Sry

Summary

Gene Symbol: Sry
Description: sex determining region of Chr Y
Alias: Tdf, Tdy, sex-determining region Y protein, testis determining-Y, testis-determining factor
Species: mouse
Products:     Sry

Top Publications

  1. Wilhelm D, Martinson F, Bradford S, Wilson M, Combes A, Beverdam A, et al. Sertoli cell differentiation is induced both cell-autonomously and through prostaglandin signaling during mammalian sex determination. Dev Biol. 2005;287:111-24 pubmed
    We have raised an antibody specifically recognizing endogenous mouse SRY protein and used it to investigate the molecular and cellular mode of action of SRY in testis determination...
  2. Dolci S, Grimaldi P, Geremia R, Pesce M, Rossi P. Identification of a promoter region generating Sry circular transcripts both in germ cells from male adult mice and in male mouse embryonal gonads. Biol Reprod. 1997;57:1128-35 pubmed
    The mouse testis determining gene Sry is expressed in somatic cells of the differentiating male gonad as a linear transcript, encoding a transcription factor containing an HMG box...
  3. Bagheri Fam S, Sim H, Bernard P, Jayakody I, Taketo M, Scherer G, et al. Loss of Fgfr2 leads to partial XY sex reversal. Dev Biol. 2008;314:71-83 pubmed
    ..In the XY gonad, presumptive Sertoli cells begin to differentiate when SRY up-regulates SOX9, which in turn activates FGF9 and PGDS to maintain its own expression...
  4. Hacker A, Capel B, Goodfellow P, Lovell Badge R. Expression of Sry, the mouse sex determining gene. Development. 1995;121:1603-14 pubmed
    In the mouse, Sry is expressed by germ cells in the adult testis and by somatic cells in the genital ridge. Transcripts in the former exist as circular RNA molecules of 1.23 kb, which are unlikely to be efficiently translated...
  5. De Vries G, Rissman E, Simerly R, Yang L, Scordalakes E, Auger C, et al. A model system for study of sex chromosome effects on sexually dimorphic neural and behavioral traits. J Neurosci. 2002;22:9005-14 pubmed
    ..We used mice in which the testis-determining gene (Sry) was moved from the Y chromosome to an autosome (by deletion of Sry from the Y and subsequent insertion of an Sry ..
  6. Kim Y, Kobayashi A, Sekido R, DiNapoli L, Brennan J, Chaboissier M, et al. Fgf9 and Wnt4 act as antagonistic signals to regulate mammalian sex determination. PLoS Biol. 2006;4:e187 pubmed
    ..However, the relationship between these signals and the male sex-determining gene, Sry, was unknown...
  7. Bradford S, Wilhelm D, Bandiera R, Vidal V, Schedl A, Koopman P. A cell-autonomous role for WT1 in regulating Sry in vivo. Hum Mol Genet. 2009;18:3429-38 pubmed publisher
    ..Mice with a targeted mutation that blocks production of these isoforms show a reduction in Sry mRNA in the gonad, but the molecular and cellular basis of this reduction has not been established...
  8. Bowles J, Cooper L, Berkman J, Koopman P. Sry requires a CAG repeat domain for male sex determination in Mus musculus. Nat Genet. 1999;22:405-8 pubmed
    b>SRY, the mammalian Y-chromosomal sex-determining gene, encodes a protein characterized by a DNA-binding and -bending domain referred to as the HMG box...
  9. Vernet N, Mahadevaiah S, Ellis P, de Rooij D, Burgoyne P. Spermatid development in XO male mice with varying Y chromosome short-arm gene content: evidence for a Y gene controlling the initiation of sperm morphogenesis. Reproduction. 2012;144:433-45 pubmed publisher
    ..has been added as a transgene to support spermatogonial proliferation, and iii) XOSry,Eif2s3y males in which the Sry transgene directs gonad development along the male pathway...

More Information

Publications73

  1. Hiramatsu R, Matoba S, Kanai Azuma M, Tsunekawa N, Katoh Fukui Y, Kurohmaru M, et al. A critical time window of Sry action in gonadal sex determination in mice. Development. 2009;136:129-38 pubmed publisher
    In mammals, the Y-linked sex-determining gene Sry cell-autonomously promotes Sertoli cell differentiation from bipotential supporting cell precursors through SRY-box containing gene 9 (Sox9), leading to testis formation...
