Gene Symbol: Srd5a1
Description: steroid 5 alpha-reductase 1
Alias: 0610031P22Rik, 4930435F02Rik, S5AR 1, Srd5a-1, 3-oxo-5-alpha-steroid 4-dehydrogenase 1, SR type 1, type 1 5alpha-reductase
Species: mouse
Products:     Srd5a1

Top Publications

  1. Mahendroo M, Cala K, Landrum D, Russell D. Fetal death in mice lacking 5alpha-reductase type 1 caused by estrogen excess. Mol Endocrinol. 1997;11:917-27 pubmed
    ..These findings indicate that the 5alpha-reduction of androgens in female animals plays a crucial role in guarding against estrogen toxicity during pregnancy. ..
  2. Windahl S, Andersson N, Börjesson A, Swanson C, Svensson J, Moverare Skrtic S, et al. Reduced bone mass and muscle strength in male 5?-reductase type 1 inactivated mice. PLoS ONE. 2011;6:e21402 pubmed publisher
    ..There are two well established isoenzymes of 5?-reductase (type 1 and type 2), encoded by separate genes (Srd5a1 and Srd5a2)...
  3. Mahendroo M, Cala K, Hess D, Russell D. Unexpected virilization in male mice lacking steroid 5 alpha-reductase enzymes. Endocrinology. 2001;142:4652-62 pubmed
    ..We conclude that T is the only androgen required for differentiation of the male urogenital tract in mice and that the synthesis of DHT serves largely as a signal amplification mechanism. ..
  4. Mahendroo M, Cala K, Russell D. 5 alpha-reduced androgens play a key role in murine parturition. Mol Endocrinol. 1996;10:380-92 pubmed
    ..embryonic stem cells was used to produce male and female mice with a disruption (null allele) in the type 1 gene (Srd5a1). Male mice lacking 5 alpha-reductase type 1 appear normal...
  5. Mahendroo M, Porter A, Russell D, Word R. The parturition defect in steroid 5alpha-reductase type 1 knockout mice is due to impaired cervical ripening. Mol Endocrinol. 1999;13:981-92 pubmed
  6. Opoku Acheampong A, Henningson J, Beck A, Lindshield B. 5?-reductase 1 mRNA levels are positively correlated with TRAMP mouse prostate most severe lesion scores. PLoS ONE. 2017;12:e0175874 pubmed publisher
    ..Downregulation of androgen receptor and 5?-reductase 2, along with upregulation of 5?-reductase 1 in tumors may promote prostatic intraepithelial neoplasia and prostate cancer development in TRAMP mice. ..
  7. Jenkins E, Hsieh C, Milatovich A, Normington K, Berman D, Francke U, et al. Characterization and chromosomal mapping of a human steroid 5 alpha-reductase gene and pseudogene and mapping of the mouse homologue. Genomics. 1991;11:1102-12 pubmed
    ..One gene (symbol SRD5A1) is functional, contains five exons separated by four introns, and maps to the distal short arm of chromosome 5...
  8. Ford M, Nickel J, Kaufman M, Finn D. Null mutation of 5α-reductase type I gene alters ethanol consumption patterns in a sex-dependent manner. Behav Genet. 2015;45:341-53 pubmed publisher
    ..The Srd5a1 gene encodes the enzyme 5α-reductase-1, which is required for the synthesis of ALLO...
  9. Juriloff D, Harris M, Dewell S. A digenic cause of cleft lip in A-strain mice and definition of candidate genes for the two loci. Birth Defects Res A Clin Mol Teratol. 2004;70:509-18 pubmed
    ..The orthologous human genes are on 17q (clf1) and 9q, 8q and 5p (clf2), and good candidate genes are WNT3 or WNT9B (17q), and PTCH (9q) or MTRR (5p). ..

More Information


  1. Karolczak M, Kuppers E, Beyer C. Developmental expression and regulation of aromatase- and 5alpha-reductase type I mRNA in the male and female mouse hypothalamus. J Neuroendocrinol. 1998;10:267-74 pubmed
    ..Our findings imply that sex differences in androgen availability and responsiveness are important regulatory factors for aromatase expression in the developing male hypothalamus. ..
  2. Koonce C, Walf A, Frye C. Type 1 5?-reductase may be required for estrous cycle changes in affective behaviors of female mice. Behav Brain Res. 2012;226:376-80 pubmed publisher
    ..Thus, 5?-reductase may be required for the estrous cycle variations in affective behavior and 3?,5?-THP levels of female mice. ..
