Gene Symbol: Srsf3
Description: serine/arginine-rich splicing factor 3
Alias: AL024116, Sfrs3, X16, serine/arginine-rich splicing factor 3, pre-mRNA-splicing factor SRP20, splicing factor, arginine/serine-rich 3 (SRp20)
Species: mouse
Products:     Srsf3

Top Publications

  1. Vorbrüggen G, Onel S, Jackle H. Localized expression of the Drosophila gene Dxl6, a novel member of the serine/arginine rich (SR) family of splicing factors. Mech Dev. 2000;90:309-12 pubmed
    ..During larval stages, Dxl6 transcripts are detected in distinct patterns in the developing imaginal discs. ..
  2. Jia R, Li C, McCoy J, Deng C, Zheng Z. SRp20 is a proto-oncogene critical for cell proliferation and tumor induction and maintenance. Int J Biol Sci. 2010;6:806-26 pubmed
    ..We found that splicing factor SRp20 (SFRS3) is highly expressed in cancers...
  3. Jumaa H, Wei G, Nielsen P. Blastocyst formation is blocked in mouse embryos lacking the splicing factor SRp20. Curr Biol. 1999;9:899-902 pubmed
    ..This is the first report of mice deficient for a member of the SR protein family. Our experiments confirm that, although similar in structure, the SR proteins are not functionally redundant...
  4. Manley J, Krainer A. A rational nomenclature for serine/arginine-rich protein splicing factors (SR proteins). Genes Dev. 2010;24:1073-4 pubmed publisher
  5. Ankö M, Morales L, Henry I, Beyer A, Neugebauer K. Global analysis reveals SRp20- and SRp75-specific mRNPs in cycling and neural cells. Nat Struct Mol Biol. 2010;17:962-70 pubmed publisher
    ..Thus, SR proteins contribute to the execution of gene-expression programs through their association with distinct endogenous mRNAs. ..
  6. Walsh C, Suchanek A, Cyphert T, Kohan A, Szeszel Fedorowicz W, Salati L. Serine arginine splicing factor 3 is involved in enhanced splicing of glucose-6-phosphate dehydrogenase RNA in response to nutrients and hormones in liver. J Biol Chem. 2013;288:2816-28 pubmed publisher
    ..of RNA affinity analysis with nuclear extracts from intact liver demonstrated that the SR splicing factor proteins SRSF3 and SRSF4 bound to the G6PD ESE...
  7. Jumaa H, Guenet J, Nielsen P. Regulated expression and RNA processing of transcripts from the Srp20 splicing factor gene during the cell cycle. Mol Cell Biol. 1997;17:3116-24 pubmed
    ..and transcriptional regulation of the gene for the smallest member of the SR family, SRp20 (previously called X16)...
  8. Loebel D, O Rourke M, Steiner K, Banyer J, Tam P. Isolation of differentially expressed genes from wild-type and Twist mutant mouse limb buds. Genesis. 2002;33:103-13 pubmed
  9. Wang Q, Chikina M, Pincas H, Sealfon S. Homer1 alternative splicing is regulated by gonadotropin-releasing hormone and modulates gonadotropin gene expression. Mol Cell Biol. 2014;34:1747-56 pubmed publisher
    ..These results indicate that the regulation of Homer1 splicing by GnRH contributes to gonadotropin gene control. ..