  2. Capel B, Swain A, Nicolis S, Hacker A, Walter M, Koopman P, et al. Circular transcripts of the testis-determining gene Sry in adult mouse testis. Cell. 1993;73:1019-30 pubmed
    b>Sry is expressed at higher levels in the adult testis, where no function has been determined, than in the genital ridge, its critical site of action...
  3. Katoh Fukui Y, Miyabayashi K, Komatsu T, Owaki A, Baba T, Shima Y, et al. Cbx2, a polycomb group gene, is required for Sry gene expression in mice. Endocrinology. 2012;153:913-24 pubmed publisher
    ..In the present study, we used microarray, RT-PCR, and immunohistochemical analyses to show that the expression of Sry, Sox9, Lhx9, Ad4BP/SF-1, Dax-1, Gata4, Arx, and Dmrt1, genes encoding transcription factors essential for gonadal ..
  4. Fujimoto Y, Tanaka S, Yamaguchi Y, Kobayashi H, Kuroki S, Tachibana M, et al. Homeoproteins Six1 and Six4 regulate male sex determination and mouse gonadal development. Dev Cell. 2013;26:416-30 pubmed publisher
    The Y-linked gene Sry regulates mammalian sex determination in bipotential embryonic gonads. Here, we report that the transcription factors Six1 and Six4 are required for male gonadal differentiation...
  5. Bradford S, Wilhelm D, Koopman P. Comparative analysis of anti-mouse SRY antibodies. Sex Dev. 2007;1:305-10 pubmed publisher
    The Y chromosome gene SRY is the initiator of male sexual differentiation in mammals, but the molecular and cellular mechanisms operating downstream of SRY remain undefined...
  6. Swain A, Narvaez V, Burgoyne P, Camerino G, Lovell Badge R. Dax1 antagonizes Sry action in mammalian sex determination. Nature. 1998;391:761-7 pubmed
    ..occurs, however, when the transgene is tested against weak alleles of the sex-determining Y-chromosome gene Sry. These results show that DAX1 is largely, if not solely, responsible for dosage-sensitive sex reversal and provide ..
  7. Toyooka Y, Tanaka S, Hirota O, Tanaka S, Takagi N, Yamanouchi K, et al. Wilms' tumor suppressor gene (WT1) as a target gene of SRY function in a mouse ES cell line transfected with SRY. Int J Dev Biol. 1998;42:1143-51 pubmed
    With the aim of identifying the gene(s) located downstream from SRY, we transfected an ES cell line with XX karyotype, TMA-18, with a Sry DNA construct and established cell lines, TS18-1 and TS18-2, where the transfected Sry was ..
  8. Graves J. The origin and function of the mammalian Y chromosome and Y-borne genes--an evolving understanding. Bioessays. 1995;17:311-20 pubmed
    ..The Y contains the testis determining factor SRY, as well as several genes important in spermatogenesis...
  9. Wilhelm D, Washburn L, Truong V, Fellous M, Eicher E, Koopman P. Antagonism of the testis- and ovary-determining pathways during ovotestis development in mice. Mech Dev. 2009;126:324-36 pubmed publisher
    ..We studied expression of several markers of mouse fetal testis (SRY, SOX9) or ovary (FOXL2, Rspo1) development in B6-XY(POS) ovotestes by immunofluorescence, using normal testes and ..
  10. Szot M, Grigoriev V, Mahadevaiah S, Ojarikre O, Toure A, von Glasenapp E, et al. Does Rbmy have a role in sperm development in mice?. Cytogenet Genome Res. 2003;103:330-6 pubmed
    ..XY(d1) mice develop as females because Sry is inactivated, probably because it is now juxtaposed to centromeric heterochromatin...
  11. Washburn L, Albrecht K, Eicher E. C57BL/6J-T-associated sex reversal in mice is caused by reduced expression of a Mus domesticus Sry allele. Genetics. 2001;158:1675-81 pubmed
    ..Testis development was restored in B6 T(Orl)/+ XY(AKR) mice carrying a Mus musculus Sry transgene. In addition, two functionally different classes of M...