  3. Frye C, Koonce C, Walf A. Progesterone, compared to medroxyprogesterone acetate, to C57BL/6, but not 5?-reductase mutant, mice enhances object recognition and placement memory and is associated with higher BDNF levels in the hippocampus and cortex. Neurosci Lett. 2013;551:53-7 pubmed publisher
    ..Levels of brain-derived neurotrophic factor (BDNF) in the prefrontal cortex and hippocampus were lowest among mice administered MPA. Thus, some of P4s effects to enhance cognitive performance may be incumbent upon its 5?-reduction. ..
  4. Roselli C, Finn T, Ronnekleiv Kelly S, Tanchuck M, Kaufman K, Finn D. Localization of brain 5?-reductase messenger RNA in mice selectively bred for high chronic alcohol withdrawal severity. Alcohol. 2011;45:763-72 pubmed publisher
    ..Our recent studies examined the activity and expression of 5?-reductase (Srd5a1), the rate-limiting enzyme in the biosynthesis of ALLO, during alcohol withdrawal in mice selectively bred for ..
  5. Timmons B, Fairhurst A, Mahendroo M. Temporal changes in myeloid cells in the cervix during pregnancy and parturition. J Immunol. 2009;182:2700-7 pubmed publisher
    ..Additionally, macrophages with diverse phenotypes (M1 and M2) are present in the cervix and are most likely involved in the postpartum repair of tissue. ..
  6. Timmons B, Mitchell S, Gilpin C, Mahendroo M. Dynamic changes in the cervical epithelial tight junction complex and differentiation occur during cervical ripening and parturition. Endocrinology. 2007;148:1278-87 pubmed
  7. Mahendroo M, Wilson J, Richardson J, Auchus R. Steroid 5alpha-reductase 1 promotes 5alpha-androstane-3alpha,17beta-diol synthesis in immature mouse testes by two pathways. Mol Cell Endocrinol. 2004;222:113-20 pubmed
  8. Provost P, Tremblay Y. Mouse 3alpha-hydroxysteroid dehydrogenase mRNA: a marker of lung maturity. J Steroid Biochem Mol Biol. 2007;103:61-4 pubmed
    ..5, when the maturation of type II pneumonocytes occurs, and followed its progression at least until gestation day 18.5. In conclusion, our data show that m3alpha-HSD mRNA is a reliable marker of lung maturity in normal pregnancy. ..
  9. Koonce C, Frye C. Female mice with deletion of Type One 5?-reductase have reduced reproductive responding during proestrus and after hormone-priming. Pharmacol Biochem Behav. 2014;122:20-9 pubmed publisher
    ..MPA did not increase 3?,5?-THP. Thus, deletion of Type One 5?-reductase among female mice may attenuate reproductive responding during the estrous cycle and after hormone-priming. ..
  10. Praktiknjo S, Llamas B, Scott Boyer M, Picard S, Robert F, Langlais D, et al. Novel effects of chromosome Y on cardiac regulation, chromatin remodeling, and neonatal programming in male mice. Endocrinology. 2013;154:4746-56 pubmed publisher
  11. Frye C, Walf A, Rhodes M, Harney J. Progesterone enhances motor, anxiolytic, analgesic, and antidepressive behavior of wild-type mice, but not those deficient in type 1 5 alpha-reductase. Brain Res. 2004;1004:116-24 pubmed
    ..Thus, these data suggest metabolism by the 5 alpha-reductase type I enzyme may mitigate P(4)'s effects on some tasks of motor, anxiety, nociception, and depression behavior. ..
  12. Livingstone D, Di Rollo E, Mak T, Sooy K, Walker B, Andrew R. Metabolic dysfunction in female mice with disruption of 5?-reductase 1. J Endocrinol. 2017;232:29-36 pubmed
  13. Araki R, Nishida S, Hiraki Y, Matsumoto K, Yabe T. DNA methylation of the GC box in the promoter region mediates isolation rearing-induced suppression of srd5a1 transcription in the prefrontal cortex. Neurosci Lett. 2015;606:135-9 pubmed publisher
    ..In this study, we examined an epigenetic mechanism for transcriptional regulation of srd5a1, which codes for steroid 5α-reductase type I, using isolation-reared mice...
