Gene Symbol: SRG4
Description: Sad1 and UNC84 domain containing 5
Alias: 1700021O15Rik, SPAG4L-2, SRG4, Spag4l, SUN domain-containing protein 5, sperm-associated antigen 4-like protein, spermatogenesis-related gene 4
Frohnert C, Schweizer S, Hoyer Fender S. SPAG4L/SPAG4L-2 are testis-specific SUN domain proteins restricted to the apical nuclear envelope of round spermatids facing the acrosome. Mol Hum Reprod. 2011;17:207-18 pubmed publisher
..We have isolated a novel SUN domain protein, SPAG4L-2, that differs from SPAG4L by an N-terminal insertion of 25 amino acids...
Jiang X, Yang M, Huang L, Li C, Xing X. SPAG4L, a novel nuclear envelope protein involved in the meiotic stage of spermatogenesis. DNA Cell Biol. 2011;30:875-82 pubmed publisher
..In this study, we sought to characterize and define the potential function of SPAG4L, a newly identified SUN protein...
Xing X, Li L, Liu G, Lu G. [Cloning of cDNA of SRG4, a mouse spermatogenesis related gene and expression in mouse different developing stages]. Yi Chuan Xue Bao. 2004;31:1066-71 pubmed
..By electrical hybridization, a 1 155 bp sequence was obtained and named as SRG4 (Spermatogenesis Related Gene 4) (GenBank accession number: AY307077), which included the full-length sequence of mouse testis ..
Yassine S, Escoffier J, Abi Nahed R, Nahed R, Pierre V, Karaouzene T, et al
. Dynamics of Sun5 localization during spermatogenesis in wild type and Dpy19l2 knock-out mice indicates that Sun5 is not involved in acrosome attachment to the nuclear envelope. PLoS ONE. 2015;10:e0118698 pubmed publisher
..In order to characterize new actors of acrosomal attachment, we focused on Sun5 (also called Spag4l), which is highly expressed in male germ cells, and investigated its localization during spermatogenesis...
Shang Y, Zhu F, Wang L, Ouyang Y, Dong M, Liu C, et al
. Essential role for SUN5 in anchoring sperm head to the tail. elife. 2017;6: pubmed publisher
..Our studies reveal the essential role of SUN5 in anchoring sperm head to the tail and provide a promising way to treat this kind of acephalic spermatozoa-associated male infertility. ..
Shang Y, Yan J, Tang W, Liu C, Xiao S, Guo Y, et al
. Mechanistic insights into acephalic spermatozoa syndrome-associated mutations in the human SUN5 gene. J Biol Chem. 2018;293:2395-2407 pubmed publisher
Xing X, Yuan H, Wang W. [Prokaryotic expression and purification of SRG4, a novel mouse spermatogenesis gene]. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2007;23:701-3 pubmed
To express SRG4, a novel mouse spermatogenesis gene in E.coli and purify its fusion protein. RT-PCR was used to amplify the 586 bp fragment that was located in SRG4 C-end and included a Sad1_UNC like domain...
Xing X, Li L, Lu G. [Expression of a novel spermatogenesis gene SRG4 in postpartum normal and cryptorchid mouse testis]. Yi Chuan. 2007;29:699-704 pubmed
To understand the function of SRG4, a novel spermatogenesis gene, we studied its expression pattern during normal mouse development and in experimental cryptorchidism...