
    ..Similarly, CCR6 on Treg cells is also important for their recruitment into inflammatory tissues. Our data indicate an important role of CCR6 in Treg and Th17 cell migration. ..
  5. Liu C, Li S, Liu T, Borjigin J, Lin J. Transcriptional coactivator PGC-1alpha integrates the mammalian clock and energy metabolism. Nature. 2007;447:477-81 pubmed
    ..We have thus identified PGC-1alpha as a key component of the circadian oscillator that integrates the mammalian clock and energy metabolism. ..
  6. Takeda Y, Jetten A. Prospero-related homeobox 1 (Prox1) functions as a novel modulator of retinoic acid-related orphan receptors ?- and ?-mediated transactivation. Nucleic Acids Res. 2013;41:6992-7008 pubmed publisher
    ..Our data suggest that Prox1 is part of a feedback loop that negatively regulates the transcriptional control of clock and metabolic networks by RORs. ..
  7. Chopra A, Louet J, Saha P, An J, DeMayo F, Xu J, et al. Absence of the SRC-2 coactivator results in a glycogenopathy resembling Von Gierke's disease. Science. 2008;322:1395-9 pubmed publisher
    ..In addition, SRC-2 ablation, in both a whole-body and liver-specific manner, resulted in a Von Gierke's disease phenotype in mice. Our results position SRC-2 as a critical regulator of mammalian glucose production. ..
  8. Kang H, Okamoto K, Takeda Y, Beak J, Gerrish K, Bortner C, et al. Transcriptional profiling reveals a role for RORalpha in regulating gene expression in obesity-associated inflammation and hepatic steatosis. Physiol Genomics. 2011;43:818-28 pubmed publisher
    ..In this study we demonstrate that ROR?-deficient staggerer mice (ROR?(sg/sg)) fed with a high-fat diet (HFD) exhibited reduced adiposity and hepatic triglyceride levels ..
  9. Dussault I, Fawcett D, Matthyssen A, Bader J, Giguere V. Orphan nuclear receptor ROR alpha-deficient mice display the cerebellar defects of staggerer. Mech Dev. 1998;70:147-53 pubmed
    ..neurological mutant mouse staggerer (sg) harbors a deletion within the Rora gene that encodes the orphan nuclear receptor ROR alpha. This deletion removes an exon encoding part of the ligand binding domain of the putative receptor, ..

More Information

Publications78

  1. Gold D, Baek S, Schork N, Rose D, Larsen D, Sachs B, et al. RORalpha coordinates reciprocal signaling in cerebellar development through sonic hedgehog and calcium-dependent pathways. Neuron. 2003;40:1119-31 pubmed
  2. Chung Y, Chang S, Martinez G, Yang X, Nurieva R, Kang H, et al. Critical regulation of early Th17 cell differentiation by interleukin-1 signaling. Immunity. 2009;30:576-87 pubmed publisher
    ..Our data thus indicate a critical role of IL-1 in Th17 cell differentiation and this pathway may serve as a unique target for Th17 cell-mediated immunopathology. ..
  3. Sotelo C. Cerebellar synaptogenesis: what we can learn from mutant mice. J Exp Biol. 1990;153:225-49 pubmed
    ..The comparative analysis of weaver, reeler, staggerer and hyperspiny Purkinje cell has allowed us to establish that the late phase of synapse stabilization or ..
  4. Giguere V, Tini M, Flock G, Ong E, Evans R, Otulakowski G. Isoform-specific amino-terminal domains dictate DNA-binding properties of ROR alpha, a novel family of orphan hormone nuclear receptors. Genes Dev. 1994;8:538-53 pubmed
  5. Angers M, Uldry M, Kong D, Gimble J, Jetten A. Mfsd2a encodes a novel major facilitator superfamily domain-containing protein highly induced in brown adipose tissue during fasting and adaptive thermogenesis. Biochem J. 2008;416:347-55 pubmed publisher
    ..The observed induction of Mfsd2a expression in cultured BAT cells by dibutyryl-cAMP is in agreement with this conclusion. The present study suggests that Mfsd2a plays a role in adaptive thermogenesis. ..
