Gene Symbol: Sstr1
Description: somatostatin receptor 1
Alias: SRIF-2, SS-1-R, SS1-R, SS1R, Smstr-1, Smstr1, sst1, somatostatin receptor type 1
Species: mouse
Products:     Sstr1

Top Publications

  1. Kreienkamp H, Akgun E, Baumeister H, Meyerhof W, Richter D. Somatostatin receptor subtype 1 modulates basal inhibition of growth hormone release in somatotrophs. FEBS Lett. 1999;462:464-6 pubmed
    ..The various functions of SST are mediated through at least five different receptor subtypes (SSTR1-5), their precise physiological roles have not been solved yet...
  2. Bodmer D, Brand Y, Radojevic V. Somatostatin receptor types 1 and 2 in the developing mammalian cochlea. Dev Neurosci. 2012;34:342-53 pubmed publisher
    ..In the developing mouse cochlea, cells immunoreactive to somatostatin receptor 1 (SSTR1) and somatostatin receptor 2 (SSTR2) were located in the embryonic cochlear duct on Kolliker's organ as early as ..
  3. Dal Monte M, Cammalleri M, Martini D, Casini G, Bagnoli P. Antiangiogenic role of somatostatin receptor 2 in a model of hypoxia-induced neovascularization in the retina: results from transgenic mice. Invest Ophthalmol Vis Sci. 2007;48:3480-9 pubmed
    ..These results suggest that sst(2) may be protective against angiogenesis. The immediate clinical importance lies in the establishment of a potential pharmacological target based on sst(2) pharmacology. ..
  4. Dal Monte M, Petrucci C, Vasilaki A, Cervia D, Grouselle D, Epelbaum J, et al. Genetic deletion of somatostatin receptor 1 alters somatostatinergic transmission in the mouse retina. Neuropharmacology. 2003;45:1080-92 pubmed
    ..Among them, the sst1 receptor has been localised to SRIF-containing amacrine cells in the rat and rabbit retina...
  5. Catalani E, Cervia D, Martini D, Bagnoli P, Simonetti E, Timperio A, et al. Changes in neuronal response to ischemia in retinas with genetic alterations of somatostatin receptor expression. Eur J Neurosci. 2007;25:1447-59 pubmed
  6. Cervia D, Martini D, Ristori C, Catalani E, Timperio A, Bagnoli P, et al. Modulation of the neuronal response to ischaemia by somatostatin analogues in wild-type and knock-out mouse retinas. J Neurochem. 2008;106:2224-35 pubmed publisher
    ..These results demonstrate that sst(2) activation protects against retinal ischaemia. However, in the presence of sst(2) over-expression sst(2) is functionally desensitised by agonists, possibly because of sustained RGS1 levels...
  7. Smith P. N-type Ca(2+) -channels in murine pancreatic beta-cells are inhibited by an exclusive coupling with somatostatin receptor subtype 1. Endocrinology. 2009;150:741-8 pubmed publisher
    ..1). This action was mimicked solely by 100 nm CH-275, a selective agonist at the somatostatin type 1 receptor (SSTR1), but not by 100 nm BIM-23027, L-362855, or NNC-269100; agonists selective for the other four SSTRs known to exist ..
  8. Videau C, Hochgeschwender U, Kreienkamp H, Brennan M, Viollet C, Richter D, et al. Characterisation of [125I]-Tyr0DTrp8-somatostatin binding in sst1- to sst4- and SRIF-gene-invalidated mouse brain. Naunyn Schmiedebergs Arch Pharmacol. 2003;367:562-71 pubmed
    Five somatostatin receptors (sst) have been cloned and mRNAs for the first four (sst1-4) are expressed in many brain regions...
  9. Kumar U. Immunohistochemical distribution of somatostatin and somatostatin receptor subtypes (SSTR1-5) in hypothalamus of ApoD knockout mice brain. J Mol Neurosci. 2012;48:684-95 pubmed
    In the present study, the expression of somatostatin (SST) and somatostatin receptor subtypes (SSTR1-5) was determined in the hypothalamus of wild-type (wt) and apolipoprotein D knockout (ApoD(-/-)) mice brain...

More Information


  1. Cristiani R, Petrucci C, Dal Monte M, Bagnoli P. Somatostatin (SRIF) and SRIF receptors in the mouse retina. Brain Res. 2002;936:1-14 pubmed
    ..These results provide a database for investigations of the functional retinal networks in mice with genetic alterations of somatostatinergic transmission. ..
  2. Fitzpatrick V, Vandlen R. 6agonist selectivity determinants in somatostatin receptor subtypes I and II. J Biol Chem. 1994;269:24621-6 pubmed
    ..We find that the regions about the second and third extracellular loops of these two receptors contain the determinants for MK-678 selectivity and affinity. ..
