Src

Summary

Gene Symbol: Src
Description: Rous sarcoma oncogene
Alias: AW259666, pp60c-src, neuronal proto-oncogene tyrosine-protein kinase Src, p60-Src, proto-oncogene c-Src
Species: mouse
Products:     Src

Top Publications

  1. Patwardhan P, Shen Y, Goldberg G, Miller W. Individual Cas phosphorylation sites are dispensable for processive phosphorylation by Src and anchorage-independent cell growth. J Biol Chem. 2006;281:20689-97 pubmed
    ..possesses a large central substrate domain containing 15 repeats of the sequence YXXP, which are phosphorylated by Src. The phosphorylation sites are essential for the roles of Cas in cell migration and in regulation of the actin ..
  2. Sperber B, Boyle Walsh E, Engleka M, Gadue P, Peterson A, Stein P, et al. A unique role for Fyn in CNS myelination. J Neurosci. 2001;21:2039-47 pubmed
    ..We found that oligodendrocytes express Src, but there was no significant reduction of myelin content in null mutants lacking the Fyn-related kinases Src, Yes, ..
  3. Lopez J, Hesling C, Prudent J, Popgeorgiev N, Gadet R, Mikaelian I, et al. Src tyrosine kinase inhibits apoptosis through the Erk1/2- dependent degradation of the death accelerator Bik. Cell Death Differ. 2012;19:1459-69 pubmed publisher
    b>Src, the canonical member of the non-receptor family of tyrosine kinases, is deregulated in numerous cancers, including colon and breast cancers...
  4. Chellaiah M, Kizer N, Silva M, Alvarez U, Kwiatkowski D, Hruska K. Gelsolin deficiency blocks podosome assembly and produces increased bone mass and strength. J Cell Biol. 2000;148:665-78 pubmed
    ..and bone resorption by activating a heteromultimeric signaling complex that includes gelsolin, pp(60c-src), and phosphatidylinositol 3'-kinase...
  5. Sandilands E, Serrels B, McEwan D, Morton J, Macagno J, McLeod K, et al. Autophagic targeting of Src promotes cancer cell survival following reduced FAK signalling. Nat Cell Biol. 2011;14:51-60 pubmed publisher
    Here we describe a mechanism that cancer cells use to survive when flux through the Src/FAK pathway is severely perturbed...
  6. Sandilands E, Serrels B, Wilkinson S, Frame M. Src-dependent autophagic degradation of Ret in FAK-signalling-defective cancer cells. EMBO Rep. 2012;13:733-40 pubmed publisher
    We have recently described that autophagic targeting of Src maintains cancer cell viability when FAK signalling is defective...
  7. Lowe C, Yoneda T, Boyce B, Chen H, Mundy G, Soriano P. Osteopetrosis in Src-deficient mice is due to an autonomous defect of osteoclasts. Proc Natl Acad Sci U S A. 1993;90:4485-9 pubmed
    ..Mice carrying a targeted disruption of the gene Src that encodes pp60c-src (Src), a nonreceptor protein tyrosine kinase, develop this phenotype but do not exhibit ..
  8. Scheppke L, Aguilar E, Gariano R, Jacobson R, Hood J, Doukas J, et al. Retinal vascular permeability suppression by topical application of a novel VEGFR2/Src kinase inhibitor in mice and rabbits. J Clin Invest. 2008;118:2337-46 pubmed publisher
    ..such as diabetes and is known to dramatically alter vascular permeability in a number of nonocular tissues via Src kinase-regulated signaling pathways...
  9. Furstoss O, Dorey K, Simon V, Barilà D, Superti Furga G, Roche S. c-Abl is an effector of Src for growth factor-induced c-myc expression and DNA synthesis. EMBO J. 2002;21:514-24 pubmed
    The mechanism by which the ubiquitously expressed Src family kinases regulate mitogenesis is not well understood...

More Information

Publications85

  1. Schlaepfer D, Broome M, Hunter T. Fibronectin-stimulated signaling from a focal adhesion kinase-c-Src complex: involvement of the Grb2, p130cas, and Nck adaptor proteins. Mol Cell Biol. 1997;17:1702-13 pubmed
    ..FAK autophosphorylation at Tyr-397 promotes Src homology 2 (SH2) domain binding of Src family PTKs, and c-Src phosphorylation of FAK at Tyr-925 creates an SH2 ..