  12. Munger S, Natarajan A, Looger L, Ohler U, Capel B. Fine time course expression analysis identifies cascades of activation and repression and maps a putative regulator of mammalian sex determination. PLoS Genet. 2013;9:e1003630 pubmed publisher
    ..This approach can be readily applied to identify regulatory interactions in other systems. ..
  13. Mahadevaiah S, Lovell Badge R, Burgoyne P. Tdy-negative XY, XXY and XYY female mice: breeding data and synaptonemal complex analysis. J Reprod Fertil. 1993;97:151-60 pubmed
    In this paper we have compared the breeding performance of Tdy-negative XY, XXY and XYY females to assess the relative importance of the lack of a second X chromosome compared with the presence of a Y chromosome, in reducing fertility...
  14. Wilhelm D, Hiramatsu R, Mizusaki H, Widjaja L, Combes A, Kanai Y, et al. SOX9 regulates prostaglandin D synthase gene transcription in vivo to ensure testis development. J Biol Chem. 2007;282:10553-60 pubmed
    In mammals, male sex is determined by the Y-chromosomal gene Sry (sex-determining region of Y chromosome)...
  15. Yamauchi Y, Riel J, Stoytcheva Z, Ward M. Two Y genes can replace the entire Y chromosome for assisted reproduction in the mouse. Science. 2014;343:69-72 pubmed publisher
    ..germ cells from males with the Y chromosome contribution limited to only two genes, the testis determinant factor Sry and the spermatogonial proliferation factor Eif2s3y...
  16. Lee C, Taketo T. Normal onset, but prolonged expression, of Sry gene in the B6.YDOM sex-reversed mouse gonad. Dev Biol. 1994;165:442-52 pubmed
    ..The results indicate that the onset of Sry, a putative testis-determining gene, transcription was normal, whereas its inactivation was delayed in all B6...
  17. Bradford S, Hiramatsu R, Maddugoda M, Bernard P, Chaboissier M, Sinclair A, et al. The cerebellin 4 precursor gene is a direct target of SRY and SOX9 in mice. Biol Reprod. 2009;80:1178-88 pubmed publisher
    In most mammals, the expression of SRY (sex-determining region on the Y chromosome) initiates the development of testes, and thus determines the sex of the individual...
  18. Chen X, McClusky R, Chen J, Beaven S, Tontonoz P, Arnold A, et al. The number of x chromosomes causes sex differences in adiposity in mice. PLoS Genet. 2012;8:e1002709 pubmed publisher
    ..Overall, our study is the first to identify sex chromosome complement, a factor distinguishing all male and female cells, as a cause of sex differences in obesity and metabolism. ..
  19. Sekido R, Lovell Badge R. Sex determination involves synergistic action of SRY and SF1 on a specific Sox9 enhancer. Nature. 2008;453:930-4 pubmed publisher
    The mammalian Y chromosome acts as a dominant male determinant as a result of the action of a single gene, Sry, whose role in sex determination is to initiate testis rather than ovary development from early bipotential gonads...
  20. Dubin R, Ostrer H. Sry is a transcriptional activator. Mol Endocrinol. 1994;8:1182-92 pubmed
    The SRY gene functions as a genetic switch in gonadal ridge initiating testis determination...
  21. Bullejos M, Koopman P. Spatially dynamic expression of Sry in mouse genital ridges. Dev Dyn. 2001;221:201-5 pubmed
    We have studied the spatial dynamics of Sry transcription in the genital ridges of mouse embryos...
  22. Park E, Taketo T. Onset and progress of meiotic prophase in the oocytes in the B6.YTIR sex-reversed mouse ovary. Biol Reprod. 2003;69:1879-89 pubmed
    ..We propose that the timing of entry into meiosis and the XY chromosomal composition influence the survival of oocytes during meiotic prophase in the fetal ovary. ..