  6. Takeda Y, Kang H, Freudenberg J, Degraff L, Jothi R, Jetten A. Retinoic acid-related orphan receptor ? (ROR?): a novel participant in the diurnal regulation of hepatic gluconeogenesis and insulin sensitivity. PLoS Genet. 2014;10:e1004331 pubmed publisher
    ..The inhibition of the activation of several metabolic gene promoters by an ROR? antagonist suggests that antagonists may provide a novel strategy in the management of metabolic diseases, including type 2 diabetes. ..
  7. Halim T, Maclaren A, Romanish M, Gold M, McNagny K, Takei F. Retinoic-acid-receptor-related orphan nuclear receptor alpha is required for natural helper cell development and allergic inflammation. Immunity. 2012;37:463-74 pubmed publisher
    ..We have also identified ROR?-dependent NH cell progenitors in the bone marrow. Thus, all NH cells belong to a unique ROR?-dependent cell lineage separate from other lymphoid cell lineages...
  8. Yang X, Pappu B, Nurieva R, Akimzhanov A, Kang H, Chung Y, et al. T helper 17 lineage differentiation is programmed by orphan nuclear receptors ROR alpha and ROR gamma. Immunity. 2008;28:29-39 pubmed publisher
    ..Therefore, Th17 differentiation is directed by two lineage-specific nuclear receptors, ROR alpha and ROR gamma. ..
  9. Duez H, Duhem C, Laitinen S, Patole P, Abdelkarim M, Bois Joyeux B, et al. Inhibition of adipocyte differentiation by RORalpha. FEBS Lett. 2009;583:2031-6 pubmed publisher
    ..By contrast, mouse embryonic fibroblasts from staggerer mice, which carry a mutation in the RORalpha gene, differentiate more efficiently into mature adipocytes ..
  10. Akashi M, Takumi T. The orphan nuclear receptor RORalpha regulates circadian transcription of the mammalian core-clock Bmal1. Nat Struct Mol Biol. 2005;12:441-8 pubmed
    ..in generation of the Bmal1 circadian oscillation was verified by behavioral analyses of RORalpha-deficient staggerer mice that showed aberrant locomotor activity and unstable rhythmicity...
  11. Dzhagalov I, Giguere V, He Y. Lymphocyte development and function in the absence of retinoic acid-related orphan receptor alpha. J Immunol. 2004;173:2952-9 pubmed
    ..RORalpha may also play a critical role in lymphocyte development and function because staggerer mice, a natural mutant strain with a disrupted expression of RORalpha, have reduced thymic and splenic ..
  12. Duplus E, Gras C, Soubeyre V, Vodjdani G, Lemaigre Dubreuil Y, Brugg B. Phosphorylation and transcriptional activity regulation of retinoid-related orphan receptor alpha 1 by protein kinases C. J Neurochem. 2008;104:1321-32 pubmed
    ..Our results bring new insights into the control of RORalpha1 activity and highlight its importance in further investigations of the mechanisms involved in neuronal cell death in neurodegenerative diseases. ..
  13. Lau P, Nixon S, Parton R, Muscat G. RORalpha regulates the expression of genes involved in lipid homeostasis in skeletal muscle cells: caveolin-3 and CPT-1 are direct targets of ROR. J Biol Chem. 2004;279:36828-40 pubmed
    The staggerer mice carry a deletion in the RORalpha gene and have a prolonged humoral response, overproduce inflammatory cytokines, and are immunodeficient...
  14. Jaradat M, Stapleton C, Tilley S, Dixon D, Erikson C, McCaskill J, et al. Modulatory role for retinoid-related orphan receptor alpha in allergen-induced lung inflammation. Am J Respir Crit Care Med. 2006;174:1299-309 pubmed
    ..Allergen-induced inflammation was compared between wild-type (WT) and staggerer (RORalpha(sg/sg)) mice, a natural mutant strain that is deficient in RORalpha expression...
  15. Takeda Y, Jothi R, Birault V, Jetten A. ROR? directly regulates the circadian expression of clock genes and downstream targets in vivo. Nucleic Acids Res. 2012;40:8519-35 pubmed
  16. Lau P, Fitzsimmons R, Raichur S, Wang S, Lechtken A, Muscat G. The orphan nuclear receptor, RORalpha, regulates gene expression that controls lipid metabolism: staggerer (SG/SG) mice are resistant to diet-induced obesity. J Biol Chem. 2008;283:18411-21 pubmed publisher
    Homozygous staggerer mice (sg/sg) display decreased and dysfunctional retinoic acid receptor-related orphan receptor alpha (RORalpha) expression...