  2. Stein P, Vogel H, Soriano P. Combined deficiencies of Src, Fyn, and Yes tyrosine kinases in mutant mice. Genes Dev. 1994;8:1999-2007 pubmed
    Three members of the Src family of tyrosine kinases, src, fyn, and yes, are broadly expressed throughout mouse development...
  3. Obergfell A, Eto K, Mocsai A, Buensuceso C, Moores S, Brugge J, et al. Coordinate interactions of Csk, Src, and Syk kinases with [alpha]IIb[beta]3 initiate integrin signaling to the cytoskeleton. J Cell Biol. 2002;157:265-75 pubmed
    ..We find here that Src associates constitutively with integrin alphaIIbbeta3 in platelets...
  4. Lowell C, Soriano P. Knockouts of Src-family kinases: stiff bones, wimpy T cells, and bad memories. Genes Dev. 1996;10:1845-57 pubmed
  5. Zhao M, Janas J, Niki M, Pandolfi P, Van Aelst L. Dok-1 independently attenuates Ras/mitogen-activated protein kinase and Src/c-myc pathways to inhibit platelet-derived growth factor-induced mitogenesis. Mol Cell Biol. 2006;26:2479-89 pubmed
    ..Specifically, Dok-1 attenuates PDGF-elicited c-myc induction by recruiting Csk to active Src kinases, whereupon their activities and consequent c-myc induction are diminished...
  6. Sandilands E, Brunton V, Frame M. The membrane targeting and spatial activation of Src, Yes and Fyn is influenced by palmitoylation and distinct RhoB/RhoD endosome requirements. J Cell Sci. 2007;120:2555-64 pubmed
    b>Src activation is a tightly regulated process which requires RhoB endosome-associated actin assembly and transit to the cell periphery...
  7. Samarakoon R, Higgins S, Higgins C, Higgins P. TGF-beta1-induced plasminogen activator inhibitor-1 expression in vascular smooth muscle cells requires pp60(c-src)/EGFR(Y845) and Rho/ROCK signaling. J Mol Cell Cardiol. 2008;44:527-38 pubmed publisher
    ..TGF-beta1-stimulated PAI-1 expression, moreover, was preceded by EGFR phosphorylation on Y845 (a src kinase target residue) and required pp60(c-src) activity...
  8. Miyazaki T, Sanjay A, Neff L, Tanaka S, Horne W, Baron R. Src kinase activity is essential for osteoclast function. J Biol Chem. 2004;279:17660-6 pubmed
    Deletion of the c-src gene impairs osteoclast bone resorbing activity, causing osteopetrosis...
  9. Soriano P, Montgomery C, Geske R, Bradley A. Targeted disruption of the c-src proto-oncogene leads to osteopetrosis in mice. Cell. 1991;64:693-702 pubmed
    To understand the normal, physiological role of the c-src proto-oncogene, a null mutation was introduced into the gene by homologous recombination in mouse embryonic stem cells...
  10. Klinghoffer R, Sachsenmaier C, Cooper J, Soriano P. Src family kinases are required for integrin but not PDGFR signal transduction. EMBO J. 1999;18:2459-71 pubmed
    b>Src family kinases (SFKs) have been implicated as important regulators of ligand-induced cellular responses including proliferation, survival, adhesion and migration...
  11. Izawa T, Zou W, Chappel J, Ashley J, Feng X, Teitelbaum S. c-Src links a RANK/?v?3 integrin complex to the osteoclast cytoskeleton. Mol Cell Biol. 2012;32:2943-53 pubmed publisher
    RANK ligand (RANKL), by mechanisms unknown, directly activates osteoclasts to resorb bone. Because c-Src is key to organizing the cell's cytoskeleton, we asked if the tyrosine kinase also mediates RANKL-stimulated osteoclast activity...
  12. Paul R, Zhang Z, Eliceiri B, Jiang Q, Boccia A, Zhang R, et al. Src deficiency or blockade of Src activity in mice provides cerebral protection following stroke. Nat Med. 2001;7:222-7 pubmed
    ..Evidence is provided that Src kinase regulates VEGF-mediated VP in the brain following stroke and that suppression of Src activity decreases VP ..
  13. Cinq Frais C, Coatrieux C, Grazide M, Hannun Y, Negre Salvayre A, Salvayre R, et al. A signaling cascade mediated by ceramide, src and PDGFR? coordinates the activation of the redox-sensitive neutral sphingomyelinase-2 and sphingosine kinase-1. Biochim Biophys Acta. 2013;1831:1344-56 pubmed publisher
    ..Further results implicated src and the trans-activation of PDGFR?, as supported by the blocking effect of specific siRNAs, pharmacological ..
