Gene Symbol: Srxn1
Description: sulfiredoxin 1 homolog (S. cerevisiae)
Alias: 1700127B04Rik, AI854065, AW488194, Npn3, Srx, Srx1, TX01, sulfiredoxin-1, neoplastic progression 3, neoplastic progression protein 3
Species: mouse
Products:     Srxn1

Top Publications

  1. Planson A, Palais G, Abbas K, Gerard M, Couvelard L, Delaunay A, et al. Sulfiredoxin protects mice from lipopolysaccharide-induced endotoxic shock. Antioxid Redox Signal. 2011;14:2071-80 pubmed publisher
    ..To address this question, we generated a mouse line with a null deletion of the Srx1-encoding Srxn1 gene...
  2. Baek J, Han S, Sung S, Lee H, Kim Y, Noh Y, et al. Sulfiredoxin protein is critical for redox balance and survival of cells exposed to low steady-state levels of H2O2. J Biol Chem. 2012;287:81-9 pubmed publisher
    Sulfiredoxin (Srx) is an enzyme that catalyzes the reduction of cysteine sulfinic acid of hyperoxidized peroxiredoxins (Prxs). Having high affinity toward H2O2, 2-Cys Prxs can efficiently reduce H2O2 at low concentration...
  3. Wu L, Jiang H, Chawsheen H, Mishra M, Young M, Gerard M, et al. Tumor promoter-induced sulfiredoxin is required for mouse skin tumorigenesis. Carcinogenesis. 2014;35:1177-84 pubmed publisher
    Sulfiredoxin (Srx), the exclusive enzyme that reduces the hyperoxidized inactive form of peroxiredoxins (Prxs), has been found highly expressed in several types of human skin cancer...
  4. Sun Y, Hegamyer G, Colburn N. Molecular cloning of five messenger RNAs differentially expressed in preneoplastic or neoplastic JB6 mouse epidermal cells: one is homologous to human tissue inhibitor of metalloproteinases-3. Cancer Res. 1994;54:1139-44 pubmed
  5. Chang T, Jeong W, Woo H, Lee S, Park S, Rhee S. Characterization of mammalian sulfiredoxin and its reactivation of hyperoxidized peroxiredoxin through reduction of cysteine sulfinic acid in the active site to cysteine. J Biol Chem. 2004;279:50994-1001 pubmed
    ..Prx enzymes undergoes reversible oxidation to sulfinic acid (Cys-SO2H) during catalysis, and sulfiredoxin (Srx) has been identified as responsible for reversal of the resulting enzyme inactivation in yeast...
  6. Singh A, Ling G, Suhasini A, Zhang P, Yamamoto M, Navas Acien A, et al. Nrf2-dependent sulfiredoxin-1 expression protects against cigarette smoke-induced oxidative stress in lungs. Free Radic Biol Med. 2009;46:376-86 pubmed publisher
    ..Sulfiredoxin-1 (Srx1) catalyzes the reduction of cysteine sulfinic acid to sulfenic acid in oxidized proteins and protects them from ..
  7. Kil I, Ryu K, Lee S, Kim J, Chu S, Kim J, et al. Circadian Oscillation of Sulfiredoxin in the Mitochondria. Mol Cell. 2015;59:651-63 pubmed publisher
    ..The coordinated import and degradation of sulfiredoxin provide the basis for sulfiredoxin oscillation and consequent PrxIII-SO2 oscillation in mitochondria and likely result in an oscillatory H2O2 release. ..
  8. Papadia S, Soriano F, Léveillé F, Martel M, Dakin K, Hansen H, et al. Synaptic NMDA receptor activity boosts intrinsic antioxidant defenses. Nat Neurosci. 2008;11:476-87 pubmed publisher
    ..Synaptic activity also upregulated the Prx reactivating genes Sesn2 (sestrin 2) and Srxn1 (sulfiredoxin), via C/EBPbeta and AP-1, respectively...
  9. Wei Q, Jiang H, Matthews C, Colburn N. Sulfiredoxin is an AP-1 target gene that is required for transformation and shows elevated expression in human skin malignancies. Proc Natl Acad Sci U S A. 2008;105:19738-43 pubmed publisher
    ..The current study identifies Sulfiredoxin (Srx) as a unique target of activator protein-1 (AP-1) activation and TAM67 inhibition...

More Information


  1. Kim H, Jung Y, Shin B, Kim H, Song H, Bae S, et al. Redox regulation of lipopolysaccharide-mediated sulfiredoxin induction, which depends on both AP-1 and Nrf2. J Biol Chem. 2010;285:34419-28 pubmed publisher
    Sulfiredoxin (Srx) is an enzyme that catalyzes the reduction of cysteine sulfinic acid of hyperoxidized peroxiredoxins and exerts a protective antioxidant role...
  2. Bae S, Sung S, Lee H, Kang H, Lee S, Oh S, et al. Peroxiredoxin III and sulfiredoxin together protect mice from pyrazole-induced oxidative liver injury. Antioxid Redox Signal. 2012;17:1351-61 pubmed publisher
    ..underlying pyrazole-induced oxidative stress and the protective role of peroxiredoxins (Prxs) and sulfiredoxin (Srx) against such stress...
  3. Cho C, Yoon H, Kim J, Woo H, Rhee S. Circadian rhythm of hyperoxidized peroxiredoxin II is determined by hemoglobin autoxidation and the 20S proteasome in red blood cells. Proc Natl Acad Sci U S A. 2014;111:12043-8 pubmed publisher
    ..Our results suggest that membrane association of PrxII-SO2H is a tightly controlled process and might play a role in the tuning of RBC function to environmental changes...
  4. Abbas K, Breton J, Planson A, Bouton C, Bignon J, Seguin C, et al. Nitric oxide activates an Nrf2/sulfiredoxin antioxidant pathway in macrophages. Free Radic Biol Med. 2011;51:107-14 pubmed publisher
    ..A small redox protein, sulfiredoxin (Srx), conserved only in eukaryotes, has been shown to reduce sulfinylated 2-Cys Prx's, adding to the complexity of the ..
  5. Wei Q, Jiang H, Baker A, Dodge L, Gerard M, Young M, et al. Loss of sulfiredoxin renders mice resistant to azoxymethane/dextran sulfate sodium-induced colon carcinogenesis. Carcinogenesis. 2013;34:1403-10 pubmed publisher
    Sulfiredoxin (Srx) is the enzyme that reduces the hyperoxidized inactive form of peroxiredoxins. To study the function of Srx in carcinogenesis in vivo, we tested whether loss of Srx protects mice from cancer development...
  6. Diet A, Abbas K, Bouton C, Guillon B, Tomasello F, Fourquet S, et al. Regulation of peroxiredoxins by nitric oxide in immunostimulated macrophages. J Biol Chem. 2007;282:36199-205 pubmed
    ..In addition, studies using macrophages from sulfiredoxin (Srx)-deficient mice indicated that regeneration of 2-Cys Prxs to the active form was dependent on Srx...
  7. Kil I, Lee S, Ryu K, Woo H, Hu M, Bae S, et al. Feedback control of adrenal steroidogenesis via H2O2-dependent, reversible inactivation of peroxiredoxin III in mitochondria. Mol Cell. 2012;46:584-94 pubmed publisher
    ..The coupling of CYP11B1 activity to PrxIII inactivation provides a feedback regulatory mechanism for steroidogenesis that functions independently of the hypothalamic-pituitary-adrenal axis. ..