Gene Symbol: St18
Description: suppression of tumorigenicity 18
Alias: AV348974, Myt3, NZF-3, Nzf3, mKIAA0535, suppression of tumorigenicity 18 protein, neural zinc finger protein NZF-3
Wang S, Zhang J, Zhao A, Hipkens S, Magnuson M, Gu G. Loss of Myt1 function partially compromises endocrine islet cell differentiation and pancreatic physiological function in the mouse. Mech Dev. 2007;124:898-910 pubmed
..vertebrate C2HC-type zinc finger transcription factors that include Myt1 (Nzf1), Myt1L (Png1), and Myt3 (Nzf3, St18). All three paralogs are widely expressed in developing neuronal cells...
Tennant B, Chen J, Shih A, Luciani D, Hoffman B. Myt3 Mediates Laminin-V/Integrin-Î²1-Induced Islet-Cell Migration via Tgfbi. Mol Endocrinol. 2015;29:1254-68 pubmed publisher
b>Myt3 is a prosurvival factor in pancreatic islets; however, its role in islet-cell development is not known...
Matsushita F, Kameyama T, Kadokawa Y, Marunouchi T. Spatiotemporal expression pattern of Myt/NZF family zinc finger transcription factors during mouse nervous system development. Dev Dyn. 2014;243:588-600 pubmed publisher
..These expression patterns suggest that the expression of NZF family genes is spatially and temporally regulated, and each Myt/NZF family gene may have a regulatory function in a specific phase during neuronal differentiation. ..
Tennant B, Vanderkruk B, Dhillon J, Dai D, Verchere C, Hoffman B. Myt3 suppression sensitizes islet cells to high glucose-induced cell death via Bim induction. Cell Death Dis. 2016;7:e2233 pubmed publisher
..To this end, we previously identified the transcription factor Myt3 as a pro-survival factor in islets following acute suppression of Myt3 in vitro...
Xu Y, Wang S, Zhang J, Zhao A, Stanger B, Gu G. The fringe molecules induce endocrine differentiation in embryonic endoderm by activating cMyt1/cMyt3. Dev Biol. 2006;297:340-9 pubmed
..These results suggest that Mfng-mediated repression of Notch signaling could serve as a trigger for endocrine islet differentiation. ..
Kameyama T, Matsushita F, Kadokawa Y, Marunouchi T. Myt/NZF family transcription factors regulate neuronal differentiation of P19 cells. Neurosci Lett. 2011;497:74-9 pubmed publisher
..Additionally, we found that St18 (or NZF-3) was induced by several bHLH transcription factors...
Tennant B, Islam R, Kramer M, Merkulova Y, Kiang R, Whiting C, et al
. The transcription factor Myt3 acts as a pro-survival factor in ?-cells. PLoS ONE. 2012;7:e51501 pubmed publisher
We previously identified the transcription factor Myt3 as specifically expressed in pancreatic islets...
Ravà M, D Andrea A, Doni M, Kress T, Ostuni R, Bianchi V, et al
. Mutual epithelium-macrophage dependency in liver carcinogenesis mediated by ST18. Hepatology. 2017;65:1708-1719 pubmed publisher
The ST18 gene has been proposed to act either as a tumor suppressor or as an oncogene in different human cancers, but direct evidence for its role in tumorigenesis has been lacking thus far...