  14. Sieg D, Ilic D, Jones K, Damsky C, Hunter T, Schlaepfer D. Pyk2 and Src-family protein-tyrosine kinases compensate for the loss of FAK in fibronectin-stimulated signaling events but Pyk2 does not fully function to enhance FAK- cell migration. EMBO J. 1998;17:5933-47 pubmed
    ..However, Pyk2 associated with active Src-family PTKs after FN but not poly-L-lysine replating of the FAK- cells...
  15. Kim H, Laing M, Muller W. c-Src-null mice exhibit defects in normal mammary gland development and ERalpha signaling. Oncogene. 2005;24:5629-36 pubmed
    The c-Src tyrosine kinase has been implicated to play an integral role in modulating growth factor receptor, integrin and steroid receptor function...
  16. Valeri N, Braconi C, Gasparini P, Murgia C, Lampis A, Paulus Hock V, et al. MicroRNA-135b promotes cancer progression by acting as a downstream effector of oncogenic pathways in colon cancer. Cancer Cell. 2014;25:469-83 pubmed publisher
    ..show that miR-135b overexpression is triggered in mice and humans by APC loss, PTEN/PI3K pathway deregulation, and SRC overexpression and promotes tumor transformation and progression...
  17. Murphy D, Diaz B, Bromann P, Tsai J, Kawakami Y, Maurer J, et al. A Src-Tks5 pathway is required for neural crest cell migration during embryonic development. PLoS ONE. 2011;6:e22499 pubmed publisher
    ..The adaptor protein and Src substrate Tks5 is necessary for cancer cell migration through extracellular matrix in vitro and tumorigenicity in ..
  18. Veracini L, Simon V, Richard V, Schraven B, Horejsi V, Roche S, et al. The Csk-binding protein PAG regulates PDGF-induced Src mitogenic signaling via GM1. J Cell Biol. 2008;182:603-14 pubmed publisher
    Spatial regulation is an important feature of signal specificity elicited by cytoplasmic tyrosine kinases of the Src family (SRC family protein tyrosine kinases [SFK])...
  19. Weis S, Cui J, Barnes L, Cheresh D. Endothelial barrier disruption by VEGF-mediated Src activity potentiates tumor cell extravasation and metastasis. J Cell Biol. 2004;167:223-9 pubmed
    ..To test this, mice lacking the Src family kinases Src or Yes, which maintain endothelial barrier function in the presence of VEGF, were injected ..
  20. Gatesman A, Walker V, Baisden J, Weed S, Flynn D. Protein kinase Calpha activates c-Src and induces podosome formation via AFAP-110. Mol Cell Biol. 2004;24:7578-97 pubmed
    ..AFAP-110 is required to mediate protein kinase Calpha (PKCalpha) activation of the nonreceptor tyrosine kinase c-Src and the subsequent formation of podosomes...
  21. Ridgway R, Serrels B, Mason S, Kinnaird A, Muir M, Patel H, et al. Focal adhesion kinase is required for ?-catenin-induced mobilization of epidermal stem cells. Carcinogenesis. 2012;33:2369-76 pubmed publisher
    ..In addition, inhibition of Src kinase activity, a major binding partner of FAK also prevents stem cell mobilization...
  22. Schlaepfer D, Jones K, Hunter T. Multiple Grb2-mediated integrin-stimulated signaling pathways to ERK2/mitogen-activated protein kinase: summation of both c-Src- and focal adhesion kinase-initiated tyrosine phosphorylation events. Mol Cell Biol. 1998;18:2571-85 pubmed
    ..In this study, we show that the nonreceptor protein-tyrosine kinases (PTKs) c-Src and focal adhesion kinase (FAK) can be independently activated after fibronectin (FN) stimulation and that their ..
  23. Boyce B, Yoneda T, Lowe C, Soriano P, Mundy G. Requirement of pp60c-src expression for osteoclasts to form ruffled borders and resorb bone in mice. J Clin Invest. 1992;90:1622-7 pubmed
    Targeted disruption of the c-src proto-oncogene in mice has shown that src expression is required for normal bone resorption, since the src-deficient mutants develop osteopetrosis...
  24. Lock P, Abram C, Gibson T, Courtneidge S. A new method for isolating tyrosine kinase substrates used to identify fish, an SH3 and PX domain-containing protein, and Src substrate. EMBO J. 1998;17:4346-57 pubmed
    ..Several potential Src substrates were identified including Fish, which has five SH3 domains and a recently discovered phox homology (PX) ..
