Gene Symbol: Srsf10
Description: serine/arginine-rich splicing factor 10
Alias: FUSIP2, Fusip1, NSSR1, NSSR2, Nssr, SRrp40, Sfrs13a, Srsf13a, TASR, TASR1, TASR2, serine/arginine-rich splicing factor 10, FUS-interacting serine-arginine-rich protein 1, Fus-associated protein with serine-arginine repeats, TLS-associated SR protein, TLS-associated protein with SR repeats, TLS-associated protein with Ser-Arg repeats, TLS-associated serine-arginine protein, neural-salient serine/arginine-rich protein, neural-specific SR protein, serine/arginine-rich splicing factor 13A
Species: mouse
Products:     Srsf10

Top Publications

  1. Komatsu M, Kominami E, Arahata K, Tsukahara T. Cloning and characterization of two neural-salient serine/arginine-rich (NSSR) proteins involved in the regulation of alternative splicing in neurones. Genes Cells. 1999;4:593-606 pubmed
    ..We cloned two new SR proteins, Neural-salient SR proteins (NSSR) 1 and 2, which are present at higher levels in brain and testis...
  2. Shin C, Manley J. The SR protein SRp38 represses splicing in M phase cells. Cell. 2002;111:407-17 pubmed
    ..Strikingly, SRp38 was found to be dephosphorylated specifically in mitotic cells, and we show that dephosphorylated SRp38 is required for the observed splicing repression. ..
  3. Liu L, Chen X, Huang J, Lin J, Lin W, Xu P. NSSR1 promotes neuronal differentiation of mouse embryonic carcinoma P19 cells. Neuroreport. 2004;15:823-8 pubmed
    ..small interference RNAs to specifically silence the expression of neural salient serine/arginine rich protein 1 (NSSR1) and showed that the inhibition of NSSR1 expression in mouse embryonic carcinoma cells (P19) reduces neuronal ..
  4. Feng Y, Valley M, Lazar J, Yang A, Bronson R, Firestein S, et al. SRp38 regulates alternative splicing and is required for Ca(2+) handling in the embryonic heart. Dev Cell. 2009;16:528-38 pubmed publisher
    ..Taken together, our results demonstrate that SRp38 regulates cardiac-specific alternative splicing of triadin pre-mRNA and, reflecting this, is essential for proper Ca(2+) handling during embryonic heart development. ..
  5. Xiao P, Hu L, Li J, Lin W, Chen X, Xu P. NSSR1 is regulated in testes development and cryptorchidism and promotes the exon 5-included splicing of CREB transcripts. Mol Reprod Dev. 2007;74:1363-72 pubmed
    Neural salient serine/arginine rich protein 1 (NSSR1, alternatively SRp38) is a newly identified splicing factor that is highly expressed in neural and reproductive tissues...
  6. Yang L, Embree L, Hickstein D. TLS-ERG leukemia fusion protein inhibits RNA splicing mediated by serine-arginine proteins. Mol Cell Biol. 2000;20:3345-54 pubmed
    ..assays, the TLS-ERG fusion protein inhibits E1A pre-mRNA splicing mediated by these TLS-associated SR proteins (TASR), and stable expression of the TLS-ERG fusion protein in K562 cells alters the splicing profile of CD44 mRNA...
  7. Cowper A, Caceres J, Mayeda A, Screaton G. Serine-arginine (SR) protein-like factors that antagonize authentic SR proteins and regulate alternative splicing. J Biol Chem. 2001;276:48908-14 pubmed
    ..Because of the similarity to SR proteins we have named these proteins SRrp40 and SRrp35, respectively, for SR-repressor proteins of approximately 40 and approximately 35 kDa...
  8. Fushimi K, Osumi N, Tsukahara T. NSSRs/TASRs/SRp38s function as splicing modulators via binding to pre-mRNAs. Genes Cells. 2005;10:531-41 pubmed
    The genes for neural-salient serine/arginine-rich (NSSR) proteins 1 and 2 have been cloned from the neuronal differentiated embryocarcinoma cell line, P19...
  9. Xiao P, Peng Z, Huang L, Li Y, Chen X. Dephosphorylated NSSR1 is induced by androgen in mouse epididymis and phosphorylated NSSR1 is increased during sperm maturation. PLoS ONE. 2011;6:e25667 pubmed publisher
    b>NSSR1 (Neural salient serine/arginine rich protein 1, alternatively SRp38) is a newly identified RNA splicing factor and predominantly expressed in neural tissues...

More Information


  1. Zhang W, Shen Q, Shen J. [Expression of neural salient serine-/arginine-rich protein 1 (NSSR1) in colorectal cancer]. Zhejiang Da Xue Xue Bao Yi Xue Ban. 2011;40:540-4 pubmed
    To investigate the expression of neural salient serine/arginine-rich protein 1 (NSSR1) in colorectal cancer...
  2. Zhang W, Li L, Chen X, Peng Z. Dephosphorylation of NSSR1 regulates alternative splicing of the GluR-B minigene. Genet Mol Res. 2014;13:1753-63 pubmed publisher
    Neural salient serine/arginine-rich protein 1 (NSSR1, alternatively SRp38) is an important splicing factor that can repress pre-mRNA alternative splicing in cells during heat shock and mitosis...
  3. Li H, Cheng Y, Wu W, Liu Y, Wei N, Feng X, et al. SRSF10 regulates alternative splicing and is required for adipocyte differentiation. Mol Cell Biol. 2014;34:2198-207 pubmed publisher
    ..We observed that mice deficient for the splicing factor SRSF10 exhibit severely impaired development of subcutaneous white adipose tissue (WAT) as a result of defects in ..
  4. Qi Y, Li Y, Cui S, Zhao J, Liu X, Ji C, et al. Splicing factor NSSR1 reduces neuronal injury after mouse transient global cerebral ischemia. Glia. 2015;63:826-45 pubmed publisher
    This study focuses on the function of NSSR1, a splicing factor, in neuronal injury in the ischemic mouse brain using the transient global cerebral ischemic mouse model and the cultured cells treated with oxygen-glucose deprivation (OGD)...
  5. Yang L, Embree L, Tsai S, Hickstein D. Oncoprotein TLS interacts with serine-arginine proteins involved in RNA splicing. J Biol Chem. 1998;273:27761-4 pubmed
    ..homolog of human splicing factor SC35, and the second SR member is a novel 183-amino acid protein that we term TASR (TLS-associated serine-arginine protein)...