  17. Herrup K. Role of staggerer gene in determining cell number in cerebellar cortex. I. Granule cell death is an indirect consequence of staggerer gene action. Brain Res. 1983;313:267-74 pubmed
    ..The results reported are an analysis of the involvement of the staggerer gene in the phenotype of granule cell death observed in staggerer mutant mice...
  18. Wang Y, Kumar N, Solt L, Richardson T, Helvering L, Crumbley C, et al. Modulation of retinoic acid receptor-related orphan receptor alpha and gamma activity by 7-oxygenated sterol ligands. J Biol Chem. 2010;285:5013-25 pubmed publisher
    The retinoic acid receptor-related orphan receptors alpha and gamma (RORalpha (NR1F1) and RORgamma (NR1F3)) are orphan nuclear receptors and perform critical roles in regulation of development, metabolism, and immune function...
  19. Kang H, Angers M, Beak J, Wu X, Gimble J, Wada T, et al. Gene expression profiling reveals a regulatory role for ROR alpha and ROR gamma in phase I and phase II metabolism. Physiol Genomics. 2007;31:281-94 pubmed
    ..of ROR receptors in liver, we analyzed the gene expression profiles of livers from WT, ROR alpha-deficient staggerer (sg) mice (ROR alpha(sg/sg)), ROR gamma(-/-), and ROR alpha(sg/sg)ROR gamma(-/-) double knockout (DKO) mice by ..
  20. Steinmayr M, Andre E, Conquet F, Rondi Reig L, Delhaye Bouchaud N, Auclair N, et al. staggerer phenotype in retinoid-related orphan receptor alpha-deficient mice. Proc Natl Acad Sci U S A. 1998;95:3960-5 pubmed
    ..Recently, it was reported that the ataxic mouse mutant staggerer (sg/sg) is caused by a deletion in the RORalpha gene...
  21. Takeda Y, Kang H, Angers M, Jetten A. Retinoic acid-related orphan receptor ? directly regulates neuronal PAS domain protein 2 transcription in vivo. Nucleic Acids Res. 2011;39:4769-82 pubmed publisher
    ..Our results indicate that ROR? and Rev-Erb? are part of a feed-back loop that regulates the circadian expression of Npas2 suggesting a regulatory role for these receptors in Npas2-dependent physiological processes. ..
  22. VanDunk C, Hunter L, Gray P. Development, maturation, and necessity of transcription factors in the mouse suprachiasmatic nucleus. J Neurosci. 2011;31:6457-67 pubmed publisher
    ..Our results provide the first description of the involvement of TFs in the specification and maturation of a neural population necessary for circadian behavior. ..
  23. Boukhtouche F, Mariani J, Tedgui A. The "CholesteROR" protective pathway in the vascular system. Arterioscler Thromb Vasc Biol. 2004;24:637-43 pubmed
    ..The spontaneous staggerer (sg/sg) mutation is a deletion in the Rora gene that prevents the translation of the ligand-binding domain (LBD),..
  24. Gold D, Gent P, Hamilton B. ROR alpha in genetic control of cerebellum development: 50 staggering years. Brain Res. 2007;1140:19-25 pubmed
    The staggerer mutation was first identified at the Jackson Laboratory in 1955...
  25. Lau P, Fitzsimmons R, Pearen M, Watt M, Muscat G. Homozygous staggerer (sg/sg) mice display improved insulin sensitivity and enhanced glucose uptake in skeletal muscle. Diabetologia. 2011;54:1169-80 pubmed publisher
    Homozygous staggerer (sg/sg) mice, which have decreased and dysfunctional Ror? (also known as Rora) expression in all tissues, display a lean and dyslipidaemic phenotype. They are also resistant to (high fat) diet-induced obesity...
  26. Yang X, Nurieva R, Martinez G, Kang H, Chung Y, Pappu B, et al. Molecular antagonism and plasticity of regulatory and inflammatory T cell programs. Immunity. 2008;29:44-56 pubmed publisher
    ..STAT3 regulated Foxp3 downregulation, whereas STAT3, RORgamma, and ROR* were required for IL-17 expression in Treg cells. Our data demonstrate molecular antagonism and plasticity of Treg and Th17 cell programs. ..
