St14

Summary

Gene Symbol: St14
Description: suppression of tumorigenicity 14 (colon carcinoma)
Alias: Epithin, MT-SP1, Prss14, Tmprss14, mCAP3, matriptase, suppressor of tumorigenicity 14 protein homolog, matriptase/MT-SP1, protease, serine, 14 (epithin), serine protease 14
Species: mouse
Products:     St14

Top Publications

  1. Szabo R, Hobson J, Christoph K, Kosa P, List K, Bugge T. Regulation of cell surface protease matriptase by HAI2 is essential for placental development, neural tube closure and embryonic survival in mice. Development. 2009;136:2653-63 pubmed publisher
    ..Furthermore, we show that inhibition of the transmembrane serine protease matriptase (encoded by St14) is an essential function of HAI2 during tissue morphogenesis...
  2. List K, Haudenschild C, Szabo R, Chen W, Wahl S, Swaim W, et al. Matriptase/MT-SP1 is required for postnatal survival, epidermal barrier function, hair follicle development, and thymic homeostasis. Oncogene. 2002;21:3765-79 pubmed
    b>Matriptase/MT-SP1 is a novel tumor-associated type II transmembrane serine protease that is highly expressed in the epidermis, thymic stroma, and other epithelia...
  3. List K, Currie B, Scharschmidt T, Szabo R, Shireman J, Molinolo A, et al. Autosomal ichthyosis with hypotrichosis syndrome displays low matriptase proteolytic activity and is phenocopied in ST14 hypomorphic mice. J Biol Chem. 2007;282:36714-23 pubmed
    ..recently linked to homozygosity for a point mutation in the ST14 gene that causes a G827R mutation in the matriptase serine protease domain (G216 in chymotrypsin numbering)...
  4. Camerer E, Barker A, Duong D, Ganesan R, Kataoka H, Cornelissen I, et al. Local protease signaling contributes to neural tube closure in the mouse embryo. Dev Cell. 2010;18:25-38 pubmed publisher
    ..Among these, matriptase activated Par2 with picomolar potency, and hepsin and prostasin activated matriptase...
  5. Szabo R, Molinolo A, List K, Bugge T. Matriptase inhibition by hepatocyte growth factor activator inhibitor-1 is essential for placental development. Oncogene. 2007;26:1546-56 pubmed
    ..and all other embryonic processes is to restrict the activity of the type II transmembrane serine protease, matriptase. Enzymatic gene trapping of matriptase combined with HAI-1 immunohistochemistry revealed that matriptase is co-..
  6. Netzel Arnett S, Currie B, Szabo R, Lin C, Chen L, Chai K, et al. Evidence for a matriptase-prostasin proteolytic cascade regulating terminal epidermal differentiation. J Biol Chem. 2006;281:32941-5 pubmed
    Recent gene ablation studies in mice have shown that matriptase, a type II transmembrane serine protease, and prostasin, a glycosylphosphatidylinositol-anchored membrane serine protease, are both required for processing of the epidermis-..
  7. List K, Szabo R, Molinolo A, Nielsen B, Bugge T. Delineation of matriptase protein expression by enzymatic gene trapping suggests diverging roles in barrier function, hair formation, and squamous cell carcinogenesis. Am J Pathol. 2006;168:1513-25 pubmed
    The membrane serine protease matriptase is required for epidermal barrier function, hair formation, and thymocyte development in mice, and dysregulated matriptase expression causes epidermal squamous cell carcinoma...
  8. Kim M, Chen C, Lyu M, Cho E, Park D, Kozak C, et al. Cloning and chromosomal mapping of a gene isolated from thymic stromal cells encoding a new mouse type II membrane serine protease, epithin, containing four LDL receptor modules and two CUB domains. Immunogenetics. 1999;49:420-8 pubmed
    We cloned and sequenced a mouse gene encoding a new type of membrane bound serine protease (epithin) containing a multidomain structure...
  9. List K, Kosa P, Szabo R, Bey A, Wang C, Molinolo A, et al. Epithelial integrity is maintained by a matriptase-dependent proteolytic pathway. Am J Pathol. 2009;175:1453-63 pubmed publisher
    A pericellular proteolytic pathway initiated by the transmembrane serine protease matriptase plays a critical role in the terminal differentiation of epidermal tissues...