  25. Gertler F, Niebuhr K, Reinhard M, Wehland J, Soriano P. Mena, a relative of VASP and Drosophila Enabled, is implicated in the control of microfilament dynamics. Cell. 1996;87:227-39 pubmed
    ..Expression of neural-enriched isoforms of Mena in fibroblasts induces the formation of abnormal F-actin-rich outgrowths, supporting a role for this protein in microfilament assembly and cell motility...
  26. Marcotte R, Smith H, Sanguin Gendreau V, McDonough R, Muller W. Mammary epithelial-specific disruption of c-Src impairs cell cycle progression and tumorigenesis. Proc Natl Acad Sci U S A. 2012;109:2808-13 pubmed publisher
    The tyrosine kinase c-Src is activated in a large proportion of breast cancers, in which it is thought to play a key role in promoting the malignant phenotype...
  27. Schwartzberg P, Xing L, Hoffmann O, Lowell C, Garrett L, Boyce B, et al. Rescue of osteoclast function by transgenic expression of kinase-deficient Src in src-/- mutant mice. Genes Dev. 1997;11:2835-44 pubmed
    The Src tyrosine kinase has been implicated in a wide variety of signal transduction pathways, yet despite the nearly ubiquitous expression of c-src, src-/- mice show only one major phenotype-osteopetrosis caused by an intrinsic defect ..
  28. Eliceiri B, Paul R, Schwartzberg P, Hood J, Leng J, Cheresh D. Selective requirement for Src kinases during VEGF-induced angiogenesis and vascular permeability. Mol Cell. 1999;4:915-24 pubmed
    b>Src kinase activity was found to protect endothelial cells from apoptosis during vascular endothelial growth factor (VEGF)-, but not basic fibroblast growth factor (bFGF)-, mediated angiogenesis in chick embryos and mice...
  29. Paul R, Angele B, Popp B, Klein M, Riedel E, Pfister H, et al. Differential regulation of blood-brain barrier permeability in brain trauma and pneumococcal meningitis-role of Src kinases. Exp Neurol. 2007;203:158-67 pubmed
    ..b>Src family kinases, especially c-Src, play an important role in regulating blood-brain barrier permeability in response ..
  30. Marchetti M, Di Marco B, Cifone G, Migliorati G, Riccardi C. Dexamethasone-induced apoptosis of thymocytes: role of glucocorticoid receptor-associated Src kinase and caspase-8 activation. Blood. 2003;101:585-93 pubmed
    ..We analyzed the mechanisms of GCH-activated apoptosis by focusing on GR-associated Src kinase, cytochrome c release, and caspase-8, -9, and -3 activation...
  31. Fucik V, Beran J, Cerny Z, Macha J, Jonak J. Genomic organization of the mouse src gene. Sequencing of src introns revealed a new chromosome 2 microsatellite marker. Folia Biol (Praha). 2002;48:34-9 pubmed
    Ten introns interrupting the coding sequence of the mouse src protooncogene were sequenced (in total 11260 bp) and their general characteristics compared with the homologous genes in human and chicken...
  32. Qu H, Tu Y, Guan J, Xiao G, Wu C. Kindlin-2 tyrosine phosphorylation and interaction with Src serve as a regulatable switch in the integrin outside-in signaling circuit. J Biol Chem. 2014;289:31001-13 pubmed publisher
    ..Kindlin-2 is tyrosine-phosphorylated upon cell-ECM adhesion. Furthermore, kindlin-2 binds Src in a cell-ECM adhesion-regulatable fashion...
  33. Bi Y, Mukhopadhyay D, Drinane M, Ji B, Li X, Cao S, et al. Endocytosis of collagen by hepatic stellate cells regulates extracellular matrix dynamics. Am J Physiol Cell Physiol. 2014;307:C622-33 pubmed publisher
    ..Primary human HSCs, LX2, or mouse embryonic fibroblasts (MEFs) [wild-type; c-abl(-/-); or Yes, Src, and Fyn knockout mice (YSF(-/-))] were incubated with fluorescent-labeled collagen or gelatin...
  34. Shields B, Court N, Hauser C, Bukczynska P, Tiganis T. Cell cycle-dependent regulation of SFK, JAK1 and STAT3 signalling by the protein tyrosine phosphatase TCPTP. Cell Cycle. 2008;7:3405-16 pubmed
    Janus-activated kinases (JAKs) and Src family kinases (SFKs) and their common substrate signal transducer and activator of transcription (STAT)-3 are frequently hyperactivated in human cancer contributing to the proliferative drive by ..
