Gene Symbol: Srpk1
Description: serine/arginine-rich protein specific kinase 1
Alias: AU017960, SRSF protein kinase 1, SFRS protein kinase 1, SR-protein-specific kinase 1, serine/threonine-protein kinase SRPK1
Species: mouse
Products:     Srpk1

Top Publications

  1. Koizumi J, Okamoto Y, Onogi H, Mayeda A, Krainer A, Hagiwara M. The subcellular localization of SF2/ASF is regulated by direct interaction with SR protein kinases (SRPKs). J Biol Chem. 1999;274:11125-31 pubmed
    ..Recombinant SRPK1 and SRPK2 bound to and phosphorylated GST-SF2/ASF in vitro...
  2. Wang P, Zhou Z, Hu A, Ponte de Albuquerque C, Zhou Y, Hong L, et al. Both decreased and increased SRPK1 levels promote cancer by interfering with PHLPP-mediated dephosphorylation of Akt. Mol Cell. 2014;54:378-91 pubmed publisher
    ..Here, we report a critical mechanism for regulation of Akt activity by the splicing kinase SRPK1, a downstream Akt target for transducing growth signals to regulate splicing...
  3. Papoutsopoulou S, Nikolakaki E, Chalepakis G, Kruft V, Chevaillier P, Giannakouros T. SR protein-specific kinase 1 is highly expressed in testis and phosphorylates protamine 1. Nucleic Acids Res. 1999;27:2972-80 pubmed
    ..TwoSRprotein-specifickinases, SRPK1 and SRPK2, have been considered as highly specific for the phosphorylation of these proteins, thereby contributing ..
  4. Schenk P, Stoop H, Bokemeyer C, Mayer F, Stoter G, Oosterhuis J, et al. Resistance to platinum-containing chemotherapy in testicular germ cell tumors is associated with downregulation of the protein kinase SRPK1. Neoplasia. 2004;6:297-301 pubmed
    ..Recently, we demonstrated that the mammalian serine/arginine-rich protein-specific kinase 1 (SRPK1) is a cisplatin-sensitive gene, inactivation of which leads to cisplatin resistance...
  5. Longo Guess C, Gagnon L, Cook S, Wu J, Zheng Q, Johnson K. A missense mutation in the previously undescribed gene Tmhs underlies deafness in hurry-scurry (hscy) mice. Proc Natl Acad Sci U S A. 2005;102:7894-9 pubmed
    ..Our localization of TMHS to the apical membrane of inner ear hair cells during the period of stereocilia formation suggests a function in hair bundle morphogenesis. ..
  6. Wang H, Arden K, Bermingham J, Viars C, Lin W, Boyer A, et al. Localization of serine kinases, SRPK1 (SFRSK1) and SRPK2 (SFRSK2), specific for the SR family of splicing factors in mouse and human chromosomes. Genomics. 1999;57:310-5 pubmed
    ..We have previously characterized SRPK1 (SFRSK1) and SRPK2 (SFRSK2), which are highly specific protein kinases for the SR family of splicing factors...
  7. Gui J, Lane W, Fu X. A serine kinase regulates intracellular localization of splicing factors in the cell cycle. Nature. 1994;369:678-82 pubmed
    ..We have now identified and cloned a kinase, SRPK1, which is regulated by the cell cycle and is specific for SR proteins; this kinase is related to a Caenorhabditis ..
  8. Colwill K, Feng L, Yeakley J, Gish G, Caceres J, Pawson T, et al. SRPK1 and Clk/Sty protein kinases show distinct substrate specificities for serine/arginine-rich splicing factors. J Biol Chem. 1996;271:24569-75 pubmed
    ..Two protein kinases have been cloned that can phosphorylate SR proteins in vitro: SRPK1 and Clk/Sty...
  9. Kuroyanagi N, Onogi H, Wakabayashi T, Hagiwara M. Novel SR-protein-specific kinase, SRPK2, disassembles nuclear speckles. Biochem Biophys Res Commun. 1998;242:357-64 pubmed
    SR-protein-specific kinase 1 (SRPK1) is first identified as a specific kinase for SR splicing factors. By RT-PCR of a conserved kinase domain, novel SR-protein-specific kinase clones were isolated from mouse brain...

More Information


  1. van Roosmalen W, Le Dévédec S, Golani O, Smid M, Pulyakhina I, Timmermans A, et al. Tumor cell migration screen identifies SRPK1 as breast cancer metastasis determinant. J Clin Invest. 2015;125:1648-64 pubmed publisher
    ..Examination of genes that modulate migration indicated that SRPK1, encoding the splicing factor kinase SRSF protein kinase 1, is relevant to breast cancer outcomes, as it was highly expressed in basal breast cancer...