  14. Koonce C, Frye C. Progesterone facilitates exploration, affective and social behaviors among wildtype, but not 5?-reductase Type 1 mutant, mice. Behav Brain Res. 2013;253:232-9 pubmed publisher
    ..Thus, metabolism of P4 by the 5?-reductase enzyme may be essential for enhancement of these behaviors. ..
  15. Dowman J, Hopkins L, Reynolds G, Armstrong M, Nasiri M, Nikolaou N, et al. Loss of 5?-reductase type 1 accelerates the development of hepatic steatosis but protects against hepatocellular carcinoma in male mice. Endocrinology. 2013;154:4536-47 pubmed publisher
    ..05). 5?R1 deletion accelerates the development of hepatic steatosis but may protect against the development of NAFLD-related hepatocellular neoplasia and therefore has potential as a therapeutic target. ..
  16. Tanchuck Nipper M, Ford M, Hertzberg A, Beadles Bohling A, Cozzoli D, Finn D. Sex Differences in Ethanol's Anxiolytic Effect and Chronic Ethanol Withdrawal Severity in Mice with a Null Mutation of the 5α-Reductase Type 1 Gene. Behav Genet. 2015;45:354-67 pubmed publisher
    ..of 5α-reductase-1, an important enzyme in allopregnanolone biosynthesis encoded by the 5α-reductase-1 gene (Srd5a1)...
  17. Kanczkowski W, Sue M, Zacharowski K, Reincke M, Bornstein S. The role of adrenal gland microenvironment in the HPA axis function and dysfunction during sepsis. Mol Cell Endocrinol. 2015;408:241-8 pubmed publisher
  18. Pibiri F, Nelson M, Guidotti A, Costa E, Pinna G. Decreased corticolimbic allopregnanolone expression during social isolation enhances contextual fear: A model relevant for posttraumatic stress disorder. Proc Natl Acad Sci U S A. 2008;105:5567-72 pubmed publisher
  19. Agis Balboa R, Pinna G, Pibiri F, Kadriu B, Costa E, Guidotti A. Down-regulation of neurosteroid biosynthesis in corticolimbic circuits mediates social isolation-induced behavior in mice. Proc Natl Acad Sci U S A. 2007;104:18736-41 pubmed
    ..In socially isolated mice, this down-regulation may account for the appearance of behavioral disorders such as anxiety, aggression, and cognitive dysfunction. ..
  20. Livingstone D, Barat P, Di Rollo E, Rees G, Weldin B, Rog Zielinska E, et al. 5α-Reductase type 1 deficiency or inhibition predisposes to insulin resistance, hepatic steatosis, and liver fibrosis in rodents. Diabetes. 2015;64:447-58 pubmed publisher
    ..Variations in 5αR1 activity in obesity and with nonselective 5α-reductase inhibition in men with prostate disease may have important consequences for the onset and progression of metabolic liver disease. ..
  21. Timmons B, Mahendroo M. Timing of neutrophil activation and expression of proinflammatory markers do not support a role for neutrophils in cervical ripening in the mouse. Biol Reprod. 2006;74:236-45 pubmed
    ..cell migration in cervix through comparisons between wild-type mice and steroid 5alpha-reductase type 1 null mice (Srd5a1-/-), which fail to undergo cervical ripening due to insufficient local progesterone metabolism...
  22. Cisternas C, Tome K, Caeiro X, Dadam F, Garcia Segura L, Cambiasso M. Sex chromosome complement determines sex differences in aromatase expression and regulation in the stria terminalis and anterior amygdala of the developing mouse brain. Mol Cell Endocrinol. 2015;414:99-110 pubmed publisher
    ..In conclusion, sex chromosomes determine sex dimorphisms in aromatase expression and regulation in the developing mouse brain. ..
  23. Marshall K, Godden E, Yang F, Burgers S, Buck K, Sikela J. In silico discovery of gene-coding variants in murine quantitative trait loci using strain-specific genome sequence databases. Genome Biol. 2002;3:RESEARCH0078 pubmed
    ..As a test of this approach we focused on two QTLs on mouse chromosomes 1 and 13 that are involved in physical dependence on alcohol...
  24. Agis Balboa R, Pinna G, Zhubi A, Maloku E, Veldic M, Costa E, et al. Characterization of brain neurons that express enzymes mediating neurosteroid biosynthesis. Proc Natl Acad Sci U S A. 2006;103:14602-7 pubmed