  23. Warr N, Carré G, Siggers P, Faleato J, Brixey R, Pope M, et al. Gadd45? and Map3k4 interactions regulate mouse testis determination via p38 MAPK-mediated control of Sry expression. Dev Cell. 2012;23:1020-31 pubmed publisher
    ..MAP3K4 causes mouse embryonic gonadal sex reversal due to reduced expression of the testis-determining gene, Sry. However, because of widespread expression of MAP3K4, the cellular basis of this misregulation was unclear...
  24. Berta P, Hawkins J, Sinclair A, Taylor A, Griffiths B, Goodfellow P, et al. Genetic evidence equating SRY and the testis-determining factor. Nature. 1990;348:448-50 pubmed
    The testis-determining factor gene (TDF) lies on the Y chromosome and is responsible for initiating male sex determination...
  25. Tevosian S, Albrecht K, Crispino J, Fujiwara Y, Eicher E, Orkin S. Gonadal differentiation, sex determination and normal Sry expression in mice require direct interaction between transcription partners GATA4 and FOG2. Development. 2002;129:4627-34 pubmed
    In mammals, Sry expression in the bipotential, undifferentiated gonad directs the support cell precursors to differentiate as Sertoli cells, thus initiating the testis differentiation pathway...
  26. Jeske Y, Bowles J, Greenfield A, Koopman P. Expression of a linear Sry transcript in the mouse genital ridge. Nat Genet. 1995;10:480-2 pubmed
    b>Sry is the Y-chromosomal gene that is pivotal in the determination of sex in mammals, however the structure of the Sry transcript produced in the embryo has not been determined...
  27. Gubbay J, Vivian N, Economou A, Jackson D, Goodfellow P, Lovell Badge R. Inverted repeat structure of the Sry locus in mice. Proc Natl Acad Sci U S A. 1992;89:7953-7 pubmed
    The testis-determining gene Sry is located on the short arm of the mouse Y chromosome in a region known to have undergone duplications and rearrangements in comparison with the equivalent portion of the human Y chromosome...
  28. Kuroki S, Matoba S, Akiyoshi M, Matsumura Y, Miyachi H, Mise N, et al. Epigenetic regulation of mouse sex determination by the histone demethylase Jmjd1a. Science. 2013;341:1106-9 pubmed publisher
    ..demethylase Jmjd1a and found that Jmjd1a regulates expression of the mammalian Y chromosome sex-determining gene Sry. Jmjd1a directly and positively controls Sry expression by regulating H3K9me2 marks...
  29. Capel B, Rasberry C, Dyson J, Bishop C, Simpson E, Vivian N, et al. Deletion of Y chromosome sequences located outside the testis determining region can cause XY female sex reversal. Nat Genet. 1993;5:301-7 pubmed
    ..In all three, despite evidence for deletion of Y chromosomal material, the Sry locus was intact. Each deletion involved a repeat sequence, Sx1, located at a distance from Sry...
  30. Albrecht K, Young M, Washburn L, Eicher E. Sry expression level and protein isoform differences play a role in abnormal testis development in C57BL/6J mice carrying certain Sry alleles. Genetics. 2003;164:277-88 pubmed
    Transfer of certain Mus domesticus-derived Y chromosomes (Sry(DOM) alleles, e.g...
  31. Hammes A, Guo J, Lutsch G, Leheste J, Landrock D, Ziegler U, et al. Two splice variants of the Wilms' tumor 1 gene have distinct functions during sex determination and nephron formation. Cell. 2001;106:319-29 pubmed
    ..Strikingly, mice lacking +KTS isoforms show a complete XY sex reversal due to a dramatic reduction of Sry expression levels...
  32. Ludbrook L, Bernard P, Bagheri Fam S, Ryan J, Sekido R, Wilhelm D, et al. Excess DAX1 leads to XY ovotesticular disorder of sex development (DSD) in mice by inhibiting steroidogenic factor-1 (SF1) activation of the testis enhancer of SRY-box-9 (Sox9). Endocrinology. 2012;153:1948-58 pubmed publisher
    ..Dax1-overexpressing transgenic mice, the expression of the key testis-promoting gene sex-determining region on Y (SRY)-box-9 (Sox9) is reduced...
