Gene Symbol: St3gal4
Description: ST3 beta-galactoside alpha-2,3-sialyltransferase 4
Alias: SIAT4-C, ST3Gal IV, ST3GalIV, Siat4c, CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 4, alpha 2,3-ST 4, alpha 2,3-sialyltransferase IV, beta-galactoside alpha-2,3-sialyltransferase 4, gal-beta-1,4-GalNAc-alpha-2,3-sialyltransferase, sialyltransferase 4C (beta-galactosidase alpha-2,3-sialytransferase), sialyltransferase 4C (beta-galactoside alpha-2,3-sialytransferase)
Species: mouse
Products:     St3gal4

Top Publications

  1. Smith M, Olson T, Ley K. CXCR2- and E-selectin-induced neutrophil arrest during inflammation in vivo. J Exp Med. 2004;200:935-9 pubmed
    ..These data show that E-selectin- and chemokine-mediated arrest mechanisms are overlapping in this model and identify CXCR2 as an important neutrophil arrest chemokine in vivo. ..
  2. Frommhold D, Ludwig A, Bixel M, Zarbock A, Babushkina I, Weissinger M, et al. Sialyltransferase ST3Gal-IV controls CXCR2-mediated firm leukocyte arrest during inflammation. J Exp Med. 2008;205:1435-46 pubmed publisher
    ..Collectively, we provide substantial evidence that sialylation by ST3Gal-IV significantly contributes to CXCR2-mediated leukocyte adhesion during inflammation in vivo. ..
  3. Ellies L, Ditto D, Levy G, Wahrenbrock M, Ginsburg D, Varki A, et al. Sialyltransferase ST3Gal-IV operates as a dominant modifier of hemostasis by concealing asialoglycoprotein receptor ligands. Proc Natl Acad Sci U S A. 2002;99:10042-7 pubmed
    ..Oligosaccharide branch-specific sialylation by the ST3Gal-IV sialyltransferase is required to sustain the physiologic half-life of murine hemostatic components and may be an important modifier of plasma VWF level in humans. ..
  4. Ellies L, Sperandio M, Underhill G, Yousif J, Smith M, Priatel J, et al. Sialyltransferase specificity in selectin ligand formation. Blood. 2002;100:3618-25 pubmed
    ..Our findings indicate a high degree of functional specificity among sialyltransferases and a substantial role for ST3Gal-IV in selectin ligand formation. ..
  5. Srimontri P, Endo S, Sakamoto T, Nakayama Y, Kurosaka A, Itohara S, et al. Sialyltransferase ST3Gal IV deletion protects against temporal lobe epilepsy. J Neurochem. 2014;131:675-87 pubmed publisher
    ..We previously found that the sialyltransferase ST3Gal IV is up-regulated within the neural circuits through which amygdala-kindling stimulation propagates epileptic ..
  6. Sperandio M, Frommhold D, Babushkina I, Ellies L, Olson T, Smith M, et al. Alpha 2,3-sialyltransferase-IV is essential for L-selectin ligand function in inflammation. Eur J Immunol. 2006;36:3207-15 pubmed
  7. Underhill G, Zisoulis D, Kolli K, Ellies L, Marth J, Kansas G. A crucial role for T-bet in selectin ligand expression in T helper 1 (Th1) cells. Blood. 2005;106:3867-73 pubmed
  8. Wandall H, Rumjantseva V, Sørensen A, Patel Hett S, Josefsson E, Bennett E, et al. The origin and function of platelet glycosyltransferases. Blood. 2012;120:626-35 pubmed publisher
    ..This platelet-glycosylation machinery offers a pathway to a simple glycoengineering strategy improving storage of platelets and may serve hitherto unknown biologic functions. ..
  9. Huang Y, Chassard C, Hausmann M, von Itzstein M, Hennet T. Sialic acid catabolism drives intestinal inflammation and microbial dysbiosis in mice. Nat Commun. 2015;6:8141 pubmed publisher
    ..coli outgrowth and the severity of colitis in mice. Regulation of sialic acid catabolism opens new perspectives for the treatment of intestinal inflammation as manifested by E. coli dysbiosis. ..