More Information

Publications50

  1. Buzza M, Netzel Arnett S, Shea Donohue T, Zhao A, Lin C, List K, et al. Membrane-anchored serine protease matriptase regulates epithelial barrier formation and permeability in the intestine. Proc Natl Acad Sci U S A. 2010;107:4200-5 pubmed publisher
    ..Here we show that the transmembrane serine protease matriptase plays a pivotol role in the formation and integrity of the intestinal epithelial barrier...
  2. Lee H, Kim C, Kim S, Kim M, Park D. Epithin, a target of transforming growth factor-beta signaling, mediates epithelial-mesenchymal transition. Biochem Biophys Res Commun. 2010;395:553-9 pubmed publisher
    The epithelial-derived type II transmembrane serine protease epithin has been shown to be upregulated in a variety of cancer cell lines and tumor tissues, and its upregulation correlates well with tumor progression in many cases...
  3. Fan B, Brennan J, Grant D, Peale F, Rangell L, Kirchhofer D. Hepatocyte growth factor activator inhibitor-1 (HAI-1) is essential for the integrity of basement membranes in the developing placental labyrinth. Dev Biol. 2007;303:222-30 pubmed
    ..cell surface and extracellular serine proteases involved in tissue remodeling and tumorigenesis, such as HGFA, matriptase, prostasin and hepsin. We generated HAI-1 deficient mice, which died in utero due to placental defects...
  4. Andreasen D, Vuagniaux G, Fowler Jaeger N, Hummler E, Rossier B. Activation of epithelial sodium channels by mouse channel activating proteases (mCAP) expressed in Xenopus oocytes requires catalytic activity of mCAP3 and mCAP2 but not mCAP1. J Am Soc Nephrol. 2006;17:968-76 pubmed
    Mouse channel activating proteases 1, 2, and 3 (mCAP1, mCAP2, and mCAP3) were described recently as regulators of the epithelial sodium channel (ENaC)...
  5. Sales K, Masedunskas A, Bey A, Rasmussen A, Weigert R, List K, et al. Matriptase initiates activation of epidermal pro-kallikrein and disease onset in a mouse model of Netherton syndrome. Nat Genet. 2010;42:676-83 pubmed publisher
    ..Here we show that the membrane protease matriptase initiates Netherton syndrome in a LEKTI-deficient mouse model by premature activation of a pro-kallikrein ..
  6. List K, Szabo R, Molinolo A, Sriuranpong V, Redeye V, Murdock T, et al. Deregulated matriptase causes ras-independent multistage carcinogenesis and promotes ras-mediated malignant transformation. Genes Dev. 2005;19:1934-50 pubmed
    Overexpression of the type II transmembrane serine protease matriptase is a highly consistent feature of human epithelial tumors...
  7. Szabo R, Uzzun Sales K, Kosa P, Shylo N, Godiksen S, Hansen K, et al. Reduced prostasin (CAP1/PRSS8) activity eliminates HAI-1 and HAI-2 deficiency-associated developmental defects by preventing matriptase activation. PLoS Genet. 2012;8:e1002937 pubmed publisher
    ..in mice, which can be rescued by the simultaneous inactivation of the membrane-anchored serine protease, matriptase, thereby demonstrating that a matriptase-dependent proteolytic pathway is a critical developmental target for ..
  8. Suzuki M, Kobayashi H, Kanayama N, Saga Y, Suzuki M, Lin C, et al. Inhibition of tumor invasion by genomic down-regulation of matriptase through suppression of activation of receptor-bound pro-urokinase. J Biol Chem. 2004;279:14899-908 pubmed
    ..b>Matriptase, a membrane-bound serine protease, was shown to activate uPA in a uPA receptor-free, solution-based study...
  9. List K, Szabo R, Wertz P, Segre J, Haudenschild C, Kim S, et al. Loss of proteolytically processed filaggrin caused by epidermal deletion of Matriptase/MT-SP1. J Cell Biol. 2003;163:901-10 pubmed
    ..We show that epidermal deficiency of the transmembrane serine protease Matriptase/MT-SP1 perturbs lipid matrix formation, cornified envelope morphogenesis, and stratum corneum desquamation...
  10. Szabo R, Rasmussen A, Moyer A, Kosa P, Schafer J, Molinolo A, et al. c-Met-induced epithelial carcinogenesis is initiated by the serine protease matriptase. Oncogene. 2011;30:2003-16 pubmed publisher
    ..In this study, we show that the oncogenic protease matriptase is ubiquitously co-expressed with the c-Met in human squamous cell carcinomas and amplifies migratory and ..