  27. Wong S, Walker J, Jolin H, Drynan L, Hams E, Camelo A, et al. Transcription factor ROR? is critical for nuocyte development. Nat Immunol. 2012;13:229-36 pubmed publisher
    ..Notably, the transcription factor ROR? was critical for the development of nuocytes and their role in the expulsion of parasitic worms...
  28. Pathak P, Li T, Chiang J. Retinoic acid-related orphan receptor ? regulates diurnal rhythm and fasting induction of sterol 12?-hydroxylase in bile acid synthesis. J Biol Chem. 2013;288:37154-65 pubmed publisher
    ..Antagonizing ROR? activity may be a therapeutic strategy for treating inflammatory diseases such as non-alcoholic fatty liver disease and type 2 diabetes. ..
  29. Mamontova A, Séguret Macé S, Esposito B, Chaniale C, Bouly M, Delhaye Bouchaud N, et al. Severe atherosclerosis and hypoalphalipoproteinemia in the staggerer mouse, a mutant of the nuclear receptor RORalpha. Circulation. 1998;98:2738-43 pubmed
    ..We show that the homozygous staggerer (sg/sg) mutant mouse, which carries a deletion within the nuclear receptor RORalpha gene, develops severe ..
  30. Raspe E, Duez H, Gervois P, Fievet C, Fruchart J, Besnard S, et al. Transcriptional regulation of apolipoprotein C-III gene expression by the orphan nuclear receptor RORalpha. J Biol Chem. 2001;276:2865-71 pubmed
    ..Plasma triglyceride and apo C-III protein concentrations in staggerer (sg/sg) mice, homozygous for a deletion in the RORalpha gene, were significantly lower than in wild type ..
  31. Matysiak Scholze U, Nehls M. The structural integrity of ROR alpha isoforms is mutated in staggerer mice: cerebellar coexpression of ROR alpha1 and ROR alpha4. Genomics. 1997;43:78-84 pubmed
    ..The transcription unit of the orphan nuclear receptor ROR alpha was identified in the critical interval...
  32. Vogel M, Sinclair M, Qiu D, Fan H. Purkinje cell fate in staggerer mutants: agenesis versus cell death. J Neurobiol. 2000;42:323-37 pubmed
    b>Staggerer (sg/sg) is an autosomal recessive mutation in an orphan nuclear hormone receptor gene, RORalpha, that causes a cell-autonomous, lineage-specific block in the development of the Purkinje cell...
  33. Chou S, Babot Z, Leingartner A, Studer M, Nakagawa Y, O Leary D. Geniculocortical input drives genetic distinctions between primary and higher-order visual areas. Science. 2013;340:1239-42 pubmed publisher
  34. Wada T, Kang H, Angers M, Gong H, Bhatia S, Khadem S, et al. Identification of oxysterol 7alpha-hydroxylase (Cyp7b1) as a novel retinoid-related orphan receptor alpha (RORalpha) (NR1F1) target gene and a functional cross-talk between RORalpha and liver X receptor (NR1H3). Mol Pharmacol. 2008;73:891-9 pubmed
    ..In this study, we revealed a novel function of RORalpha (NR1F1) in regulating the oxysterol 7alpha-hydroxylase (Cyp7b1), an enzyme critical for the homeostasis of cholesterol, ..
  35. Sato T, Panda S, Miraglia L, Reyes T, Rudic R, McNamara P, et al. A functional genomics strategy reveals Rora as a component of the mammalian circadian clock. Neuron. 2004;43:527-37 pubmed
    ..These results suggest that opposing activities of the orphan nuclear receptors Rora and Rev-erb alpha, which represses Bmal1 expression, are important in the maintenance of circadian clock function. ..
  36. Journiac N, Jolly S, Jarvis C, Gautheron V, Rogard M, Trembleau A, et al. The nuclear receptor ROR(alpha) exerts a bi-directional regulation of IL-6 in resting and reactive astrocytes. Proc Natl Acad Sci U S A. 2009;106:21365-70 pubmed publisher
    ..Thus, our findings indicate that ROR(alpha) is a pluripotent molecular player in constitutive and adaptive astrocyte physiology. ..
  37. Carlberg C, Hooft van Huijsduijnen R, Staple J, DeLamarter J, Becker Andre M. RZRs, a new family of retinoid-related orphan receptors that function as both monomers and homodimers. Mol Endocrinol. 1994;8:757-70 pubmed
    ..On monomeric as well as dimeric binding sites, RZRs show constitutive transactivational activity that can be enhanced by unidentified components of fetal calf serum. ..