More Information


  1. Kato K. Differential effects of dietary oils on emotional and cognitive behaviors. PLoS ONE. 2015;10:e0120753 pubmed publisher
    ..Wild-type (WT) mice and sialyltransferase ST3Gal IV-knockout (KO) mice, which exhibit increased emotional and cognitive behaviors, were fed diets containing 20% ..
  2. Sage A, Mallat Z. Sialyltransferase activity and atherosclerosis. Circ Res. 2014;114:935-7 pubmed publisher
  3. Döring Y, Noels H, Mandl M, Kramp B, Neideck C, Lievens D, et al. Deficiency of the sialyltransferase St3Gal4 reduces Ccl5-mediated myeloid cell recruitment and arrest: short communication. Circ Res. 2014;114:976-81 pubmed publisher
    ..b>St3Gal4-deficient myeloid cells showed a reduced binding of Ccl5 and an impaired Ccl5-triggered integrin activation...
  4. Nadeau J. Modifier genes and protective alleles in humans and mice. Curr Opin Genet Dev. 2003;13:290-5 pubmed
    ..Together these modifier genes and protective alleles provide important glimpses into the molecular and cellular basis for the functional networks that provide robustness and homeostasis in complex biological systems. ..
  5. Fuhrer A, Sprenger N, Kurakevich E, Borsig L, Chassard C, Hennet T. Milk sialyllactose influences colitis in mice through selective intestinal bacterial colonization. J Exp Med. 2010;207:2843-54 pubmed publisher
    ..Thus, exposure to sialyllactose during infancy affects bacterial colonization of the intestine, which influences the susceptibility to DSS-induced colitis in adult mice. ..
  6. Kono M, Ohyama Y, Lee Y, Hamamoto T, Kojima N, Tsuji S. Mouse beta-galactoside alpha 2,3-sialyltransferases: comparison of in vitro substrate specificities and tissue specific expression. Glycobiology. 1997;7:469-79 pubmed
    ..The ST3Gal III and IV genes were expressed in a wide variety of tissues. These differences in tissue specific expression suggest the expression of each ST3Gal influences the distribution of sialyl-glycoconjugates in vivo. ..
  7. Yang W, Nussbaum C, Grewal P, Marth J, Sperandio M. Coordinated roles of ST3Gal-VI and ST3Gal-IV sialyltransferases in the synthesis of selectin ligands. Blood. 2012;120:1015-26 pubmed publisher
    ..By generating and analyzing St3gal6-null mice and St3gal4/St3gal6 double-deficient mice, in the present study, we found that binding of E- and P-selectin to neutrophils ..
  8. Kurakevich E, Hennet T, Hausmann M, Rogler G, Borsig L. Milk oligosaccharide sialyl(?2,3)lactose activates intestinal CD11c+ cells through TLR4. Proc Natl Acad Sci U S A. 2013;110:17444-9 pubmed publisher
    ..progression of intestinal inflammation were delayed in Il10(-/-) mice deficient for the ?2,3 sialyltransferase 4 (ST3GAL4) responsible for 3SL biosynthesis...
  9. Grewal P, Uchiyama S, Ditto D, Varki N, Le D, Nizet V, et al. The Ashwell receptor mitigates the lethal coagulopathy of sepsis. Nat Med. 2008;14:648-55 pubmed publisher
    ..Hemostatic adaptation by the Ashwell receptor moderates the onset and severity of disseminated intravascular coagulation during sepsis and improves the probability of host survival. ..
  10. Ednie A, Bennett E. Reduced sialylation impacts ventricular repolarization by modulating specific K+ channel isoforms distinctly. J Biol Chem. 2015;290:2769-83 pubmed publisher
    ..the impact of reduced sialylation on ventricular repolarization through gene deletion of the sialyltransferase ST3Gal4. ST3Gal4-deficient mice (ST3Gal4(-/-)) had prolonged QT intervals with a concomitant increase in ventricular ..
  11. Takashima S, Tachida Y, Nakagawa T, Hamamoto T, Tsuji S. Quantitative analysis of expression of mouse sialyltransferase genes by competitive PCR. Biochem Biophys Res Commun. 1999;260:23-7 pubmed
    ..Using this method, we can investigate the levels of gene expression of sialyltransferases in various cell lines and various tissues of mice, and can accurately determine their expression levels. ..
  12. Ednie A, Horton K, Wu J, Bennett E. Expression of the sialyltransferase, ST3Gal4, impacts cardiac voltage-gated sodium channel activity, refractory period and ventricular conduction. J Mol Cell Cardiol. 2013;59:117-27 pubmed publisher
    ..the impact of gene deletion of the uniformly expressed beta-galactoside alpha-2,3-sialyltransferase 4 (ST3Gal4) on cardiac Nav activity, cellular refractory period and ventricular conduction...
  13. Teruel R, Martínez Martínez I, Guerrero J, Gonzalez Conejero R, de la Morena Barrio M, Salloum Asfar S, et al. Control of post-translational modifications in antithrombin during murine post-natal development by miR-200a. J Biomed Sci. 2013;20:29 pubmed publisher
    ..mRNA levels of St3gal3 and St3gal4, two sialyltransferases potentially involved in antithrombin sialylation, were 85% lower in neonates in ..
  14. Grozovsky R, Begonja A, Liu K, Visner G, Hartwig J, Falet H, et al. The Ashwell-Morell receptor regulates hepatic thrombopoietin production via JAK2-STAT3 signaling. Nat Med. 2015;21:47-54 pubmed publisher
  15. Takashima S, Tsuji S. Comparison of genomic structures of four members of beta-galactoside alpha2,3-sialyltransferase genes in the mouse. Cytogenet Cell Genet. 2000;89:101-6 pubmed
    ..alpha2, 3-sialyltransferases-Siat4 (ST3Gal I), Siat5 (ST3Gal II), Siat3 (ST3Gal III), and Siat4c (ST3Gal IV)-were isolated and characterized. Siat4 and Siat5 comprise 8...