  11. Szabo R, Hobson J, List K, Molinolo A, Lin C, Bugge T. Potent inhibition and global co-localization implicate the transmembrane Kunitz-type serine protease inhibitor hepatocyte growth factor activator inhibitor-2 in the regulation of epithelial matriptase activity. J Biol Chem. 2008;283:29495-504 pubmed publisher
    ..Whereas HAI-1 is well established as an inhibitor of the serine proteases matriptase and hepatocyte growth factor activator, the physiological targets of HAI-2 are unknown...
  12. Vuagniaux G, Vallet V, Jaeger N, Hummler E, Rossier B. Synergistic activation of ENaC by three membrane-bound channel-activating serine proteases (mCAP1, mCAP2, and mCAP3) and serum- and glucocorticoid-regulated kinase (Sgk1) in Xenopus Oocytes. J Gen Physiol. 2002;120:191-201 pubmed
    ..In the present study, we have identified two additional membrane-bound serine proteases (mCAP2 and mCAP3) that are expressed in the same cell line...
  13. Szabo R, Kosa P, List K, Bugge T. Loss of matriptase suppression underlies spint1 mutation-associated ichthyosis and postnatal lethality. Am J Pathol. 2009;174:2015-22 pubmed publisher
    ..that loss of inhibition of a proteolytic pathway that is dependent on the type II transmembrane serine protease, matriptase, underlies the detrimental effects of postnatal Spint1 deficiency...
  14. Fang J, Lee S. Matriptase is required for the active form of hepatocyte growth factor induced Met, focal adhesion kinase and protein kinase B activation on neural stem/progenitor cell motility. Biochim Biophys Acta. 2014;1843:1285-94 pubmed publisher
    ..Although the type II transmembrane serine protease, matriptase (MTP) is an activator of the latent HGF, MTP is indispensable on NS/P cell motility induced by the active form ..
  15. Buzza M, Johnson T, Conway G, Martin E, Mukhopadhyay S, Shea Donohue T, et al. Inflammatory cytokines down-regulate the barrier-protective prostasin-matriptase proteolytic cascade early in experimental colitis. J Biol Chem. 2017;292:10801-10812 pubmed publisher
    ..b>Matriptase is a membrane-anchored serine protease encoded by suppression of tumorigenicity-14 (ST14)..
  16. Nath A, Krauthammer M, Li P, Davidov E, Butler L, Copel J, et al. Proteomic-based detection of a protein cluster dysregulated during cardiovascular development identifies biomarkers of congenital heart defects. PLoS ONE. 2009;4:e4221 pubmed publisher
    ..The proteins detected by mass spectrometry (WNT16, ST14, Pcsk1, Jumonji, Morca2a, TRPC5, and others) were validated by Western blotting and immunoflorescent staining of ..
  17. Nagaike K, Kawaguchi M, Takeda N, Fukushima T, Sawaguchi A, Kohama K, et al. Defect of hepatocyte growth factor activator inhibitor type 1/serine protease inhibitor, Kunitz type 1 (Hai-1/Spint1) leads to ichthyosis-like condition and abnormal hair development in mice. Am J Pathol. 2008;173:1464-75 pubmed publisher
    ..It also inhibits matriptase and prostasin, both of which are membrane-bound serine proteinases that have critical roles in epidermal ..
  18. Cho E, Kim M, Kim C, Kim S, Seong I, Chung C, et al. N-terminal processing is essential for release of epithin, a mouse type II membrane serine protease. J Biol Chem. 2001;276:44581-9 pubmed
    ..Its human orthologue membrane type-serine protease 1 (MT-SP1)/matriptase has been reported to be localized on the plasma membrane...
  19. Scharschmidt T, List K, Grice E, Szabo R, Renaud G, Lee C, et al. Matriptase-deficient mice exhibit ichthyotic skin with a selective shift in skin microbiota. J Invest Dermatol. 2009;129:2435-42 pubmed publisher
    Suppressor of tumorigenicity 14 (St14) encodes matriptase, a serine protease, which regulates processing of profilaggrin to filaggin in vivo...
  20. Sales K, Friis S, Abusleme L, Moutsopoulos N, Bugge T. Matriptase promotes inflammatory cell accumulation and progression of established epidermal tumors. Oncogene. 2015;34:4664-72 pubmed publisher
    Deregulation of matriptase is a consistent feature of human epithelial cancers and correlates with poor disease outcome...