  38. Zhou C, Pinson K, Pleasure S. Severe defects in dorsal thalamic development in low-density lipoprotein receptor-related protein-6 mutants. J Neurosci. 2004;24:7632-9 pubmed
    ..This study provides compelling in vivo evidence that thalamic development requires normal activity of the LRP6-mediated canonical Wnt signaling pathway. ..
  39. Saito T, Hirano M, Ide T, Ichiki T, Koibuchi N, Sunagawa K, et al. Pivotal role of Rho-associated kinase 2 in generating the intrinsic circadian rhythm of vascular contractility. Circulation. 2013;127:104-14 pubmed publisher
    ..The circadian rhythm of ROCK2 expression and myofilament Ca(2+) sensitivity was abolished in staggerer mutant mice, which lack a functional ROR?...
  40. Lalonde R, Filali M, Bensoula A, Monnier C, Guastavino J. Spatial learning in a Z-maze by cerebellar mutant mice. Physiol Behav. 1996;59:83-6 pubmed
    Two types of cerebellar mutant mice (staggerer and lurcher) were evaluated during 5-day acquisition of a spatial learning task in a Z-maze filled with water...
  41. Nakagawa S, Watanabe M, Inoue Y. Altered gene expression of the N-methyl-D-aspartate receptor channel subunits in Purkinje cells of the staggerer mutant mouse. Eur J Neurosci. 1996;8:2644-51 pubmed
    ..epsilon(2), epsilon(3), epsilon(4) and zeta(1) subunits, was examined in cerebellar Purkinje cells of the staggerer mouse at postnatal day 21...
  42. Deiss V, Strazielle C, Lalonde R. Regional brain variations of cytochrome oxidase activity and motor co-ordination in staggerer mutant mice. Neuroscience. 2000;95:903-11 pubmed
    A mutant mouse with cerebellar cortical atrophy, staggerer, was examined in tests of motor activity and co-ordination as well as in regional brain metabolism as assessed by cytochrome oxidase activity...
  43. Michel V, Monnier Z, Guastavino J, Propper A, Math F. Functional alterations in the olfactory bulb of the staggerer mutant mouse. Neurosci Lett. 2000;280:1-4 pubmed
    Putative alterations of the functional activity in the staggerer mutant mouse olfactory bulb neuronal network have been studied by recording odor induced evoked field potentials (EFP) in the mitral cells layer...
  44. Le Roy Duflos I. Possible causal relationships between cerebellar patterns of foliation and hindlimb coordination in laboratory mice: a quantitative trait locus analysis. Behav Genet. 2001;31:29-37 pubmed
    ..Only one significant QTL was found for the measure of hindpaw coordination (Tne-1q). It was linked with Cpfd-1q and Cpfd-2q on the telomeric part of chromosome 1. ..
  45. Chen X, Heck N, Lohof A, Rochefort C, Morel M, Wehrle R, et al. Mature Purkinje cells require the retinoic acid-related orphan receptor-? (ROR?) to maintain climbing fiber mono-innervation and other adult characteristics. J Neurosci. 2013;33:9546-62 pubmed publisher
    ..Thus, the differentiation state of adult neurons is under the control of transcription factors; and in their absence, adult neurons lose their mature characteristics and acquire some characteristics of an earlier developmental stage. ..
  46. Ha T, Swanson D, Larouche M, Glenn R, Weeden D, Zhang P, et al. CbGRiTS: cerebellar gene regulation in time and space. Dev Biol. 2015;397:18-30 pubmed publisher
    ..We demonstrate the use of CbGRiTS dataset as a community resource to explore patterns of gene expression and develop hypotheses concerning gene regulatory networks in brain development. ..
  47. Bourane S, Grossmann K, Britz O, Dalet A, Del Barrio M, Stam F, et al. Identification of a spinal circuit for light touch and fine motor control. Cell. 2015;160:503-15 pubmed publisher
  48. Kopmels B, Wollman E, Guastavino J, Delhaye Bouchaud N, Fradelizi D, Mariani J. Interleukin-1 hyperproduction by in vitro activated peripheral macrophages from cerebellar mutant mice. J Neurochem. 1990;55:1980-5 pubmed
    ..In the staggerer (sg/sg) mutant, atrophy of the lymphoid organs and immunological abnormalities have been described...