  33. Kidokoro T, Matoba S, Hiramatsu R, Fujisawa M, Kanai Azuma M, Taya C, et al. Influence on spatiotemporal patterns of a male-specific Sox9 activation by ectopic Sry expression during early phases of testis differentiation in mice. Dev Biol. 2005;278:511-25 pubmed
    Testis induction is associated with gonadal Sry and Sox9 expression in mammals. This study investigated whether Sry expression directly induces male-specific Sox9 activation during early phases of testis differentiation...
  34. Eicher E, Washburn L. Inherited sex reversal in mice: identification of a new primary sex-determining gene. J Exp Zool. 1983;228:297-304 pubmed
    ..involved in gonad determination and development as well as at the testis-determining locus on the Y chromosome (Tdy). This newly identified gene is named testis-determining, autosomal-1 (tda-1)...
  35. Bouma G, Washburn L, Albrecht K, Eicher E. Correct dosage of Fog2 and Gata4 transcription factors is critical for fetal testis development in mice. Proc Natl Acad Sci U S A. 2007;104:14994-9 pubmed
    ..Furthermore, DBA/2J (D2) Fog2-/+ XY(AKR) mice and (B6 x D2)F1 hybrid Gata4(ki)/+ XY(AKR) mice develop testes. Sry is expressed in the mutant XY gonads, indicating that the lack of Sry expression is not the cause of ovarian tissue ..
  36. Harley V, Goodfellow P. The biochemical role of SRY in sex determination. Mol Reprod Dev. 1994;39:184-93 pubmed
    ..isolated by positional cloning; compelling evidence now exists equating SRY with the testis-determining factor, TDF. The SRY gene product is an HMG box protein whose DNA-binding activity is vital for testis formation as sex-..
  37. Koopman P, Munsterberg A, Capel B, Vivian N, Lovell Badge R. Expression of a candidate sex-determining gene during mouse testis differentiation. Nature. 1990;348:450-2 pubmed
    ..Sex determination therefore hinges on the action of this testis-determining gene, known as Tdy in mice and TDF in humans...
  38. Biddle F, Nishioka Y. Assays of testis development in the mouse distinguish three classes of domesticus-type Y chromosome. Genome. 1988;30:870-8 pubmed
    ..Both overall frequency and phenotypic distribution of types of gonadal hermaphrodites identify three classes of domesticus-type Y chromosome by their differential interaction with the C57BL/6J genetic background. ..
  39. Vernet N, Mahadevaiah S, Ojarikre O, Longepied G, Prosser H, Bradley A, et al. The Y-encoded gene zfy2 acts to remove cells with unpaired chromosomes at the first meiotic metaphase in male mice. Curr Biol. 2011;21:787-93 pubmed publisher
    ..chromosome carries Sxr(a) [3, 4], the Y-chromosome-derived sex-reversal factor that includes the testis determinant Sry. Sxr(b) is an Sxr(a)-derived variant in which a deletion has removed six Y short-arm genes and created a Zfy2/Zfy1 ..
  40. Kashimada K, Koopman P. Sry: the master switch in mammalian sex determination. Development. 2010;137:3921-30 pubmed publisher
    b>SRY, the mammalian Y-chromosomal testis-determining gene, induces male sex determination...
  41. Barrionuevo F, Bagheri Fam S, Klattig J, Kist R, Taketo M, Englert C, et al. Homozygous inactivation of Sox9 causes complete XY sex reversal in mice. Biol Reprod. 2006;74:195-201 pubmed
    In the presence of the Y-chromosomal gene Sry, the bipotential mouse gonads develop as testes rather than as ovaries. The autosomal gene Sox9, a likely and possibly direct Sry target, can induce testis development in the absence of Sry...
  42. Li B, Zhang W, Chan G, Jancso Radek A, Liu S, Weiss M. Human sex reversal due to impaired nuclear localization of SRY. A clinical correlation. J Biol Chem. 2001;276:46480-4 pubmed
    b>SRY, an architectural transcription factor encoded by the sex-determining region of the Y chromosome, initiates testicular differentiation in mammalian embryogenesis...