  21. Szabo R, Peters D, Kosa P, Camerer E, Bugge T. Regulation of feto-maternal barrier by matriptase- and PAR-2-mediated signaling is required for placental morphogenesis and mouse embryonic survival. PLoS Genet. 2014;10:e1004470 pubmed publisher
    ..and partially redundant protease signaling pathways that include the membrane-anchored serine proteases, matriptase and prostasin, and the G protein-coupled receptor PAR-2 that mediate the establishment of a functional feto-..
  22. Cho E, Schwartz R, Kim M. Shedding of membrane epithin is blocked without LDLRA4 and its protease activation site. Biochem Biophys Res Commun. 2005;327:328-34 pubmed
    b>Epithin, a mouse type II transmembrane serine protease, is processed at Gly149 and released from the membrane...
  23. Sales K, Friis S, Konkel J, Godiksen S, Hatakeyama M, Hansen K, et al. Non-hematopoietic PAR-2 is essential for matriptase-driven pre-malignant progression and potentiation of ras-mediated squamous cell carcinogenesis. Oncogene. 2015;34:346-56 pubmed publisher
    The membrane-anchored serine protease, matriptase, is consistently dysregulated in a range of human carcinomas, and high matriptase activity correlates with poor prognosis...
  24. Welman A, Sproul D, Mullen P, Muir M, Kinnaird A, Harrison D, et al. Diversity of matriptase expression level and function in breast cancer. PLoS ONE. 2012;7:e34182 pubmed publisher
    Overexpression of matriptase has been reported in a variety of human cancers and is sufficient to trigger tumor formation in mice, but the importance of matriptase in breast cancer remains unclear...
  25. Netzel Arnett S, Buzza M, Shea Donohue T, Desilets A, Leduc R, Fasano A, et al. Matriptase protects against experimental colitis and promotes intestinal barrier recovery. Inflamm Bowel Dis. 2012;18:1303-14 pubmed publisher
    b>Matriptase is a membrane-anchored serine protease encoded by suppression of tumorigenicity-14 (ST14) that is required for epithelial barrier homeostasis. However, its functional role in inflammatory bowel disease (IBD) is unexplored...
  26. Sanders A, Parr C, Davies G, Martin T, Lane J, Mason M, et al. Genetic reduction of matriptase-1 expression is associated with a reduction in the aggressive phenotype of prostate cancer cells in vitro and in vivo. J Exp Ther Oncol. 2006;6:39-48 pubmed
    b>Matriptase-1 has been implicated as playing an important role in various types of cancer progression through many different cancer related pathways...
  27. List K, Hobson J, Molinolo A, Bugge T. Co-localization of the channel activating protease prostasin/(CAP1/PRSS8) with its candidate activator, matriptase. J Cell Physiol. 2007;213:237-45 pubmed
    ..We have recently reported that the tumor-associated type II transmembrane serine protease, matriptase is necessary and sufficient for prostasin activation in the epidermis...
  28. Godiksen S, Selzer Plon J, Pedersen E, Abell K, Rasmussen H, Szabo R, et al. Hepatocyte growth factor activator inhibitor-1 has a complex subcellular itinerary. Biochem J. 2008;413:251-9 pubmed publisher
    ..transmembrane serine protease inhibitor that forms inhibitor complexes with the trypsin-like serine protease, matriptase. HAI-1 is essential for mouse placental development and embryo survival and together with matriptase it is a key ..
  29. Lee S, Huang P, Roller P, Cho E, Park D, Dickson R. Matriptase/epithin participates in mammary epithelial cell growth and morphogenesis through HGF activation. Mech Dev. 2010;127:82-95 pubmed publisher
    The epithelial-derived, type II transmembrane serine protease matriptase, the mouse homologue of which is epithin, has been shown to be involved in epidermal differentiation, hair formation, and thymus function...
  30. Kim C, Cho Y, Kang C, Kim M, Lee H, Cho E, et al. Filamin is essential for shedding of the transmembrane serine protease, epithin. EMBO Rep. 2005;6:1045-51 pubmed
    b>Epithin is a type II transmembrane serine protease that exists in a soluble and membrane-bound form...
  31. Fang J, Chou H, Tung H, Huang P, Lee S. Endogenous expression of matriptase in neural progenitor cells promotes cell migration and neuron differentiation. J Biol Chem. 2011;286:5667-79 pubmed publisher
    ..In this study, we show that the expression of one such member, matriptase (MTP), was cell type-restricted and primarily expressed in neural progenitor (NP) cells and neurons...