  3. Hannon J, Petrucci C, Fehlmann D, Viollet C, Epelbaum J, Hoyer D. Somatostatin sst2 receptor knock-out mice: localisation of sst1-5 receptor mRNA and binding in mouse brain by semi-quantitative RT-PCR, in situ hybridisation histochemistry and receptor autoradiography. Neuropharmacology. 2002;42:396-413 pubmed
    ..Finally, since the relative distribution of these two ligands were not entirely superimposable, it suggests that their respective selectivity profiles towards the different SRIF receptor subtypes in situ are not identical. ..
  4. Casini G, Dal Monte M, Petrucci C, Gambellini G, Grouselle D, Allen J, et al. Altered morphology of rod bipolar cell axonal terminals in the retinas of mice carrying genetic deletion of somatostatin subtype receptor 1 or 2. Eur J Neurosci. 2004;19:43-54 pubmed
    ..possible morphological alterations of mouse retinal neurons following genetic deletion of SRIF subtype receptor 1 [sst1 knockout (KO)] or 2 (sst2 KO)...
  5. Bates C, Kegg H, Grady S. Expression of somatostatin receptors 1 and 2 in the adult mouse kidney. Regul Pept. 2004;119:11-20 pubmed
    ..Among the five different G-protein-coupled somatostatin receptors (SSTRs), SSTR1 is expressed in human kidney collecting ducts and SSTR2 is expressed in rat and human collecting ducts and ..
  6. Radojevic V, Bodmer D. Expression and localization of somatostatin receptor types 3, 4 and 5 in the wild-type, SSTR1 and SSTR1/SSTR2 knockout mouse cochlea. Cell Tissue Res. 2014;358:717-27 pubmed publisher
    ..mediated through binding to specific cell surface G protein-coupled receptors, of which five distinct subtypes (SSTR1-SSTR5) have been characterized...
  7. Stengel A, Goebel Stengel M, Wang L, Larauche M, Rivier J, Tache Y. Central somatostatin receptor 1 activation reverses acute stress-related alterations of gastric and colonic motor function in mice. Neurogastroenterol Motil. 2011;23:e223-36 pubmed publisher
    ..These data opens new insight to brain somatostatinergic signaling pathways interfering with brain circuitries involved in gut motor responses to acute stress. ..
  8. Boyle A, Gill K. Sensitivity of AXB/BXA recombinant inbred lines of mice to the locomotor activating effects of cocaine: a quantitative trait loci analysis. Pharmacogenetics. 2001;11:255-64 pubmed
    ..QTLs were identified on chromosomes 12 and 15 map to regions in proximity to genes for the somatostatin 1 (Smstr1 -23 cM) and 3 (Smstr3 -46.3 cM) receptors, respectively...
  9. Brand Y, Radojevic V, Sung M, Wei E, Setz C, Glutz A, et al. Role of somatostatin receptor-2 in gentamicin-induced auditory hair cell loss in the Mammalian inner ear. PLoS ONE. 2014;9:e108146 pubmed publisher
    ..Finally, we show that octreotide affects auditory hair cells, enhances spiral ganglion neurite number, and decreases spiral ganglion neurite length. ..
  10. Husain B, Nanavaty I, Marathe S, Rajendran R, Vaidya V. Hippocampal transcriptional and neurogenic changes evoked by combination yohimbine and imipramine treatment. Prog Neuropsychopharmacol Biol Psychiatry. 2015;61:1-9 pubmed publisher
    ..expression of the α2A-adrenoceptor (Adra2a), serotonin 5HT2C receptor (Htr2c) and the somatostatin receptor 1 (Sstr1), which modulate antidepressant action...
  11. Dal Monte M, Ristori C, Cammalleri M, Bagnoli P. Effects of somatostatin analogues on retinal angiogenesis in a mouse model of oxygen-induced retinopathy: involvement of the somatostatin receptor subtype 2. Invest Ophthalmol Vis Sci. 2009;50:3596-606 pubmed publisher
    ..The present results further support the possibility of the use of sst(2)-selective ligands in the treatment of retinopathy. ..
  12. Yamada Y, Post S, Wang K, Tager H, Bell G, Seino S. Cloning and functional characterization of a family of human and mouse somatostatin receptors expressed in brain, gastrointestinal tract, and kidney. Proc Natl Acad Sci U S A. 1992;89:251-5 pubmed
    ..b>SSTR1 and SSTR2 contain 391 and 369 amino acids, respectively, and are members of the superfamily of receptors having ..
  13. Debus N, Dutour A, Vuaroqueaux V, Oliver C, Ouafik L. The ovine somatostatin receptor subtype 1 (osst1): partial cloning and tissue distribution. Domest Anim Endocrinol. 2001;21:73-84 pubmed
    ..Somatostatin receptor subtype 1 (sst1) appears to be important in central regulation of GH but ovine sst1 (osst1) has not yet been cloned...
  14. Zeyda T, Hochgeschwender U. Null mutant mouse models of somatostatin and cortistatin, and their receptors. Mol Cell Endocrinol. 2008;286:18-25 pubmed publisher
    ..The physiological responses of SRIF and CST are mediated by five widely distributed G protein-coupled receptors (sst1-5) which have been implicated in regulating numerous biological processes...
