Gene Symbol: Srsf5
Description: serine/arginine-rich splicing factor 5
Alias: Sfrs5, serine/arginine-rich splicing factor 5, delayed-early protein HRS, pre-mRNA-splicing factor SRP40, splicing factor, arginine/serine-rich 5 (SRp40, HRS)
Du K, Taub R. Alternative splicing and structure of the human and mouse SFRS5/HRS/SRp40 genes. Gene. 1997;204:243-9 pubmed
HRS/SRp40/SFRS5 (HRS) is an SR (serine-arginine-rich) protein which regulates both alternative splicing and basal splicing...
Patel N, Kaneko S, Apostolatos H, Bae S, Watson J, Davidowitz K, et al
. Molecular and genetic studies imply Akt-mediated signaling promotes protein kinase CbetaII alternative splicing via phosphorylation of serine/arginine-rich splicing factor SRp40. J Biol Chem. 2005;280:14302-9 pubmed
..This model is upheld in Akt2-deficient mice with insulin resistance leading to diabetes mellitus. ..
Han F, Gilbert J, Harrison G, Adams C, Freeman T, Tao Z, et al
. Transforming growth factor-beta1 regulates fibronectin isoform expression and splicing factor SRp40 expression during ATDC5 chondrogenic maturation. Exp Cell Res. 2007;313:1518-32 pubmed
..Therefore, we conclude that the effects of TGF-beta1 on FN splicing during chondrogenesis may be largely dependent on its effect on SRp40 isoform expression. ..
Cazalla D, Newton K, Caceres J. A novel SR-related protein is required for the second step of Pre-mRNA splicing. Mol Cell Biol. 2005;25:2969-80 pubmed
..SRrp53 also regulates alternative splicing in a concentration-dependent manner. Taken together, these results suggest that SRrp53 is a novel SR-related protein that has a role both in constitutive and in alternative splicing. ..
Rzymski T, Grzmil P, Meinhardt A, Wolf S, Burfeind P. PHF5A represents a bridge protein between splicing proteins and ATP-dependent helicases and is differentially expressed during mouse spermatogenesis. Cytogenet Genome Res. 2008;121:232-44 pubmed publisher
..ATP-dependent helicases EP400 and DDX1 and with arginine-serine (RS)-rich domains of splicing factors U2AF1 and SFRS5 in mouse...
Du K, Leu J, Peng Y, Taub R. Transcriptional up-regulation of the delayed early gene HRS/SRp40 during liver regeneration. Interactions among YY1, GA-binding proteins, and mitogenic signals. J Biol Chem. 1998;273:35208-15 pubmed
..The combined effect of small changes in the level of existing transcription factors and mitogenic signals may explain the transcriptional activation of the HRS gene during cell growth. ..
Manley J, Krainer A. A rational nomenclature for serine/arginine-rich protein splicing factors (SR proteins). Genes Dev. 2010;24:1073-4 pubmed publisher
Breig O, Baklouti F. Proteasome-mediated proteolysis of SRSF5 splicing factor intriguingly co-occurs with SRSF5 mRNA upregulation during late erythroid differentiation. PLoS ONE. 2013;8:e59137 pubmed publisher
..In this study, we show that SRSF5 protein decreases drastically during erythroid cell differentiation, contrasting with a concomitant upregulation ..
Botti V, McNicoll F, Steiner M, Richter F, Solovyeva A, Wegener M, et al
. Cellular differentiation state modulates the mRNA export activity of SR proteins. J Cell Biol. 2017;216:1993-2009 pubmed publisher
..As expected, SRSF2 and SRSF5 shuttle poorly in HeLa cells but surprisingly display considerable shuttling in pluripotent murine P19 cells...