  32. Kosa P, Szabo R, Molinolo A, Bugge T. Suppression of Tumorigenicity-14, encoding matriptase, is a critical suppressor of colitis and colitis-associated colon carcinogenesis. Oncogene. 2012;31:3679-95 pubmed publisher
    ..b>Matriptase is a membrane-anchored serine protease encoded by Suppression of Tumorigenicity-14 (ST14) that strengthens the ..
  33. Kim T, Heinlein C, Hackman R, Nelson P. Phenotypic analysis of mice lacking the Tmprss2-encoded protease. Mol Cell Biol. 2006;26:965-75 pubmed
    ..Alternatively, TMPRSS2 may contribute a specialized but nonvital function that is apparent only in the context of stress, disease, or other systemic perturbation. ..
  34. Kim S, Lee D, Jeong J, Kim C, Park D, Kim M. Soluble epithin/PRSS14 secreted from cancer cells contains active angiogenic potential. Mol Cells. 2010;29:617-23 pubmed publisher
    Epithin (PRSS14/matriptase/ST14), a type II membrane protein, is involved in progression of epithelial cancers and metastasis as well as in the normal epidermal barrier function...
  35. Yin H, Kosa P, Liu X, Swaim W, Lai Z, Cabrera Perez J, et al. Matriptase deletion initiates a Sjögren's syndrome-like disease in mice. PLoS ONE. 2014;9:e82852 pubmed publisher
    ..the effect of epithelial barrier disruption, caused by deficiency of the membrane-anchored serine protease, matriptase, on salivary gland function and the induction of autoimmunity in an animal model...
  36. Lee H, Park B, Cho Y, Kim S, Kim C, Kim M, et al. Shedding of epithin/PRSS14 is induced by TGF-β and mediated by tumor necrosis factor-α converting enzyme. Biochem Biophys Res Commun. 2014;452:1084-90 pubmed publisher
    b>Epithin/PRSS14, a type II transmembrane serine protease, plays critical roles in cancer metastasis. Previously, we have reported that epithin/PRSS14 undergoes ectodomain shedding in response to phorbol myristate acetate (PMA) stimulation...
  37. Zoratti G, Tanabe L, Varela F, Murray A, Bergum C, Colombo Ã, et al. Targeting matriptase in breast cancer abrogates tumour progression via impairment of stromal-epithelial growth factor signalling. Nat Commun. 2015;6:6776 pubmed publisher
    b>Matriptase is an epithelia-specific membrane-anchored serine protease that has received considerable attention in recent years because of its consistent dysregulation in human epithelial tumours, including breast cancer...
  38. Szabo R, Lantsman T, Peters D, Bugge T. Delineation of proteolytic and non-proteolytic functions of the membrane-anchored serine protease prostasin. Development. 2016;143:2818-28 pubmed publisher
    The membrane-anchored serine proteases prostasin (PRSS8) and matriptase (ST14) initiate a cell surface proteolytic pathway essential for epithelial function...
  39. Wu C, Feng X, Lu M, Morimura S, Udey M. Matriptase-mediated cleavage of EpCAM destabilizes claudins and dysregulates intestinal epithelial homeostasis. J Clin Invest. 2017;127:623-634 pubmed publisher
    ..EpCAM stabilizes claudin-7 in IECs, and HAI-2 regulates the cell surface serine protease matriptase, a known modifier of intestinal epithelial physiology...
  40. Khang I, Sonn S, Park J, Rhee K, Park D, Kim K. Expression of epithin in mouse preimplantation development: its functional role in compaction. Dev Biol. 2005;281:134-44 pubmed
    ..In the present study, we explored the expression patterns and function of epithin, a mouse type II transmembrane serine protease, during preimplantation embryo development...
  41. Friis S, Sales K, Schafer J, Vogel L, Kataoka H, Bugge T. The protease inhibitor HAI-2, but not HAI-1, regulates matriptase activation and shedding through prostasin. J Biol Chem. 2014;289:22319-32 pubmed publisher
    The membrane-anchored serine proteases, matriptase and prostasin, and the membrane-anchored serine protease inhibitors, hepatocyte growth factor activator inhibitor (HAI)-1 and HAI-2, are critical effectors of epithelial development and ..