  35. Buitrago C, Costabel M, Boland R. PKC and PTP? participate in Src activation by 1?,25OH2 vitamin D3 in C2C12 skeletal muscle cells. Mol Cell Endocrinol. 2011;339:81-9 pubmed publisher
    We previously demonstrated that 1?,25(OH)(2)-vitamin D(3) [1?,25(OH)(2)D(3)] induces Src activation, which mediates the hormone-dependent ERK1/2 and p38 MAPK phosphorylation in skeletal muscle cells...
  36. Kawasaki B, Liao Y, Birnbaumer L. Role of Src in C3 transient receptor potential channel function and evidence for a heterogeneous makeup of receptor- and store-operated Ca2+ entry channels. Proc Natl Acad Sci U S A. 2006;103:335-40 pubmed
    ..isoform 3 (TRPC3), a cation channel thought to be involved in SOCE and/or ROCE, was recently shown to depend on src tyrosine kinase activity...
  37. Nanda N, Iismaa S, Copeland N, Gilbert D, Jenkins N, Graham R, et al. Organization and chromosomal mapping of mouse Gh/tissue transglutaminase gene (Tgm2). Arch Biochem Biophys. 1999;366:151-6 pubmed
    ..Tgm2 is in the vicinity of two uncloned mouse mutations, diminutive (dm) and blind-sterile (bs). Genomic DNA from dm mice was unavailable; however, Southern blot analysis of bs DNA showed no gross rearrangements of Tgm2. ..
  38. Song K, Scherer P, Tang Z, Okamoto T, Li S, Chafel M, et al. Expression of caveolin-3 in skeletal, cardiac, and smooth muscle cells. Caveolin-3 is a component of the sarcolemma and co-fractionates with dystrophin and dystrophin-associated glycoproteins. J Biol Chem. 1996;271:15160-5 pubmed
    ..as a model system, we observe that caveolin-3 co-fractionates with cytoplasmic signaling molecules (G-proteins and Src-like kinases) and members of the dystrophin complex (dystrophin, alpha-sarcoglycan, and beta-dystroglycan), but is ..
  39. Rooke N, Markovtsov V, Cagavi E, Black D. Roles for SR proteins and hnRNP A1 in the regulation of c-src exon N1. Mol Cell Biol. 2003;23:1874-84 pubmed
    The splicing of the c-src exon N1 is controlled by an intricate combination of positive and negative RNA elements. Most previous work on these sequences focused on intronic elements found upstream and downstream of exon N1...
  40. Takeshita S, Fumoto T, Matsuoka K, Park K, Aburatani H, Kato S, et al. Osteoclast-secreted CTHRC1 in the coupling of bone resorption to formation. J Clin Invest. 2013;123:3914-24 pubmed publisher
    ..These data demonstrate that CTHRC1 is an osteoclast-secreted coupling factor that regulates bone remodeling. ..
  41. Osborne D, Wetzel S. Trogocytosis results in sustained intracellular signaling in CD4(+) T cells. J Immunol. 2012;189:4728-39 pubmed publisher
    ..Through the use of the Src inhibitor PP2, we demonstrate that trogocytosed molecules directly sustain TCR signaling...
  42. Check J, Byrd C, Menio J, Rippe R, Hines I, Wheeler M. Src kinase participates in LPS-induced activation of NADPH oxidase. Mol Immunol. 2010;47:756-62 pubmed publisher
    ..The hypothesis is that LPS-induced src kinase and PI3 kinase (PI3K) facilitates the activation of p47(phox), the regulatory subunit of NADPH oxidase...
  43. Chojnacka K, Mruk D. The Src non-receptor tyrosine kinase paradigm: New insights into mammalian Sertoli cell biology. Mol Cell Endocrinol. 2015;415:133-42 pubmed publisher
    b>Src kinases are non-receptor tyrosine kinases that phosphorylate diverse substrates, which control processes such as cell proliferation, differentiation and survival; cell adhesion; and cell motility...
  44. Huang Y, Yang H, Huang S, Ou G, Hsu Y, Hsu M. Interleukin-6 Induces Vascular Endothelial Growth Factor-C Expression via Src-FAK-STAT3 Signaling in Lymphatic Endothelial Cells. PLoS ONE. 2016;11:e0158839 pubmed publisher
    ..STAT3 knockdown by STAT3 siRNA abrogated IL-6's actions in elevating VEGF-C mRNA and protein levels. Moreover, Src-FAK signaling blockade reduced IL-6's enhancing effects of increasing STAT3 binding to the VEGF-C promoter region, ..