  43. Gierl M, Gruhn W, von Seggern A, Maltry N, Niehrs C. GADD45G functions in male sex determination by promoting p38 signaling and Sry expression. Dev Cell. 2012;23:1032-42 pubmed publisher
    Male sex determination in mammals is induced by Sry, a gene whose regulation is poorly understood. Here we show that mice mutant for the stress-response gene Gadd45g display complete male-to-female sex reversal...
  44. Washburn L, Eicher E. Normal testis determination in the mouse depends on genetic interaction of a locus on chromosome 17 and the Y chromosome. Genetics. 1989;123:173-9 pubmed
    ..on Chr 17 common to the deletions associated with Thp, and TOrl, and (2) the Y-linked testis determining gene, Tdy, carried by the AKR/J inbred strain differs from that of the C57BL/6J inbred strain...
  45. Bogani D, Siggers P, Brixey R, Warr N, Beddow S, Edwards J, et al. Loss of mitogen-activated protein kinase kinase kinase 4 (MAP3K4) reveals a requirement for MAPK signalling in mouse sex determination. PLoS Biol. 2009;7:e1000196 pubmed publisher
    Sex determination in mammals is controlled by the presence or absence of the Y-linked gene SRY. In the developing male (XY) gonad, sex-determining region of the Y (SRY) protein acts to up-regulate expression of the related gene, SOX9, a ..
  46. Capel B. The battle of the sexes. Mech Dev. 2000;92:89-103 pubmed
    The sex determining gene, Sry, determines the sex of the organism by initiating development of a testis rather than an ovary from the cells of the bipotential gonad...
  47. Goodfellow P, Lovell Badge R. SRY and sex determination in mammals. Annu Rev Genet. 1993;27:71-92 pubmed
  48. Nagamine C, Chan K, Kozak C, Lau Y. Chromosome mapping and expression of a putative testis-determining gene in mouse. Science. 1989;243:80-3 pubmed
    ..0 kb) was mapped to chromosome 10. Hence, mYfin sequences have been duplicated several times in the mouse, although they are not duplicated in humans. ..
  49. Bowles J, Bullejos M, Koopman P. A subtractive gene expression screen suggests a role for vanin-1 in testis development in mice. Genesis. 2000;27:124-35 pubmed
    ..A number of genes, including the Y-linked sex determining gene SRY, have been shown to play roles in sex determination or differentiation, but there are clearly many missing elements ..
  50. Cocquet J, Ellis P, Yamauchi Y, Mahadevaiah S, Affara N, Ward M, et al. The multicopy gene Sly represses the sex chromosomes in the male mouse germline after meiosis. PLoS Biol. 2009;7:e1000244 pubmed publisher
    ..Our results also suggest that the expansion of sex-linked spermatid-expressed genes in mouse is a consequence of the enhancement of PSCR that accompanies Sly amplification. ..
  51. Jeays Ward K, Dandonneau M, Swain A. Wnt4 is required for proper male as well as female sexual development. Dev Biol. 2004;276:431-40 pubmed
    ..is compromised in Wnt4 mutant testes and that this defect occurs downstream of the testis-determining gene Sry but upstream of Sox9 and Dhh, two early Sertoli cell markers...
  52. Warr N, Bogani D, Siggers P, Brixey R, Tateossian H, Dopplapudi A, et al. Minor abnormalities of testis development in mice lacking the gene encoding the MAPK signalling component, MAP3K1. PLoS ONE. 2011;6:e19572 pubmed publisher
    ..Based on these observations, we conclude that MAP3K1 is not required for mouse testis determination. We discuss the significance of these data for the functional interpretation of sex-reversing MAP3K1 mutations in humans. ..
  53. Eicher E, Washburn L, Whitney J, Morrow K. Mus poschiavinus Y chromosome in the C57BL/6J murine genome causes sex reversal. Science. 1982;217:535-7 pubmed
  54. Daneau I, Ethier J, Lussier J, Silversides D. Porcine SRY gene locus and genital ridge expression. Biol Reprod. 1996;55:47-53 pubmed
    Porcine SRY gene locus was cloned through use of a strategy of anchored polymerase chain reaction (PCR) amplification from a male pig genomic DNA size-selected library constructed in a plasmid vector as well as 3' reverse transcription (..