More Information


  1. Bavelloni A, Faenza I, Cioffi G, Piazzi M, Parisi D, Matic I, et al. Proteomic-based analysis of nuclear signaling: PLCbeta1 affects the expression of the splicing factor SRp20 in Friend erythroleukemia cells. Proteomics. 2006;6:5725-34 pubmed
    ..Here we show the existence of a PLCbeta(1)-specific target, the splicing factor SRp20, whose expression is specifically down-regulated by the nuclear signaling evoked by PLCbeta(1). ..
  2. Roberts J, Ennajdaoui H, Edmondson C, Wirth B, Sanford J, Chen B. Splicing factor TRA2B is required for neural progenitor survival. J Comp Neurol. 2014;522:372-92 pubmed publisher
    ..Thus, TRA2B is essential for proper development of the cerebral cortex. ..
  3. Sen S, Jumaa H, Webster N. Splicing factor SRSF3 is crucial for hepatocyte differentiation and metabolic function. Nat Commun. 2013;4:1336 pubmed publisher
    ..Here we show that SRSF3HKO mice carrying a hepatocyte-specific deletion of Srsf3 (homologous to human SRSF3/SRp20) have a disrupted hepatic architecture and show pre- and postnatal growth ..
  4. Änkö M, Müller McNicoll M, Brandl H, Curk T, Gorup C, Henry I, et al. The RNA-binding landscapes of two SR proteins reveal unique functions and binding to diverse RNA classes. Genome Biol. 2012;13:R17 pubmed publisher
    ..Here we use iCLIP to globally analyze and compare the RNA binding properties of two SR proteins, SRSF3 and SRSF4, in murine cells...
  5. Ajiro M, Jia R, Wang R, Deng C, Zheng Z. Adapted Resistance to the Knockdown Effect of shRNA-Derived Srsf3 siRNAs in Mouse Littermates. Int J Biol Sci. 2015;11:1248-56 pubmed publisher
    ..In this report, transgenic mouse lines were created for conditional knockdown of Srsf3 (SRp20) expression in liver and mammary gland tissues by expressing Srsf3-specific shRNAs driven by a U6 promoter...
  6. Ayane M, Preuss U, Kohler G, Nielsen P. A differentially expressed murine RNA encoding a protein with similarities to two types of nucleic acid binding motifs. Nucleic Acids Res. 1991;19:1273-8 pubmed
    Using differential screening, a murine cDNA, termed X16, was isolated corresponding to an mRNA which is more strongly expressed in pre-B cell lines relative to mature B-cell lines...
  7. Sen S, Langiewicz M, Jumaa H, Webster N. Deletion of serine/arginine-rich splicing factor 3 in hepatocytes predisposes to hepatocellular carcinoma in mice. Hepatology. 2015;61:171-83 pubmed publisher
    ..We show here that hepatocyte-specific deletion of serine/arginine-rich splicing factor 3 (SRSF3) impairs hepatocyte maturation and metabolism in early adult life, and mice develop spontaneous hepatocellular ..
  8. Cocco L, Faenza I, Follo M, Billi A, Ramazzotti G, Papa V, et al. Nuclear inositides: PI-PLC signaling in cell growth, differentiation and pathology. Adv Enzyme Regul. 2009;49:2-10 pubmed publisher
  9. Antunes Martins A, Mizuno K, Irvine E, Lepicard E, Giese K. Sex-dependent up-regulation of two splicing factors, Psf and Srp20, during hippocampal memory formation. Learn Mem. 2007;14:693-702 pubmed
    ..Here we show that the hippocampal mRNA expression of two splicing factors, splicing factor arginine/serine-rich 3 (Sfrs3/Srp20) and polypyrimidine tract-binding protein-associated splicing factor (Psf), is altered in CaMKKbeta-..
  10. LU J, Qian J, Izvolsky K, Cardoso W. Global analysis of genes differentially expressed in branching and non-branching regions of the mouse embryonic lung. Dev Biol. 2004;273:418-35 pubmed
    ..Our data suggest that these genes may regulate focal developmental events specific of each of these regions during respiratory tract formation. ..
  11. Colwill K, Pawson T, Andrews B, Prasad J, Manley J, Bell J, et al. The Clk/Sty protein kinase phosphorylates SR splicing factors and regulates their intranuclear distribution. EMBO J. 1996;15:265-75 pubmed
    ..Overexpression of the active Clk/Sty kinase caused a redistribution of SR proteins within the nucleus. These results suggest that Clk/Sty kinase directly regulates the activity and compartmentalization of SR splicing factors. ..
  12. Thoren L, Nørgaard G, Weischenfeldt J, Waage J, Jakobsen J, Damgaard I, et al. UPF2 is a critical regulator of liver development, function and regeneration. PLoS ONE. 2010;5:e11650 pubmed publisher
    ..Collectively, our data demonstrate the critical role of the NMD pathway in liver development, function and regeneration and highlights the importance of NMD for mammalian biology. ..
  13. Hobeika E, Thiemann S, Storch B, Jumaa H, Nielsen P, Pelanda R, et al. Testing gene function early in the B cell lineage in mb1-cre mice. Proc Natl Acad Sci U S A. 2006;103:13789-94 pubmed
    ..The availability of a mouse line with efficient cre-mediated recombination at an early developmental stage in the B lineage provides an opportunity to study the role of various genes specifically in B cell development and function. ..