  45. Chang L, Huang C, Cheng C, Chen B, Chen H. Differential effect of the focal adhesion kinase Y397F mutant on v-Src-stimulated cell invasion and tumor growth. J Biomed Sci. 2005;12:571-85 pubmed
    ..FAK) rapidly undergoes autophosphorylation on its Tyr-397 which consequently serves as a binding site for the Src homology 2 domains of the Src family protein kinases and several other intracellular signaling molecules...
  46. Terada N, Saitoh Y, Ohno N, Komada M, Yamauchi J, Ohno S. Involvement of Src in the membrane skeletal complex, MPP6-4.1G, in Schmidt-Lanterman incisures of mouse myelinated nerve fibers in PNS. Histochem Cell Biol. 2013;140:213-22 pubmed publisher
    ..In this study, we report localization of a signal transduction protein, Src, in the SLIs of mouse sciatic nerves, and its phosphorylation states in Y527 and Y418 (P527 and P418, respectively) ..
  47. Gout I, Dhand R, Hiles I, Fry M, Panayotou G, Das P, et al. The GTPase dynamin binds to and is activated by a subset of SH3 domains. Cell. 1993;75:25-36 pubmed
    b>Src homology 3 (SH3) domains have been implicated in mediating protein-protein interactions in receptor signaling processes; however, the precise role of this domain remains unclear...
  48. Curcio M, Batista W, Linares E, Nascimento F, Moraes M, Borges R, et al. Regulatory effects of nitric oxide on Src kinase, FAK, p130Cas, and receptor protein tyrosine phosphatase alpha (PTP-alpha): a role for the cellular redox environment. Antioxid Redox Signal. 2010;13:109-25 pubmed publisher
    The role of NO in regulating the focal adhesion proteins, Src, FAK, p130 Cas, and PTP-alpha, was investigated...
  49. Davis M, Cai H, McCann L, Fukai T, Harrison D. Role of c-Src in regulation of endothelial nitric oxide synthase expression during exercise training. Am J Physiol Heart Circ Physiol. 2003;284:H1449-53 pubmed
    We have shown that c-Src plays a role in shear stress stimulation of endothelial nitric oxide synthase (eNOS) expression in cultured cells...
  50. West J, Carrier E, Bloodworth N, Schroer A, Chen P, Ryzhova L, et al. Serotonin 2B Receptor Antagonism Prevents Heritable Pulmonary Arterial Hypertension. PLoS ONE. 2016;11:e0148657 pubmed publisher
    ..Both BMPR2 mutation and agonists to the serotonin receptor HTR2B have been shown to cause activation of SRC tyrosine kinase; conversely, antagonists to HTR2B inhibit SRC trafficking and downstream function...
  51. Kuroiwa M, Oneyama C, Nada S, Okada M. The guanine nucleotide exchange factor Arhgef5 plays crucial roles in Src-induced podosome formation. J Cell Sci. 2011;124:1726-38 pubmed publisher
    ..Here, we show that a guanine nucleotide exchange factor (GEF) for Rho family GTPases (Arhgef5) is crucial for Src-induced podosome formation...
  52. Larner A, Finbloom D. Protein tyrosine phosphorylation as a mechanism which regulates cytokine activation of early response genes. Biochim Biophys Acta. 1995;1266:278-87 pubmed
    ..Recent advances have been made in purification and cloning of Src homology 2 and 3 (SH2/SH3) domain-containing transcription factors which are required for the activation of early ..
  53. Sekimoto H, Eipper Mains J, Pond Tor S, Boney C. (alpha)v(beta)3 integrins and Pyk2 mediate insulin-like growth factor I activation of Src and mitogen-activated protein kinase in 3T3-L1 cells. Mol Endocrinol. 2005;19:1859-67 pubmed
    ..We have previously shown that IGF-I-stimulated 3T3-L1 cell proliferation is dependent on Src activation of the ERK-1/2 MAPK pathway...
  54. Tyryshkin A, Gorgun F, Abdel Fattah E, Mazumdar T, Pandit L, Zeng S, et al. Src kinase-mediated phosphorylation stabilizes inducible nitric-oxide synthase in normal cells and cancer cells. J Biol Chem. 2010;285:784-92 pubmed publisher
    b>Src kinases are key regulators of cellular proliferation, survival, motility, and invasiveness. They play important roles in the regulation of inflammation and cancer...