  49. Croci L, Chung S, Masserdotti G, Gianola S, Bizzoca A, Gennarini G, et al. A key role for the HLH transcription factor EBF2COE2,O/E-3 in Purkinje neuron migration and cerebellar cortical topography. Development. 2006;133:2719-29 pubmed
  50. Lalonde R, Strazielle C. Spontaneous and induced mouse mutations with cerebellar dysfunctions: behavior and neurochemistry. Brain Res. 2007;1140:51-74 pubmed
    Grid2(Lc) (Lurcher), Grid2(ho) (hot-foot), Rora(sg) (staggerer), nr (nervous), Agtpbp1(pcd) (Purkinje cell degeneration), Reln(rl) (reeler), and Girk2(Wv) (Weaver) are spontaneous mutations with cerebellar atrophy, ataxia, and deficits ..
  51. Lemaigre Dubreuil Y, Brugg B, Chianale C, Delhaye Bouchaud N, Mariani J. Over-expression of interleukin-1 beta-converting enzyme mRNA in staggerer cerebellum. Neuroreport. 1996;7:1777-80 pubmed
    ..We show that ICE mRNA expression is increased 4-fold in the cerebellum of homozygous staggerer mice, where IL-1 beta mRNA is overexpressed and programmed neuronal cell death occurs...
  52. D EUSTACHIO P, Davisson M. Resolution of the staggerer (sg) mutation from the neural cell adhesion molecule locus (Ncam) on mouse chromosome 9. Mamm Genome. 1993;4:278-80 pubmed
  53. Messer A, Plummer Siegard J, Eisenberg B. Staggerer mutant mouse Purkinje cells do not contain detectable calmodulin mRNA. J Neurochem. 1990;55:293-302 pubmed
    ..The message shows developmental increases during the first 14 days postnatally. Surviving Purkinje cells of the staggerer (sg/sg) mutant, which are grossly stunted and lack tertiary dendritic spines, contain no detectable calmodulin ..
  54. Stapleton C, Jaradat M, Dixon D, Kang H, Kim S, Liao G, et al. Enhanced susceptibility of staggerer (RORalphasg/sg) mice to lipopolysaccharide-induced lung inflammation. Am J Physiol Lung Cell Mol Physiol. 2005;289:L144-52 pubmed
    ..analyzed the induction of airway inflammation in response to lipopolysaccharide (LPS) challenge in wild-type and staggerer (RORalpha(sg/sg)) mice, a natural mutant strain lacking RORalpha expression...
  55. Euler P, Friedrich B, Ziegler R, Kuhn A, Lindenberg K, Weiller C, et al. Gene expression analysis on a single cell level in Purkinje cells of Huntington's disease transgenic mice. Neurosci Lett. 2012;517:7-12 pubmed
    ..the data suggest common pathogenic mechanisms for both polyglutamine diseases. ..
  56. Guo H, Sekiguchi M, Tanaka O, Inoue T, Shima H, Nagao M, et al. Protein phosphatase mRNA expression in Purkinje cells of staggerer and reeler mutant mice. Brain Res Mol Brain Res. 1995;33:121-6 pubmed
    ..to search for the expression of three protein phosphatase (PP) mRNAs in Purkinje cells of normal mice, and staggerer (sg/sg) and reeler (rl/rl) mutant mice, two strains with known Purkinje cell disorders...
  57. He B, Zhao Y, Xu L, Gao L, Su Y, Lin N, et al. The nuclear melatonin receptor RORα is a novel endogenous defender against myocardial ischemia/reperfusion injury. J Pineal Res. 2016;60:313-26 pubmed publisher
    ..To determine the pathological consequence of MI/R-induced reduction of RORα, we subjected RORα-deficient staggerer mice and wild-type (WT) littermates to MI/R injury, resulting in significantly increased myocardial infarct size,..
  58. Schaal H, Wille C, Wille W. Changes of ganglioside pattern during cerebellar development of normal and staggerer mice. J Neurochem. 1985;45:544-51 pubmed
    ..The cerebellum of the neurological mutant staggerer (sg/sg) was characterized by a low amount of GD1a in adult animals, due to the massive death of neurons in the ..