  15. Wang X, Norman M, Yang J, Magnusson J, Kreienkamp H, Richter D, et al. Alterations in glucose homeostasis in SSTR1 gene-ablated mice. Mol Cell Endocrinol. 2006;247:82-90 pubmed
    b>SSTR1 is found on the majority of human pancreatic beta cells, however, its role in insulin secretion has yet to be elucidated...
  16. Lin X, Janovick J, Cardenas R, Conn P, Peter R. Molecular cloning and expression of a type-two somatostatin receptor in goldfish brain and pituitary. Mol Cell Endocrinol. 2000;166:75-87 pubmed
    ..The decrease in pituitary sst(2) mRNA levels following estradiol implantation suggests the presence of a negative feedback mechanism on sst(2) gene expression. ..
  17. Cai C, Li H, Kangasniemi A, Pihlajamaa T, von Ossowski L, Kerkelä K, et al. Somatostatin receptor subtype 1 is a PDZ ligand for synapse-associated protein 97 and a potential regulator of growth cone dynamics. Neuroscience. 2008;157:833-43 pubmed publisher
    We report that somatostatin receptor subtype 1 (sst1) associates in vivo and in vitro with synapse-associated protein SAP) 97, a membrane-associated guanylate kinase homolog implicated as a scaffolding protein in the structural ..
  18. Cammalleri M, Cervia D, Langenegger D, Liu Y, Dal Monte M, Hoyer D, et al. Somatostatin receptors differentially affect spontaneous epileptiform activity in mouse hippocampal slices. Eur J Neurosci. 2004;20:2711-21 pubmed
    ..factor (SRIF)] reduces hippocampal epileptiform activity but the contribution of its specific receptors (sst1-5) is poorly understood...
  19. Bigiani A, Petrucci C, Ghiaroni V, Dal Monte M, Cozzi A, Kreienkamp H, et al. Functional correlates of somatostatin receptor 2 overexpression in the retina of mice with genetic deletion of somatostatin receptor 1. Brain Res. 2004;1025:177-85 pubmed
    ..The level of expression of sst(2) receptors may therefore represent a key step in the regulation of sst(2) receptor-mediated responses, at least in the retina. ..
  20. Viollet C, Lanneau C, Faivre Bauman A, Zhang J, Djordjijevic D, Loudes C, et al. Distinct patterns of expression and physiological effects of sst1 and sst2 receptor subtypes in mouse hypothalamic neurons and astrocytes in culture. J Neurochem. 1997;68:2273-80 pubmed a ligand in ionic conditions discriminating between SRIF-1 (sst2, -3, and -5 receptors) and SRIF-2 (sst1 and -4 receptors) binding sites...
  21. Christenn M, Kindler S, Schulz S, Buck F, Richter D, Kreienkamp H. Interaction of brain somatostatin receptors with the PDZ domains of PSD-95. FEBS Lett. 2007;581:5173-7 pubmed
    Using peptide affinity purification, we identified an interaction between somatostatin receptors SSTR4 and SSTR1 and PDZ domains 1 and 2 of the postsynaptic proteins postsynaptic density protein of 95kDa (PSD-95) and PSD-93...
  22. Mastrodimou N, Vasilaki A, Papadioti A, Low M, Hoyer D, Thermos K. Somatostatin receptors in wildtype and somatostatin deficient mice and their involvement in nitric oxide physiology in the retina. Neuropeptides. 2006;40:365-73 pubmed
    ..These results demonstrate an upregulation of SRIF receptors in mice lacking SRIF, but no evident SRIF-NO(*) interaction was observed in the mouse retina. ..
  23. Cammalleri M, Martini D, Timperio A, Bagnoli P. Functional effects of somatostatin receptor 1 activation on synaptic transmission in the mouse hippocampus. J Neurochem. 2009;111:1466-77 pubmed publisher
    ..We conclude that SRIF control of excitatory transmission through an action at sst(1) may represent an important contribution to the regulation of hippocampal activity. ..
  24. Rajput P, Kharmate G, Norman M, Liu S, Sastry B, Brunicardi C, et al. Somatostatin receptor 1 and 5 double knockout mice mimic neurochemical changes of Huntington's disease transgenic mice. PLoS ONE. 2011;6:e24467 pubmed publisher
    ..role in excitotoxicity and the biological effects of SST are mediated by five somatostatin receptor subtypes (SSTR1-5)...
  25. Ramirez J, Mouchantaf R, Kumar U, Otero Corchon V, Rubinstein M, Low M, et al. Brain somatostatin receptors are up-regulated in somatostatin-deficient mice. Mol Endocrinol. 2002;16:1951-63 pubmed
    ..somatostatin (SST) is widely synthesized in the brain and periphery and acts through a family of five receptors (SSTR1-5) to exert numerous effects. A gene product related to SST, cortistatin (CST), also interacts with SSTR1-5...