  55. Gordon E, Fukuhara D, Weström S, Padhan N, Sjöström E, van Meeteren L, et al. The endothelial adaptor molecule TSAd is required for VEGF-induced angiogenic sprouting through junctional c-Src activation. Sci Signal. 2016;9:ra72 pubmed publisher
    ..a process mediated by the VEGFR2 downstream effectors T cell-specific adaptor (TSAd) and the tyrosine kinase c-Src. We investigated whether the VEGFR2-TSAd-c-Src pathway was required for angiogenic sprouting...
  56. Amling M, Neff L, Priemel M, Schilling A, Rueger J, Baron R. Progressive increase in bone mass and development of odontomas in aging osteopetrotic c-src-deficient mice. Bone. 2000;27:603-10 pubmed
    The critical role of c-src in osteoclast-mediated bone resorption has been emphasized by gene deletion experiments in mice...
  57. Laplante P, Raymond M, Labelle A, Abe J, Iozzo R, Hébert M. Perlecan proteolysis induces an alpha2beta1 integrin- and Src family kinase-dependent anti-apoptotic pathway in fibroblasts in the absence of focal adhesion kinase activation. J Biol Chem. 2006;281:30383-92 pubmed
    ..Co-incubation of fibroblasts for 24 h with SSC or LG3 in the presence of PP2 (AG1879), a biochemical inhibitor of Src family kinases (SFKs) and focal adhesion kinase, showed a significantly decreased anti-apoptotic response...
  58. Jiang G, den Hertog J, Su J, Noel J, Sap J, Hunter T. Dimerization inhibits the activity of receptor-like protein-tyrosine phosphatase-alpha. Nature. 1999;401:606-10 pubmed
    ..mouse embryo cells increased dephosphorylation and activity of Tyr 529 in the protein tyrosine kinase c-Src; in contrast, expression of a Pro137Cys mutant did not...
  59. Koh A, Demiralp B, Neiva K, Hooten J, Nohutcu R, Shim H, et al. Cells of the osteoclast lineage as mediators of the anabolic actions of parathyroid hormone in bone. Endocrinology. 2005;146:4584-96 pubmed
    ..In contrast, using c-src mutant mice with a late osteoclast differentiation defect did not hinder the anabolic action, suggesting key target ..
  60. Pham N, Magalhaes J, Do T, Schwock J, Dhani N, Cao P, et al. Activation of Src and Src-associated signaling pathways in relation to hypoxia in human cancer xenograft models. Int J Cancer. 2009;124:280-6 pubmed publisher
    The hypoxic response in vitro involves alterations in signaling proteins, including Src, STAT3 and AKT that are considered to be broadly pro-survival...
  61. Hosking C, Ulloa F, Hogan C, Ferber E, Figueroa A, Gevaert K, et al. The transcriptional repressor Glis2 is a novel binding partner for p120 catenin. Mol Biol Cell. 2007;18:1918-27 pubmed
    ..In this study, we show that coexpression of Glis2 and Src induces nuclear translocation of p120...
  62. Lopez R, Carron C, Ghysdael J. v-SRC specifically regulates the nucleo-cytoplasmic delocalization of the major isoform of TEL (ETV6). J Biol Chem. 2003;278:41316-25 pubmed
    ..Here we show that the v-SRC protein-tyrosine kinase relieves the repressive activity of TEL-M1, an activity that is associated with the v-SRC-..
  63. Martinez Quiles N, Ho H, Kirschner M, Ramesh N, Geha R. Erk/Src phosphorylation of cortactin acts as a switch on-switch off mechanism that controls its ability to activate N-WASP. Mol Cell Biol. 2004;24:5269-80 pubmed
    ..Cortactin is a target for phosphorylation by Src tyrosine kinases and by serine/threonine kinases that include Erk...
  64. Cordes S, Barsh G. The mouse segmentation gene kr encodes a novel basic domain-leucine zipper transcription factor. Cell. 1994;79:1025-34 pubmed
    ..The identity, expression, and mutant phenotype of kr indicate an early role in axial patterning and provide insights into the molecular and embryologic mechanisms that govern hindbrain and otic development. ..
  65. Lesourne R, Zvezdova E, Song K, El Khoury D, Uehara S, Barr V, et al. Interchangeability of Themis1 and Themis2 in thymocyte development reveals two related proteins with conserved molecular function. J Immunol. 2012;189:1154-61 pubmed publisher
    ..These results suggest that conserved molecular features of the Themis1 and Themis2 proteins are important for their biological activity and predict that Themis1 and Themis2 may perform similar functions in T and B cells, respectively. ..