  55. Albrecht K, Eicher E. Evidence that Sry is expressed in pre-Sertoli cells and Sertoli and granulosa cells have a common precursor. Dev Biol. 2001;240:92-107 pubmed
    The expression of Sry in the undifferentiated, bipotential genital ridges of mammalian XY fetuses initiates testis development and is hypothesized to do so by directing supporting cell precursors to develop as Sertoli cells and not as ..
  56. Albrecht K, Eicher E. DNA sequence analysis of Sry alleles (subgenus Mus) implicates misregulation as the cause of C57BL/6J-Y(POS) sex reversal and defines the SRY functional unit. Genetics. 1997;147:1267-77 pubmed
    The Sry (sex determining region, Y chromosome) open reading frame from mice representing four species of the genus Mus was sequenced in an effort to understand the conditional dysfunction of some M...
  57. Laval S, Glenister P, Rasberry C, Thornton C, Mahadevaiah S, Cooke H, et al. Y chromosome short arm-Sxr recombination in XSxr/Y males causes deletion of Rbm and XY female sex reversal. Proc Natl Acad Sci U S A. 1995;92:10403-7 pubmed
    ..three lines of sex-reversed XY female mice deleted for sequences believed close to the testes-determining gene (Sry) on the Y chromosome short arm (Yp)...
  58. Touré A, Clemente E, Ellis P, Mahadevaiah S, Ojarikre O, Ball P, et al. Identification of novel Y chromosome encoded transcripts by testis transcriptome analysis of mice with deletions of the Y chromosome long arm. Genome Biol. 2005;6:R102 pubmed
    ..We identified further MSYq-encoded transcripts expressed in spermatids and deriving from multicopy Y genes, deficiency of which may underlie the defects in sperm development associated with MSYq deletions. ..
  59. Lovell Badge R, Robertson E. XY female mice resulting from a heritable mutation in the primary testis-determining gene, Tdy. Development. 1990;109:635-46 pubmed
    ..Moreover, the mutation is complemented by Sxr', the minimum portion of the mouse Y known to carry Tdy. From the phenotype and deduced location of the mutation, we conclude that it is within the Tdy locus...
  60. Touré A, Szot M, Mahadevaiah S, Rattigan A, Ojarikre O, Burgoyne P. A new deletion of the mouse Y chromosome long arm associated with the loss of Ssty expression, abnormal sperm development and sterility. Genetics. 2004;166:901-12 pubmed
    ..However, we have recently shown that only two Y genes, the testis determinant Sry and the translation initiation factor Eif2s3y, are essential for spermatogenesis to proceed to the round spermatid ..
  61. Gubbay J, Collignon J, Koopman P, Capel B, Economou A, Munsterberg A, et al. A gene mapping to the sex-determining region of the mouse Y chromosome is a member of a novel family of embryonically expressed genes. Nature. 1990;346:245-50 pubmed
    ..mapping to the sex-determining region of the mouse Y chromosome is deleted in a line of XY female mice mutant for Tdy, and is expressed at a stage during male gonadal development consistent with its having a role in testis ..
  62. Nef S, Verma Kurvari S, Merenmies J, Vassalli J, Efstratiadis A, Accili D, et al. Testis determination requires insulin receptor family function in mice. Nature. 2003;426:291-5 pubmed
    ..The male sex-determining process is set in motion by the sex-determining region of the Y chromosome (Sry), which triggers differentiation of the Sertoli cell lineage...
  63. Sekido R, Bar I, Narvaez V, Penny G, Lovell Badge R. SOX9 is up-regulated by the transient expression of SRY specifically in Sertoli cell precursors. Dev Biol. 2004;274:271-9 pubmed
    The Y chromosome gene Sry encodes a transcription factor required to initiate testis development...
  64. DiNapoli L, Batchvarov J, Capel B. FGF9 promotes survival of germ cells in the fetal testis. Development. 2006;133:1519-27 pubmed
    ..FGF9 is necessary for 11.5 dpc XY gonocyte survival and is the earliest reported factor with a sex-specific role in regulating germ cell survival. ..