  59. Bakalian A, Kopmels B, Messer A, Fradelizi D, Delhaye Bouchaud N, Wollman E, et al. Peripheral macrophage abnormalities in mutant mice with spinocerebellar degeneration. Res Immunol. 1992;143:129-39 pubmed
    ..e. staggerer, lurcher, pcd and reeler, that exhibit patterns of neuronal degeneration in the cerebellum; in the present study,..
  60. Xiao L, Zhang Z, Luo X, Yang H, Li F, Wang N. Retinoid acid receptor-related orphan receptor alpha (ROR?) regulates macrophage M2 polarization via activation of AMPK?. Mol Immunol. 2016;80:17-23 pubmed publisher
    ..Together these findings reveal that ROR? regulates macrophage M2 polarization via activation of AMPK?, which may provide a novel beneficial effect of ROR? against inflammation. ..
  61. Caston J, Delhaye Bouchaud N, Mariani J. Motor behavior of heterozygous staggerer mutant (+/sg) versus normal (+/+) mice during aging. Behav Brain Res. 1995;72:97-102 pubmed
    Three- to 24-month-old heterozygous staggerer (+/sg) and control (+/+) C57B16 mice were subjected to a motor test on a rota rod rotating at 30 or 40 revolutions per minute...
  62. Koch S, Del Barrio M, Dalet A, Gatto G, Günther T, Zhang J, et al. RORβ Spinal Interneurons Gate Sensory Transmission during Locomotion to Secure a Fluid Walking Gait. Neuron. 2017;96:1419-1431.e5 pubmed publisher
    ..video abstract. ..
  63. Okamoto K, Iwai Y, Oh Hora M, Yamamoto M, Morio T, Aoki K, et al. IkappaBzeta regulates T(H)17 development by cooperating with ROR nuclear receptors. Nature. 2010;464:1381-5 pubmed publisher
    ..This study provides evidence for the transcriptional mechanisms underlying T(H)17 development and points to a molecular basis for a novel therapeutic strategy against autoimmune disease. ..
  64. Sun Y, Liu C, SanGiovanni J, Evans L, Tian K, Zhang B, et al. Nuclear receptor RORα regulates pathologic retinal angiogenesis by modulating SOCS3-dependent inflammation. Proc Natl Acad Sci U S A. 2015;112:10401-6 pubmed publisher
    ..Our data demonstrate that RORα is a novel regulator of pathologic retinal neovascularization, and RORα inhibition may represent a new way to treat ocular neovascularization. ..
  65. Lalonde R, Strazielle C. Behavioral effects of neonatal lesions on the cerebellar system. Int J Dev Neurosci. 2015;43:58-65 pubmed publisher
    ..As in animal subjects, sensorimotor disturbances have been described in children with cerebellar lesions. These results underline the importance of the cerebellum and its connections in the development of motor functions. ..
  66. Guastavino J, Larsson K, Allain C, Jaisson P. Neonatal vestibular stimulation and mating in cerebellar mutants. Behav Genet. 1993;23:265-9 pubmed
    Two cerebellar mutants, staggerer and reeler, and their congenic nonmutants were used in this experiment...
  67. Radrizzani M, Carminatti H, Pivetta O, Idoyaga Vargas V. Developmental regulation of Thy 1.2 rate of synthesis in the mouse cerebellum. J Neurosci Res. 1995;42:220-7 pubmed
    ..approach these problems we studied the synthesis of the molecule in the developing cerebellum of wild-type and staggerer mutant mice...
  68. Rausa F, Samadani U, Ye H, Lim L, Fletcher C, Jenkins N, et al. The cut-homeodomain transcriptional activator HNF-6 is coexpressed with its target gene HNF-3 beta in the developing murine liver and pancreas. Dev Biol. 1997;192:228-46 pubmed
    ..We discuss these expression patterns with respect to specification of hepatocytes and differentiation of the endocrine and exocrine pancreas. ..
  69. Frederic F, Chianale C, Oliver C, Mariani J. Enhanced endocrine response to novel environment stress and lack of corticosterone circadian rhythm in staggerer (Rora sg/sg) mutant mice. J Neurosci Res. 2006;83:1525-32 pubmed
    The staggerer (Rora sg/sg) mutation is a deletion in the retinoid-related orphan receptor (RORalpha) gene that prevents translation of the ligand-binding domain (LBD), leading to the loss of RORalpha activity...