  66. Lee E, Kim J, Gong J, Park S, Kang Y. Inhibition of osteoclast activation by phloretin through disturbing αvβ3 integrin-c-Src pathway. Biomed Res Int. 2015;2015:680145 pubmed publisher
    ..The RANKL induction of actin rings and vacuolar-type H(+)-ATPase entailed Pyk2 phosphorylation and c-Src and c-Cbl induction, all of which were blunted by phloretin...
  67. Ware M, Tice D, Parsons S, Lauffenburger D. Overexpression of cellular Src in fibroblasts enhances endocytic internalization of epidermal growth factor receptor. J Biol Chem. 1997;272:30185-90 pubmed
    Previous studies have demonstrated a requirement for the nonreceptor tyrosine kinase, cellular Src (c-Src), in epidermal growth factor (EGF)-induced mitogenesis and a synergistic interaction between c-Src and EGF receptor (EGFR) in ..
  68. Fedida Metula S, Feldman B, Koshelev V, Levin Gromiko U, Voronov E, Fishman D. Lipid rafts couple store-operated Ca2+ entry to constitutive activation of PKB/Akt in a Ca2+/calmodulin-, Src- and PP2A-mediated pathway and promote melanoma tumor growth. Carcinogenesis. 2012;33:740-50 pubmed publisher
    ..melanoma model, we show that ablation of rafts with methyl-?-cyclodextrin (M?CD) inactivated PKB by inhibiting Src kinase and reactivating the negative PKB modulator, PP2A phosphatase...
  69. Wang L, Vervoort V, Wallez Y, Coré N, Cremer H, Pasquale E. The SRC homology 2 domain protein Shep1 plays an important role in the penetration of olfactory sensory axons into the forebrain. J Neurosci. 2010;30:13201-10 pubmed publisher
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    The Src homology 3 (SH3) region is a small protein domain present in a very large group of proteins, including cytoskeletal elements and signaling proteins...
  71. Broecker F, Hardt C, Herwig R, Timmermann B, Kerick M, Wunderlich A, et al. Transcriptional signature induced by a metastasis-promoting c-Src mutant in a human breast cell line. FEBS J. 2016;283:1669-88 pubmed publisher
    Deletions at the C-terminus of the proto-oncogene protein c-Src kinase are found in the viral oncogene protein v-Src as well as in some advanced human colon cancers...
  72. Tai G, Hohenstein P, Davies J. FAK-Src signalling is important to renal collecting duct morphogenesis: discovery using a hierarchical screening technique. Biol Open. 2013;2:416-23 pubmed publisher
    ..The final stage is ex vivo organ culture. We demonstrate the utility of the screen by using it to identify the FAK-Src-pathway signalling as being important for collecting duct development, specifically for the cell proliferation on ..
  73. Thobe B, Frink M, Choudhry M, Schwacha M, Bland K, Chaudry I. Src family kinases regulate p38 MAPK-mediated IL-6 production in Kupffer cells following hypoxia. Am J Physiol Cell Physiol. 2006;291:C476-82 pubmed
    ..We hypothesized that Src family kinases play a role in mediating KC mitogen-activated protein kinase (MAPK) signaling and their cytokine ..
  74. Schlaepfer D, Hunter T. Evidence for in vivo phosphorylation of the Grb2 SH2-domain binding site on focal adhesion kinase by Src-family protein-tyrosine kinases. Mol Cell Biol. 1996;16:5623-33 pubmed
    ..We showed previously that the c-Src nonreceptor PTK and the Grb2 SH2/SH3 adaptor protein bound directly to FAK after fibronectin stimulation (D. D...
  75. Sun J, Pedersen M, Ronnstrand L. The D816V mutation of c-Kit circumvents a requirement for Src family kinases in c-Kit signal transduction. J Biol Chem. 2009;284:11039-47 pubmed publisher
    ..In this study, we aimed to investigate the role of Src family kinases in c-Kit/D816V signaling...
  76. Cheriyath V, Desgranges Z, Roy A. c-Src-dependent transcriptional activation of TFII-I. J Biol Chem. 2002;277:22798-805 pubmed
    ..Here we show that TFII-I undergoes a c-Src-dependent tyrosine phosphorylation on tyrosine residues 248 and 611 and translocates to the nucleus in response to ..