Gene Symbol: Ss18
Description: SS18, nBAF chromatin remodeling complex subunit
Alias: D130059H17, Ssxt, Syt, protein SSXT, synovial sarcoma associated SS18-beta, synovial sarcoma associated SS18-delta, synovial sarcoma associated SS18-gamma, synovial sarcoma translocation, Chromosome 18, synovial sarcoma, translocated to X chromosome, synovial sarcoma-associated Ss18-alpha
Su L, Sampaio A, Jones K, Pacheco M, Goytain A, Lin S, et al
. Deconstruction of the SS18-SSX fusion oncoprotein complex: insights into disease etiology and therapeutics. Cancer Cell. 2012;21:333-47 pubmed publisher
Synovial sarcoma is a translocation-associated sarcoma where the underlying chromosomal event generates SS18-SSX fusion transcripts...
de Bruijn D, Baats E, Zechner U, de Leeuw B, Balemans M, Olde Weghuis D, et al
. Isolation and characterization of the mouse homolog of SYT, a gene implicated in the development of human synovial sarcomas. Oncogene. 1996;13:643-8 pubmed
..As a result of this translocation, the SYT gene on chromosome 18 fuses to either the SSX1 or the SSX2 gene on the X chromosome, depending on the exact ..
de Bruijn D, Peters W, Chuva de Sousa Lopes S, van Dijk A, Willemse M, Pfundt R, et al
. Targeted disruption of the synovial sarcoma-associated SS18 gene causes early embryonic lethality and affects PPARBP expression. Hum Mol Genet. 2006;15:2936-44 pubmed
The synovial sarcoma-associated protein SS18 (also known as SYT or SSXT) is thought to act as a transcriptional co-activator...
Kadoch C, Crabtree G. Reversible disruption of mSWI/SNF (BAF) complexes by the SS18-SSX oncogenic fusion in synovial sarcoma. Cell. 2013;153:71-85 pubmed publisher
..sarcoma (SS), in which transformation results from the translocation of exactly 78 amino acids of SSX to the SS18 subunit of BAF complexes...
Staahl B, Tang J, Wu W, Sun A, Gitler A, Yoo A, et al
. Kinetic analysis of npBAF to nBAF switching reveals exchange of SS18 with CREST and integration with neural developmental pathways. J Neurosci. 2013;33:10348-61 pubmed publisher
..mouse neural differentiation and, using proteomic analysis, found that this switch also includes the removal of SS18 and its replacement by CREST at mitotic exit...
Phelan J. Genetic variability and rodent models of human aging. Exp Gerontol. 1992;27:147-59 pubmed
..Ultimately, a consideration of the range of animal models available and a more careful matching of the goals of a study with the genetic system of the model will prove fruitful to gerontology. ..
de Bruijn D, Kater Baats E, Eleveld M, Merkx G, Geurts van Kessel A. Mapping and characterization of the mouse and human SS18 genes, two human SS18-like genes and a mouse Ss18 pseudogene. Cytogenet Cell Genet. 2001;92:310-9 pubmed
..isolated and characterized a mouse cDNA orthologous to the human synovial sarcoma associated SS18 (formerly named SSXT and SYT) cDNA. Here, we report the characterization of the genomic structure of the mouse Ss18 gene...
Barco R, Hunt L, Frump A, Garcia C, Benesh A, Caldwell R, et al
. The synovial sarcoma SYT-SSX2 oncogene remodels the cytoskeleton through activation of the ephrin pathway. Mol Biol Cell. 2007;18:4003-12 pubmed
..a soft tissue cancer associated with a recurrent t(X:18) translocation that generates one of two fusion proteins, SYT-SSX1 or SYT-SSX2. In this study, we demonstrate that SYT-SSX2 is a unique oncogene...
Kimura T, Sakai M, Tabu K, Wang L, Tsunematsu R, Tsuda M, et al
. Human synovial sarcoma proto-oncogene Syt is essential for early embryonic development through the regulation of cell migration. Lab Invest. 2009;89:645-56 pubmed publisher
..However, biological functions of SYT (synovial sarcoma translocation), also known as SS18, are largely unclear, whereas it has been proven that Syt-null mice die at early stages of embryonic development...